#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99972	uniprotkb:P09486	intact:EBI-11692272|uniprotkb:B2RD84|uniprotkb:O00620|uniprotkb:Q7Z6Q9|ensembl:ENSP00000037502	intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061	psi-mi:myoc_human(display_long)|uniprotkb:Myocilin 55 kDa subunit(gene name synonym)|uniprotkb:Trabecular meshwork-induced glucocorticoid response protein(gene name synonym)|uniprotkb:MYOC(gene name)|psi-mi:MYOC(display_short)|uniprotkb:GLC1A(gene name synonym)|uniprotkb:TIGR(gene name synonym)	psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short)	psi-mi:"MI:0018"(two hybrid)	Aroca-Aguilar et al. (2011)	pubmed:20926826|imex:IM-25201	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11692270|imex:IM-25201-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000252.1|ensembl:ENSG00000034971(gene)|ensembl:ENST00000037502(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005929"(cilium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014734"(skeletal muscle hypertrophy)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0038133"(ERBB2-ERBB3 signaling pathway)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR031213|rcsb pdb:4WXQ|rcsb pdb:4WXS|rcsb pdb:4WXU|rcsb pdb:6OU0|rcsb pdb:6OU1|rcsb pdb:6OU2|rcsb pdb:6OU3|rcsb pdb:6PKD|rcsb pdb:6PKE|rcsb pdb:6PKF	refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N	-	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/05/03	2016/05/03	rogid:pku0+OsoErOjbVJK0Q+k6ToyDfw9606	rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606	rigid:MJ+cfP96URBTyo97B01ahljvg6o	false	sufficient binding region:233-504	sufficient binding region:152-303(IPR019577)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99972	uniprotkb:Q14515	intact:EBI-11692272|uniprotkb:B2RD84|uniprotkb:O00620|uniprotkb:Q7Z6Q9|ensembl:ENSP00000037502	intact:EBI-2682673|uniprotkb:B4E2Z0|uniprotkb:E7ESU2|uniprotkb:Q14800|ensembl:ENSP00000282470|ensembl:ENSP00000414856	psi-mi:myoc_human(display_long)|uniprotkb:Myocilin 55 kDa subunit(gene name synonym)|uniprotkb:Trabecular meshwork-induced glucocorticoid response protein(gene name synonym)|uniprotkb:MYOC(gene name)|psi-mi:MYOC(display_short)|uniprotkb:GLC1A(gene name synonym)|uniprotkb:TIGR(gene name synonym)	psi-mi:sprl1_human(display_long)|uniprotkb:High endothelial venule protein(gene name synonym)|uniprotkb:MAST 9(gene name synonym)|uniprotkb:SPARCL1(gene name)|psi-mi:SPARCL1(display_short)	psi-mi:"MI:0018"(two hybrid)	Aroca-Aguilar et al. (2011)	pubmed:20926826|imex:IM-25201	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11692335|imex:IM-25201-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000252.1|ensembl:ENSG00000034971(gene)|ensembl:ENST00000037502(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005929"(cilium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014734"(skeletal muscle hypertrophy)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0038133"(ERBB2-ERBB3 signaling pathway)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR031213|rcsb pdb:4WXQ|rcsb pdb:4WXS|rcsb pdb:4WXU|rcsb pdb:6OU0|rcsb pdb:6OU1|rcsb pdb:6OU2|rcsb pdb:6OU3|rcsb pdb:6PKD|rcsb pdb:6PKE|rcsb pdb:6PKF	refseq:NP_001278905.1|refseq:NP_001278906.1|refseq:NP_001121782.1|refseq:NP_004675.3|ensembl:ENSG00000152583(gene)|ensembl:ENST00000282470(transcript)|ensembl:ENST00000418378(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR016359(SPARC-like protein 1)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|mint:Q14515|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/05/03	2016/05/03	rogid:pku0+OsoErOjbVJK0Q+k6ToyDfw9606	rogid:0HWQK3GxsY5R4UiaTQdwJKFKo509606	rigid:vLgRybvDBZpA8YB0Rm8iMm3z3o4	false	sufficient binding region:233-504	sufficient binding