#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P22091 uniprotkb:O70374 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592234|imex:IM-25593-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint figure legend:1C and 2A|antagonist:"DMSO (causing cell differentiation)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O54972 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592234|imex:IM-25593-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein figure legend:1C and 2A|antagonist:"DMSO (causing cell differentiation)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O70374 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592248|imex:IM-25593-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false v5 tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O54972 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592248|imex:IM-25593-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false v5 tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O54972 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592592|imex:IM-25593-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2016/11/02 2016/11/02 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false gal4 dna binding domain:?-?|sufficient binding region:142-329 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O70374 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592592|imex:IM-25593-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2016/11/02 2016/11/02 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false gal4 dna binding domain:?-?|sufficient binding region:142-329 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O54972 uniprotkb:P22091 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592639|imex:IM-25593-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2016/11/02 2016/11/02 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rigid:SmzE2RmN7vKIa/9NFmTN4WdF300 false sufficient binding region:461-510|gal4 dna binding domain:?-?|sufficient binding region:46-242 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O54972 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592277|imex:IM-25593-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein figure legend:supplemental figure and text|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/02 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rigid:K3BPfIJHypQcS0qnrKzzFfzbKac false calmodulin binding peptide plus protein a tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22091 uniprotkb:O70374 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592277|imex:IM-25593-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint figure legend:supplemental figure and text|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/02 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rigid:K3BPfIJHypQcS0qnrKzzFfzbKac false calmodulin binding peptide plus protein a tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22091 uniprotkb:P70662 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592277|imex:IM-25593-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells - figure legend:supplemental figure and text|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/02 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 rigid:K3BPfIJHypQcS0qnrKzzFfzbKac false calmodulin binding peptide plus protein a tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22091 uniprotkb:P25801 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-3903256|ensembl:ENSMUSP00000117703|ensembl:ENSMUSP00000128317 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:rbtn2_mouse(display_long)|uniprotkb:Lmo2(gene name)|psi-mi:Lmo2(display_short)|uniprotkb:Rbtn-2(gene name synonym)|uniprotkb:Rbtn2(gene name synonym)|uniprotkb:Rhom-2(gene name synonym)|uniprotkb:Cysteine-rich protein TTG-2(gene name synonym)|uniprotkb:LIM domain only protein 2(gene name synonym)|uniprotkb:T-cell translocation protein 2(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592277|imex:IM-25593-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_001135808.1|refseq:NP_001135809.1|dip:DIP-24247N|refseq:XP_006498883.1|ensembl:ENSMUSG00000032698(gene)|ensembl:ENSMUST00000123437(transcript)|ensembl:ENSMUST00000170926(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|interpro:IPR001781(Zinc finger, LIM-type)|mint:P25801|rcsb pdb:1J2O|rcsb pdb:2L6Y|rcsb pdb:2L6Z|go:"GO:0003682"(chromatin binding)|reactome:R-MMU-8939236|rcsb pdb:2LXD - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells - figure legend:supplemental figure and text|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/02 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:kIZ60YCK4hzGaxmi6+zOSaMDlNY10090 rigid:K3BPfIJHypQcS0qnrKzzFfzbKac false calmodulin binding peptide plus protein a tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22091 uniprotkb:P17679 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592277|imex:IM-25593-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells - figure legend:supplemental figure and text|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/02 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 rigid:K3BPfIJHypQcS0qnrKzzFfzbKac false calmodulin binding peptide plus protein a tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22091 uniprotkb:O54972 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592353|imex:IM-25593-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein figure legend:2B|antagonist:"Erythropoetin (causing cell differentiation)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-fva)|taxid:10090(mouse splenic proerythrocytoblasts infected with Friend erythroleukemia virus) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O70374 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592353|imex:IM-25593-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint figure legend:2B|antagonist:"Erythropoetin (causing cell differentiation)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-fva)|taxid:10090(mouse splenic proerythrocytoblasts infected with Friend erythroleukemia virus) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O54972 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592382|imex:IM-25593-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein figure legend:3A|comment:Greater amounts of Eto2 and Mtgr1 were precipitated in cells transduced with both proteins, rather than one.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O70374 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592382|imex:IM-25593-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells comment:mint figure legend:3A|comment:Greater amounts of Eto2 and Mtgr1 were precipitated in cells transduced with both proteins, rather than one.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2016/11/02 2016/11/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rigid:zgLmiEQRqg0+8f0yplTOSykTj8k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O70374 uniprotkb:P22091 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:"MI:0096"(pull down) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592408|imex:IM-25593-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 - comment:mint comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells figure legend:3C|agonist:Cbfa2t3/Eto2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/02 2016/11/16 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rigid:E5vqL3e4kYDeBRS39zVbAcjss1g false 35s radiolabel:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O54972 uniprotkb:P22091 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:"MI:0096"(pull down) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12592403|imex:IM-25593-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236 - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells figure legend:3B|agonist:Tcf3/E47|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/02 2016/11/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rigid:SmzE2RmN7vKIa/9NFmTN4WdF300 false 35s radiolabel:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O54972 ensembl:ENSMUSG00000023216 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-12598425 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) uniprotkb:Epb42(gene name)|psi-mi:Epb42(display_short)|uniprotkb:Epb4.2(gene name synonym)|ensembl:epb42_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000023216(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12598416|imex:IM-25593-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") refseq:NP_038541.1 - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein - figure legend:4E|antagonist:DMSO|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 - - false - binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:O54972 ensembl:ENSMUSG00000051839 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-12598441 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) uniprotkb:Gypa(gene name)|psi-mi:Gypa(display_short)|ensembl:glpa_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000051839(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Cai et al. (2009) pubmed:19799863|imex:IM-25593 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12598434|imex:IM-25593-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)") refseq:NP_034499.3 - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein - figure legend:4Ei|antagonist:DMSO|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus) - 2016/11/02 2016/11/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 - - false - binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr)