#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03920	uniprotkb:P53738	intact:EBI-31378|uniprotkb:D6VSC3|ensemblfungi:YDR140W	intact:EBI-28520|uniprotkb:D6W1M1|ensemblfungi:YNR046W	psi-mi:mtq2_yeast(display_long)|uniprotkb:MTQ2(gene name)|psi-mi:MTQ2(display_short)|uniprotkb:MTC6(gene name synonym)|uniprotkb:"N(5)-glutamine methyltransferase MTQ2"(gene name synonym)|uniprotkb:YDR140W(locus name)	psi-mi:tr112_yeast(display_long)|uniprotkb:YNR046W(locus name)|uniprotkb:N3445(orf name)|uniprotkb:TRM112(gene name)|psi-mi:TRM112(display_short)|uniprotkb:tRNA methyltransferase 112(gene name synonym)|uniprotkb:eRF1 methyltransferase subunit TRM112(gene name synonym)	psi-mi:"MI:0096"(pull down)	Heurgué-Hamard et al. (2006)	pubmed:17008308|imex:IM-25282	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702657|imex:IM-25282-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010424.3|sgd:S000002547|dip:DIP-1755N|mint:Q03920|ensemblfungi:YDR140W(gene)|ensemblfungi:YDR140W_mRNA(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0018364"(peptidyl-glutamine methylation)|go:"GO:0035657"(eRF1 methyltransferase complex)|go:"GO:0102559"("protein-(glutamine-N5) methyltransferase activity")|interpro:IPR002052(N-6 adenine-specific DNA methylase, conserved site)|interpro:IPR004557(Putative methylase)|interpro:IPR007848(Methyltransferase small)|interpro:IPR029063|reactome:R-SCE-156581|reactome:R-SCE-72764	refseq:NP_014444.1|sgd:S000005329|dip:DIP-2052N|mint:P53738|ensemblfungi:YNR046W(gene)|ensemblfungi:YNR046W_mRNA(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0018364"(peptidyl-glutamine methylation)|go:"GO:0030488"(tRNA methylation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0035657"(eRF1 methyltransferase complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0043528"("tRNA (m2G10) methyltransferase complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070476"("rRNA (guanine-N7)-methylation")|interpro:IPR005651(Protein of unknown function DUF343)|interpro:IPR039127|rcsb pdb:2J6A|rcsb pdb:4QTT|rcsb pdb:4QTU|reactome:R-SCE-156581|reactome:R-SCE-72764	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2016/05/17	2016/05/17	rogid:pu/ERTe9ojnsy8nxRKkRA+sHq80559292	rogid:nYQNLSc+7sh49MoMpeJZaY8Ag2s559292	rigid:N55tfgfrQHP6ZVjqjw1QepJfTxY	false	his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12385	uniprotkb:P05453	intact:EBI-6533|uniprotkb:D6VQD9|ensemblfungi:YBR143C	intact:EBI-6540|uniprotkb:P05420|uniprotkb:D6VSF4|ensemblfungi:YDR172W	psi-mi:erf1_yeast(display_long)|uniprotkb:SUP45(gene name)|psi-mi:SUP45(display_short)|uniprotkb:SAL4(gene name synonym)|uniprotkb:SUP1(gene name synonym)|uniprotkb:YBR143C(locus name)|uniprotkb:YBR1120(orf name)|uniprotkb:Omnipotent suppressor protein 1(gene name synonym)	psi-mi:erf3_yeast(display_long)|uniprotkb:SUP35(gene name)|psi-mi:SUP35(display_short)|uniprotkb:GST1(gene name synonym)|uniprotkb:PNM2(gene name synonym)|uniprotkb:SAL3(gene name synonym)|uniprotkb:SUF12(gene name synonym)|uniprotkb:SUP2(gene name synonym)|uniprotkb:YDR172W(locus name)|uniprotkb:YD9395.05(orf name)|uniprotkb:ERF2(gene name synonym)|uniprotkb:ERF-3(gene name synonym)|uniprotkb:Translation release factor 3(gene name synonym)|uniprotkb:Polypeptide release factor 3(gene name synonym)|uniprotkb:Omnipotent suppressor protein 2(gene name synonym)|uniprotkb:G1 to S phase transition protein 1(gene name synonym)|uniprotkb:PSI no more protein 2(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Heurgué-Hamard et al. (2006)	pubmed:17008308|imex:IM-25282	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11710236|imex:IM-25282-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000347|refseq:NP_009701.3|mint:P12385|dip:DIP-800N|ensemblfungi:YBR143C(gene)|ensemblfungi:YBR143C_mRNA(transcript)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006415"(translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|rcsb pdb:4CRM|rcsb pdb:4CRN|reactome:R-SCE-72764|reactome:R-SCE-975956|reactome:R-SCE-975957	