#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19235	uniprotkb:P01588-PRO_0000008401	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	intact:EBI-11508463	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:p01588-pro_0000008401(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:1247"(microscale thermophoresis)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508434|imex:IM-25004-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	intact:EBI-1027362(chain-parent)	-	-	chain-seq-start:28|chain-seq-end:193	figure legend:1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:28.0x10^-9 ~14.0(molar)	2015/12/09	2016/02/09	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	rogid:qL1IYLGZ1Q6znFxEnCn60Pq+RC89606	rigid:6kIWOpeezE7Jwk0c4SDpuAJMQ7M	false	sufficient binding region:25-250	fluorescent dye label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54760-1	uniprotkb:P01588-PRO_0000008401	intact:EBI-11565809|ensembl:ENSP00000350896	intact:EBI-11508463	psi-mi:p54760-1(display_long)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:MYK1(gene name synonym)|uniprotkb:TYRO11(gene name synonym)	psi-mi:p01588-pro_0000008401(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:1247"(microscale thermophoresis)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508499|imex:IM-25004-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-702121(isoform-parent)|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)	intact:EBI-1027362(chain-parent)	-	-	chain-seq-start:28|chain-seq-end:193	figure legend:1C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:880.0x10^-9 ~128.6(molar)	2015/12/09	2016/02/09	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:qL1IYLGZ1Q6znFxEnCn60Pq+RC89606	rigid:rYBpfbt6MvicMHy1EGVQG2xM0KI	false	flag tag:c-c|sufficient binding region:1-539|fluorescent dye label:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52799	uniprotkb:P54760-1	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-11565809|ensembl:ENSP00000350896	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:p54760-1(display_long)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:MYK1(gene name synonym)|uniprotkb:TYRO11(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508506|imex:IM-25004-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	intact:EBI-702121(isoform-parent)|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)	-	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	-	figure legend:1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:140.0x10^-9 ~28.3(molar)	2015/12/09	2016/02/09	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rigid:+uhRh7XbLy4FHYoqHL8aCxsCeTs	false	sufficient binding region:1-229	flag tag:c-c|sufficient binding region:1-539|fluorescent dye label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52799	uniprotkb:P54760	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508652|imex:IM-25004-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	-	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	-	figure legend:1 E/Fi, Supp 1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/25	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rigid:+uhRh7XbLy4FHYoqHL8aCxsCeTs	false	tag:c-c|sufficient binding region:1-229	sufficient binding region:1..16-537..539|tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19235	uniprotkb:P01588-PRO_0000008401	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	intact:EBI-11508463	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:p01588-pro_0000008401(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508916|imex:IM-25004-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	intact:EBI-1027362(chain-parent)	-	-	chain-seq-start:28|chain-seq-end:193	figure legend:Supp 1E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/25	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	rogid:qL1IYLGZ1Q6znFxEnCn60Pq+RC89606	rigid:6kIWOpeezE7Jwk0c4SDpuAJMQ7M	false	sufficient binding region:25-250|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52799	uniprotkb:P54760	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11566032|imex:IM-25004-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	-	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	-	figure legend:1 E/Fi|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/02/09	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rigid:3e0Z9H6MlpP2XrfAwI8BBiv/cnk	false	tag:c-c|sufficient binding region:1-229	sufficient binding region:1..16-537..539|tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52799	uniprotkb:P01588-PRO_0000008401	intact:EBI-7532268|intact:MINT-3019741|uniprotkb:Q5JV56|ensembl:ENSP00000493716	intact:EBI-11508463	psi-mi:efnb2_human(display_long)|uniprotkb:EFNB2(gene name)|psi-mi:EFNB2(display_short)|uniprotkb:EPLG5(gene name synonym)|uniprotkb:HTKL(gene name synonym)|uniprotkb:LERK5(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 5(gene name synonym)|uniprotkb:HTK ligand(gene name synonym)	psi-mi:p01588-pro_0000008401(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11566032|imex:IM-25004-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004084.1|ensembl:ENSG00000125266(gene)|ensembl:ENST00000646441(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52799|rcsb pdb:2HLE|rcsb pdb:2I85|rcsb pdb:2VSK|rcsb pdb:2VSM|rcsb pdb:2WO2|rcsb pdb:3GXU|rcsb pdb:4UF7|rcsb pdb:6P7Y|rcsb pdb:6PDL|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|dip:DIP-46378N	intact:EBI-1027362(chain-parent)	-	comment:mint|function:Binds to the receptor tyrosine kinases EPHB4 and EPHA3. May play a role in constraining the orientation of longitudinally projecting axons	chain-seq-start:28|chain-seq-end:193	figure legend:1 E/Fi|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/02/09	rogid:Ie9xTJNgMD4VdbCiT9rJf1XCgqE9606	rogid:qL1IYLGZ1Q6znFxEnCn60Pq+RC89606	rigid:3e0Z9H6MlpP2XrfAwI8BBiv/cnk	false	tag:c-c|sufficient binding region:1-229	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54760	intact:EBI-11508711	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	-	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:chlae_erythropoietin_protein(display_short)|psi-mi:EBI-11508711(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508697|imex:IM-25004-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	-	-	-	-	figure legend:2E/F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2015/12/09	2016/01/22	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	-	-	false	mutation disrupting interaction strength:46-46,44-44,48-48,50-50,58-58	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-11508711	uniprotkb:P19235	-	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	psi-mi:chlae_erythropoietin_protein(display_short)|psi-mi:EBI-11508711(display_long)	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508704|imex:IM-25004-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	