#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97260	uniprotkb:O15503	intact:EBI-11508251|uniprotkb:Q2WEK9	intact:EBI-6252425|ensembl:ENSP00000344741|uniprotkb:A8K6L0|uniprotkb:Q53XW8|uniprotkb:Q9BUV5|uniprotkb:A4D2N1	psi-mi:scap_crigr(display_long)|uniprotkb:SCAP(gene name)|psi-mi:SCAP(display_short)	psi-mi:insi1_human(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2015)	imex:IM-24994|pubmed:26555173	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508239|imex:IM-24994-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230965.1|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032936"(SREBP-SCAP complex)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|go:"GO:0008203"(cholesterol metabolic process)|dip:DIP-60914N	ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:1901303"(negative regulation of cargo loading into COPII-coated vesicle)|interpro:IPR009904(Insulin-induced)|interpro:IPR025929|mint:O15503|rcsb pdb:4J81|reactome:R-HSA-1655829|go:"GO:0070862"(negative regulation of protein exit from endoplasmic reticulum)|refseq:NP_001333519.1|refseq:NP_001333520.1|refseq:NP_001333521.1|refseq:NP_001333522.1|refseq:NP_001333523.1|refseq:NP_005533.2|refseq:NP_938150.2|refseq:NP_938151.1|dip:DIP-61157N|refseq:XP_016867666.1	-	-	-	figure legend:3 A/C|antagonist:glucose|comment:Addition of Tunicamycin,  an inhibitor of N-glycan synthesis, restored the binding of GFP-SCAP to Myc-Insig-1.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/12/09	2016/01/21	rogid:QoHuAk4vAFqw3/i2H8XKda01FYs10029	rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606	rigid:dPoEWx1QFjh1MuXKDRcbArabZew	false	green fluorescent protein tag:n-n|mutation increasing interaction strength:263-263,590-590,641-641	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)