#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41221	uniprotkb:Q9Y5W5	intact:EBI-6594545|uniprotkb:A8K4A4|uniprotkb:Q6P278|ensembl:ENSP00000264634|ensembl:ENSP00000417310	intact:EBI-3922719|uniprotkb:Q8WVG4|uniprotkb:Q6UXI1|ensembl:ENSP00000286574	psi-mi:wnt5a_human(display_long)|uniprotkb:WNT5A(gene name)|psi-mi:WNT5A(display_short)	psi-mi:wif1_human(display_long)|uniprotkb:WIF1(gene name)|psi-mi:WIF1(display_short)|uniprotkb:UNQ191/PRO217(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Kerekes et al. (2015)	pubmed:26342861|imex:IM-24703	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11360840|imex:IM-24703-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006713387.1|refseq:XP_011532389.1|refseq:XP_011532387.1|refseq:XP_011532388.1|refseq:XP_011532390.1|refseq:XP_011532391.1|refseq:NP_001243034.1|refseq:NP_003383.2|refseq:XP_016862617.1|dip:DIP-29735N|ensembl:ENSG00000114251(gene)|ensembl:ENST00000264634(transcript)|ensembl:ENST00000474267(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001756"(somitogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003283"(atrial septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0003408"(optic cup formation involved in camera-type eye development)|go:"GO:0005109"(frizzled binding)|go:"GO:0005115"(receptor tyrosine kinase-like orphan receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007411"(axon guidance)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008584"(male gonad development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021891"(olfactory bulb interneuron development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036517"(chemoattraction of serotonergic neuron axon)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0036518"(chemorepulsion of dopaminergic neuron axon)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048806"(genitalia development)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048850"(hypophysis morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051885"(positive regulation of timing of anagen)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060065"(uterus development)|go:"GO:0060067"(cervix development)|go:"GO:0060068"(vagina development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060157"(urinary bladder development)|go:"GO:0060324"(face development)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060638"(mesenchymal-epithelial cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0060775"(planar cell polarity pathway involved in gastrula mediolateral intercalation)|go:"GO:0060809"(mesodermal to mesenchymal transition involved in gastrulation)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061347"(planar cell polarity pathway involved in outflow tract morphogenesis)|go:"GO:0061348"(planar cell polarity pathway involved in ventricular septum morphogenesis)|go:"GO:0061349"(planar cell polarity pathway involved in cardiac right atrium morphogenesis)|go:"GO:0061350"(planar cell polarity pathway involved in cardiac muscle tissue morphogenesis)|go:"GO:0061354"(planar cell polarity pathway involved in pericardium morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0090082"(positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902379"(chemoattractant activity involved in axon guidance)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1903827"|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1904934"(negative regulation of cell proliferation in midbrain)|go:"GO:1904938"(planar cell polarity pathway involved in axon guidance)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1904955"(planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR018161|interpro:IPR026538|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4086398|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|go:"GO:1900020"(positive regulation of protein kinase C activity)	dip:DIP-59097N|refseq:NP_009122.2|ensembl:ENSG00000156076(gene)|ensembl:ENST00000286574(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048856"(anatomical structure development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR003306(WIF domain)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013309("Wnt inhibitory factor (WIF)-1")|interpro:IPR038677|rcsb pdb:2D3J|rcsb pdb:2YGN|rcsb pdb:2YGO|rcsb pdb:2YGP|rcsb pdb:2YGQ|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	figure legend:f2a t1 t2 t4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.46x10^7(molar)	2015/11/04	2015/11/04	rogid:weJx4JkAu87Y6SLhWcc7GvgHLIU9606	rogid:19NePdPffERDUhuJlk1Wg4OHKVc9606	rigid:OzA4F+Ttj11zH8xYemHgIwKGt3Q	false	binding-associated region:269-365	binding-associated region:32-181|mutation disrupting interaction:155-155	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00755	uniprotkb:Q9Y5W5	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	intact:EBI-3922719|uniprotkb:Q8WVG4|uniprotkb:Q6UXI1|ensembl:ENSP00000286574	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:wif1_human(display_long)|uniprotkb:WIF1(gene name)|psi-mi:WIF1(display_short)|uniprotkb:UNQ191/PRO217(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Kerekes et al. (2015)	pubmed:26342861|imex:IM-24703	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11360851|imex:IM-24703-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	dip:DIP-59097N|refseq:NP_009122.2|ensembl:ENSG00000156076(gene)|ensembl:ENST00000286574(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048856"(anatomical structure development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR003306(WIF domain)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013309("Wnt inhibitory factor (WIF)-1")|interpro:IPR038677|rcsb pdb:2D3J|rcsb pdb:2YGN|rcsb pdb:2YGO|rcsb pdb:2YGP|rcsb pdb:2YGQ|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	figure legend:f2b t1 t2 t3 f4 t4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.22x10^-8(molar)	2015/11/04	2015/11/04	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rogid:19NePdPffERDUhuJlk1Wg4OHKVc9606	rigid:5br8q83ZIGEjJLdmTJ4pdT3K38c	false	binding-associated region:264-349	mutation decreasing interaction:123-123|mutation decreasing interaction:155-155|mutation decreasing