region:510-664(IPR019577)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99972	uniprotkb:Q14515	intact:EBI-11692272|uniprotkb:B2RD84|uniprotkb:O00620|uniprotkb:Q7Z6Q9|ensembl:ENSP00000037502	intact:EBI-2682673|uniprotkb:B4E2Z0|uniprotkb:E7ESU2|uniprotkb:Q14800|ensembl:ENSP00000282470|ensembl:ENSP00000414856	psi-mi:myoc_human(display_long)|uniprotkb:Myocilin 55 kDa subunit(gene name synonym)|uniprotkb:Trabecular meshwork-induced glucocorticoid response protein(gene name synonym)|uniprotkb:MYOC(gene name)|psi-mi:MYOC(display_short)|uniprotkb:GLC1A(gene name synonym)|uniprotkb:TIGR(gene name synonym)	psi-mi:sprl1_human(display_long)|uniprotkb:High endothelial venule protein(gene name synonym)|uniprotkb:MAST 9(gene name synonym)|uniprotkb:SPARCL1(gene name)|psi-mi:SPARCL1(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Aroca-Aguilar et al. (2011)	pubmed:20926826|imex:IM-25201	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11692350|imex:IM-25201-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000252.1|ensembl:ENSG00000034971(gene)|ensembl:ENST00000037502(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005929"(cilium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014734"(skeletal muscle hypertrophy)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0038133"(ERBB2-ERBB3 signaling pathway)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR031213|rcsb pdb:4WXQ|rcsb pdb:4WXS|rcsb pdb:4WXU|rcsb pdb:6OU0|rcsb pdb:6OU1|rcsb pdb:6OU2|rcsb pdb:6OU3|rcsb pdb:6PKD|rcsb pdb:6PKE|rcsb pdb:6PKF	refseq:NP_001278905.1|refseq:NP_001278906.1|refseq:NP_001121782.1|refseq:NP_004675.3|ensembl:ENSG00000152583(gene)|ensembl:ENST00000282470(transcript)|ensembl:ENST00000418378(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR016359(SPARC-like protein 1)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|mint:Q14515|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:5 C/D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2017/08/09	rogid:pku0+OsoErOjbVJK0Q+k6ToyDfw9606	rogid:0HWQK3GxsY5R4UiaTQdwJKFKo509606	rigid:vLgRybvDBZpA8YB0Rm8iMm3z3o4	false	sufficient binding region:217-504|ha tag:c-c|his tag:c-c	sufficient binding region:401-664(IPR019577)|myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q99972	uniprotkb:P09486	intact:EBI-11692272|uniprotkb:B2RD84|uniprotkb:O00620|uniprotkb:Q7Z6Q9|ensembl:ENSP00000037502	intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061	psi-mi:myoc_human(display_long)|uniprotkb:Myocilin 55 kDa subunit(gene name synonym)|uniprotkb:Trabecular meshwork-induced glucocorticoid response protein(gene name synonym)|uniprotkb:MYOC(gene name)|psi-mi:MYOC(display_short)|uniprotkb:GLC1A(gene name synonym)|uniprotkb:TIGR(gene name synonym)	psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Aroca-Aguilar et al. (2011)	pubmed:20926826|imex:IM-25201	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11692359|imex:IM-25201-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000252.1|ensembl:ENSG00000034971(gene)|ensembl:ENST00000037502(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005929"(cilium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014734"(skeletal muscle hypertrophy)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0038133"(ERBB2-ERBB3 signaling pathway)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR031213|rcsb pdb:4WXQ|rcsb pdb:4WXS|rcsb pdb:4WXU|rcsb pdb:6OU0|rcsb pdb:6OU1|rcsb pdb:6OU2|rcsb pdb:6OU3|rcsb pdb:6PKD|rcsb pdb:6PKE|rcsb pdb:6PKF	refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N	-	-	-	figure legend:5 A/B|comment:"Myocilin-Ct-HA showed reduced interaction affinity (compared to \"full length\" Myocilin) with SPARC, hevin, and the C-terminal fragments of these two proteins (½Bmax ranging from 19.4 to 38.2 