#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UGM3	uniprotkb:P35247	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	intact:EBI-11316157|uniprotkb:Q5T0M3|uniprotkb:Q6FH08|uniprotkb:Q86YK9|uniprotkb:Q8TCD8|uniprotkb:Q9UCJ2|uniprotkb:Q9UCJ3|ensembl:ENSP00000361366	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:sftpd_human(display_long)|uniprotkb:SFTPD(gene name)|psi-mi:SFTPD(display_short)|uniprotkb:COLEC7(gene name synonym)|uniprotkb:PSPD(gene name synonym)|uniprotkb:SFTP4(gene name synonym)|uniprotkb:Collectin-7(gene name synonym)|uniprotkb:Lung surfactant protein D(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Holmskov et al. (1997)	imex:IM-24728|pubmed:9153228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316228|imex:IM-24728-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	refseq:NP_003010.4|refseq:XP_011538389.1|rcsb pdb:2GGU|rcsb pdb:2GGX|rcsb pdb:2ORJ|rcsb pdb:2ORK|rcsb pdb:2OS9|rcsb pdb:2RIA|rcsb pdb:2RIB|rcsb pdb:2RIC|rcsb pdb:2RID|rcsb pdb:2RIE|rcsb pdb:3DBZ|rcsb pdb:3G81|rcsb pdb:3G83|rcsb pdb:3G84|rcsb pdb:3IKN|rcsb pdb:3IKP|rcsb pdb:3IKQ|rcsb pdb:3IKR|rcsb pdb:4E52|rcsb pdb:4M17|rcsb pdb:4M18|rcsb pdb:5OXR|rcsb pdb:5OXS|reactome:R-HSA-166016|reactome:R-HSA-168179|reactome:R-HSA-198933|reactome:R-HSA-391160|reactome:R-HSA-5683826|reactome:R-HSA-5686938|reactome:R-HSA-5688849|reactome:R-HSA-5688890|ensembl:ENSG00000133661(gene)|ensembl:ENST00000372292(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0052405"|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1905226"(regulation of adhesion of symbiont to host epithelial cell)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR015097(Lung surfactant protein D coiled-coil trimerisation)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033990|rcsb pdb:1B08|rcsb pdb:1M7L|rcsb pdb:1PW9|rcsb pdb:1PWB	-	-	-	figure legend:Fig.6, Fig.7B, and Fig. 8B|comment:Binding of SP-D to gp-340 occurs in the presence of calcium alone or calcium plus maltose.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/12	2015/10/28	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rogid:YVPGpA6rwjdTjpc67Y8V8EoFiWo9606	rigid:hXiZVjb+IFTjt/K4ARq7hQqpAvw	false	-	glutathione s tranferase tag:c-c|sufficient binding region:220..220-375..375	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P48740	uniprotkb:P35247	intact:EBI-6380536|ensembl:ENSP00000336792|uniprotkb:A8K542|uniprotkb:A8K6M1|uniprotkb:B4E2L7|uniprotkb:O95570|uniprotkb:Q68D21|uniprotkb:Q8IUV8|uniprotkb:Q96RS4|uniprotkb:Q9UF09	intact:EBI-11316157|uniprotkb:Q5T0M3|uniprotkb:Q6FH08|uniprotkb:Q86YK9|uniprotkb:Q8TCD8|uniprotkb:Q9UCJ2|uniprotkb:Q9UCJ3|ensembl:ENSP00000361366	psi-mi:masp1_human(display_long)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)	psi-mi:sftpd_human(display_long)|uniprotkb:SFTPD(gene name)|psi-mi:SFTPD(display_short)|uniprotkb:COLEC7(gene name synonym)|uniprotkb:PSPD(gene name synonym)|uniprotkb:SFTP4(gene name synonym)|uniprotkb:Collectin-7(gene name synonym)|uniprotkb:Lung surfactant protein D(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Holmskov et al. (1997)	imex:IM-24728|pubmed:9153228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316249|imex:IM-24728-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016862361.1|ensembl:ENSG00000127241(gene)|ensembl:ENST00000337774(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:3DEM|rcsb pdb:3GOV|rcsb pdb:4AQB|rcsb pdb:4DJZ|rcsb pdb:4IGD|rcsb pdb:4IW4|rcsb pdb:4KKD|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-3000480|dip:DIP-61382N|refseq:NP_001027019.1|refseq:NP_001870.3|refseq:NP_624302.1	refseq:NP_003010.4|refseq:XP_011538389.1|rcsb pdb:2GGU|rcsb pdb:2GGX|rcsb pdb:2ORJ|rcsb pdb:2ORK|rcsb pdb:2OS9|rcsb pdb:2RIA|rcsb pdb:2RIB|rcsb pdb:2RIC|rcsb pdb:2RID|rcsb pdb:2RIE|rcsb pdb:3DBZ|rcsb pdb:3G81|rcsb pdb:3G83|rcsb pdb:3G84|rcsb pdb:3IKN|rcsb pdb:3IKP|rcsb pdb:3IKQ|rcsb pdb:3IKR|rcsb pdb:4E52|rcsb pdb:4M17|rcsb pdb:4M18|rcsb pdb:5OXR|rcsb pdb:5OXS|reactome:R-HSA-166016|reactome:R-HSA-168179|reactome:R-HSA-198933|reactome:R-HSA-391160|reactome:R-HSA-5683826|reactome:R-HSA-5686938|reactome:R-HSA-5688849|reactome:R-HSA-5688890|ensembl:ENSG00000133661(gene)|ensembl:ENST00000372292(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0052405"|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1905226"(regulation of adhesion of symbiont to host epithelial cell)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR015097(Lung surfactant protein D coiled-coil trimerisation)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033990|rcsb pdb:1B08|rcsb pdb:1M7L|rcsb pdb:1PW9|rcsb pdb:1PWB	-	-	-	figure legend:Fig. 7A, Fig. 8A|comment:SP-D binds to mannan in the presence of calcium alone.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/12	2015/10/28	rogid:Yqzsp6f/Mg3AyvyK42mX/kQ3s389606	rogid:YVPGpA6rwjdTjpc67Y8V8EoFiWo9606	rigid:iqVEWYnJzebZ2BfSaxasR7OrYgk	false	-	glutathione s tranferase tag:c-c|sufficient binding region:220..220-375..375	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)