#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:43602"	uniprotkb:Q61026	intact:EBI-11508470|chebi:"CHEBI:41467"|chebi:"CHEBI:43599"	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	psi-mi:6-ethyl-chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:43602"(display_long)	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507984|imex:IM-25002-1|pdbe:1osv	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	-	-	figure legend:1, Table 1|3d-resolution:2.5 A|3d-r-factors:"working: 24,2 %;   free:  27,6 %"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2016/02/01	-	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	-	false	-	sufficient binding region:741-752	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:43602"	uniprotkb:Q62735	intact:EBI-11508470|chebi:"CHEBI:41467"|chebi:"CHEBI:43599"	intact:EBI-11507940|ensembl:ENSRNOP00000009910	psi-mi:6-ethyl-chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:43602"(display_long)	psi-mi:nr1h4_rat(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507984|imex:IM-25002-1|pdbe:1osv	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:628831|refseq:NP_068513.1|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSV|rcsb pdb:1OT7|reactome:R-RNO-159418|reactome:R-RNO-192105|reactome:R-RNO-193368|reactome:R-RNO-193807|reactome:R-RNO-211976|reactome:R-RNO-383280|reactome:R-RNO-4090294|go:"GO:0034971"(histone H3-R17 methylation)|ensembl:ENSRNOG00000007197(gene)|ensembl:ENSRNOT00000009910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)	-	-	-	figure legend:1, Table 1|3d-resolution:2.5 A|3d-r-factors:"working: 24,2 %;   free:  27,6 %"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2016/02/01	-	rogid:ab+XZ+/YJqhNoUu24noqXiGvY3s10116	-	false	-	sufficient binding region:241-469(IPR000536)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:73676"	uniprotkb:Q61026	intact:EBI-11508098	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	psi-mi:3-deoxychenodeoxycholic acid(display_short)|psi-mi:"CHEBI:73676"(display_long)|intact:3-deoxy-CDCA(synonym)|intact:3-deoxyCDCA(synonym)|intact:7alpha-hydroxy-5beta-cholan-24-oic acid(synonym)|intact:7alpha-hydroxy-5beta-cholanic acid(synonym)|intact:"(5beta,7alpha)-7-hydroxycholan-24-oic acid"(iupac name)	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508082|pdbe:1ot7|imex:IM-25002-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	-	-	figure legend:1, Table 1|3d-resolution:2.9 A|3d-r-factors:"working: 25.4 %;   free:  29.0 %"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2016/02/01	-	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	-	false	-	sufficient binding region:741-752	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:73676"	uniprotkb:Q62735	intact:EBI-11508098	intact:EBI-11507940|ensembl:ENSRNOP00000009910	psi-mi:3-deoxychenodeoxycholic acid(display_short)|psi-mi:"CHEBI:73676"(display_long)|intact:3-deoxy-CDCA(synonym)|intact:3-deoxyCDCA(synonym)|intact:7alpha-hydroxy-5beta-cholan-24-oic acid(synonym)|intact:7alpha-hydroxy-5beta-cholanic acid(synonym)|intact:"(5beta,7alpha)-7-hydroxycholan-24-oic acid"(iupac name)	psi-mi:nr1h4_rat(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508082|pdbe:1ot7|imex:IM-25002-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:628831|refseq:NP_068513.1|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSV|rcsb pdb:1OT7|reactome:R-RNO-159418|reactome:R-RNO-192105|reactome:R-RNO-193368|reactome:R-RNO-193807|reactome:R-RNO-211976|reactome:R-RNO-383280|reactome:R-RNO-4090294|go:"GO:0034971"(histone H3-R17 methylation)|ensembl:ENSRNOG00000007197(gene)|ensembl:ENSRNOT00000009910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)	-	-	-	figure legend:1, Table 1|3d-resolution:2.9 A|3d-r-factors:"working: 25.4 %;   free:  29.0 %"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2016/02/01	-	rogid:ab+XZ+/YJqhNoUu24noqXiGvY3s10116	-	false	-	his tag:n-n|sufficient binding region:241-469(IPR000536)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16755"	