#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:29108"	uniprotkb:Q96QV1	intact:EBI-1169353	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11666884|imex:IM-25072-24|wwpdb:3ho5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	-	-	-	figure legend:Table 1|3d-resolution:3.0A|3d-r-factors:R work 0.231  R Free  0.287|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2020/02/18	-	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	-	false	-	sufficient binding region:193-667(IPR011042)|his tag:c-c	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:Q15465	intact:EBI-1169353	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11666884|imex:IM-25072-24|wwpdb:3ho5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Table 1|3d-resolution:3.0A|3d-r-factors:R work 0.231  R Free  0.287|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2020/02/18	-	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	-	false	-	sufficient binding region:29-197(IPR009045)	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11666884|imex:IM-25072-24|wwpdb:3ho5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Table 1|3d-resolution:3.0A|3d-r-factors:R work 0.231  R Free  0.287|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2020/02/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15465	uniprotkb:Q96QV1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667103|imex:IM-25072-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/29	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	sufficient binding region:25-197(IPR009045)|flag tag:c-c	sufficient binding region:193-637(IPR011042)|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q15465	uniprotkb:Q96QV1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667140|imex:IM-25072-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	-	-	-	figure legend:3Ci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:150.0x10^-6(molar)	2016/03/08	2016/03/29	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	sufficient binding region:25-197(IPR009045)|flag tag:c-c	sufficient binding region:370-390	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q15465	uniprotkb:Q96QV1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667140|imex:IM-25072-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	-	-	-	figure legend:3Ci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:150.0x10^-6(molar)	2016/03/08	2016/03/29	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	sufficient binding region:25-197(IPR009045)|flag tag:c-c	sufficient binding region:193-637(IPR011042)|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q15465	uniprotkb:Q96QV1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667184|imex:IM-25072-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	-	-	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/29	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	sufficient binding region:29-197(IPR009045)|13c label:?-?	sufficient binding region:371-389(IPR011042)|mutation:389-389,371-371	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13635	uniprotkb:Q15465	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667219|imex:IM-25072-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/29	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:zxC/clhQCdWjOGTZLZKjRS9EByU	false	sufficient binding region:899-918|mutation:899-900,917-918	13c label:?-?|sufficient binding region:29-197(IPR009045)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QV1	uniprotkb:Q13635	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667290|imex:IM-25072-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	-	-	figure legend:4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/30	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:MQ979YbbuDVbVt3QeTtCx8fOU3U	false	sufficient binding region:371-389|mutation:371-371,389-389	sufficient binding region:899-918|mutation:899-900,917-918	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QV1	uniprotkb:Q15465	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667290|imex:IM-25072-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/30	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:MQ979YbbuDVbVt3QeTtCx8fOU3U	false	sufficient binding region:371-389|mutation:371-371,389-389	13c label:?-?|sufficient binding region:29-197(IPR009045)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15465	uniprotkb:Q96QV1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668275|imex:IM-25072-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	-	-	-	figure legend:Supp 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/29	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	sufficient binding region:29-197(IPR009045)|15n label:?-?	sufficient binding region:371-389(IPR000742)|mutation:389-389,371-371	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13635	uniprotkb:Q15465	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668291|imex:IM-25072-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Supp 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/29	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:zxC/clhQCdWjOGTZLZKjRS9EByU	false	sufficient binding region:899-918|mutation:899-900,917-918	15n label:?-?|sufficient binding region:29-197(IPR009045)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15465	uniprotkb:Q96QV1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:"MI:0892"(solid phase assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667319|imex:IM-25072-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	-	-	-	figure legend:Supp 7B|antagonist:"Antibody  \"5E1\"  (a high-affinity anti-Shh monoclonal antibody)  competes for SHH binding"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/29	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	biotin tag:n-n|sufficient binding region:24-197(IPR009045)|his tag:n-n	his tag:c-c|sufficient binding region:193-667(IPR011042)	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q96QV1	uniprotkb:Q15465	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667745|imex:IM-25072-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Supp 1Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:53.0x10^-9(molar)	2016/03/08	2016/03/29	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	his tag:c-c|sufficient binding