#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:16755"	uniprotkb:Q15788	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507047|imex:IM-25010-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	-	-	-	figure legend:1 A/B|causality statement:"CHEBI:16755 increases the binding of Q96RI1 to Q15788"|causality statement:"CHEBI:16755 increases the expression at protein level of Q96RI1"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	-	false	-	biotin tag:?-?|sufficient binding region:568-780	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:16755"	uniprotkb:Q96RI1	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507047|imex:IM-25010-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:1 A/B|causality statement:"CHEBI:16755 increases the binding of Q96RI1 to Q15788"|causality statement:"CHEBI:16755 increases the expression at protein level of Q96RI1"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	-	glutathione s tranferase tag:?-?|sufficient binding region:256..256-474..474(IPR000536)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:29747"	uniprotkb:Q15788	intact:EBI-11507080|chebi:"CHEBI:13978"|chebi:"CHEBI:11895"|chebi:"CHEBI:20216"|chebi:"CHEBI:23168"|chebi:"CHEBI:57748"	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	psi-mi:cholate(display_short)|psi-mi:"CHEBI:29747"(display_long)|intact:cholate(synonym)|intact:3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oate(iupac name)|intact:3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate(synonym)	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507067|imex:IM-25010-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	-	-	-	figure legend:1 A/B|causality statement:"CHEBI:29747   increases the binding of Q96RI1 to Q15788"|causality statement:"CHEBI:29747  increases the expression at protein level of Q96RI1"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	-	false	-	biotin tag:?-?|sufficient binding region:568-780	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:29747"	uniprotkb:Q96RI1	intact:EBI-11507080|chebi:"CHEBI:13978"|chebi:"CHEBI:11895"|chebi:"CHEBI:20216"|chebi:"CHEBI:23168"|chebi:"CHEBI:57748"	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:cholate(display_short)|psi-mi:"CHEBI:29747"(display_long)|intact:cholate(synonym)|intact:3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oate(iupac name)|intact:3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate(synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507067|imex:IM-25010-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:1 A/B|causality statement:"CHEBI:29747   increases the binding of Q96RI1 to Q15788"|causality statement:"CHEBI:29747  increases the expression at protein level of Q96RI1"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	-	glutathione s tranferase tag:?-?|sufficient binding region:256..256-474..474(IPR000536)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q15788	uniprotkb:Q96RI1	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507094|imex:IM-25010-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:1B|causality statement:"CHEBI:16525 increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	biotin tag:?-?|sufficient binding region:568-780	glutathione s tranferase tag:?-?|sufficient binding region:256..256-474..474(IPR000536)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:16525"	uniprotkb:Q15788	intact:EBI-11477649|chebi:"CHEBI:46136"|chebi:"CHEBI:3590"|chebi:"CHEBI:13961"|chebi:"CHEBI:23096"	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	psi-mi:taurochenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16525"(display_long)|intact:Chenodeoxycholoyltaurine(synonym)|intact:taurine chenodeoxycholate(synonym)|intact:taurochenodeoxycholate(synonym)|intact:taurochenodeoxycholic acid(synonym)|intact:Taurochenodeoxycholic acid(synonym)|intact:"2-[(3alpha,7alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid"(iupac name)	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507094|imex:IM-25010-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	-	-	-	figure legend:1B|causality statement:"CHEBI:16525 increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	-	false	-	biotin tag:?