#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06858	uniprotkb:Q9BY76	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lee et al. (2009)	imex:IM-25016|pubmed:19318355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11572398|imex:IM-25016-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1	-	-	-	figure legend:2, S4e, f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/10	2016/02/10	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606	rigid:ICr5zdb5an5E7WbOApOt/kgdZTM	false	flag tag:c-c	sufficient binding region:26-176|binding-associated region:29-53|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y5C1	uniprotkb:P06858	intact:EBI-298276|ensembl:ENSP00000360170|uniprotkb:A0JLS0|uniprotkb:B1ALJ0|uniprotkb:B2RCW1	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	psi-mi:angl3_human(display_long)|uniprotkb:ANGPTL3(gene name)|psi-mi:ANGPTL3(display_short)|uniprotkb:ANGPT5(gene name synonym)|uniprotkb:UNQ153/PRO179(orf name)|uniprotkb:Angiopoietin-like protein 3(gene name synonym)|uniprotkb:Angiopoietin-5(gene name synonym)	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lee et al. (2009)	imex:IM-25016|pubmed:19318355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11572411|imex:IM-25016-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132855(gene)|ensembl:ENST00000371129(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004859"(phospholipase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010519"(negative regulation of phospholipase activity)|go:"GO:0019915"(lipid storage)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055090"(acylglycerol homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR036056|rcsb pdb:6EUA|reactome:R-HSA-8963889|reactome:R-HSA-9029558|refseq:NP_055310.1	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	-	-	-	figure legend:6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/10	2016/02/10	rogid:IIGAiaAcO6Oi3w4rA4vdXQdy5EA9606	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rigid:6HeejTUuXjrgk+LxxPXO0xyUBmE	false	binding-associated region:32..32-56..56|sufficient binding region:20-243|his tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:91111"	uniprotkb:Q9Y5C1	intact:EBI-11565333	intact:EBI-298276|ensembl:ENSP00000360170|uniprotkb:A0JLS0|uniprotkb:B1ALJ0|uniprotkb:B2RCW1	psi-mi:1,2-di-o-lauryl-rac-glycero-3-glutaric acid 6'-methylresorufin ester(display_short)|psi-mi:"CHEBI:91111"(display_long)|intact:1,2-di-O-dodecyl-rac-glycero-3-glutaric acid 6'-methylresorufin ester(synonym)|intact:DGGR(synonym)|intact:"1-[2,3-bis(dodecyloxy)propyl] 6-methyl-3-oxo-3H-phenoxazin-7-yl pentanedioate"(iupac name)	psi-mi:angl3_human(display_long)|uniprotkb:ANGPTL3(gene name)|psi-mi:ANGPTL3(display_short)|uniprotkb:ANGPT5(gene name synonym)|uniprotkb:UNQ153/PRO179(orf name)|uniprotkb:Angiopoietin-like protein 3(gene name synonym)|uniprotkb:Angiopoietin-5(gene name synonym)	psi-mi:"MI:1354"(lipase assay)	Lee et al. (2009)	imex:IM-25016|pubmed:19318355	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11575443|imex:IM-25016-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000132855(gene)|ensembl:ENST00000371129(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004859"(phospholipase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010519"(negative regulation of phospholipase activity)|go:"GO:0019915"(lipid storage)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055090"(acylglycerol homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR036056|rcsb pdb:6EUA|reactome:R-HSA-8963889|reactome:R-HSA-9029558|refseq:NP_055310.1	-	-	-	figure legend:5a and b|comment:ANGPTL3 inhibits LPL activity by approximat. 50%. Addition of epitope-specific antibody prevented inhibition by ANGPTL3 with an Ec of 22 nM.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/10	2016/02/12	-	rogid:IIGAiaAcO6Oi3w4rA4vdXQdy5EA9606	-	false	-	his tag:c-c|necessary binding region:32..32-56..56	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:91111"	uniprotkb:P06858	intact:EBI-11565333	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	psi-mi:1,2-di-o-lauryl-rac-glycero-3-glutaric acid 6'-methylresorufin ester(display_short)|psi-mi:"CHEBI:91111"(display_long)|intact:1,2-di-O-dodecyl-rac-glycero-3-glutaric acid 6'-methylresorufin ester(synonym)|intact:DGGR(synonym)|intact:"1-[2,3-bis(dodecyloxy)propyl] 6-methyl-3-oxo-3H-phenoxazin-7-yl pentanedioate"(iupac name)	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:"MI:1354"(lipase assay)	Lee et al. (2009)	imex:IM-25016|pubmed:19318355	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11575443|imex:IM-25016-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	-	-	-	figure legend:5a and b|comment:ANGPTL3 inhibits LPL activity by approximat. 50%. Addition of epitope-specific antibody prevented inhibition by ANGPTL3 with an Ec of 22 nM.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/10	2016/02/12	-	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	-	false	-	flag tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:91111"	uniprotkb:P06858	intact:EBI-11565333	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	psi-mi:1,2-di-o-lauryl-rac-glycero-3-glutaric acid 6'-methylresorufin ester(display_short)|psi-mi:"CHEBI:91111"(display_long)|intact:1,2-di-O-dodecyl-rac-glycero-3-glutaric acid 6'-methylresorufin ester(synonym)|intact:DGGR(synonym)|intact:"1-[2,3-bis(dodecyloxy)propyl] 6-methyl-3-oxo-3H-phenoxazin-7-yl pentanedioate"(iupac name)	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:"MI:1354"(lipase assay)	Lee et al. (2009)	imex:IM-25016|pubmed:19318355	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11575448|imex:IM-25016-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/10	2016/02/10	-	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	-	false	-	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)