uniprotkb:Q61026	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508114|imex:IM-25002-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	-	-	figure legend:3D and 2B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:330.0x10^-6(molar)|ec50:16.0x10^-6(molar)	2016/01/21	2016/02/01	-	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	-	false	-	sufficient binding region:740-752|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:16755"	uniprotkb:Q62735	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-11507940|ensembl:ENSRNOP00000009910	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:nr1h4_rat(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508114|imex:IM-25002-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:628831|refseq:NP_068513.1|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSV|rcsb pdb:1OT7|reactome:R-RNO-159418|reactome:R-RNO-192105|reactome:R-RNO-193368|reactome:R-RNO-193807|reactome:R-RNO-211976|reactome:R-RNO-383280|reactome:R-RNO-4090294|go:"GO:0034971"(histone H3-R17 methylation)|ensembl:ENSRNOG00000007197(gene)|ensembl:ENSRNOT00000009910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)	-	-	-	figure legend:3D and 2B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:330.0x10^-6(molar)|ec50:16.0x10^-6(molar)	2016/01/21	2016/02/01	-	rogid:ab+XZ+/YJqhNoUu24noqXiGvY3s10116	-	false	-	sufficient binding region:240-468(IPR000536)|his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:16755"	uniprotkb:Q61026	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508147|imex:IM-25002-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	-	-	figure legend:3D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:160.0x10^-6(molar)	2016/01/21	2016/02/01	-	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	-	false	-	sufficient binding region:685-697|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:16755"	uniprotkb:Q62735	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-11507940|ensembl:ENSRNOP00000009910	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:nr1h4_rat(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508147|imex:IM-25002-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:628831|refseq:NP_068513.1|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSV|rcsb pdb:1OT7|reactome:R-RNO-159418|reactome:R-RNO-192105|reactome:R-RNO-193368|reactome:R-RNO-193807|reactome:R-RNO-211976|reactome:R-RNO-383280|reactome:R-RNO-4090294|go:"GO:0034971"(histone H3-R17 methylation)|ensembl:ENSRNOG00000007197(gene)|ensembl:ENSRNOT00000009910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)	-	-	-	figure legend:3D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:160.0x10^-6(molar)	2016/01/21	2016/02/01	-	rogid:ab+XZ+/YJqhNoUu24noqXiGvY3s10116	-	false	-	sufficient binding region:240-468(IPR000536)|his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:16755"	uniprotkb:Q61026	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508172|imex:IM-25002-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	-	-	figure legend:3D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.8x10^-6(molar)	2016/01/21	2016/02/01	-	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	-	false	-	sufficient binding region:563-767|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:16755"	uniprotkb:Q62735	intact:EBI-11477538|chebi:"CHEBI:3593"|chebi:"CHEBI:23094"|chebi:"CHEBI:3588"	intact:EBI-11507940|ensembl:ENSRNOP00000009910	psi-mi:chenodeoxycholic acid(display_short)|psi-mi:"CHEBI:16755"(display_long)|intact:3alpha,7alpha-Dihydroxy-5beta-cholanic acid(synonym)|intact:7alpha-hydroxylithocholic acid(synonym)|intact:anthropodeoxycholic acid(synonym)|intact:anthropodesoxycholic acid(synonym)|intact:CDCA(synonym)|intact:chenic acid(synonym)|intact:Chenix(synonym)|intact:Chenodeoxycholic acid(synonym)|intact:Chenodiol(synonym)|intact:gallodesoxycholic acid(synonym)|intact:3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid(iupac name)	