#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8TDQ0	uniprotkb:P60484	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P19174	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:Q9NP31	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P78314	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-727062|uniprotkb:O00500|uniprotkb:O15373|uniprotkb:P78315|uniprotkb:A6NNC2|uniprotkb:B2R5R6|uniprotkb:B4DT04|uniprotkb:D3DVR0|intact:EBI-28985856|ensembl:ENSP00000348685|ensembl:ENSP00000422168|uniprotkb:D6R919	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:3bp2_human(display_long)|uniprotkb:SH3BP2(gene name)|psi-mi:SH3BP2(display_short)|uniprotkb:3BP2(gene name synonym)|uniprotkb:RES4-23(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001116153.1|refseq:NP_001139327.1|refseq:NP_001139328.1|refseq:NP_003014.3|ensembl:ENSP00000348685|ensembl:ENST00000435136|ensembl:ENSP00000403231|ensembl:ENSP00000422168|ensembl:ENST00000511747|ensembl:ENSP00000424846|ensembl:ENST00000513020|ensembl:ENSP00000424072|ensembl:ENST00000515737|ensembl:ENSP00000422605|ensembl:ENSG00000087266(gene)|ensembl:ENST00000356331(transcript)|ensembl:ENST00000503393(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|mint:P78314|rcsb pdb:2CR4|rcsb pdb:3TWR	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:W+/geQfSvLlQA6UvDPYN4zQCzh89606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P06241	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P27986	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P43405	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P43403	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-1211276|uniprotkb:A6NFP4|uniprotkb:Q6PIA4|uniprotkb:Q8IXD6|uniprotkb:Q9UBS6|ensembl:ENSP00000264972	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:zap70_human(display_long)|uniprotkb:ZAP70(gene name)|psi-mi:ZAP70(display_short)|uniprotkb:SRK(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001070.2|refseq:NP_997402.1|dip:DIP-38781N|ensembl:ENSG00000115085(gene)|ensembl:ENST00000264972(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042113"(B cell activation)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070489"(T cell aggregation)|go:"GO:0072678"(T cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43403|rcsb pdb:1FBV|rcsb pdb:1M61|rcsb pdb:1U59|rcsb pdb:2CBL|rcsb pdb:2OQ1|rcsb pdb:2OZO|rcsb pdb:2Y1N|rcsb pdb:3ZNI|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4K2R|rcsb pdb:4XZ0|rcsb pdb:4XZ1|rcsb pdb:5O76|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-9013407|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:21kVb/nxY2BBZPBNVwWba+qUOgc9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:Q13094	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P15498	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472954|imex:IM-24876-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	-	-	-	figure legend:5|comment:In unactivated T cells|comment:Akt present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	rigid:oUCo0wTQs55jtVOU6EOJ0e8q/2A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P78314	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-727062|uniprotkb:O00500|uniprotkb:O15373|uniprotkb:P78315|uniprotkb:A6NNC2|uniprotkb:B2R5R6|uniprotkb:B4DT04|uniprotkb:D3DVR0|intact:EBI-28985856|ensembl:ENSP00000348685|ensembl:ENSP00000422168|uniprotkb:D6R919	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:3bp2_human(display_long)|uniprotkb:SH3BP2(gene name)|psi-mi:SH3BP2(display_short)|uniprotkb:3BP2(gene name synonym)|uniprotkb:RES4-23(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472967|imex:IM-24876-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001116153.1|refseq:NP_001139327.1|refseq:NP_001139328.1|refseq:NP_003014.3|ensembl:ENSP00000348685|ensembl:ENST00000435136|ensembl:ENSP00000403231|ensembl:ENSP00000422168|ensembl:ENST00000511747|ensembl:ENSP00000424846|ensembl:ENST00000513020|ensembl:ENSP00000424072|ensembl:ENST00000515737|ensembl:ENSP00000422605|ensembl:ENSG00000087266(gene)|ensembl:ENST00000356331(transcript)|ensembl:ENST00000503393(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|mint:P78314|rcsb pdb:2CR4|rcsb pdb:3TWR	-	-	-	figure legend:5|comment:In CD3/CD28 stimulated T cells|comment:p38MAPK present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:W+/geQfSvLlQA6UvDPYN4zQCzh89606	rigid:j206BY7LkBSXHK6Q/uVGX7PU4z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P19174	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472967|imex:IM-24876-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:5|comment:In CD3/CD28 stimulated T cells|comment:p38MAPK present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:j206BY7LkBSXHK6Q/uVGX7PU4z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P06239	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472967|imex:IM-24876-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	-	-	-	figure legend:5|comment:In CD3/CD28 stimulated T cells|comment:p38MAPK present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rigid:j206BY7LkBSXHK6Q/uVGX7PU4z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:Q9NP31	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472967|imex:IM-24876-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)	-	-	-	figure legend:5|comment:In CD3/CD28 stimulated T cells|comment:p38MAPK present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rigid:j206BY7LkBSXHK6Q/uVGX7PU4z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P60484	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472967|imex:IM-24876-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	-	-	-	figure legend:5|comment:In CD3/CD28 stimulated T cells|comment:p38MAPK present in precipitate, not mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rigid:j206BY7LkBSXHK6Q/uVGX7PU4z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P43405	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472990|imex:IM-24876-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:supplemental 1|comment:JNK and p38MAPK present in precipitate; cannot be mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	rigid:JiT+0VMJFBgjjErpQNRPz4RH0xI	false	sufficient binding region:264-277|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P43403	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-1211276|uniprotkb:A6NFP4|uniprotkb:Q6PIA4|uniprotkb:Q8IXD6|uniprotkb:Q9UBS6|ensembl:ENSP00000264972	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:zap70_human(display_long)|uniprotkb:ZAP70(gene