region:193-667(IPR011042)	biotin tag:n-n|sufficient binding region:24-197(IPR009045)|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q96QV1	uniprotkb:Q15465	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667745|imex:IM-25072-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Supp 1Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:53.0x10^-9(molar)	2016/03/08	2016/03/29	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	his tag:c-c|sufficient binding region:193-667(IPR011042)	sufficient binding region:25-197(IPR009045)|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q96QV1	uniprotkb:Q15465	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667771|imex:IM-25072-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Supp 1Aii|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)	2016/03/08	2016/03/29	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:PYqUkf6uWymm0+4akRcPnCIQugc	false	sufficient binding region:193-667(IPR011042)|his tag:c-c	biotin tag:n-n|sufficient binding region:24-197(IPR009045)|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q96QV1	uniprotkb:O43323	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-11667804|uniprotkb:Q15794|ensembl:ENSP00000497483	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:dhh_human(display_long)|uniprotkb:HHG-3(gene name synonym)|uniprotkb:DHH(gene name)|psi-mi:DHH(display_short)	psi-mi:"MI:0892"(solid phase assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667771|imex:IM-25072-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	refseq:NP_066382.1|ensembl:ENSG00000139549(gene)|ensembl:ENST00000649637(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007286"(spermatid development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030238"(male sex determination)|go:"GO:0032355"(response to estradiol)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043627"(response to estrogen)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|rcsb pdb:2WFQ|rcsb pdb:2WFR|rcsb pdb:2WG3|rcsb pdb:3N1G|rcsb pdb:3N1Q|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-9690406|dip:DIP-48538N	-	-	-	figure legend:Supp 1Aii|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)	2016/03/08	2016/03/29	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:np53v7gpwEphQ7mPKwzvTwjy0DU9606	rigid:PYqUkf6uWymm0+4akRcPnCIQugc	false	sufficient binding region:193-667(IPR011042)|his tag:c-c	sufficient binding region:24-198(IPR009045)|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q96QV1	uniprotkb:Q15465	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667843|imex:IM-25072-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Supp 1Aiii|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)	2016/03/08	2016/03/29	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:LHrkD120l0hDJUMV548QT+tVgyY	false	sufficient binding region:193-667(IPR011042)|his tag:c-c	biotin tag:n-n|sufficient binding region:24-197(IPR009045)|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q96QV1	uniprotkb:Q14623	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-3918622|ensembl:ENSP00000295731|uniprotkb:B9EGM5|uniprotkb:Q8N4B9|uniprotkb:O43322	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:ihh_human(display_long)|uniprotkb:IHH(gene name)|psi-mi:IHH(display_short)|uniprotkb:HHG-2(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667843|imex:IM-25072-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	ensembl:ENST00000295731(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008233"(peptidase activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030704"(vitelline membrane formation)|ensembl:ENSG00000163501(gene)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031016"(pancreas development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048074"(negative regulation of eye pigmentation)|go:"GO:0048469"(cell maturation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060220"(camera-type eye photoreceptor cell fate commitment)|go:"GO:0060323"(head morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0072498"(embryonic skeletal joint development)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097421"(liver regeneration)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR033385|interpro:IPR036844|rcsb pdb:3K7G|rcsb pdb:3K7H|rcsb pdb:3K7I|rcsb pdb:3K7J|rcsb pdb:3N1F|rcsb pdb:3N1M|rcsb pdb:3N1O|rcsb pdb:3N1P|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-8941284|go:"GO:0048745"(smooth muscle tissue development)|refseq:NP_002172.2	-	-	-	figure legend:Supp 1Aiii|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)	2016/03/08	2016/03/29	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:TabhDnEaZgjsUhv57AKpLUf7++c9606	rigid:LHrkD120l0hDJUMV548QT+tVgyY	false	sufficient binding region:193-667(IPR011042)|his tag:c-c	sufficient binding region:29-202(IPR009045)|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q96QV1	uniprotkb:Q15465	intact:EBI-6598521|ensembl:ENSP00000296575|uniprotkb:Q6PK09|uniprotkb:Q8NCI7|uniprotkb:Q9BXK3|uniprotkb:Q9H1J4|uniprotkb:Q9H7E7	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:hhip_human(display_long)|uniprotkb:HHIP(gene name)|psi-mi:HHIP(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:UNQ5825/PRO19644(orf name)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Bosanac et al. (2009)	imex:IM-25072|pubmed:19561609	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667924|imex:IM-25072-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164161(gene)|ensembl:ENST00000296575(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0097108"(hedgehog family protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR012938(Glucose sorbosone dehydrogenase)|interpro:IPR018143|rcsb pdb:2WFT|rcsb pdb:2WFX|rcsb pdb:2WG3|rcsb pdb:2WG4|rcsb pdb:3HO3|rcsb pdb:3HO4|rcsb pdb:3HO5|reactome:R-HSA-5632681|refseq:NP_071920.1|dip:DIP-48536N	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Supp 4|antagonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:53.0x10^-9(molar)	2016/03/08	2016/03/29	rogid:6KwcG5O8W9cLg1m/NISJN5ZH2Uk9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:nbtJer96hrrWMF43bfQbTc2APOI	false	sufficient binding region:193-637(IPR011042)	biotin tag:n-n|sufficient binding region:24-197(IPR009045)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)