#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BTP7 uniprotkb:Q8IYD8 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506096|imex:IM-25488-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/08/04 2016/08/15 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rigid:cIJkKjEhrSVOuxKRCfHE3rlQUnQ false his tag:?-? sufficient binding region:1727-2048 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BTP7 uniprotkb:Q8IYD8 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0096"(pull down) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506136|imex:IM-25488-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2016/08/04 2016/08/15 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rigid:cIJkKjEhrSVOuxKRCfHE3rlQUnQ false - flag tag:c-c|his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92889 uniprotkb:Q96AY2 intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym) psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506318|imex:IM-25488-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310 refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N - - - figure legend:2B-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/08/04 2016/08/15 rogid:A42t082dZNQH72TF3QRa+Msuoms9606 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 rigid:PmlofvifLfYjOpaBwkxpmdZPACM false glutathione s tranferase tag:n-n|sufficient binding region:606-905 his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92889 uniprotkb:P07992 intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520 intact:EBI-750962|ensembl:ENSP00000300853|ensembl:ENSP00000468035|uniprotkb:B2RC01|uniprotkb:B3KRR0|uniprotkb:Q7Z7F5|uniprotkb:Q96S40 psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym) psi-mi:ercc1_human(display_long)|uniprotkb:ERCC1(gene name)|psi-mi:ERCC1(display_short) psi-mi:"MI:0096"(pull down) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506329|imex:IM-25488-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310 refseq:NP_001974.1|ensembl:ENSG00000012061(gene)|ensembl:ENST00000300853(transcript)|ensembl:ENST00000589165(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|refseq:XP_011524912.1|refseq:NP_001159521.1|refseq:NP_973730.1|refseq:XP_005258691.1|refseq:XP_005258692.1|refseq:XP_005258693.1|refseq:XP_016881948.1|refseq:XP_016881949.1|refseq:XP_016881950.1|refseq:XP_016881951.1|refseq:XP_016881952.1|refseq:XP_016881953.1|refseq:XP_016881954.1|refseq:XP_016881955.1|dip:DIP-24235N|reactome:R-HSA-6783310|reactome:R-HSA-6782135|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006949"(syncytium formation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009650"(UV protection)|go:"GO:0009744"(response to sucrose)|go:"GO:0010165"(response to X-ray)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045190"(isotype switching)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048477"(oogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0090399"(replicative senescence)|go:"GO:0090656"(t-circle formation)|go:"GO:1904431"(positive regulation of t-circle formation)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR004579(DNA repair protein rad10)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|rcsb pdb:1Z00|rcsb pdb:2A1I|rcsb pdb:2A1J|rcsb pdb:2JNW|rcsb pdb:2JPD|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400 - - - figure legend:2B-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/08/04 2016/08/15 rogid:A42t082dZNQH72TF3QRa+Msuoms9606 rogid:wgacfBH+F2NRhpzRsTChE4zSPho9606 rigid:+gWkM4c7rKvMZTNqEI2b/PThZxE false glutathione s tranferase tag:n-n|sufficient binding region:606-905 his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:Q96AY2 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506341|imex:IM-25488-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N - - - figure legend:2B-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/08/04 2016/08/15 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 rigid:VpPRAiSOGAp09OMC7edRMK8mRXw false glutathione s tranferase tag:n-n|sufficient binding region:1727-2048 his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:Q9BTP7 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0096"(pull down) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506358|imex:IM-25488-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:2B-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/08/04 2016/08/15 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rigid:cIJkKjEhrSVOuxKRCfHE3rlQUnQ false glutathione s tranferase tag:n-n|sufficient binding region:1727-2048 his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96NY9 uniprotkb:Q96AY2 intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short) psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506371|imex:IM-25488-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310 refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N - - - figure legend:2B-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/08/04 2016/08/15 rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 rigid:1wxpwdixnWXzeyxARRU8qLIMboA false glutathione s tranferase tag:n-n his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A4GXA9 uniprotkb:Q96NY9 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853 psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short) psi-mi:"MI:0096"(pull down) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506381|imex:IM-25488-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310 - comment:mint|comment:homomint - figure legend:2B-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/08/04 2016/08/15 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606 rigid:FtAYJaH/bMlED5feGR5JFUZaKCI false his tag:n-n glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:Q9BTP7 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506454|imex:IM-25488-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:3A/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rigid:cIJkKjEhrSVOuxKRCfHE3rlQUnQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96NY9 uniprotkb:Q96AY2 intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short) psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506458|imex:IM-25488-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310 refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N - - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/08/04 2016/08/16 rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 rigid:1wxpwdixnWXzeyxARRU8qLIMboA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTP7 uniprotkb:Q8IYD8 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506470|imex:IM-25488-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N go:"GO:0005634"(nucleus) - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/08/04 2016/08/16 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rigid:cIJkKjEhrSVOuxKRCfHE3rlQUnQ false - flag tag:n-n|necessary binding region:1847-2048|mutation with no effect:117-117 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:Q9H9A7 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-621339|ensembl:ENSP00000317039|ensembl:ENSP00000402433|uniprotkb:Q5SQG8|uniprotkb:Q5SQG9|uniprotkb:Q6P1Q4|uniprotkb:Q6PI89|uniprotkb:Q7Z6L6|uniprotkb:Q05BX1|uniprotkb:Q05CW3|intact:EBI-2555508 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:rmi1_human(display_long)|uniprotkb:BLM-associated protein of 75 kDa(gene name synonym)|uniprotkb:FAAP75(gene name synonym)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:C9orf76(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506512|imex:IM-25488-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N ensembl:ENSG00000178966(gene)|ensembl:ENST00000325875(transcript)|ensembl:ENST00000445877(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR032199|interpro:IPR033472|interpro:IPR042470|rcsb pdb:3MXN|rcsb pdb:3NBH|rcsb pdb:3NBI|rcsb pdb:4CGY|rcsb pdb:4CHT|rcsb pdb:4DAY|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:XP_011517336.1|refseq:NP_079221.2|refseq:XP_005252268.1|refseq:XP_005252270.1|refseq:XP_016870629.1|dip:DIP-33324N go:"GO:0005634"(nucleus) - - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:yB9i9QLqh7s19GI2ZG6WJpWXwOo9606 rigid:6L1g8y4HSBPmkn5CcOztne7nJKI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IYD8 uniprotkb:Q9NPI8 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-81589|ensembl:ENSP00000330875|uniprotkb:Q52LM0 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fancf_human(display_long)|uniprotkb:FANCF(gene name)|psi-mi:FANCF(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506512|imex:IM-25488-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N ensembl:ENSG00000183161(gene)|ensembl:ENST00000327470(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR035428|interpro:IPR038505|mint:Q9NPI8|rcsb pdb:2IQC|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|refseq:NP_073562.1 go:"GO:0005634"(nucleus) - - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:Muoiy5Y/g3FEdtc9Bp9JLmm7dFo9606 rigid:6L1g8y4HSBPmkn5CcOztne7nJKI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IYD8 uniprotkb:Q00597 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506512|imex:IM-25488-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N go:"GO:0005634"(nucleus) - - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606 rigid:6L1g8y4HSBPmkn5CcOztne7nJKI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IYD8 uniprotkb:Q9HB96 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-396803|uniprotkb:Q4ZGH2|uniprotkb:A8K907|ensembl:ENSP00000229769 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fance_human(display_long)|uniprotkb:FANCE(gene name)|psi-mi:FANCE(display_short)|uniprotkb:FACE(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506512|imex:IM-25488-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_068741.1|ensembl:ENSG00000112039(gene)|ensembl:ENST00000229769(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR021025|interpro:IPR039685|rcsb pdb:2ILR|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-32845N go:"GO:0005634"(nucleus) - - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:1EZu1iPweaq6JSLK+81fdoiY7O49606 rigid:6L1g8y4HSBPmkn5CcOztne7nJKI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IYD8 uniprotkb:Q9BTP7 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506512|imex:IM-25488-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N go:"GO:0005634"(nucleus) - - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rigid:6L1g8y4HSBPmkn5CcOztne7nJKI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IYD8 uniprotkb:O15287 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-81610|ensembl:ENSP00000367910 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fancg_human(display_long)|uniprotkb:FANCG(gene name)|psi-mi:FANCG(display_short)|uniprotkb:XRCC9(gene name synonym)|uniprotkb:DNA repair protein XRCC9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506540|imex:IM-25488-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N ensembl:ENSG00000221829(gene)|refseq:NP_004620.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007286"(spermatid development)|go:"GO:0009314"(response to radiation)|ensembl:ENST00000378643(transcript)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039684|mint:O15287|rcsb pdb:7KZP|rcsb pdb:7KZQ|go:"GO:0001541"(ovarian follicle development)|rcsb pdb:7KZR|go:"GO:0003684"(damaged DNA binding)|rcsb pdb:7KZS|go:"GO:0005654"(nucleoplasm)|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|go:"GO:0005730"(nucleolus) go:"GO:0005634"(nucleus) - - figure legend:4D lane a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:jVGeic2vn/qrZgro3IKXWhNteHo9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:Q8NB91 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-2557983|uniprotkb:B2RMZ4|uniprotkb:Q7Z2U2|uniprotkb:Q86XG1|ensembl:ENSP00000326819|ensembl:ENSP00000381378|ensembl:ENSP00000498215 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fancb_human(display_long)|uniprotkb:FANCB(gene name)|psi-mi:FANCB(display_short)|uniprotkb:Fanconi anemia-associated polypeptide of 95 