interaction:172-172|binding-associated region:32-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00755	uniprotkb:Q9Y5W5	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	intact:EBI-3922719|uniprotkb:Q8WVG4|uniprotkb:Q6UXI1|ensembl:ENSP00000286574	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:wif1_human(display_long)|uniprotkb:WIF1(gene name)|psi-mi:WIF1(display_short)|uniprotkb:UNQ191/PRO217(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Kerekes et al. (2015)	pubmed:26342861|imex:IM-24703	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11361462|imex:IM-24703-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	dip:DIP-59097N|refseq:NP_009122.2|ensembl:ENSG00000156076(gene)|ensembl:ENST00000286574(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048856"(anatomical structure development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR003306(WIF domain)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013309("Wnt inhibitory factor (WIF)-1")|interpro:IPR038677|rcsb pdb:2D3J|rcsb pdb:2YGN|rcsb pdb:2YGO|rcsb pdb:2YGP|rcsb pdb:2YGQ|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	figure legend:t4 f4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.52x10^-4(second -1)	2015/11/04	2015/11/06	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rogid:19NePdPffERDUhuJlk1Wg4OHKVc9606	rigid:5br8q83ZIGEjJLdmTJ4pdT3K38c	false	-	mutation increasing interaction:155-155|binding-associated region:32-181	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41221	uniprotkb:Q9Y5W5	intact:EBI-6594545|uniprotkb:A8K4A4|uniprotkb:Q6P278|ensembl:ENSP00000264634|ensembl:ENSP00000417310	intact:EBI-3922719|uniprotkb:Q8WVG4|uniprotkb:Q6UXI1|ensembl:ENSP00000286574	psi-mi:wnt5a_human(display_long)|uniprotkb:WNT5A(gene name)|psi-mi:WNT5A(display_short)	psi-mi:wif1_human(display_long)|uniprotkb:WIF1(gene name)|psi-mi:WIF1(display_short)|uniprotkb:UNQ191/PRO217(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Kerekes et al. (2015)	pubmed:26342861|imex:IM-24703	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11361484|imex:IM-24703-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006713387.1|refseq:XP_011532389.1|refseq:XP_011532387.1|refseq:XP_011532388.1|refseq:XP_011532390.1|refseq:XP_011532391.1|refseq:NP_001243034.1|refseq:NP_003383.2|refseq:XP_016862617.1|dip:DIP-29735N|ensembl:ENSG00000114251(gene)|ensembl:ENST00000264634(transcript)|ensembl:ENST00000474267(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001756"(somitogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003283"(atrial septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0003408"(optic cup formation involved in camera-type eye development)|go:"GO:0005109"(frizzled binding)|go:"GO:0005115"(receptor tyrosine kinase-like orphan receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007411"(axon guidance)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008584"(male gonad development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021891"(olfactory bulb interneuron development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036517"(chemoattraction of serotonergic neuron axon)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0036518"(chemorepulsion of dopaminergic neuron axon)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048806"(genitalia development)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048850"(hypophysis morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051885"(positive regulation of timing of anagen)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060065"(uterus development)|go:"GO:0060067"(cervix development)|go:"GO:0060068"(vagina development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060157"(urinary bladder development)|go:"GO:0060324"(face development)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060638"(mesenchymal-epithelial cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0060775"(planar cell polarity pathway involved in gastrula mediolateral intercalation)|go:"GO:0060809"(mesodermal to mesenchymal transition involved in gastrulation)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061347"(planar cell polarity pathway involved in outflow tract morphogenesis)|go:"GO:0061348"(planar cell polarity pathway involved in ventricular septum morphogenesis)|go:"GO:0061349"(planar cell polarity pathway involved in cardiac right atrium morphogenesis)|go:"GO:0061350"(planar cell polarity pathway involved in cardiac muscle tissue morphogenesis)|go:"GO:0061354"(planar cell polarity pathway involved in pericardium morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0090082"(positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902379"(chemoattractant activity involved in axon guidance)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1903827"|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1904934"(negative regulation of cell proliferation in midbrain)|go:"GO:1904938"(planar cell polarity pathway involved in axon guidance)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1904955"(planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR018161|interpro:IPR026538|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4086398|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|go:"GO:1900020"(positive regulation of protein kinase C activity)	dip:DIP-59097N|refseq:NP_009122.2|ensembl:ENSG00000156076(gene)|ensembl:ENST00000286574(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048856"(anatomical structure development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR003306(WIF domain)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013309("Wnt inhibitory factor (WIF)-1")|interpro:IPR038677|rcsb pdb:2D3J|rcsb pdb:2YGN|rcsb pdb:2YGO|rcsb pdb:2YGP|rcsb pdb:2YGQ|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	figure legend:t4 f4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.6x10^-4(second -1)	2015/11/04	2015/11/06	rogid:weJx4JkAu87Y6SLhWcc7GvgHLIU9606	rogid:19NePdPffERDUhuJlk1Wg4OHKVc9606	rigid:OzA4F+Ttj11zH8xYemHgIwKGt3Q	false	-	binding-associated region:32-181|mutation decreasing interaction:155-155	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)