-	-	-	figure legend:2E/F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2015/12/09	2016/01/22	-	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-11508771	uniprotkb:P40763	-	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:stat3_oligo_consensus_binding_ site(display_short)|psi-mi:EBI-11508771(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508766|imex:IM-25004-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:3F|agonist:Erythropoietin|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/22	-	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54760	uniprotkb:P01588	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0892"(solid phase assay)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508958|imex:IM-25004-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	-	-	-	figure legend:Supp 1 M/N|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/25	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rigid:E1yz5y2exVOt2fsIRHbzYBeC3BI	false	sufficient binding region:1..16-537..539|tag:?-?	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P54760	uniprotkb:P01588	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0892"(solid phase assay)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508983|imex:IM-25004-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	-	-	-	figure legend:Supp 1M|comment:"Epo-alpha is a dimeric, glycosylated, polypeptide chain consisting of two mature human EPO molecules linked to the Fc portion of human IgG1. It has been assumed the \"mature\" sequence refers to the full length molecule minus the signal sequence -aas 28 – 193, although this is not stated."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/25	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rigid:EE3LJZR768F5ucYKP0wfjyJS7x0	false	sufficient binding region:1..16-537..539|tag:?-?	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P54760	uniprotkb:P01588-PRO_0000008401	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	intact:EBI-11508463	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:p01588-pro_0000008401(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0892"(solid phase assay)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508983|imex:IM-25004-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	intact:EBI-1027362(chain-parent)	-	-	chain-seq-start:28|chain-seq-end:193	figure legend:Supp 1M|comment:"Epo-alpha is a dimeric, glycosylated, polypeptide chain consisting of two mature human EPO molecules linked to the Fc portion of human IgG1. It has been assumed the \"mature\" sequence refers to the full length molecule minus the signal sequence -aas 28 – 193, although this is not stated."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/25	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:qL1IYLGZ1Q6znFxEnCn60Pq+RC89606	rigid:EE3LJZR768F5ucYKP0wfjyJS7x0	false	sufficient binding region:1..16-537..539|tag:?-?	fc-igg tag:?-?	-	2	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P54760	uniprotkb:P01588	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0892"(solid phase assay)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508998|imex:IM-25004-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	-	-	-	figure legend:Supp 1Ni|comment:"EPO-beta is a single, polypeptide chain containing 165 amino acids (sequence numbering unspecified)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/25	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rigid:E1yz5y2exVOt2fsIRHbzYBeC3BI	false	tag:?-?|sufficient binding region:1..16-537..539	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P54760	uniprotkb:P01588	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0892"(solid phase assay)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11508998|imex:IM-25004-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	-	-	-	figure legend:Supp 1Ni|comment:"EPO-beta is a single, polypeptide chain containing 165 amino acids (sequence numbering unspecified)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/12/09	2016/01/25	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rigid:E1yz5y2exVOt2fsIRHbzYBeC3BI	false	tag:?-?|sufficient binding region:1..16-537..539	fc-igg tag:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P54760	uniprotkb:P01588	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11509073|imex:IM-25004-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	-	-	-	figure legend:Supp 3F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a2780)|taxid:9606(A2780 Human ovarian cancer cell line)	-	2015/12/09	2016/01/25	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rigid:E1yz5y2exVOt2fsIRHbzYBeC3BI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54760	uniprotkb:P01588	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11509091|imex:IM-25004-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	-	-	-	figure legend:Supp 3F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skov_3)|taxid:9606(Homo sapiens ovarian adenocarcinoma cell line)	-	2015/12/09	2016/01/25	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rigid:E1yz5y2exVOt2fsIRHbzYBeC3BI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01588	uniprotkb:P54760	intact:EBI-1027362|uniprotkb:Q2M2L6|uniprotkb:Q549U2|uniprotkb:Q9UDZ0|uniprotkb:Q9UEZ5|uniprotkb:Q9UHA0|ensembl:ENSP00000252723	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	psi-mi:epo_human(display_long)|uniprotkb:EPO(gene name)|psi-mi:EPO(display_short)	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pradeep et al. (2015)	pubmed:26481148|imex:IM-25004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11509117|imex:IM-25004-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130427(gene)|ensembl:ENST00000252723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005125"(cytokine activity)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033574"(response to testosterone)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048678"(response to axon injury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071548"(response to dexamethasone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1902251"(negative regulation of erythrocyte apoptotic process)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001323(Erythropoietin/thrombopoeitin)|interpro:IPR003013(Erythropoietin)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019767|rcsb pdb:1BUY|rcsb pdb:1CN4|rcsb pdb:1EER|reactome:R-HSA-1234158|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|refseq:NP_000790.2|dip:DIP-5731N	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	-	-	-	figure legend:Supp 3F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2015/12/09	2016/01/25	rogid:60h2LdtVdr9clHmpscOO35dSVOM9606	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	rigid:E1yz5y2exVOt2fsIRHbzYBeC3BI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)