-?|sufficient binding region:568-780	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:36274"	uniprotkb:Q15788	intact:EBI-11506944|chebi:"CHEBI:5463"|chebi:"CHEBI:41520"|chebi:"CHEBI:3591"	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	psi-mi:glycochenodeoxycholic acid(display_short)|psi-mi:"CHEBI:36274"(display_long)|intact:chenodeoxycholylglycine(synonym)|intact:Chenodeoxyglycocholate(synonym)|intact:chenodeoxyglycocholic acid(synonym)|intact:GCDCA(synonym)|intact:glycine chenodeoxycholate(synonym)|intact:Glycochenodeoxycholate(synonym)|intact:GLYCOCHENODEOXYCHOLIC ACID(synonym)|intact:Glycochenodeoxycholic acid(synonym)|intact:"[(3alpha,7alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]acetic acid"(iupac name)|intact:"N-(3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl)glycine"(iupac name)	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507111|imex:IM-25010-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	-	-	-	figure legend:1B|causality statement:"CHEBI:36274   increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	-	false	-	biotin tag:?-?|sufficient binding region:568-780	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:36274"	uniprotkb:Q96RI1	intact:EBI-11506944|chebi:"CHEBI:5463"|chebi:"CHEBI:41520"|chebi:"CHEBI:3591"	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:glycochenodeoxycholic acid(display_short)|psi-mi:"CHEBI:36274"(display_long)|intact:chenodeoxycholylglycine(synonym)|intact:Chenodeoxyglycocholate(synonym)|intact:chenodeoxyglycocholic acid(synonym)|intact:GCDCA(synonym)|intact:glycine chenodeoxycholate(synonym)|intact:Glycochenodeoxycholate(synonym)|intact:GLYCOCHENODEOXYCHOLIC ACID(synonym)|intact:Glycochenodeoxycholic acid(synonym)|intact:"[(3alpha,7alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]acetic acid"(iupac name)|intact:"N-(3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl)glycine"(iupac name)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507111|imex:IM-25010-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:1B|causality statement:"CHEBI:36274   increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	-	glutathione s tranferase tag:?-?|sufficient binding region:256..256-474..474(IPR000536)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:17687"	uniprotkb:Q15788	intact:EBI-11507138|chebi:"CHEBI:11894"|chebi:"CHEBI:42804"|chebi:"CHEBI:5464"|chebi:"CHEBI:24378"|chebi:"CHEBI:20215"|chebi:"CHEBI:29080"	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	psi-mi:glycocholic acid(display_short)|psi-mi:"CHEBI:17687"(display_long)|intact:3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine(synonym)|intact:3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine(synonym)|intact:Glycocholic acid(synonym)|intact:GLYCOCHOLIC ACID(synonym)|intact:"N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine"(synonym)|intact:N-choloylglycine(synonym)|intact:"N-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oyl)glycine"(iupac name)	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507125|imex:IM-25010-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	-	-	-	figure legend:1B|causality statement:"CHEBI:17687  increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	-	false	-	sufficient binding region:568-780|biotin tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:17687"	uniprotkb:Q96RI1	intact:EBI-11507138|chebi:"CHEBI:11894"|chebi:"CHEBI:42804"|chebi:"CHEBI:5464"|chebi:"CHEBI:24378"|chebi:"CHEBI:20215"|chebi:"CHEBI:29080"	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:glycocholic acid(display_short)|psi-mi:"CHEBI:17687"(display_long)|intact:3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine(synonym)|intact:3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine(synonym)|intact:Glycocholic acid(synonym)|intact:GLYCOCHOLIC ACID(synonym)|intact:"N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine"(synonym)|intact:N-choloylglycine(synonym)|intact:"N-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oyl)glycine"(iupac name)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507125|imex:IM-25010-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:1B|causality statement:"CHEBI:17687  increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	-	glutathione s tranferase tag:?-?|sufficient binding region:256..256-474..474(IPR000536)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q15788	uniprotkb:Q96RI1	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507157|imex:IM-25010-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:1B|causality statement:"CHEBI:28865  increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	biotin tag:?-?|sufficient binding region:568-780	glutathione s tranferase tag:?-?|sufficient binding region:256..256-474..474(IPR000536)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:28865"	uniprotkb:Q15788	intact:EBI-9818030|chebi:"CHEBI:9408"|chebi:"CHEBI:26854"|chebi:"CHEBI:3672"|chebi:"CHEBI:45901"	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	psi-mi:taurocholic acid(display_short)|psi-mi:"CHEBI:28865"(display_long)|intact:3alpha,7alpha,12alpha-trihydroxy-5beta-cholanic acid 24-taurine(synonym)|intact:cholic acid taurine conjugate(synonym)|intact:Choloyl-taurine(synonym)|intact:Cholyltaurine(synonym)|intact:N-choloyltaurine(synonym)|intact:Taurocholate(synonym)|intact:Taurocholic acid(synonym)|intact:"2-[(3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid"(iupac name)	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507157|imex:IM-25010-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	-	inchi key:WBWWGRHZICKQGZ-HZAMXZRMSA-N	-	figure legend:1B|causality statement:"CHEBI:28865  increases the binding of Q96RI1 to Q15788"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	-	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	-	false	-	biotin tag:?-?|sufficient binding region:568-780	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q15788	uniprotkb:Q96RI1	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0510"(homogeneous time resolved fluorescence)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11565105|imex:IM-25010-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:1 A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/02/05	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rigid:RSBhlN0jm62+lojDk2PjLxD+bnM	false	biotin tag:?-?|sufficient binding region:568-780	glutathione s tranferase tag:?-?|sufficient binding region:256..256-474..474(IPR000536)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q15788	uniprotkb:Q96RI1	intact:EBI-455189|uniprotkb:O00150|uniprotkb:O43792|uniprotkb:O43793|uniprotkb:Q13071|uniprotkb:Q13420|uniprotkb:Q2T9G5|uniprotkb:Q53SX3|uniprotkb:Q6GVI5|uniprotkb:Q7KYV3|ensembl:ENSP00000320940|ensembl:ENSP00000385216	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:ncoa1_human(display_long)|uniprotkb:Steroid receptor coactivator 1(gene name synonym)|uniprotkb:RIP160(gene name synonym)|uniprotkb:Protein Hin-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-52(gene name synonym)|uniprotkb:NCOA1(gene name)|psi-mi:NCOA1(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:BHLHE74(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 74(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lew et al. (2004)	imex:IM-25010|pubmed:14684751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507194|imex:IM-25010-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671756.1|refseq:NP_671766.1|refseq:NP_003734.3|ensembl:ENSP00000379197|ensembl:ENST00000405141|ensembl:ENSP00000385097|ensembl:ENSP00000385216|ensembl:ENSP00000320940|ensembl:ENST00000395856|ensembl:ENST00000288599|ensembl:ENSP00000288599|refseq:XP_005264682.1|refseq:XP_005264683.1|refseq:XP_005264685.1|refseq:XP_016860657.1|refseq:XP_016860658.1|dip:DIP-30877N|ensembl:ENSG00000084676(gene)|ensembl:ENST00000348332(transcript)|ensembl:ENST00000406961(transcript)|go:"GO:0000435"(positive regulation of transcription from RNA polymerase II promoter by galactose)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007595"(lactation)|go:"GO:0008584"(male gonad development)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060179"(male mating behavior)|go:"GO:0060713"(labyrinthine layer morphogenesis)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|rcsb pdb:2NV7|rcsb pdb:2P54|rcsb pdb:2PRG|rcsb pdb:3BEJ|rcsb pdb:3BQD|rcsb pdb:3CTB|rcsb pdb:3CWD|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3DR1|rcsb pdb:3ET1|rcsb pdb:3ET3|rcsb pdb:3FEI|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3FXV|rcsb pdb:3G8I|rcsb pdb:3G9E|rcsb pdb:3GYT|rcsb pdb:3GYU|rcsb pdb:3H0A|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3HVL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:3KMR|rcsb pdb:3LMP|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OLL|rcsb pdb:3OLS|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OMO|rcsb pdb:3OMP|rcsb pdb:3OMQ|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3QT0|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:3S9S|rcsb pdb:3T03|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUD|rcsb pdb:3V9Y|rcsb pdb:3VN2|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4DM6|rcsb pdb:4DM8|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028819|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15788|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1K4W|rcsb pdb:1K74|rcsb pdb:1K7L|rcsb pdb:1KV6|rcsb pdb:1N4H|rcsb pdb:1NQ7|rcsb pdb:1NRL|rcsb pdb:1P8D|rcsb pdb:1PZL|rcsb pdb:1RDT|rcsb pdb:1TFC|rcsb pdb:1U3R|rcsb pdb:1U3S|rcsb pdb:1X76|rcsb pdb:1X78|rcsb pdb:1X7B|rcsb pdb:1X7J|rcsb pdb:1XIU|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YY4|rcsb pdb:1YYE|rcsb pdb:1ZAF|rcsb pdb:2A3I|rcsb pdb:2C52|rcsb pdb:2FVJ|rcsb pdb:2GTK|rcsb pdb:2HBH|rcsb pdb:2HC4|rcsb pdb:2HCD|rcsb pdb:2HFP|rcsb pdb:2NPA|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5E7V|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HJS|rcsb pdb:5JI0|rcsb pdb:5JMM|rcsb pdb:5L7E|rcsb pdb:5L7G|rcsb pdb:5L7H|rcsb pdb:5MWP|rcsb pdb:5MWY|rcsb pdb:5MX7|rcsb pdb:5NKY|rcsb pdb:5NMA|rcsb pdb:5NMB|rcsb pdb:5NWM|rcsb pdb:5OW7|rcsb pdb:5OW9|rcsb pdb:5OWD|rcsb pdb:4G1Z|rcsb pdb:4G20|rcsb pdb:4G21|rcsb pdb:4G2H|rcsb pdb:4HEE|rcsb pdb:4J5X|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4DQM|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4RUJ|rcsb pdb:4RUP|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4UDA|rcsb pdb:4UDB|rcsb pdb:4Y29|rcsb pdb:5A86|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4G1D|rcsb pdb:4G1Y|rcsb pdb:5AZT|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:6L96|rcsb pdb:6NX1|rcsb pdb:6P9F|rcsb pdb:6SSQ|rcsb pdb:6T2M|rcsb pdb:6TFI|rcsb pdb:6U25|rcsb pdb:6W9H|rcsb pdb:6W9I|rcsb pdb:6XP9|rcsb pdb:7BPY|rcsb pdb:7BPZ|rcsb pdb:7BQ0|rcsb pdb:7BQ1|rcsb pdb:7BQ2|rcsb pdb:7BQ3|rcsb pdb:7BQ4|rcsb pdb:7JYM|rcsb pdb:7KXD|rcsb pdb:7KXE|rcsb pdb:7KXF|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-193807|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6BNS|rcsb pdb:6E3G|rcsb pdb:6FO7|rcsb pdb:6FO8|rcsb pdb:6FO9|rcsb pdb:6FOB|rcsb pdb:6FOD|rcsb pdb:6GEV|rcsb pdb:6GG8|rcsb pdb:5Q1D|rcsb pdb:6HTY|rcsb pdb:6ICJ|rcsb pdb:5Q1E|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6ITM|rcsb pdb:6JNR|rcsb pdb:6JQ7|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5X0R|rcsb pdb:5X8U|rcsb pdb:5X8W|rcsb pdb:5Y44|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5YP6|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L6K|interpro:IPR011598(Helix-loop-helix DNA-binding)	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:2|agonist:"chenodeoxycholic acid (CHEBI:16755)"|comment:"GW4064 (a synthetic FXR agonist) also promoted interaction"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/02/01	rogid:OKjGLyCEDCW1kgUe6qB9bnKO4Rs9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rigid:RSBhlN0jm62+lojDk2PjLxD+bnM	false	sufficient binding region:568-780|glutathione s tranferase tag:?-?	sufficient binding region:256..256-474..474(IPR000536)|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)