#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O76090 uniprotkb:O76090 intact:EBI-11693370|uniprotkb:A8K0W6|uniprotkb:B7Z3J8|uniprotkb:B7Z736|uniprotkb:O75904|uniprotkb:Q53YQ9|uniprotkb:Q8IUR9|uniprotkb:Q8IZ80|intact:EBI-28986811|ensembl:ENSP00000367282 intact:EBI-11693370|uniprotkb:A8K0W6|uniprotkb:B7Z3J8|uniprotkb:B7Z736|uniprotkb:O75904|uniprotkb:Q53YQ9|uniprotkb:Q8IUR9|uniprotkb:Q8IZ80|intact:EBI-28986811|ensembl:ENSP00000367282 psi-mi:best1_human(display_long)|uniprotkb:TU15B(gene name synonym)|uniprotkb:Vitelliform macular dystrophy protein 2(gene name synonym)|uniprotkb:BEST1(gene name)|psi-mi:BEST1(display_short)|uniprotkb:VMD2(gene name synonym) psi-mi:best1_human(display_long)|uniprotkb:TU15B(gene name synonym)|uniprotkb:Vitelliform macular dystrophy protein 2(gene name synonym)|uniprotkb:BEST1(gene name)|psi-mi:BEST1(display_short)|uniprotkb:VMD2(gene name synonym) psi-mi:"MI:0096"(pull down) Qu et al. (2009) pubmed:19372599|imex:IM-25212 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11693368|imex:IM-25212-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001132915.1|refseq:NP_001287715.1|refseq:NP_001287716.1|refseq:NP_004174.1|refseq:XP_005274272.1|ensembl:ENSP00000367282|ensembl:ENST00000449131|ensembl:ENSP00000399709|ensembl:ENSG00000167995(gene)|ensembl:ENST00000378043(transcript)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0007601"(visual perception)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR000615(Bestrophin)|interpro:IPR021134|interpro:IPR033041|reactome:R-HSA-2672351|refseq:XP_016873718.1 refseq:NP_001132915.1|refseq:NP_001287715.1|refseq:NP_001287716.1|refseq:NP_004174.1|refseq:XP_005274272.1|ensembl:ENSP00000367282|ensembl:ENST00000449131|ensembl:ENSP00000399709|ensembl:ENSG00000167995(gene)|ensembl:ENST00000378043(transcript)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0007601"(visual perception)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR000615(Bestrophin)|interpro:IPR021134|interpro:IPR033041|reactome:R-HSA-2672351|refseq:XP_016873718.1 - - - figure legend:3 C/D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/05/03 2016/05/05 rogid:W9iUkeZRF5zntcFyYSVtFTW0puc9606 rogid:W9iUkeZRF5zntcFyYSVtFTW0puc9606 rigid:LCE0q95AA+hKl4HdG/b75hi87Fk false mutation disrupting interaction strength:299-299|mutation disrupting interaction strength:301-301|mutation disrupting interaction strength:312-312|sufficient binding region:292-585|myc tag:c-c sufficient binding region:1-30|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:25-25 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O76090 uniprotkb:O76090 intact:EBI-11693370|uniprotkb:A8K0W6|uniprotkb:B7Z3J8|uniprotkb:B7Z736|uniprotkb:O75904|uniprotkb:Q53YQ9|uniprotkb:Q8IUR9|uniprotkb:Q8IZ80|intact:EBI-28986811|ensembl:ENSP00000367282 intact:EBI-11693370|uniprotkb:A8K0W6|uniprotkb:B7Z3J8|uniprotkb:B7Z736|uniprotkb:O75904|uniprotkb:Q53YQ9|uniprotkb:Q8IUR9|uniprotkb:Q8IZ80|intact:EBI-28986811|ensembl:ENSP00000367282 psi-mi:best1_human(display_long)|uniprotkb:TU15B(gene name synonym)|uniprotkb:Vitelliform macular dystrophy protein 2(gene name synonym)|uniprotkb:BEST1(gene name)|psi-mi:BEST1(display_short)|uniprotkb:VMD2(gene name synonym) psi-mi:best1_human(display_long)|uniprotkb:TU15B(gene name synonym)|uniprotkb:Vitelliform macular dystrophy protein 2(gene name synonym)|uniprotkb:BEST1(gene name)|psi-mi:BEST1(display_short)|uniprotkb:VMD2(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Qu et al. (2009) pubmed:19372599|imex:IM-25212 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11693459|imex:IM-25212-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001132915.1|refseq:NP_001287715.1|refseq:NP_001287716.1|refseq:NP_004174.1|refseq:XP_005274272.1|ensembl:ENSP00000367282|ensembl:ENST00000449131|ensembl:ENSP00000399709|ensembl:ENSG00000167995(gene)|ensembl:ENST00000378043(transcript)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0007601"(visual perception)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR000615(Bestrophin)|interpro:IPR021134|interpro:IPR033041|reactome:R-HSA-2672351|refseq:XP_016873718.1 refseq:NP_001132915.1|refseq:NP_001287715.1|refseq:NP_001287716.1|refseq:NP_004174.1|refseq:XP_005274272.1|ensembl:ENSP00000367282|ensembl:ENST00000449131|ensembl:ENSP00000399709|ensembl:ENSG00000167995(gene)|ensembl:ENST00000378043(transcript)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0007601"(visual perception)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR000615(Bestrophin)|interpro:IPR021134|interpro:IPR033041|reactome:R-HSA-2672351|refseq:XP_016873718.1 - - - figure legend:6, 7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/05/03 2016/05/05 rogid:W9iUkeZRF5zntcFyYSVtFTW0puc9606 rogid:W9iUkeZRF5zntcFyYSVtFTW0puc9606 rigid:LCE0q95AA+hKl4HdG/b75hi87Fk false cyan fluorescent protein tag:c-c|mutation decreasing interaction strength:301-301|mutation decreasing interaction strength:312-312 yellow fluorescent protein tag:c-c|mutation decreasing interaction strength:301-301|mutation decreasing interaction strength:312-312 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation)