#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07585	uniprotkb:P13497-2	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	intact:EBI-12509497|ensembl:ENSP00000306121|ensembl:ENSP00000428332	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:p13497-2(display_long)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	von et al. (2010)	imex:IM-25493|pubmed:20026052	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12509491|imex:IM-25493-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	ensembl:ENSG00000168487(gene)|ensembl:ENST00000306349(transcript)|ensembl:ENST00000520970(transcript)|intact:EBI-489827(isoform-parent)	-	-	-	figure legend:2A, 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/07/20	2016/08/19	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	rogid:lObdtVRHmod2GwGddF7d51zcmVE9606	rigid:TvNuMZAxc784U+Bx56+0s3l7acM	false	sufficient binding region:17-359	sufficient binding region:121-730|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28653	uniprotkb:P13497-2	intact:EBI-310037|uniprotkb:Q61355|ensembl:ENSMUSP00000033741|ensembl:ENSMUSP00000126768	intact:EBI-12509497|ensembl:ENSP00000306121|ensembl:ENSP00000428332	psi-mi:pgs1_mouse(display_long)|uniprotkb:Bgn(gene name)|psi-mi:Bgn(display_short)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)	psi-mi:p13497-2(display_long)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	von et al. (2010)	imex:IM-25493|pubmed:20026052	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12509592|imex:IM-25493-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031568.2|ensembl:ENSMUSG00000031375(gene)|ensembl:ENSMUST00000033741(transcript)|ensembl:ENSMUST00000169489(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|mint:P28653|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	ensembl:ENSG00000168487(gene)|ensembl:ENST00000306349(transcript)|ensembl:ENST00000520970(transcript)|intact:EBI-489827(isoform-parent)	-	-	-	figure legend:2B, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/07/20	2016/08/19	rogid:JMzFTZDaoqlvJxXPkUgXCiit9TE10090	rogid:lObdtVRHmod2GwGddF7d51zcmVE9606	rigid:yy8/7jjS3OZYi37VkZWYRYoMQAs	false	sufficient binding region:17-369	sufficient binding region:121-730|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13497-4	uniprotkb:P07585	intact:EBI-12509753|ensembl:ENSP00000428665	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	psi-mi:p13497-4(display_long)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:"MI:0435"(protease assay)	von et al. (2010)	imex:IM-25493|pubmed:20026052	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12509742|imex:IM-25493-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168487(gene)|ensembl:ENST00000471755(transcript)|intact:EBI-489827(isoform-parent)	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	-	isoform-comment:May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/07/20	2016/08/19	rogid:w4ZTSIQtURemCbb1f+Fg1Vhaf2g9606	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	rigid:8d3A0LZ6Zw2DTRPMBvWc3cIXbtU	false	-	sufficient binding region:17-359	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98063	uniprotkb:P07585	intact:EBI-12509853|ensembl:ENSMUSP00000022693|uniprotkb:Q6NZM2	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	psi-mi:bmp1_mouse(display_long)|uniprotkb:Bmp1(gene name)|psi-mi:Bmp1(display_short)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:"MI:0435"(protease assay)	von et al. (2010)	imex:IM-25493|pubmed:20026052	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12509846|imex:IM-25493-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022098(gene)|ensembl:ENSMUST00000022693(transcript)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0051216"(cartilage development)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR006026(Peptidase, metallopeptidases)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|reactome:R-MMU-1474228|reactome:R-MMU-1650814|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-8963896|refseq:NP_033885.2|refseq:XP_006518523.1	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	-	-	-	figure legend:3A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/07/20	2016/08/19	rogid:xH9Eee00zxYUgCyIw5I4aFGsCng10090	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	rigid:4dqHDf5lPdMKH1nN2ULtCWoy8j0	false	-	sufficient binding region:17-359	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28653	uniprotkb:P13497-4	intact:EBI-310037|uniprotkb:Q61355|ensembl:ENSMUSP00000033741|ensembl:ENSMUSP00000126768	intact:EBI-12509753|ensembl:ENSP00000428665	psi-mi:pgs1_mouse(display_long)|uniprotkb:Bgn(gene name)|psi-mi:Bgn(display_short)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)	psi-mi:p13497-4(display_long)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:"MI:0435"(protease assay)	von et al. (2010)	imex:IM-25493|pubmed:20026052	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12509898|imex:IM-25493-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031568.2|ensembl:ENSMUSG00000031375(gene)|ensembl:ENSMUST00000033741(transcript)|ensembl:ENSMUST00000169489(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|mint:P28653|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	ensembl:ENSG00000168487(gene)|ensembl:ENST00000471755(transcript)|intact:EBI-489827(isoform-parent)	-	-	isoform-comment:May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/07/20	2016/08/19	rogid:JMzFTZDaoqlvJxXPkUgXCiit9TE10090	rogid:w4ZTSIQtURemCbb1f+Fg1Vhaf2g9606	rigid:PVj5y1KMjT4b30r1AL82uw591kg	false	sufficient binding region:17-369	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28653	uniprotkb:P98063	intact:EBI-310037|uniprotkb:Q61355|ensembl:ENSMUSP00000033741|ensembl:ENSMUSP00000126768	intact:EBI-12509853|ensembl:ENSMUSP00000022693|uniprotkb:Q6NZM2	psi-mi:pgs1_mouse(display_long)|uniprotkb:Bgn(gene name)|psi-mi:Bgn(display_short)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)	psi-mi:bmp1_mouse(display_long)|uniprotkb:Bmp1(gene name)|psi-mi:Bmp1(display_short)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	von et al. (2010)	imex:IM-25493|pubmed:20026052	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12509944|imex:IM-25493-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031568.2|ensembl:ENSMUSG00000031375(gene)|ensembl:ENSMUST00000033741(transcript)|ensembl:ENSMUST00000169489(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|mint:P28653|reactome:R-MMU-1971475|reactome:R-MMU-2022870|reactome:R-MMU-2022923|reactome:R-MMU-2024101|reactome:R-MMU-3000178	ensembl:ENSMUSG00000022098(gene)|ensembl:ENSMUST00000022693(transcript)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0051216"(cartilage development)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR006026(Peptidase, metallopeptidases)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|reactome:R-MMU-1474228|reactome:R-MMU-1650814|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-8963896|refseq:NP_033885.2|refseq:XP_006518523.1	-	-	-	figure legend:3B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/07/20	2016/08/19	rogid:JMzFTZDaoqlvJxXPkUgXCiit9TE10090	rogid:xH9Eee00zxYUgCyIw5I4aFGsCng10090	rigid:P+ZZKN379yczmoWELByFRaf3lSM	false	sufficient binding region:17-369	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07585	uniprotkb:P13497-2	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	intact:EBI-12509497|ensembl:ENSP00000306121|ensembl:ENSP00000428332	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:p13497-2(display_long)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	von et al. (2010)	imex:IM-25493|pubmed:20026052	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12509962|imex:IM-25493-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	ensembl:ENSG00000168487(gene)|ensembl:ENST00000306349(transcript)|ensembl:ENST00000520970(transcript)|intact:EBI-489827(isoform-parent)	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/07/20	2016/08/19	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	rogid:lObdtVRHmod2GwGddF7d51zcmVE9606	rigid:TvNuMZAxc784U+Bx56+0s3l7acM	false	sufficient binding region:17-359|biological feature:30-31	sufficient binding region:121-730|his tag:c-c	-	-	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)