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506540|imex:IM-25488-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001018123.1|refseq:NP_689846.1|refseq:NP_001311091.1|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR033333|mint:Q8NB91|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000181544(gene)|ensembl:ENST00000324138(transcript)|ensembl:ENST00000398334(transcript)|ensembl:ENST00000650831(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|refseq:XP_016884844.1 go:"GO:0005634"(nucleus) - - figure legend:4D lane a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:ZbWwzfTgl5qyFf4PUo/Hvh19gSQ9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:Q9BTP7 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506540|imex:IM-25488-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N go:"GO:0005634"(nucleus) - - figure legend:4D lane a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:Q9NW38 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-2339898|uniprotkb:Q6GU60|ensembl:ENSP00000233741 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fancl_human(display_long)|uniprotkb:FANCL(gene name)|psi-mi:FANCL(display_short)|uniprotkb:PHF9(gene name synonym)|uniprotkb:Fanconi anemia group L protein(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 43 kDa(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase FANCL(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506540|imex:IM-25488-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001108108.1|refseq:NP_060532.2|dip:DIP-43975N|ensembl:ENSG00000115392(gene)|ensembl:ENST00000233741(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007276"(gamete generation)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019162|interpro:IPR026848|interpro:IPR026850|interpro:IPR043003|interpro:IPR043898|interpro:IPR044037|mint:Q9NW38|rcsb pdb:3ZQS|rcsb pdb:4CCG|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310 go:"GO:0005634"(nucleus) - - figure legend:4D lane a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:/zKdeyrga9pwhTbVoZsUFbMBj5g9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IYD8 uniprotkb:O15360 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-81570|uniprotkb:Q9UEA5|uniprotkb:Q9UEL8|uniprotkb:Q9UEL9|uniprotkb:Q9UPK3|uniprotkb:Q9Y6M2|uniprotkb:O75266|uniprotkb:Q6PL10|uniprotkb:Q92497|uniprotkb:Q96H18|intact:EBI-1754425|intact:EBI-1959457|uniprotkb:A5D923|ensembl:ENSP00000373952|uniprotkb:B4DRI7|uniprotkb:H3BSR5 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fanca_human(display_long)|uniprotkb:FANCA(gene name)|psi-mi:FANCA(display_short)|uniprotkb:FAA(gene name synonym)|uniprotkb:FACA(gene name synonym)|uniprotkb:FANCH(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506540|imex:IM-25488-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001273096.1|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR003516(Fanconi anaemia group A protein)|interpro:IPR031729|mint:O15360|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000187741(gene)|ensembl:ENST00000389301(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|refseq:NP_000126.2|refseq:NP_001018122.1|dip:DIP-32650N go:"GO:0005634"(nucleus) - - figure legend:4D lane a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:yUXv9VOIUPDiXN65MvkrpaozAS89606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BTP7 uniprotkb:O15287 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-81610|ensembl:ENSP00000367910 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fancg_human(display_long)|uniprotkb:FANCG(gene name)|psi-mi:FANCG(display_short)|uniprotkb:XRCC9(gene name synonym)|uniprotkb:DNA repair protein XRCC9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506600|imex:IM-25488-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N ensembl:ENSG00000221829(gene)|refseq:NP_004620.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007286"(spermatid development)|go:"GO:0009314"(response to radiation)|ensembl:ENST00000378643(transcript)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039684|mint:O15287|rcsb pdb:7KZP|rcsb pdb:7KZQ|go:"GO:0001541"(ovarian follicle development)|rcsb pdb:7KZR|go:"GO:0003684"(damaged DNA binding)|rcsb pdb:7KZS|go:"GO:0005654"(nucleoplasm)|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|go:"GO:0005730"(nucleolus) go:"GO:0005634"(nucleus) - - figure legend:4D lane b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:jVGeic2vn/qrZgro3IKXWhNteHo9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BTP7 uniprotkb:Q8NB91 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-2557983|uniprotkb:B2RMZ4|uniprotkb:Q7Z2U2|uniprotkb:Q86XG1|ensembl:ENSP00000326819|ensembl:ENSP00000381378|ensembl:ENSP00000498215 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fancb_human(display_long)|uniprotkb:FANCB(gene name)|psi-mi:FANCB(display_short)|uniprotkb:Fanconi anemia-associated polypeptide of 95 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506600|imex:IM-25488-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N refseq:NP_001018123.1|refseq:NP_689846.1|refseq:NP_001311091.1|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR033333|mint:Q8NB91|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000181544(gene)|ensembl:ENST00000324138(transcript)|ensembl:ENST00000398334(transcript)|ensembl:ENST00000650831(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|refseq:XP_016884844.1 go:"GO:0005634"(nucleus) - - figure legend:4D lane b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:ZbWwzfTgl5qyFf4PUo/Hvh19gSQ9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BTP7 uniprotkb:Q9NW38 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-2339898|uniprotkb:Q6GU60|ensembl:ENSP00000233741 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fancl_human(display_long)|uniprotkb:FANCL(gene name)|psi-mi:FANCL(display_short)|uniprotkb:PHF9(gene name synonym)|uniprotkb:Fanconi anemia group L protein(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 43 kDa(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase FANCL(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506600|imex:IM-25488-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N refseq:NP_001108108.1|refseq:NP_060532.2|dip:DIP-43975N|ensembl:ENSG00000115392(gene)|ensembl:ENST00000233741(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007276"(gamete