#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95999	uniprotkb:Q66677	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-11709474	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:vclap_ehv2(display_long)|uniprotkb:E10(gene name)|psi-mi:E10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thome et al. (1999)	pubmed:10187771|imex:IM-25874	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:82831(EHV-2)|taxid:82831("Equine herpesvirus 2 (strain 86/87)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11709450|imex:IM-25874-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	refseq:NP_042674.2|interpro:IPR033238|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|go:"GO:0075131"(induction by symbiont of host protein kinase-mediated signal transduction)|go:"GO:0085033"(induction by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)	-	-	-	figure legend:4A & B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/27	2016/05/27	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:GW1mrnmWlsMBfbYzCOslPztSh0I82831	rigid:E44t0EnqcoswVRxiz353uZHMKT0	false	ha tag:n-n	necessary binding region:109-311|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95999	uniprotkb:O95999	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thome et al. (1999)	pubmed:10187771|imex:IM-25874	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11709491|imex:IM-25874-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	-	-	-	figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/27	2016/05/27	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rigid:gbw+q7KswVRFpHSLVhOVrrnr65g	false	ha tag:n-n	necessary binding region:85-233|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z0H7	uniprotkb:Q9Z0H7	intact:EBI-8545413|intact:UNK-5560748|uniprotkb:Q3UBN4|ensembl:ENSMUSP00000029842	intact:EBI-8545413|intact:UNK-5560748|uniprotkb:Q3UBN4|ensembl:ENSMUSP00000029842	psi-mi:bcl10_mouse(display_long)|uniprotkb:Bcl10(gene name)|psi-mi:Bcl10(display_short)|uniprotkb:Ciper(gene name synonym)|uniprotkb:Clap(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)	psi-mi:bcl10_mouse(display_long)|uniprotkb:Bcl10(gene name)|psi-mi:Bcl10(display_short)|uniprotkb:Ciper(gene name synonym)|uniprotkb:Clap(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thome et al. (1999)	pubmed:10187771|imex:IM-25874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11709501|imex:IM-25874-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033870.1|dip:DIP-60309N|ensembl:ENSMUSG00000028191(gene)|ensembl:ENSMUST00000029842(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009620"(response to fungus)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0043621"(protein self-association)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-8866654	refseq:NP_033870.1|dip:DIP-60309N|ensembl:ENSMUSG00000028191(gene)|ensembl:ENSMUST00000029842(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009620"(response to fungus)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0043621"(protein self-association)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-8866654	-	comment:mint|comment:homomint|function:Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex	comment:mint|comment:homomint|function:Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex	figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/27	2016/05/27	rogid:20gxkBjtsGLmnabow2Dv/z8Vew410090	rogid:20gxkBjtsGLmnabow2Dv/z8Vew410090	rigid:8tgD6+Ki+w+eSevidesgbEegwps	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z0H7	uniprotkb:Q66677	intact:EBI-8545413|intact:UNK-5560748|uniprotkb:Q3UBN4|ensembl:ENSMUSP00000029842	intact:EBI-11709474	psi-mi:bcl10_mouse(display_long)|uniprotkb:Bcl10(gene name)|psi-mi:Bcl10(display_short)|uniprotkb:Ciper(gene name synonym)|uniprotkb:Clap(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)	psi-mi:vclap_ehv2(display_long)|uniprotkb:E10(gene name)|psi-mi:E10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thome et al. (1999)	pubmed:10187771|imex:IM-25874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:82831(EHV-2)|taxid:82831("Equine herpesvirus 2 (strain 86/87)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11709509|imex:IM-25874-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033870.1|dip:DIP-60309N|ensembl:ENSMUSG00000028191(gene)|ensembl:ENSMUST00000029842(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009620"(response to fungus)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0043621"(protein self-association)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-5607764|reactome:R-MMU-8866654	refseq:NP_042674.2|interpro:IPR033238|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|go:"GO:0075131"(induction by symbiont of host protein kinase-mediated signal transduction)|go:"GO:0085033"(induction by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)	-	comment:mint|comment:homomint|function:Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex	-	figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/27	2016/05/27	rogid:20gxkBjtsGLmnabow2Dv/z8Vew410090	rogid:GW1mrnmWlsMBfbYzCOslPztSh0I82831	rigid:8LdZQN1GnolOe3xlR7oInKh1aKw	false	ha tag:n-n	necessary binding region:109-311|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95999	uniprotkb:Q66677	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-11709474	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:vclap_ehv2(display_long)|uniprotkb:E10(gene name)|psi-mi:E10(display_short)	psi-mi:"MI:0018"(two hybrid)	Thome et al. (1999)	pubmed:10187771|imex:IM-25874	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:82831(EHV-2)|taxid:82831("Equine herpesvirus 2 (strain 86/87)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11709536|imex:IM-25874-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	refseq:NP_042674.2|interpro:IPR033238|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|go:"GO:0075131"(induction by symbiont of host protein kinase-mediated signal transduction)|go:"GO:0085033"(induction by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)	-	-	-	figure legend:table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/05/27	2016/05/27	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:GW1mrnmWlsMBfbYzCOslPztSh0I82831	rigid:E44t0EnqcoswVRxiz353uZHMKT0	false	necessary binding region:85-233	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q66677	uniprotkb:Q66677	intact:EBI-11709474	intact:EBI-11709474	psi-mi:vclap_ehv2(display_long)|uniprotkb:E10(gene name)|psi-mi:E10(display_short)	psi-mi:vclap_ehv2(display_long)|uniprotkb:E10(gene name)|psi-mi:E10(display_short)	psi-mi:"MI:0018"(two hybrid)	Thome et al. (1999)	pubmed:10187771|imex:IM-25874	taxid:82831(EHV-2)|taxid:82831("Equine herpesvirus 2 (strain 86/87)")	taxid:82831(EHV-2)|taxid:82831("Equine herpesvirus 2 (strain 86/87)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11709567|imex:IM-25874-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_042674.2|interpro:IPR033238|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|go:"GO:0075131"(induction by symbiont of host protein kinase-mediated signal transduction)|go:"GO:0085033"(induction by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)	refseq:NP_042674.2|interpro:IPR033238|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|go:"GO:0075131"(induction by symbiont of host protein kinase-mediated signal transduction)|go:"GO:0085033"(induction by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)	-	-	-	figure legend:table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/05/27	2016/05/27	rogid:GW1mrnmWlsMBfbYzCOslPztSh0I82831	rogid:GW1mrnmWlsMBfbYzCOslPztSh0I82831	rigid:nHP/hz2v9656sDOcgY7WMciOrzw	false	-	necessary binding region:109-311	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)