#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07686	uniprotkb:P06865	intact:EBI-7133736|ensembl:ENSP00000261416|intact:MINT-4528380	intact:EBI-723519|ensembl:ENSP00000268097|uniprotkb:Q53HS8|uniprotkb:Q6AI32|uniprotkb:B4DKE7|uniprotkb:E7ENH7	psi-mi:hexb_human(display_long)|uniprotkb:HEXB(gene name)|psi-mi:HEXB(display_short)|uniprotkb:HCC7(orf name)|uniprotkb:N-acetyl-beta-glucosaminidase subunit beta(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase subunit beta(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 7 protein(gene name synonym)	psi-mi:hexa_human(display_long)|uniprotkb:N-acetyl-beta-glucosaminidase subunit alpha(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase subunit alpha(gene name synonym)|uniprotkb:HEXA(gene name)|psi-mi:HEXA(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Lemieux et al. (2006)	pubmed:16698036|imex:IM-25817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592726|wwpdb:2gjx|imex:IM-25817-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000049860(gene)|ensembl:ENST00000261416(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004563"(beta-N-acetylhexosaminidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007040"(lysosome organization)|go:"GO:0007338"(single fertilization)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0009313"(oligosaccharide catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042552"(myelination)|go:"GO:0042582"(azurophil granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|rcsb pdb:1NOU|rcsb pdb:1NOW|rcsb pdb:1NP0|rcsb pdb:1O7A|rcsb pdb:1QBD|rcsb pdb:2GJX|rcsb pdb:2GK1|rcsb pdb:3LMY|rcsb pdb:5BRO|reactome:R-HSA-1660662|reactome:R-HSA-2022857|reactome:R-HSA-2024101|reactome:R-HSA-2160916|reactome:R-HSA-3656248|reactome:R-HSA-6798695|refseq:NP_000512.1|refseq:NP_001278933.1	refseq:NP_000511.2|ensembl:ENSG00000213614(gene)|ensembl:ENST00000268097(transcript)|go:"GO:0004563"(beta-N-acetylhexosaminidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0042582"(azurophil granule)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|rcsb pdb:1QBC|rcsb pdb:2GJX|rcsb pdb:2GK1|reactome:R-HSA-1660662|go:"GO:0006689"(ganglioside catabolic process)|reactome:R-HSA-2024101|reactome:R-HSA-2160916|reactome:R-HSA-2022857|reactome:R-HSA-3656234|refseq:NP_001305754.1	-	function:"Defects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2) [MIM:268800]; also known as Sandhoff disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2-gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula"|comment:mint|comment:homomint|function:Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues	-	figure legend:Table 1|3d-resolution:2.8A|3d-r-factors:Rw = 0.269  Rfree = 0.288|comment:Both subunits have many N-linked glycosyl residues and there are oligosaccharides bound at most of the known glycosylation sites.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/06	2016/11/03	rogid:1cc9u+fdr9Y0llAa3Aji4SrTh2k9606	rogid:vb+06UjAmegWcUOZUILPR2Ycuo09606	rigid:jCv8b0LdKBRl8JG53VmkZtMBoP0	false	glycosylated residue:?-?	glycosylated residue:?-?	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06865	uniprotkb:P07686	intact:EBI-723519|ensembl:ENSP00000268097|uniprotkb:Q53HS8|uniprotkb:Q6AI32|uniprotkb:B4DKE7|uniprotkb:E7ENH7	intact:EBI-7133736|ensembl:ENSP00000261416|intact:MINT-4528380	psi-mi:hexa_human(display_long)|uniprotkb:N-acetyl-beta-glucosaminidase subunit alpha(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase subunit alpha(gene name synonym)|uniprotkb:HEXA(gene name)|psi-mi:HEXA(display_short)	psi-mi:hexb_human(display_long)|uniprotkb:HEXB(gene name)|psi-mi:HEXB(display_short)|uniprotkb:HCC7(orf name)|uniprotkb:N-acetyl-beta-glucosaminidase subunit beta(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase subunit beta(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 7 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lemieux