generation)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019162|interpro:IPR026848|interpro:IPR026850|interpro:IPR043003|interpro:IPR043898|interpro:IPR044037|mint:Q9NW38|rcsb pdb:3ZQS|rcsb pdb:4CCG|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310 go:"GO:0005634"(nucleus) - - figure legend:4D lane b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:/zKdeyrga9pwhTbVoZsUFbMBj5g9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BTP7 uniprotkb:O15360 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-81570|uniprotkb:Q9UEA5|uniprotkb:Q9UEL8|uniprotkb:Q9UEL9|uniprotkb:Q9UPK3|uniprotkb:Q9Y6M2|uniprotkb:O75266|uniprotkb:Q6PL10|uniprotkb:Q92497|uniprotkb:Q96H18|intact:EBI-1754425|intact:EBI-1959457|uniprotkb:A5D923|ensembl:ENSP00000373952|uniprotkb:B4DRI7|uniprotkb:H3BSR5 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fanca_human(display_long)|uniprotkb:FANCA(gene name)|psi-mi:FANCA(display_short)|uniprotkb:FAA(gene name synonym)|uniprotkb:FACA(gene name synonym)|uniprotkb:FANCH(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506600|imex:IM-25488-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N refseq:NP_001273096.1|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR003516(Fanconi anaemia group A protein)|interpro:IPR031729|mint:O15360|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000187741(gene)|ensembl:ENST00000389301(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|refseq:NP_000126.2|refseq:NP_001018122.1|dip:DIP-32650N go:"GO:0005634"(nucleus) - - figure legend:4D lane b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:yUXv9VOIUPDiXN65MvkrpaozAS89606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BTP7 uniprotkb:Q8IYD8 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506600|imex:IM-25488-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N go:"GO:0005634"(nucleus) - - figure legend:4D lane b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15360 uniprotkb:O15287 intact:EBI-81570|uniprotkb:Q9UEA5|uniprotkb:Q9UEL8|uniprotkb:Q9UEL9|uniprotkb:Q9UPK3|uniprotkb:Q9Y6M2|uniprotkb:O75266|uniprotkb:Q6PL10|uniprotkb:Q92497|uniprotkb:Q96H18|intact:EBI-1754425|intact:EBI-1959457|uniprotkb:A5D923|ensembl:ENSP00000373952|uniprotkb:B4DRI7|uniprotkb:H3BSR5 intact:EBI-81610|ensembl:ENSP00000367910 psi-mi:fanca_human(display_long)|uniprotkb:FANCA(gene name)|psi-mi:FANCA(display_short)|uniprotkb:FAA(gene name synonym)|uniprotkb:FACA(gene name synonym)|uniprotkb:FANCH(gene name synonym) psi-mi:fancg_human(display_long)|uniprotkb:FANCG(gene name)|psi-mi:FANCG(display_short)|uniprotkb:XRCC9(gene name synonym)|uniprotkb:DNA repair protein XRCC9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506610|imex:IM-25488-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273096.1|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR003516(Fanconi anaemia group A protein)|interpro:IPR031729|mint:O15360|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000187741(gene)|ensembl:ENST00000389301(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|refseq:NP_000126.2|refseq:NP_001018122.1|dip:DIP-32650N ensembl:ENSG00000221829(gene)|refseq:NP_004620.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007286"(spermatid development)|go:"GO:0009314"(response to radiation)|ensembl:ENST00000378643(transcript)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039684|mint:O15287|rcsb pdb:7KZP|rcsb pdb:7KZQ|go:"GO:0001541"(ovarian follicle development)|rcsb pdb:7KZR|go:"GO:0003684"(damaged DNA binding)|rcsb pdb:7KZS|go:"GO:0005654"(nucleoplasm)|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|go:"GO:0005730"(nucleolus) go:"GO:0005634"(nucleus) - - figure legend:4D lane c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:yUXv9VOIUPDiXN65MvkrpaozAS89606 rogid:jVGeic2vn/qrZgro3IKXWhNteHo9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15360 uniprotkb:Q8NB91 intact:EBI-81570|uniprotkb:Q9UEA5|uniprotkb:Q9UEL8|uniprotkb:Q9UEL9|uniprotkb:Q9UPK3|uniprotkb:Q9Y6M2|uniprotkb:O75266|uniprotkb:Q6PL10|uniprotkb:Q92497|uniprotkb:Q96H18|intact:EBI-1754425|intact:EBI-1959457|uniprotkb:A5D923|ensembl:ENSP00000373952|uniprotkb:B4DRI7|uniprotkb:H3BSR5 intact:EBI-2557983|uniprotkb:B2RMZ4|uniprotkb:Q7Z2U2|uniprotkb:Q86XG1|ensembl:ENSP00000326819|ensembl:ENSP00000381378|ensembl:ENSP00000498215 psi-mi:fanca_human(display_long)|uniprotkb:FANCA(gene name)|psi-mi:FANCA(display_short)|uniprotkb:FAA(gene name synonym)|uniprotkb:FACA(gene name synonym)|uniprotkb:FANCH(gene name synonym) psi-mi:fancb_human(display_long)|uniprotkb:FANCB(gene name)|psi-mi:FANCB(display_short)|uniprotkb:Fanconi anemia-associated polypeptide of 95 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506610|imex:IM-25488-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273096.1|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR003516(Fanconi anaemia group A protein)|interpro:IPR031729|mint:O15360|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000187741(gene)|ensembl:ENST00000389301(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|refseq:NP_000126.2|refseq:NP_001018122.1|dip:DIP-32650N refseq:NP_001018123.1|refseq:NP_689846.1|refseq:NP_001311091.1|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR033333|mint:Q8NB91|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000181544(gene)|ensembl:ENST00000324138(transcript)|ensembl:ENST00000398334(transcript)|ensembl:ENST00000650831(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|refseq:XP_016884844.1 go:"GO:0005634"(nucleus) - - figure legend:4D lane c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:yUXv9VOIUPDiXN65MvkrpaozAS89606 rogid:ZbWwzfTgl5qyFf4PUo/Hvh19gSQ9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15360 uniprotkb:Q9BTP7 intact:EBI-81570|uniprotkb:Q9UEA5|uniprotkb:Q9UEL8|uniprotkb:Q9UEL9|uniprotkb:Q9UPK3|uniprotkb:Q9Y6M2|uniprotkb:O75266|uniprotkb:Q6PL10|uniprotkb:Q92497|uniprotkb:Q96H18|intact:EBI-1754425|intact:EBI-1959457|uniprotkb:A5D923|ensembl:ENSP00000373952|uniprotkb:B4DRI7|uniprotkb:H3BSR5 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:fanca_human(display_long)|uniprotkb:FANCA(gene name)|psi-mi:FANCA(display_short)|uniprotkb:FAA(gene name