#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35670	uniprotkb:Q8N668	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668498|imex:IM-25076-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	-	-	-	figure legend:1 A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2017/08/08	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35670	uniprotkb:Q8N668	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668574|imex:IM-25076-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	-	-	-	figure legend:1 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2017/08/08	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35670	uniprotkb:O00244	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-10179267|uniprotkb:Q2M1R6|uniprotkb:A8KAJ8|uniprotkb:D3DQI2|uniprotkb:Q56AP3|ensembl:ENSP00000316854|ensembl:ENSP00000429814|ensembl:ENSP00000430598	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:atox1_human(display_long)|uniprotkb:ATOX1(gene name)|psi-mi:ATOX1(display_short)|uniprotkb:HAH1(gene name synonym)|uniprotkb:Metal transport protein ATX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668591|imex:IM-25076-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_004036.1|ensembl:ENSG00000177556(gene)|ensembl:ENST00000313115(transcript)|ensembl:ENST00000522710(transcript)|ensembl:ENST00000524142(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016530"(metallochaperone activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0060003"(copper ion export)|go:"GO:1903136"(cuprous ion binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR017969|interpro:IPR036163|rcsb pdb:1FE0|rcsb pdb:1FE4|rcsb pdb:1FEE|rcsb pdb:1TL4|rcsb pdb:1TL5|rcsb pdb:2K1R|rcsb pdb:2LQ9|rcsb pdb:3CJK|rcsb pdb:3IWL|rcsb pdb:3IWX|rcsb pdb:4QOT|rcsb pdb:4YDX|rcsb pdb:4YEA|rcsb pdb:5F0W|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544	-	-	-	figure legend:1Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/30	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:+aoVGSDXbzrq71ZKogtE9LHtHss9606	rigid:ll0sBD9AgddW1QQLEvsQXtXV47E	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35670	uniprotkb:O00244	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-10179267|uniprotkb:Q2M1R6|uniprotkb:A8KAJ8|uniprotkb:D3DQI2|uniprotkb:Q56AP3|ensembl:ENSP00000316854|ensembl:ENSP00000429814|ensembl:ENSP00000430598	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:atox1_human(display_long)|uniprotkb:ATOX1(gene name)|psi-mi:ATOX1(display_short)|uniprotkb:HAH1(gene name synonym)|uniprotkb:Metal transport protein ATX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11669088|imex:IM-25076-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_004036.1|ensembl:ENSG00000177556(gene)|ensembl:ENST00000313115(transcript)|ensembl:ENST00000522710(transcript)|ensembl:ENST00000524142(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016530"(metallochaperone activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0060003"(copper ion export)|go:"GO:1903136"(cuprous ion binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR017969|interpro:IPR036163|rcsb pdb:1FE0|rcsb pdb:1FE4|rcsb pdb:1FEE|rcsb pdb:1TL4|rcsb pdb:1TL5|rcsb pdb:2K1R|rcsb pdb:2LQ9|rcsb pdb:3CJK|rcsb pdb:3IWL|rcsb pdb:3IWX|rcsb pdb:4QOT|rcsb pdb:4YDX|rcsb pdb:4YEA|rcsb pdb:5F0W|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2017/08/08	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:+aoVGSDXbzrq71ZKogtE9LHtHss9606	