#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04601	uniprotkb:O14734	intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587	intact:EBI-1237371|uniprotkb:O15261|uniprotkb:Q17RX4|ensembl:ENSP00000217455	psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym)	psi-mi:acot8_human(display_long)|uniprotkb:ACOT8(gene name)|psi-mi:ACOT8(display_short)|uniprotkb:ACTEIII(gene name synonym)|uniprotkb:PTE1(gene name synonym)|uniprotkb:Choloyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:Peroxisomal acyl-coenzyme A thioester hydrolase 1(gene name synonym)|uniprotkb:Peroxisomal long-chain acyl-CoA thioesterase 1(gene name synonym)|uniprotkb:HIV-Nef-associated acyl-CoA thioesterase(gene name synonym)|uniprotkb:Thioesterase II(gene name synonym)|uniprotkb:Peroxisomal acyl-CoA thioesterase 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Watanabe et al. (1997)	pubmed:9299485|imex:IM-24030	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10705476|imex:IM-24030-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590	refseq:NP_005460.2|dip:DIP-38179N|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043649"(dicarboxylic acid catabolic process)|go:"GO:0044466"(glutaryl-CoA hydrolase activity)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0047603"(acetoacetyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047994"(hydroxymethylglutaryl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR003703(Acyl-CoA thioesterase)|interpro:IPR029069|interpro:IPR042171|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|ensembl:ENSG00000101473(gene)|ensembl:ENST00000217455(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0004778"(succinyl-CoA hydrolase activity)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016289"(CoA hydrolase activity)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033882"(choloyl-CoA hydrolase activity)	-	-	-	figure legend:n/a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2015/03/17	2015/03/17	rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706	rogid:Q8Y3l4ysgKPMi3mJU2/g8mVxWE09606	rigid:pqGZLh2NRrO7R/orsj9GgQXKzAo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04601	uniprotkb:O14734	intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587	intact:EBI-1237371|uniprotkb:O15261|uniprotkb:Q17RX4|ensembl:ENSP00000217455	psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym)	psi-mi:acot8_human(display_long)|uniprotkb:ACOT8(gene name)|psi-mi:ACOT8(display_short)|uniprotkb:ACTEIII(gene name synonym)|uniprotkb:PTE1(gene name synonym)|uniprotkb:Choloyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:Peroxisomal acyl-coenzyme A thioester hydrolase 1(gene name synonym)|uniprotkb:Peroxisomal long-chain acyl-CoA thioesterase 1(gene name synonym)|uniprotkb:HIV-Nef-associated acyl-CoA thioesterase(gene name synonym)|uniprotkb:Thioesterase II(gene name synonym)|uniprotkb:Peroxisomal acyl-CoA thioesterase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Watanabe et al. (1997)	pubmed:9299485|imex:IM-24030	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10705489|imex:IM-24030-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590	refseq:NP_005460.2|dip:DIP-38179N|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043649"(dicarboxylic acid catabolic process)|go:"GO:0044466"(glutaryl-CoA hydrolase activity)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0047603"(acetoacetyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047994"(hydroxymethylglutaryl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR003703(Acyl-CoA thioesterase)|interpro:IPR029069|interpro:IPR042171|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|ensembl:ENSG00000101473(gene)|ensembl:ENST00000217455(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0004778"(succinyl-CoA hydrolase activity)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016289"(CoA hydrolase activity)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033882"(choloyl-CoA hydrolase activity)	-	-	-	figure legend:3A and B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/17	2015/03/17	rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706	rogid:Q8Y3l4ysgKPMi3mJU2/g8mVxWE09606	rigid:pqGZLh2NRrO7R/orsj9GgQXKzAo	false	glutathione s tranferase tag:?-?|necessary binding region:108-152	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)