#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:46889" uniprotkb:P08571 intact:EBI-1546891 intact:EBI-3905196|uniprotkb:Q96L99|uniprotkb:Q53XT5|uniprotkb:Q9UNS3|uniprotkb:Q96FR6|ensembl:ENSP00000304236|ensembl:ENSP00000385519 psi-mi:"s-[2,3-bis(palmitoyloxy)propyl]-cys-ser-lys-lys-lys-lys"(display_short)|psi-mi:"CHEBI:46889"(display_long) psi-mi:cd14_human(display_long)|uniprotkb:CD14(gene name)|psi-mi:CD14(display_short)|uniprotkb:Myeloid cell-specific leucine-rich glycoprotein(gene name synonym) psi-mi:"MI:0982"(electrophoretic mobility-based method) Schröder et al. (2004) pubmed:15294986|imex:IM-25869 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:1335"(HPIDb) intact:EBI-12736162|imex:IM-25869-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_000582.1|refseq:NP_001035110.1|refseq:NP_001167575.1|refseq:NP_001167576.1|dip:DIP-1030N|ensembl:ENSG00000170458(gene)|ensembl:ENST00000302014(transcript)|ensembl:ENST00000401743(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001847"(opsonin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016019"(peptidoglycan immune receptor activity)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR016337(Monocyte differentiation antigen CD14)|interpro:IPR032675|rcsb pdb:4GLP|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling) - - - figure legend:2C-D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/12/15 2017/02/08 - rogid:MpfQfOF+t0EMlzBio2kyYeJU3hE9606 - false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:46889" uniprotkb:P18428 intact:EBI-1546891 intact:EBI-3927059|uniprotkb:B2R938|uniprotkb:Q9UD66|uniprotkb:O43438|uniprotkb:Q9H403|uniprotkb:Q92672|ensembl:ENSP00000217407 psi-mi:"s-[2,3-bis(palmitoyloxy)propyl]-cys-ser-lys-lys-lys-lys"(display_short)|psi-mi:"CHEBI:46889"(display_long) psi-mi:lbp_human(display_long)|uniprotkb:LBP(gene name)|psi-mi:LBP(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Schröder et al. (2004) pubmed:15294986|imex:IM-25869 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-12736172|imex:IM-25869-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_004130.2|ensembl:ENSG00000129988(gene)|ensembl:ENST00000217407(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006968"(cellular defense response)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0015920"(lipopolysaccharide transport)|go:"GO:0016020"(membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032490"(detection of molecule of bacterial origin)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033036"(macromolecule localization)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045919"(positive regulation of cytolysis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR001124(Lipid-binding serum glycoprotein)|interpro:IPR017942|interpro:IPR017943|interpro:IPR017954|interpro:IPR030180|interpro:IPR030675|interpro:IPR032942|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-5686938|reactome:R-HSA-6785807|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|dip:DIP-90N - - - figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/12/15 2017/02/08 - rogid:dSU+dnC7sUIeRc5ff52LhvrF58o9606 - false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:134411" uniprotkb:P18428 intact:EBI-13643021 intact:EBI-3927059|uniprotkb:B2R938|uniprotkb:Q9UD66|uniprotkb:O43438|uniprotkb:Q9H403|uniprotkb:Q92672|ensembl:ENSP00000217407 psi-mi:pam3csk4(display_short)|psi-mi:"CHEBI:134411"(display_long) psi-mi:lbp_human(display_long)|uniprotkb:LBP(gene name)|psi-mi:LBP(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Schröder et al. (2004) pubmed:15294986|imex:IM-25869 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-12736175|imex:IM-25869-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_004130.2|ensembl:ENSG00000129988(gene)|ensembl:ENST00000217407(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006968"(cellular defense response)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0015920"(lipopolysaccharide transport)|go:"GO:0016020"(membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032490"(detection of molecule of bacterial origin)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033036"(macromolecule localization)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045919"(positive regulation of cytolysis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR001124(Lipid-binding serum glycoprotein)|interpro:IPR017942|interpro:IPR017943|interpro:IPR017954|interpro:IPR030180|interpro:IPR030675|interpro:IPR032942|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-5686938|reactome:R-HSA-6785807|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|dip:DIP-90N - - - figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/12/15 2017/02/08 - rogid:dSU+dnC7sUIeRc5ff52LhvrF58o9606 - false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9R3N6 uniprotkb:P18428 intact:EBI-12736182 intact:EBI-3927059|uniprotkb:B2R938|uniprotkb:Q9UD66|uniprotkb:O43438|uniprotkb:Q9H403|uniprotkb:Q92672|ensembl:ENSP00000217407 psi-mi:q9r3n6_mycfe(display_long)|uniprotkb:malP(gene name)|psi-mi:malP(display_short)|uniprotkb:malp(gene name synonym) psi-mi:lbp_human(display_long)|uniprotkb:LBP(gene name)|psi-mi:LBP(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Schröder et al. (2004) pubmed:15294986|imex:IM-25869 taxid:2115(Mycoplasma fermentans)|taxid:2115(Mycoplasma fermentans) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-12736178|imex:IM-25869-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|interpro:IPR008107(Mycoplasma P48 major surface lipoprotein)|interpro:IPR003760(Basic membrane lipoprotein) refseq:NP_004130.2|ensembl:ENSG00000129988(gene)|ensembl:ENST00000217407(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006968"(cellular defense response)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0015920"(lipopolysaccharide transport)|go:"GO:0016020"(membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032490"(detection of molecule of bacterial origin)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033036"(macromolecule localization)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045919"(positive regulation of cytolysis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR001124(Lipid-binding serum glycoprotein)|interpro:IPR017942|interpro:IPR017943|interpro:IPR017954|interpro:IPR030180|interpro:IPR030675|interpro:IPR032942|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-5686938|reactome:R-HSA-6785807|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|dip:DIP-90N - - - figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/12/15 2017/01/09 rogid:Z0ZmItXp/69B7YMbOl+4i/ENOP42115 rogid:dSU+dnC7sUIeRc5ff52LhvrF58o9606 rigid:3byGzGmsRJcB8/xR/dWm1ixHjAw false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)