psi-mi:nr1h4_rat(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508172|imex:IM-25002-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:628831|refseq:NP_068513.1|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSV|rcsb pdb:1OT7|reactome:R-RNO-159418|reactome:R-RNO-192105|reactome:R-RNO-193368|reactome:R-RNO-193807|reactome:R-RNO-211976|reactome:R-RNO-383280|reactome:R-RNO-4090294|go:"GO:0034971"(histone H3-R17 methylation)|ensembl:ENSRNOG00000007197(gene)|ensembl:ENSRNOT00000009910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)	-	-	-	figure legend:3D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.8x10^-6(molar)	2016/01/21	2016/02/01	-	rogid:ab+XZ+/YJqhNoUu24noqXiGvY3s10116	-	false	-	sufficient binding region:240-468(IPR000536)|his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:73676"	uniprotkb:Q61026	intact:EBI-11508098	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	psi-mi:3-deoxychenodeoxycholic acid(display_short)|psi-mi:"CHEBI:73676"(display_long)|intact:3-deoxy-CDCA(synonym)|intact:3-deoxyCDCA(synonym)|intact:7alpha-hydroxy-5beta-cholan-24-oic acid(synonym)|intact:7alpha-hydroxy-5beta-cholanic acid(synonym)|intact:"(5beta,7alpha)-7-hydroxycholan-24-oic acid"(iupac name)	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11513314|imex:IM-25002-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	-	-	figure legend:2B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:3.0x10^-6(molar)	2016/01/21	2016/02/02	-	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	-	false	-	sufficient binding region:740-752|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:73676"	uniprotkb:Q62735	intact:EBI-11508098	intact:EBI-11507940|ensembl:ENSRNOP00000009910	psi-mi:3-deoxychenodeoxycholic acid(display_short)|psi-mi:"CHEBI:73676"(display_long)|intact:3-deoxy-CDCA(synonym)|intact:3-deoxyCDCA(synonym)|intact:7alpha-hydroxy-5beta-cholan-24-oic acid(synonym)|intact:7alpha-hydroxy-5beta-cholanic acid(synonym)|intact:"(5beta,7alpha)-7-hydroxycholan-24-oic acid"(iupac name)	psi-mi:nr1h4_rat(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11513314|imex:IM-25002-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:628831|refseq:NP_068513.1|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSV|rcsb pdb:1OT7|reactome:R-RNO-159418|reactome:R-RNO-192105|reactome:R-RNO-193368|reactome:R-RNO-193807|reactome:R-RNO-211976|reactome:R-RNO-383280|reactome:R-RNO-4090294|go:"GO:0034971"(histone H3-R17 methylation)|ensembl:ENSRNOG00000007197(gene)|ensembl:ENSRNOT00000009910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)	-	-	-	figure legend:2B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:3.0x10^-6(molar)	2016/01/21	2016/02/02	-	rogid:ab+XZ+/YJqhNoUu24noqXiGvY3s10116	-	false	-	sufficient binding region:240-468(IPR000536)|his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q61026	uniprotkb:Q62735	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	intact:EBI-11507940|ensembl:ENSRNOP00000009910	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:nr1h4_rat(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Mi et al. (2003)	pubmed:12718893|imex:IM-25002	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11508211|imex:IM-25002-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	rgd:628831|refseq:NP_068513.1|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSV|rcsb pdb:1OT7|reactome:R-RNO-159418|reactome:R-RNO-192105|reactome:R-RNO-193368|reactome:R-RNO-193807|reactome:R-RNO-211976|reactome:R-RNO-383280|reactome:R-RNO-4090294|go:"GO:0034971"(histone H3-R17 methylation)|ensembl:ENSRNOG00000007197(gene)|ensembl:ENSRNOT00000009910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)	-	-	-	figure legend:3E|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.8x10^-6(molar)	2016/01/21	2016/01/21	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	rogid:ab+XZ+/YJqhNoUu24noqXiGvY3s10116	rigid:Klp8LuXyDAba1sTtNx6pvVAWyrw	false	sufficient binding region:563-767	sufficient binding region:240-468(IPR000536)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)