rigid:ll0sBD9AgddW1QQLEvsQXtXV47E	false	tag:n-n|sufficient binding region:1-650	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35670	uniprotkb:Q8N668	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11669137|imex:IM-25076-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2017/08/08	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	sufficient binding region:1-650|tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35670	uniprotkb:Q8N668	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11669263|imex:IM-25076-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	-	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/30	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	sufficient binding region:1-650|tag:n-n|his tag:?-?|his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35670	uniprotkb:O00244	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-10179267|uniprotkb:Q2M1R6|uniprotkb:A8KAJ8|uniprotkb:D3DQI2|uniprotkb:Q56AP3|ensembl:ENSP00000316854|ensembl:ENSP00000429814|ensembl:ENSP00000430598	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:atox1_human(display_long)|uniprotkb:ATOX1(gene name)|psi-mi:ATOX1(display_short)|uniprotkb:HAH1(gene name synonym)|uniprotkb:Metal transport protein ATX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668564|imex:IM-25076-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_004036.1|ensembl:ENSG00000177556(gene)|ensembl:ENST00000313115(transcript)|ensembl:ENST00000522710(transcript)|ensembl:ENST00000524142(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016530"(metallochaperone activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0060003"(copper ion export)|go:"GO:1903136"(cuprous ion binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR017969|interpro:IPR036163|rcsb pdb:1FE0|rcsb pdb:1FE4|rcsb pdb:1FEE|rcsb pdb:1TL4|rcsb pdb:1TL5|rcsb pdb:2K1R|rcsb pdb:2LQ9|rcsb pdb:3CJK|rcsb pdb:3IWL|rcsb pdb:3IWX|rcsb pdb:4QOT|rcsb pdb:4YDX|rcsb pdb:4YEA|rcsb pdb:5F0W|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544	-	-	-	figure legend:1 C, 3A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/30	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:+aoVGSDXbzrq71ZKogtE9LHtHss9606	rigid:ll0sBD9AgddW1QQLEvsQXtXV47E	false	35s radiolabel:?-?|sufficient binding region:1-1009	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P35670	uniprotkb:Q8N668	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668623|imex:IM-25076-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	-	-	-	figure legend:1C, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2017/08/08	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	35s radiolabel:?-?|sufficient binding region:1-1009	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P00441	uniprotkb:O14618	intact:EBI-990792|uniprotkb:A6NHJ0|uniprotkb:Q16669|uniprotkb:Q16711|uniprotkb:Q16838|uniprotkb:Q16839|uniprotkb:Q16840|uniprotkb:Q6NR85|ensembl:ENSP00000270142|uniprotkb:D3DSE4	intact:EBI-11668690|uniprotkb:Q2M366|uniprotkb:Q8NEV0|ensembl:ENSP00000436318	psi-mi:sodc_human(display_long)|uniprotkb:Superoxide dismutase 1(gene name synonym)|uniprotkb:SOD1(gene name)|psi-mi:SOD1(display_short)	psi-mi:ccs_human(display_long)|uniprotkb:CCS(gene name)|psi-mi:CCS(display_short)|uniprotkb:Superoxide dismutase copper chaperone(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668675|imex:IM-25076-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142168(gene)|ensembl:ENST00000270142(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0001975"(response