name)|psi-mi:ZAP70(display_short)|uniprotkb:SRK(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472990|imex:IM-24876-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001070.2|refseq:NP_997402.1|dip:DIP-38781N|ensembl:ENSG00000115085(gene)|ensembl:ENST00000264972(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042113"(B cell activation)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070489"(T cell aggregation)|go:"GO:0072678"(T cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43403|rcsb pdb:1FBV|rcsb pdb:1M61|rcsb pdb:1U59|rcsb pdb:2CBL|rcsb pdb:2OQ1|rcsb pdb:2OZO|rcsb pdb:2Y1N|rcsb pdb:3ZNI|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4K2R|rcsb pdb:4XZ0|rcsb pdb:4XZ1|rcsb pdb:5O76|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-9013407|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)	-	-	-	figure legend:supplemental 1|comment:JNK and p38MAPK present in precipitate; cannot be mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:21kVb/nxY2BBZPBNVwWba+qUOgc9606	rigid:JiT+0VMJFBgjjErpQNRPz4RH0xI	false	sufficient binding region:264-277|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P06239	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472990|imex:IM-24876-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	-	-	-	figure legend:supplemental 1|comment:JNK and p38MAPK present in precipitate; cannot be mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rigid:JiT+0VMJFBgjjErpQNRPz4RH0xI	false	sufficient binding region:264-277|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P19174	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472990|imex:IM-24876-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686	-	-	-	figure legend:supplemental 1|comment:JNK and p38MAPK present in precipitate; cannot be mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rigid:JiT+0VMJFBgjjErpQNRPz4RH0xI	false	sufficient binding region:264-277|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:Q9NP31	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-490630|uniprotkb:Q5UBZ1|uniprotkb:Q5VZS4|uniprotkb:O43817|uniprotkb:Q5VZS5|uniprotkb:Q9UPA7|ensembl:ENSP00000357182	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:sh22a_human(display_long)|uniprotkb:T cell-specific adapter protein(gene name synonym)|uniprotkb:VEGF receptor-associated protein(gene name synonym)|uniprotkb:SH2 domain-containing adapter protein(gene name synonym)|uniprotkb:SH2D2A(gene name)|psi-mi:SH2D2A(display_short)|uniprotkb:SCAP(gene name synonym)|uniprotkb:TSAD(gene name synonym)|uniprotkb:VRAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472990|imex:IM-24876-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001154914.1|refseq:NP_001154916.1|refseq:NP_003966.2|ensembl:ENSG00000027869(gene)|ensembl:ENST00000368199(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|interpro:IPR000980(SH2 motif)|interpro:IPR035884|interpro:IPR036860|mint:Q9NP31|reactome:R-HSA-4420097|go:"GO:0017124"(SH3 domain binding)	-	-	-	figure legend:supplemental 1|comment:JNK and p38MAPK present in precipitate; cannot be mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:lE8uzkmZMG6agp/xfgPxc9Uq76o9606	rigid:JiT+0VMJFBgjjErpQNRPz4RH0xI	false	sufficient binding region:264-277|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P27986	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472990|imex:IM-24876-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	-	-	figure legend:supplemental 1|comment:JNK and p38MAPK present in precipitate; cannot be mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:JiT+0VMJFBgjjErpQNRPz4RH0xI	false	sufficient binding region:264-277|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P06241	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11472990|imex:IM-24876-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439	-	-	-	figure legend:supplemental 1|comment:JNK and p38MAPK present in precipitate; cannot be mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2016/01/06	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rigid:JiT+0VMJFBgjjErpQNRPz4RH0xI	false	sufficient binding region:264-277|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:Q9UQQ2	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-7879749|uniprotkb:B9EGG5|uniprotkb:O95184|intact:MINT-1494618|ensembl:ENSP00000345492	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:sh2b3_human(display_long)|uniprotkb:LNK(gene name synonym)|uniprotkb:SH2B3(gene name)|psi-mi:SH2B3(display_short)|uniprotkb:Lymphocyte-specific adapter protein Lnk(gene name synonym)|uniprotkb:Signal transduction protein Lnk(gene name synonym)|uniprotkb:Lymphocyte adapter protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11473005|imex:IM-24876-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_005466.1|refseq:NP_001278353.1|ensembl:ENSG00000111252(gene)|ensembl:ENST00000341259(transcript)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005173"(stem cell factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038163"(thrombopoietin-mediated signaling pathway)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1900235"(negative regulation of Kit signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015012(Phenylalanine zipper)|interpro:IPR030522|interpro:IPR030523|interpro:IPR035059|interpro:IPR036290|interpro:IPR036860|go:"GO:0035702"(monocyte homeostasis)|mint:Q9UQQ2|reactome:R-HSA-1433559|reactome:R-HSA-9706369|reactome:R-HSA-983231	-	-	comment:mint|function:Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase	figure legend:supplemental 1|comment:p38MAPK present in precipitate; cannot ne mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:gAdVvAM0oinTg6Ice+rQKLSiRZo9606	rigid:nrTt+uMRfnLO1xzl6S0WiUvOHVg	false	sufficient binding region:264-277|biotin tag:?-?|O4'-phospho-L-tyrosine:265-265|O4'-phospho-L-tyrosine:272-272	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TDQ0	uniprotkb:P43405	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tomkowicz et al. (2014)	imex:IM-24876|pubmed:26492563	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11473005|imex:IM-24876-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	-	-	-	figure legend:supplemental 1|comment:p38MAPK present in precipitate; cannot ne mapped to UniProt|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/18	2015/12/18	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	rigid:nrTt+uMRfnLO1xzl6S0WiUvOHVg	false	sufficient binding region:264-277|biotin tag:?-?|O4'-phospho-L-tyrosine:265-265|O4'-phospho-L-tyrosine:272-272	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)