#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61743	uniprotkb:G3I1T3	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-10953250	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:g3i1t3_crigr(display_long)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)|uniprotkb:I79_017352(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lorenz et al. (1998)	imex:IM-24448|pubmed:9488482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953272|imex:IM-24448-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR027417|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0005524"(ATP binding)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|interpro:IPR036034|interpro:IPR036640|interpro:IPR041647|interpro:IPR040445	-	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	-	figure legend:"Fig.s 1a (Lane 5), 2 (Lanes 3 & 4)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/03	2015/08/05	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:2A20N1gz+bxludWq9Mt/5ev4flo10029	rigid:Ylas8oHKcP1yDvZrs/iPQxwzjEo	false	sufficient binding region:1-353	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q61743	uniprotkb:G3I1T3	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-10953250	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:g3i1t3_crigr(display_long)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)|uniprotkb:I79_017352(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lorenz et al. (1998)	imex:IM-24448|pubmed:9488482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953297|imex:IM-24448-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR027417|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0005524"(ATP binding)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|interpro:IPR036034|interpro:IPR036640|interpro:IPR041647|interpro:IPR040445	-	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	-	figure legend:"Fig. 1B (Lane 1)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_6)|taxid:9534(African green monkey kidney cell line)	-	2015/08/03	2015/08/05	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:2A20N1gz+bxludWq9Mt/5ev4flo10029	rigid:Ylas8oHKcP1yDvZrs/iPQxwzjEo	false	sufficient binding region:1-353	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61743	uniprotkb:G3I1T3	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-10953250	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:g3i1t3_crigr(display_long)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)|uniprotkb:I79_017352(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lorenz et al. (1998)	imex:IM-24448|pubmed:9488482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10955242|imex:IM-24448-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR027417|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0005524"(ATP binding)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|interpro:IPR036034|interpro:IPR036640|interpro:IPR041647|interpro:IPR040445	-	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	-	figure legend:"Fig. 1B (Lane 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_6)|taxid:9534(African green monkey kidney cell line)	-	2015/08/03	2015/08/05	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:2A20N1gz+bxludWq9Mt/5ev4flo10029	rigid:v707T+BHJjppdOmHUzLeuPqAs/c	false	sufficient binding region:1-353	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61743	uniprotkb:Q14654	intact:EBI-8603527|ensembl:ENSMUSP00000147439|intact:MINT-2982880|uniprotkb:Q9QX21	intact:EBI-2866553|uniprotkb:Q58EX3|uniprotkb:Q2M1H7|uniprotkb:B4DWI4|uniprotkb:E9PNK0|uniprotkb:Q8IW96|ensembl:ENSP00000345708|ensembl:ENSP00000434755	psi-mi:kcj11_mouse(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:kcj11_human(display_long)|uniprotkb:KCNJ11(gene name)|psi-mi:KCNJ11(display_short)|uniprotkb:IKATP(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lorenz et al. (1998)	imex:IM-24448|pubmed:9488482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10955242|imex:IM-24448-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000096146(gene)|ensembl:ENSMUST00000211674(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:Q61743|rcsb pdb:5WUA|rcsb pdb:5YKE|rcsb pdb:5YKF|rcsb pdb:5YKG|rcsb pdb:5YW8|rcsb pdb:5YW9|rcsb pdb:5YWA|rcsb pdb:5YWB|rcsb pdb:5YWC|rcsb pdb:6JB1|reactome:R-MMU-1296025|reactome:R-MMU-382556|reactome:R-MMU-422356|reactome:R-MMU-5578775|refseq:NP_034732.1|dip:DIP-42790N	refseq:NP_001159762.1|dip:DIP-58643N|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6C3O|rcsb pdb:6C3P|reactome:R-HSA-1296025|reactome:R-HSA-382556|reactome:R-HSA-422356|reactome:R-HSA-5578775|reactome:R-HSA-5678420|reactome:R-HSA-5683177|ensembl:ENST00000339994(transcript)|ensembl:ENST00000528731(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|ensembl:ENSG00000187486(gene)	-	comment:mint|function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium	-	figure legend:"Fig. 1B (Lane 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_6)|taxid:9534(African green monkey kidney cell line)	-	2015/08/03	2015/08/05	rogid:YH8BUXfxLJ46b4AxxBmt1RmrNtM10090	rogid:EgyckzNz0VCMnwzK/U9vz8J2auk9606	rigid:v707T+BHJjppdOmHUzLeuPqAs/c	false	sufficient binding region:1-353	necessary binding region:19-30	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)