to amphetamine)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|interpro:IPR024134|interpro:IPR036423|mint:P00441|rcsb pdb:1AZV|rcsb pdb:1BA9|rcsb pdb:1DSW|rcsb pdb:1FUN|rcsb pdb:1HL4|rcsb pdb:1HL5|rcsb pdb:1KMG|rcsb pdb:1L3N|rcsb pdb:1MFM|rcsb pdb:1N18|rcsb pdb:1N19|interpro:IPR018152|rcsb pdb:1OEZ|rcsb pdb:1OZT|rcsb pdb:1OZU|rcsb pdb:1P1V|rcsb pdb:1PTZ|rcsb pdb:1PU0|rcsb pdb:1RK7|rcsb pdb:1SOS|rcsb pdb:1SPD|rcsb pdb:1UXL|rcsb pdb:1UXM|rcsb pdb:2AF2|rcsb pdb:2C9S|rcsb pdb:2C9U|rcsb pdb:2C9V|rcsb pdb:2GBT|rcsb pdb:2GBU|rcsb pdb:2GBV|rcsb pdb:2LU5|rcsb pdb:2MP3|rcsb pdb:2NAM|rcsb pdb:2NNX|rcsb pdb:2R27|rcsb pdb:2V0A|rcsb pdb:2VR6|rcsb pdb:2VR7|rcsb pdb:2VR8|rcsb pdb:2WKO|rcsb pdb:2WYT|rcsb pdb:2WYZ|rcsb pdb:2WZ0|rcsb pdb:2WZ5|rcsb pdb:2WZ6|rcsb pdb:2XJK|rcsb pdb:2XJL|rcsb pdb:2ZKW|rcsb pdb:2ZKX|rcsb pdb:2ZKY|rcsb pdb:3CQP|rcsb pdb:3CQQ|rcsb pdb:3ECU|rcsb pdb:3ECV|rcsb pdb:3ECW|rcsb pdb:3GQF|rcsb pdb:3GTV|rcsb pdb:3GZO|rcsb pdb:3GZP|rcsb pdb:3GZQ|rcsb pdb:3H2P|rcsb pdb:3H2Q|rcsb pdb:3HFF|rcsb pdb:3K91|rcsb pdb:3KH3|rcsb pdb:3KH4|rcsb pdb:3LTV|rcsb pdb:3QQD|rcsb pdb:3RE0|rcsb pdb:3T5W|rcsb pdb:4A7G|rcsb pdb:4A7Q|rcsb pdb:4A7S|rcsb pdb:4A7T|rcsb pdb:4A7U|rcsb pdb:4A7V|rcsb pdb:4B3E|rcsb pdb:4BCY|rcsb pdb:4BCZ|rcsb pdb:4BD4|rcsb pdb:4FF9|rcsb pdb:4MCM|rcsb pdb:4MCN|rcsb pdb:4NIN|rcsb pdb:4NIO|rcsb pdb:4NIP|rcsb pdb:4OH2|rcsb pdb:4SOD|rcsb pdb:4XCR|rcsb pdb:5DLI|rcsb pdb:5IIW|rcsb pdb:5J07|rcsb pdb:5J0C|rcsb pdb:5J0F|rcsb pdb:5J0G|rcsb pdb:5K02|rcsb pdb:5O3Y|rcsb pdb:5O40|rcsb pdb:5U9M|rcsb pdb:5WOR|rcsb pdb:5YTO|rcsb pdb:5YTU|rcsb pdb:5YUL|rcsb pdb:6A9O|rcsb pdb:6B79|rcsb pdb:6DTK|rcsb pdb:6FFK|rcsb pdb:6FLH|rcsb pdb:6FOI|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|rcsb pdb:6SPA|rcsb pdb:6SPH|rcsb pdb:6SPI|rcsb pdb:6SPJ|rcsb pdb:6SPK|rcsb pdb:6Z3V|rcsb pdb:6Z4G|rcsb pdb:6Z4H|rcsb pdb:6Z4I|rcsb pdb:6Z4J|rcsb pdb:6Z4K|rcsb pdb:6Z4L|rcsb pdb:6Z4M|rcsb pdb:6Z4O|reactome:R-HSA-114608|reactome:R-HSA-3299685|reactome:R-HSA-8950505|rcsb pdb:5WMJ|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|refseq:NP_000445.1|dip:DIP-44941N	refseq:NP_005116.1|ensembl:ENSG00000173992(gene)|ensembl:ENST00000533244(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015680"(protein maturation by copper ion transfer)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0045296"(cadherin binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR018152|interpro:IPR024134|interpro:IPR036163|interpro:IPR036423|mint:O14618|rcsb pdb:1DO5|rcsb pdb:2CRL|rcsb pdb:2RSQ|rcsb pdb:6FN8|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|reactome:R-HSA-3299685	-	-	-	figure legend:1Cii|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/08	2016/03/30	rogid:W5O3CdnrxKm1kudXW04wxnCxTY09606	rogid:r5pGUXbIewnEFuTqrKn78aG7N309606	rigid:FdsA6r3uHjUUdOTJZVH5NaXJwNA	false	35s radiolabel:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8N668	uniprotkb:P35670	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tao et al. (2003)	imex:IM-25076|pubmed:12968035	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11668785|imex:IM-25076-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	-	-	-	figure legend:2 A/D/E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/03/08	2016/03/30	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	ha tag:c-c	sufficient binding region:1-1372..1372	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)