synonym)|uniprotkb:FACA(gene name synonym)|uniprotkb:FANCH(gene name synonym) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506610|imex:IM-25488-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273096.1|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR003516(Fanconi anaemia group A protein)|interpro:IPR031729|mint:O15360|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000187741(gene)|ensembl:ENST00000389301(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|refseq:NP_000126.2|refseq:NP_001018122.1|dip:DIP-32650N refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N go:"GO:0005634"(nucleus) - - figure legend:4D lane c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:yUXv9VOIUPDiXN65MvkrpaozAS89606 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15360 uniprotkb:Q9NW38 intact:EBI-81570|uniprotkb:Q9UEA5|uniprotkb:Q9UEL8|uniprotkb:Q9UEL9|uniprotkb:Q9UPK3|uniprotkb:Q9Y6M2|uniprotkb:O75266|uniprotkb:Q6PL10|uniprotkb:Q92497|uniprotkb:Q96H18|intact:EBI-1754425|intact:EBI-1959457|uniprotkb:A5D923|ensembl:ENSP00000373952|uniprotkb:B4DRI7|uniprotkb:H3BSR5 intact:EBI-2339898|uniprotkb:Q6GU60|ensembl:ENSP00000233741 psi-mi:fanca_human(display_long)|uniprotkb:FANCA(gene name)|psi-mi:FANCA(display_short)|uniprotkb:FAA(gene name synonym)|uniprotkb:FACA(gene name synonym)|uniprotkb:FANCH(gene name synonym) psi-mi:fancl_human(display_long)|uniprotkb:FANCL(gene name)|psi-mi:FANCL(display_short)|uniprotkb:PHF9(gene name synonym)|uniprotkb:Fanconi anemia group L protein(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 43 kDa(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase FANCL(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506610|imex:IM-25488-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273096.1|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR003516(Fanconi anaemia group A protein)|interpro:IPR031729|mint:O15360|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000187741(gene)|ensembl:ENST00000389301(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|refseq:NP_000126.2|refseq:NP_001018122.1|dip:DIP-32650N refseq:NP_001108108.1|refseq:NP_060532.2|dip:DIP-43975N|ensembl:ENSG00000115392(gene)|ensembl:ENST00000233741(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007276"(gamete generation)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019162|interpro:IPR026848|interpro:IPR026850|interpro:IPR043003|interpro:IPR043898|interpro:IPR044037|mint:Q9NW38|rcsb pdb:3ZQS|rcsb pdb:4CCG|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310 go:"GO:0005634"(nucleus) - - figure legend:4D lane c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:yUXv9VOIUPDiXN65MvkrpaozAS89606 rogid:/zKdeyrga9pwhTbVoZsUFbMBj5g9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15360 uniprotkb:Q8IYD8 intact:EBI-81570|uniprotkb:Q9UEA5|uniprotkb:Q9UEL8|uniprotkb:Q9UEL9|uniprotkb:Q9UPK3|uniprotkb:Q9Y6M2|uniprotkb:O75266|uniprotkb:Q6PL10|uniprotkb:Q92497|uniprotkb:Q96H18|intact:EBI-1754425|intact:EBI-1959457|uniprotkb:A5D923|ensembl:ENSP00000373952|uniprotkb:B4DRI7|uniprotkb:H3BSR5 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:fanca_human(display_long)|uniprotkb:FANCA(gene name)|psi-mi:FANCA(display_short)|uniprotkb:FAA(gene name synonym)|uniprotkb:FACA(gene name synonym)|uniprotkb:FANCH(gene name synonym) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12506610|imex:IM-25488-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273096.1|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR003516(Fanconi anaemia group A protein)|interpro:IPR031729|mint:O15360|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|ensembl:ENSG00000187741(gene)|ensembl:ENST00000389301(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|refseq:NP_000126.2|refseq:NP_001018122.1|dip:DIP-32650N ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N go:"GO:0005634"(nucleus) - - figure legend:4D lane c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/08/04 2016/08/16 rogid:yUXv9VOIUPDiXN65MvkrpaozAS89606 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rigid:F9EwSadUZhNqE+f1CkdpX7j57zU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BTP7 intact:EBI-12506682 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 - psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:ss_dna-oligo_1_j26(display_short)|psi-mi:EBI-12506682(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-12506691|imex:IM-25488-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - - figure legend:6B lane_b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - - false his tag:?-? 32p radiolabel:1-1 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506721 uniprotkb:Q9BTP7 - intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-12506713|imex:IM-25488-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:6B lane_h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 - rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false 32p radiolabel:1-1|sufficient binding region:2-31 his tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506721 intact:EBI-12507940 - - psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-12506713|imex:IM-25488-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - - - - figure legend:6B lane_h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 - - - false 32p radiolabel:1-1|sufficient binding region:2-31 sufficient binding region:1-31 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506721 intact:EBI-12506732 - - psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-12506713|imex:IM-25488-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - - - - figure legend:6B lane_h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 - - - false 32p radiolabel:1-1|sufficient binding region:2-31 sufficient binding region:33-62|sufficient binding region:2-32 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506732 uniprotkb:Q9BTP7 - intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-12506725|imex:IM-25488-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:6B lane_f, 7D lane_c.