#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667287|imex:IM-25071-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.5x10^-8(molar)	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:1FWVMuXMqdVhiIAnf5DcB+VbGPI	false	his tag:?-?	sufficient binding region:22-300|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667344|imex:IM-25071-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.1x10^-8(molar)	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	binding-associated region:?-?|his tag:?-?	his tag:?-?|sufficient binding region:22-300	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667344|imex:IM-25071-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.1x10^-8(molar)	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	binding-associated region:?-?|his tag:?-?	sufficient binding region:101-325|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42702	uniprotkb:P26441	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667413|imex:IM-25071-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:77.0x10^-9(molar)	2016/03/29	2016/03/29	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rigid:A0O7UwlPzb4LfJGj6MYctGkPfgA	false	sufficient binding region:27-515|his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667428|imex:IM-25071-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.8x10^-8(molar)	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?|binding-associated region:?-?|binding-associated region:?-?	sufficient binding region:22-300	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667428|imex:IM-25071-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.8x10^-8(molar)	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?|binding-associated region:?-?|binding-associated region:?-?	sufficient binding region:101-325|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P42702	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667428|imex:IM-25071-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	-	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.8x10^-8(molar)	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?|binding-associated region:?-?|binding-associated region:?-?	sufficient binding region:27-515|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708334|imex:IM-25071-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-8(molar)	2016/03/29	2016/05/26	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:D4E7onJxuX+5urd0W/+d1F5GmZI	false	his tag:?-?|binding-associated region:?-?	sufficient binding region:22-300	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P42702	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708334|imex:IM-25071-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	-	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-8(molar)	2016/03/29	2016/05/26	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rigid:D4E7onJxuX+5urd0W/+d1F5GmZI	false	his tag:?-?|binding-associated region:?-?	sufficient binding region:27-515|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667565|imex:IM-25071-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	his tag:?-?	his tag:?-?|sufficient binding region:22-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667565|imex:IM-25071-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	his tag:?-?	sufficient binding region:101-325|his tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667546|imex:IM-25071-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:22-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667546|imex:IM-25071-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:101-325|his tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P42702	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667546|imex:IM-25071-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	-	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:27-515|his tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667582|imex:IM-25071-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:1FWVMuXMqdVhiIAnf5DcB+VbGPI	false	his tag:?-?	sufficient binding region:22-300|his tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42702	uniprotkb:P26441	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667535|imex:IM-25071-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	-	figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rigid:A0O7UwlPzb4LfJGj6MYctGkPfgA	false	sufficient binding region:27-515|his tag:?-?	his tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667993|imex:IM-25071-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Supp. Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	his tag:?-?	sufficient binding region:22-300|tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667993|imex:IM-25071-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Supp. Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	his tag:?-?	tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708398|imex:IM-25071-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/05/26	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:22-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708398|imex:IM-25071-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/05/26	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:23-918|tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P42702	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:"MI:0071"(molecular sieving)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708398|imex:IM-25071-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	-	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/05/26	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:27-1078|tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667874|imex:IM-25071-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 3B,  Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:22-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667874|imex:IM-25071-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Fig. 3B,  Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:23-918|tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P42702	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667874|imex:IM-25071-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	-	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	figure legend:Fig. 3B,  Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:?-?	sufficient binding region:27-1078|tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667901|imex:IM-25071-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 3C, Supp. Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	his tag:?-?	sufficient binding region:22-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667901|imex:IM-25071-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Fig. 3C, Supp. Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:wDY+IVKIdeC6yWLdUxeUswgufNg	false	his tag:?-?	his tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05231	uniprotkb:P08887	intact:EBI-720533|uniprotkb:Q9UCU4|uniprotkb:Q9UCU2|uniprotkb:Q9UCU3|ensembl:ENSP00000258743|ensembl:ENSP00000385675	intact:EBI-299383|ensembl:ENSP00000357470|uniprotkb:Q16202|uniprotkb:Q53EQ7|uniprotkb:Q5FWG2|uniprotkb:Q5VZ23|uniprotkb:B2R6V4|uniprotkb:A8KAE8	psi-mi:il6_human(display_long)|uniprotkb:B-cell stimulatory factor 2(gene name synonym)|uniprotkb:Interferon beta-2(gene name synonym)|uniprotkb:Hybridoma growth factor(gene name synonym)|uniprotkb:CTL differentiation factor(gene name synonym)|uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)	psi-mi:il6ra_human(display_long)|uniprotkb:IL6R(gene name)|psi-mi:IL6R(display_short)|uniprotkb:IL-6R 1(gene name synonym)|uniprotkb:Membrane glycoprotein 80(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667967|imex:IM-25071-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0050871"(positive regulation of B cell activation)|refseq:NP_000591.1|refseq:XP_011513692.1|dip:DIP-482N|ensembl:ENSG00000136244(gene)|ensembl:ENST00000258743(transcript)|ensembl:ENST00000404625(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014823"(response to activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051607"(defense response to virus)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061888"(regulation of astrocyte activation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070091"(glucagon secretion)|go:"GO:0070092"(regulation of glucagon secretion)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0097421"(liver regeneration)|go:"GO:0098586"(cellular response to virus)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003574(Interleukin-6)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030473|interpro:IPR030474|rcsb pdb:1ALU|rcsb pdb:1IL6|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2IL6|rcsb pdb:4CNI|rcsb pdb:4J4L|rcsb pdb:4NI7|rcsb pdb:4NI9|rcsb pdb:4O9H|rcsb pdb:4ZS7|rcsb pdb:5FUC|rcsb pdb:7NXZ|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-2559582|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8853884|reactome:R-HSA-8957275|reactome:R-HSA-9660821|reactome:R-HSA-9662834	go:"GO:0004915"(interleukin-6 receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|ensembl:ENSG00000160712(gene)|ensembl:ENST00000368485(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0019981"(interleukin-6 binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034097"(response to cytokine)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070119"(ciliary neurotrophic factor binding)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1N26|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2ARW|rcsb pdb:5FUC|rcsb pdb:7DC8|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6785807|reactome:R-HSA-9616222|reactome:R-HSA-9679191|refseq:NP_000556.1|refseq:NP_001193795.1|refseq:NP_852004.1|dip:DIP-162N	-	-	-	figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:6vjM8nCX9dFO2PtS54SfLqw0K0w9606	rogid:qV0FIgWdLU9dOASd1U1jOhFFdt09606	rigid:j1divgkZ2OZ4PezRgn9OZLca/vo	false	-	sufficient binding region:1-310|his tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05231	uniprotkb:P40189	intact:EBI-720533|uniprotkb:Q9UCU4|uniprotkb:Q9UCU2|uniprotkb:Q9UCU3|ensembl:ENSP00000258743|ensembl:ENSP00000385675	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:il6_human(display_long)|uniprotkb:B-cell stimulatory factor 2(gene name synonym)|uniprotkb:Interferon beta-2(gene name synonym)|uniprotkb:Hybridoma growth factor(gene name synonym)|uniprotkb:CTL differentiation factor(gene name synonym)|uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11667967|imex:IM-25071-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0050871"(positive regulation of B cell activation)|refseq:NP_000591.1|refseq:XP_011513692.1|dip:DIP-482N|ensembl:ENSG00000136244(gene)|ensembl:ENST00000258743(transcript)|ensembl:ENST00000404625(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014823"(response to activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051607"(defense response to virus)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061888"(regulation of astrocyte activation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070091"(glucagon secretion)|go:"GO:0070092"(regulation of glucagon secretion)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0097421"(liver regeneration)|go:"GO:0098586"(cellular response to virus)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003574(Interleukin-6)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030473|interpro:IPR030474|rcsb pdb:1ALU|rcsb pdb:1IL6|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2IL6|rcsb pdb:4CNI|rcsb pdb:4J4L|rcsb pdb:4NI7|rcsb pdb:4NI9|rcsb pdb:4O9H|rcsb pdb:4ZS7|rcsb pdb:5FUC|rcsb pdb:7NXZ|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-2559582|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8853884|reactome:R-HSA-8957275|reactome:R-HSA-9660821|reactome:R-HSA-9662834	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/03/29	rogid:6vjM8nCX9dFO2PtS54SfLqw0K0w9606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:j1divgkZ2OZ4PezRgn9OZLca/vo	false	-	his tag:c-c|sufficient binding region:1-610	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P26992	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708964|imex:IM-25071-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:Fig. 3Ci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/05/27	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:c-c	sufficient binding region:22-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P40189	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708964|imex:IM-25071-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	-	-	-	figure legend:Fig. 3Ci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/05/27	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:c-c	his tag:c-c|sufficient binding region:1-610	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26441	uniprotkb:P42702	intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370	intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123	psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short)	psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short)	psi-mi:"MI:0040"(electron microscopy)	Skiniotis et al. (2008)	imex:IM-25071|pubmed:18775332	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708964|imex:IM-25071-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N	refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N	-	-	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"	figure legend:Fig. 3Ci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/29	2016/05/27	rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606	rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606	rigid:ZiTHb5LEhjRDCPamhO+3MJq5/Xs	false	his tag:c-c	tag:c-c|sufficient binding region:27-1078	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)