sgd:S000002579|refseq:NP_010457.3|mint:P05453|dip:DIP-376N|ensemblfungi:YDR172W(gene)|ensemblfungi:YDR172W_mRNA(transcript)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003729"(mRNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006415"(translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0018444"(translation release factor complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR003285(Yeast eukaryotic release factor)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|rcsb pdb:1YJO|rcsb pdb:1YJP|rcsb pdb:2OMM|rcsb pdb:4CRN|rcsb pdb:5K2E|rcsb pdb:5K2F|rcsb pdb:5K2G|rcsb pdb:5K2H|reactome:R-SCE-72764|reactome:R-SCE-975956|reactome:R-SCE-975957	-	crc64:9B59133EE3B1F61E	crc64:43912A6D77DFA153	figure legend:Figs. 4, 5|comment:Enzyme complex was active rrespective of whether the 2 components were co-expressed or reconstituted in vitro. GTP was also required in the assay mix.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/17	2016/06/01	rogid:gy6qwRrMC3d3s/uaS2PzFoK6/Do559292	rogid:R4xSkfzHnSuHRDxWOd2dWMEuseI559292	-	false	his tag:c-c	his tag:?-?|sufficient binding region:?-385	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12385	intenz:2.1.1	intact:EBI-6533|uniprotkb:D6VQD9|ensemblfungi:YBR143C	intact:EBI-11702627	psi-mi:erf1_yeast(display_long)|uniprotkb:SUP45(gene name)|psi-mi:SUP45(display_short)|uniprotkb:SAL4(gene name synonym)|uniprotkb:SUP1(gene name synonym)|uniprotkb:YBR143C(locus name)|uniprotkb:YBR1120(orf name)|uniprotkb:Omnipotent suppressor protein 1(gene name synonym)	psi-mi:mtq2-trm112(display_short)|psi-mi:2.1.1(display_long)|intact:S-adenosylmethionine-dependent eRF1 methyltransferase complex(complex synonym)|intact:MTQ2-TRM112 eRF1 methyltransferase complex(complex recommended name)|intact:"MTQ2:TRM112"(complex systematic name)|intact:S-adenosylmethionine-dependent methyltransferase complex(complex synonym)|intact:S-adenosyl-L-methionine-dependent methyltransferase complex(complex synonym)|intact:SAM-dependent methyltransferase complex(complex synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Heurgué-Hamard et al. (2006)	pubmed:17008308|imex:IM-25282	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11710236|imex:IM-25282-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	sgd:S000000347|refseq:NP_009701.3|mint:P12385|dip:DIP-800N|ensemblfungi:YBR143C(gene)|ensemblfungi:YBR143C_mRNA(transcript)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006415"(translational termination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|rcsb pdb:4CRM|rcsb pdb:4CRN|reactome:R-SCE-72764|reactome:R-SCE-975956|reactome:R-SCE-975957	go:"GO:0008276"(protein methyltransferase activity)|intact:EBI-11702657(exp-evidence)|pubmed:28134793(see-also)|go:"GO:0035657"(eRF1 methyltransferase complex)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0005840"(ribosome)|go:"GO:0018364"(peptidyl-glutamine methylation)|evidence ontology:"ECO:0000353"|pubmed:17008308(see-also)|go:"GO:0060566"(positive regulation of DNA-templated transcription, termination)|complex portal:CPX-418(complex-primary)	-	crc64:9B59133EE3B1F61E	curated-complex:S-adenosylmethionine-dependent methyltransferase  responsible for methylating Gln-182 present in the conserved GGQ motif of the eRF1 subunit of the class 1 peptide chain release factor eRF1-eRF3 complex. Methylation occurs in the presence of GTP. This terminates the translation of nascent peptides in response to the termination codons UAA, UAG and UGA. Uses S-adenosyl L-methionine as methyl donor.|complex-assembly:Heterodimer|complex-properties:MW = 40.8 kDa	figure legend:Figs. 4, 5|comment:Enzyme complex was active rrespective of whether the 2 components were co-expressed or reconstituted in vitro. GTP was also required in the assay mix.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/17	2016/06/01	rogid:gy6qwRrMC3d3s/uaS2PzFoK6/Do559292	-	-	false	his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)