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 - rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false sufficient binding region:33-62 his tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506732 intact:EBI-12506721 - - psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-12506725|imex:IM-25488-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - - - - figure legend:6B lane_f, 7D lane_c.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 - - - false sufficient binding region:33-62 sufficient binding region:2-31|32p radiolabel:1-1 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506682 uniprotkb:Q8IYD8 - intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:ss_dna-oligo_1_j26(display_short)|psi-mi:EBI-12506682(display_long) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507128|imex:IM-25488-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - figure legend:7 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 - rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 - false 32p radiolabel:1-1 glutathione s tranferase tag:n-n|sufficient binding region:1727-2048 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506682 uniprotkb:Q9BTP7 - intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:ss_dna-oligo_1_j26(display_short)|psi-mi:EBI-12506682(display_long) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507128|imex:IM-25488-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:7 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 - rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false 32p radiolabel:1-1 his tag:n-n|sufficient binding region:1-215 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506732 intact:EBI-12506721 - - psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507230|imex:IM-25488-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - - - - figure legend:7 B/C/D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 - - - false sufficient binding region:33-62 32p radiolabel:1-1|sufficient binding region:2-31 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506732 uniprotkb:Q8IYD8 - intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507230|imex:IM-25488-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - figure legend:7 B/C/D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 - rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 - false sufficient binding region:33-62 glutathione s tranferase tag:n-n|sufficient binding region:1727-2048 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12506732 uniprotkb:Q9BTP7 - intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507230|imex:IM-25488-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:7 B/C/D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 - rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false sufficient binding region:33-62 his tag:n-n|sufficient binding region:1-215 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12507940 uniprotkb:Q8IYD8 - intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507256|imex:IM-25488-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - figure legend:7 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 - rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 - false sufficient binding region:1-31 glutathione s tranferase tag:n-n|sufficient binding region:1727-2048 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12507940 uniprotkb:Q9BTP7 - intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507256|imex:IM-25488-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:7 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 - rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false sufficient binding region:1-31 his tag:n-n|sufficient binding region:1-215 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12507940 intact:EBI-12506721 - - psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507256|imex:IM-25488-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - - - - figure legend:7 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 - - - false sufficient binding region:1-31 32p radiolabel:1-1|sufficient binding region:2-31 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-12507940 intact:EBI-12506732 - - psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507256|imex:IM-25488-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - - - - figure legend:7 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 - - - false sufficient binding region:1-31 sufficient binding region:33-62|sufficient binding region:2-32 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A4GXA9 uniprotkb:Q96NY9 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853 psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507379|imex:IM-25488-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310 go:"GO:0004520"(endodeoxyribonuclease activity) comment:mint|comment:homomint - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606 - false his tag:n-n glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A4GXA9 intact:EBI-12506721 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 - psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507379|imex:IM-25488-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 - go:"GO:0004520"(endodeoxyribonuclease activity) comment:mint|comment:homomint - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 - - false his tag:n-n sufficient binding region:2-31|32p radiolabel:1-1 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A4GXA9 intact:EBI-12506732 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 - psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507379|imex:IM-25488-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 - go:"GO:0004520"(endodeoxyribonuclease activity) comment:mint|comment:homomint - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/16 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 - - false his tag:n-n sufficient binding region:33-62 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q96AY2 uniprotkb:Q96NY9 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853 psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507315|imex:IM-25488-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310 go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0048257"(3'-flap