et al. (2006)	pubmed:16698036|imex:IM-25817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592751|pdbe:2gk1|imex:IM-25817-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000511.2|ensembl:ENSG00000213614(gene)|ensembl:ENST00000268097(transcript)|go:"GO:0004563"(beta-N-acetylhexosaminidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0042582"(azurophil granule)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|rcsb pdb:1QBC|rcsb pdb:2GJX|rcsb pdb:2GK1|reactome:R-HSA-1660662|go:"GO:0006689"(ganglioside catabolic process)|reactome:R-HSA-2024101|reactome:R-HSA-2160916|reactome:R-HSA-2022857|reactome:R-HSA-3656234|refseq:NP_001305754.1	ensembl:ENSG00000049860(gene)|ensembl:ENST00000261416(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004563"(beta-N-acetylhexosaminidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007040"(lysosome organization)|go:"GO:0007338"(single fertilization)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0009313"(oligosaccharide catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042552"(myelination)|go:"GO:0042582"(azurophil granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|rcsb pdb:1NOU|rcsb pdb:1NOW|rcsb pdb:1NP0|rcsb pdb:1O7A|rcsb pdb:1QBD|rcsb pdb:2GJX|rcsb pdb:2GK1|rcsb pdb:3LMY|rcsb pdb:5BRO|reactome:R-HSA-1660662|reactome:R-HSA-2022857|reactome:R-HSA-2024101|reactome:R-HSA-2160916|reactome:R-HSA-3656248|reactome:R-HSA-6798695|refseq:NP_000512.1|refseq:NP_001278933.1	-	-	function:"Defects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2) [MIM:268800]; also known as Sandhoff disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2-gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula"|comment:mint|comment:homomint|function:Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues	figure legend:Table 1i|3d-resolution:3.25A|3d-r-factors:Rw = 0.274  Rfree = 0.322|comment:Both subunits have many N-linked glycosyl residues and there are oligosaccharides bound at most of the known glycosylation sites.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/06	2017/08/09	rogid:vb+06UjAmegWcUOZUILPR2Ycuo09606	rogid:1cc9u+fdr9Y0llAa3Aji4SrTh2k9606	-	false	glycosylated residue:?-?	glycosylated residue:?-?	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-12592764	uniprotkb:P06865	chembl:CHEMBL257158	intact:EBI-723519|ensembl:ENSP00000268097|uniprotkb:Q53HS8|uniprotkb:Q6AI32|uniprotkb:B4DKE7|uniprotkb:E7ENH7	psi-mi:nag-thiazoline(display_short)|psi-mi:EBI-12592764(display_long)	psi-mi:hexa_human(display_long)|uniprotkb:N-acetyl-beta-glucosaminidase subunit alpha(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase subunit alpha(gene name synonym)|uniprotkb:HEXA(gene name)|psi-mi:HEXA(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Lemieux et al. (2006)	pubmed:16698036|imex:IM-25817	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592751|pdbe:2gk1|imex:IM-25817-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000511.2|ensembl:ENSG00000213614(gene)|ensembl:ENST00000268097(transcript)|go:"GO:0004563"(beta-N-acetylhexosaminidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0042582"(azurophil granule)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|rcsb pdb:1QBC|rcsb pdb:2GJX|rcsb pdb:2GK1|reactome:R-HSA-1660662|go:"GO:0006689"(ganglioside catabolic process)|reactome:R-HSA-2024101|reactome:R-HSA-2160916|reactome:R-HSA-2022857|reactome:R-HSA-3656234|refseq:NP_001305754.1	-	-	-	figure legend:Table 1i|3d-resolution:3.25A|3d-r-factors:Rw = 0.274  Rfree = 0.322|comment:Both subunits have many N-linked glycosyl residues and there are oligosaccharides bound at most of the known glycosylation sites.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/06	2017/08/09	-	rogid:vb+06UjAmegWcUOZUILPR2Ycuo09606	-	false	-	glycosylated residue:?-?	-	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)