pmol; Table 3)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2017/08/09	rogid:pku0+OsoErOjbVJK0Q+k6ToyDfw9606	rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606	rigid:MJ+cfP96URBTyo97B01ahljvg6o	false	sufficient binding region:217-504|his tag:c-c|ha tag:c-c	sufficient binding region:152-303(IPR019577)|his tag:c-c|myc tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P09486	uniprotkb:Q99972	intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061	intact:EBI-11692272|uniprotkb:B2RD84|uniprotkb:O00620|uniprotkb:Q7Z6Q9|ensembl:ENSP00000037502	psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short)	psi-mi:myoc_human(display_long)|uniprotkb:Myocilin 55 kDa subunit(gene name synonym)|uniprotkb:Trabecular meshwork-induced glucocorticoid response protein(gene name synonym)|uniprotkb:MYOC(gene name)|psi-mi:MYOC(display_short)|uniprotkb:GLC1A(gene name synonym)|uniprotkb:TIGR(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Aroca-Aguilar et al. (2011)	pubmed:20926826|imex:IM-25201	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11692405|imex:IM-25201-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N	refseq:NP_000252.1|ensembl:ENSG00000034971(gene)|ensembl:ENST00000037502(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005929"(cilium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014734"(skeletal muscle hypertrophy)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0038133"(ERBB2-ERBB3 signaling pathway)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR031213|rcsb pdb:4WXQ|rcsb pdb:4WXS|rcsb pdb:4WXU|rcsb pdb:6OU0|rcsb pdb:6OU1|rcsb pdb:6OU2|rcsb pdb:6OU3|rcsb pdb:6PKD|rcsb pdb:6PKE|rcsb pdb:6PKF	-	-	-	figure legend:5 A/B, Figure 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2017/08/09	rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606	rogid:pku0+OsoErOjbVJK0Q+k6ToyDfw9606	rigid:MJ+cfP96URBTyo97B01ahljvg6o	false	sufficient binding region:152-303(IPR019577)|his tag:c-c|myc tag:c-c	myc tag:c-c|sufficient binding region:217-504|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P09486	uniprotkb:Q99972	intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061	intact:EBI-11692272|uniprotkb:B2RD84|uniprotkb:O00620|uniprotkb:Q7Z6Q9|ensembl:ENSP00000037502	psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short)	psi-mi:myoc_human(display_long)|uniprotkb:Myocilin 55 kDa subunit(gene name synonym)|uniprotkb:Trabecular meshwork-induced glucocorticoid response protein(gene name synonym)|uniprotkb:MYOC(gene name)|psi-mi:MYOC(display_short)|uniprotkb:GLC1A(gene name synonym)|uniprotkb:TIGR(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Aroca-Aguilar et al. (2011)	pubmed:20926826|imex:IM-25201	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11692405|imex:IM-25201-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N	refseq:NP_000252.1|ensembl:ENSG00000034971(gene)|ensembl:ENST00000037502(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005929"(cilium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014734"(skeletal muscle hypertrophy)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0038133"(ERBB2-ERBB3 signaling pathway)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR031213|rcsb pdb:4WXQ|rcsb pdb:4WXS|rcsb pdb:4WXU|rcsb pdb:6OU0|rcsb pdb:6OU1|rcsb pdb:6OU2|rcsb pdb:6OU3|rcsb pdb:6PKD|rcsb pdb:6PKE|rcsb pdb:6PKF	-	-	-	figure legend:5 A/B, Figure 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2017/08/09	rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606	rogid:pku0+OsoErOjbVJK0Q+k6ToyDfw9606	rigid:MJ+cfP96URBTyo97B01ahljvg6o	false	sufficient binding region:152-303(IPR019577)|his tag:c-c|myc tag:c-c	sufficient binding region:217-504|his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)