endonuclease activity) - - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606 - false his tag:n-n glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q96AY2 intact:EBI-12507940 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 - psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507315|imex:IM-25488-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N - go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0048257"(3'-flap endonuclease activity) - - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 - - false his tag:n-n sufficient binding region:1-31 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q96AY2 intact:EBI-12506721 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 - psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507315|imex:IM-25488-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N - go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0048257"(3'-flap endonuclease activity) - - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 - - false his tag:n-n 32p radiolabel:1-1|sufficient binding region:2-31 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q96AY2 intact:EBI-12506732 intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747 - psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym) psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507315|imex:IM-25488-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N - go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0048257"(3'-flap endonuclease activity) - - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606 - - false his tag:n-n sufficient binding region:33-62|sufficient binding region:2-32 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A4GXA9 uniprotkb:Q96NY9 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853 psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507355|imex:IM-25488-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310 go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity) comment:mint|comment:homomint - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606 - false his tag:n-n glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A4GXA9 intact:EBI-12507940 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 - psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507355|imex:IM-25488-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 - go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity) comment:mint|comment:homomint - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 - - false his tag:n-n sufficient binding region:1-31 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A4GXA9 intact:EBI-12506721 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 - psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507355|imex:IM-25488-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 - go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity) comment:mint|comment:homomint - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 - - false his tag:n-n 32p radiolabel:1-1|sufficient binding region:2-31 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A4GXA9 intact:EBI-12506732 intact:EBI-7838486|ensembl:ENSP00000457353|uniprotkb:Q8TEP2|intact:MINT-8373003|uniprotkb:Q96RY3 - psi-mi:eme2_human(display_long)|uniprotkb:EME2(gene name)|psi-mi:EME2(display_short) psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:"MI:1034"(nuclease assay) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0572"(dna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-12507355|imex:IM-25488-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) ensembl:ENSG00000197774(gene)|ensembl:ENST00000568449(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|reactome:R-HSA-5693568|reactome:R-HSA-6783310|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|refseq:NP_001244299.1 - go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity) comment:mint|comment:homomint - figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/04 2016/08/17 rogid:aMbLzujtdljtwSLjtXisKNpoQk89606 - - false his tag:n-n sufficient binding region:33-62|sufficient binding region:2-32 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q8IYD8 uniprotkb:Q9BTP7 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507795|imex:IM-25488-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:Supp Fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.26x10^-6(molar) 2016/08/04 2016/08/17 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false glutathione s tranferase tag:n-n|sufficient binding region:1799-2048 his tag:n-n|sufficient binding region:1-215 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q8IYD8 intact:EBI-12507793 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 - psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:ss_dna_for_fps(display_short)|psi-mi:EBI-12507793(display_long) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507795|imex:IM-25488-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - - figure legend:Supp Fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.26x10^-6(molar) 2016/08/04 2016/08/17 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 - - false glutathione s tranferase tag:n-n|sufficient binding region:1799-2048 fluorescein label:1-1 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-12507822 uniprotkb:Q8IYD8 - intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:complementary_dna_for_fps_1(display_short)|psi-mi:EBI-12507822(display_long) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507824|imex:IM-25488-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - figure legend:Supp Fig 3-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.31x10^-6(molar) 2016/08/04 2016/08/17 - rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 - false sufficient binding region:1-20 glutathione s tranferase tag:n-n|sufficient binding region:1799-2048 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-12507822 uniprotkb:Q9BTP7 - intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:complementary_dna_for_fps_1(display_short)|psi-mi:EBI-12507822(display_long) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507824|imex:IM-25488-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:Supp Fig 3-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.31x10^-6(molar) 2016/08/04 2016/08/17 - rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false sufficient binding region:1-20 his tag:n-n|sufficient binding region:1-215 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-12507822 intact:EBI-12507793 - - psi-mi:complementary_dna_for_fps_1(display_short)|psi-mi:EBI-12507822(display_long) psi-mi:ss_dna_for_fps(display_short)|psi-mi:EBI-12507793(display_long) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507824|imex:IM-25488-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - - - - figure legend:Supp Fig 3-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.31x10^-6(molar) 2016/08/04 2016/08/17 - - - false sufficient binding region:1-20 sufficient binding region:1-21|fluorescein label:1-1 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q8IYD8 uniprotkb:Q9BTP7 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507902|imex:IM-25488-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:Supp Fig 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.37x10^-6(molar) 2016/08/04 2016/08/17 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false glutathione s tranferase tag:n-n|sufficient binding region:1799-2048 his tag:n-n|sufficient binding region:1-215 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q8IYD8 intact:EBI-12507895 intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 - psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:splayed_dna_for_fps(display_short)|psi-mi:EBI-12507895(display_long) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507902|imex:IM-25488-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - - figure legend:Supp Fig 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.37x10^-6(molar) 2016/08/04 2016/08/17 rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 - - false glutathione s tranferase tag:n-n|sufficient binding region:1799-2048 fluorescein label:1-1 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-12506732 intact:EBI-12507940 - - psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:oligo_3_short(display_short)|psi-mi:EBI-12507940(display_long) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507920|imex:IM-25488-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - - - - figure legend:Supp fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.3x10^-6(molar) 2016/08/04 2016/08/17 - - - false sufficient binding region:33-62|sufficient binding region:2-32 sufficient binding region:1-31 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-12506732 intact:EBI-12506721 - - psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:splayed_arm_oligo1(display_short)|psi-mi:EBI-12506721(display_long) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507920|imex:IM-25488-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - - - - figure legend:Supp fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.3x10^-6(molar) 2016/08/04 2016/08/17 - - - false sufficient binding region:33-62|sufficient binding region:2-32 fluorescein label:1-1|sufficient binding region:2-31 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-12506732 uniprotkb:Q8IYD8 - intact:EBI-3957237|ensembl:ENSP00000267430|uniprotkb:Q3YFH9|uniprotkb:Q8N9X6|uniprotkb:Q9HCH6|uniprotkb:B2RTQ9|intact:EBI-10977447|intact:EBI-14204029|intact:EBI-12869570 psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:fancm_human(display_long)|uniprotkb:FANCM(gene name)|psi-mi:FANCM(display_short)|uniprotkb:KIAA1596(gene name synonym)|uniprotkb:ATP-dependent RNA helicase FANCM(gene name synonym)|uniprotkb:Fanconi anemia-associated polypeptide of 250 kDa(gene name synonym)|uniprotkb:Protein Hef ortholog(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507920|imex:IM-25488-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000187790(gene)|ensembl:ENST00000267430(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003682"(chromatin binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0045003"(double-strand break repair via synthesis-dependent strand annealing)|go:"GO:0071821"(FANCM-MHF complex)|go:"GO:0071932"(replication fork reversal)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031879|interpro:IPR039686|interpro:IPR044749|mint:Q8IYD8|rcsb pdb:4DAY|rcsb pdb:4DRB|rcsb pdb:4E45|rcsb pdb:4M6W|reactome:R-HSA-6783310|rcsb pdb:4BXO|refseq:NP_001295062.1|refseq:NP_001295063.1|refseq:NP_065988.1|dip:DIP-43972N - - - figure legend:Supp fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.3x10^-6(molar) 2016/08/04 2016/08/17 - rogid:APU9Ya2dfdgJgIwZPl5Z8/QMbgM9606 - false sufficient binding region:33-62|sufficient binding region:2-32 glutathione s tranferase tag:n-n|sufficient binding region:1799-2048 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-12506732 uniprotkb:Q9BTP7 - intact:EBI-1045650|uniprotkb:Q8WUJ7|uniprotkb:Q96FX6|uniprotkb:B3KY46|ensembl:ENSP00000466121|ensembl:ENSP00000468475 psi-mi:splayed_arm_oligo4(display_short)|psi-mi:EBI-12506732(display_long) psi-mi:fap24_human(display_long)|uniprotkb:FAAP24(gene name)|psi-mi:FAAP24(display_short)|uniprotkb:C19orf40(gene name synonym)|uniprotkb:Fanconi anemia-associated protein of 24 kDa(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ciccia et al. (2007) pubmed:17289582|imex:IM-25488 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12507920|imex:IM-25488-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001287907.1|refseq:NP_689479.1|ensembl:ENSG00000131944(gene)|ensembl:ENST00000588258(transcript)|ensembl:ENST00000590281(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR026985|interpro:IPR040646|interpro:IPR041663|rcsb pdb:2LYH|rcsb pdb:2M9M|rcsb pdb:2M9N|rcsb pdb:4BXO|rcsb pdb:4M6W|reactome:R-HSA-6783310|dip:DIP-50466N - - - figure legend:Supp fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.3x10^-6(molar) 2016/08/04 2016/08/17 - rogid:uKJOmZtWgTz5wtC5+emk4m1EFxw9606 - false sufficient binding region:33-62|sufficient binding region:2-32 his tag:n-n|sufficient binding region:1-215 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)