#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22907	uniprotkb:P08397	intact:EBI-8321919|intact:MINT-4097350|uniprotkb:Q3TIV0|ensembl:ENSMUSP00000076575	intact:EBI-9090148|uniprotkb:G3V1P4|uniprotkb:G5EA58|uniprotkb:A8K2L0|uniprotkb:Q16012|uniprotkb:P08396|ensembl:ENSP00000498786	psi-mi:hem3_mouse(display_long)|uniprotkb:Hmbs(gene name)|psi-mi:Hmbs(display_short)|uniprotkb:Uros1(gene name synonym)|uniprotkb:Pre-uroporphyrinogen synthase(gene name synonym)|uniprotkb:Hydroxymethylbilane synthase(gene name synonym)	psi-mi:hem3_human(display_long)|uniprotkb:Hydroxymethylbilane synthase(gene name synonym)|uniprotkb:PBGD(gene name synonym)|uniprotkb:Pre-uroporphyrinogen synthase(gene name synonym)|uniprotkb:UPS(gene name synonym)|uniprotkb:HMBS(gene name)|psi-mi:HMBS(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767335|imex:IM-24072-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038579.2|ensembl:ENSMUSG00000032126(gene)|ensembl:ENSMUST00000077353(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004418"(hydroxymethylbilane synthase activity)|go:"GO:0004852"(uroporphyrinogen-III synthase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006778"(porphyrin-containing compound metabolic process)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0018160"(peptidyl-pyrromethane cofactor linkage)|go:"GO:0030424"(axon)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0033014"(tetrapyrrole biosynthetic process)|go:"GO:0042493"|go:"GO:0043176"(amine binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000860(Tetrapyrrole biosynthesis, hydroxymethylbilane synthase)|interpro:IPR022417|interpro:IPR022418|interpro:IPR022419|interpro:IPR036803|mint:P22907|reactome:R-MMU-189451	refseq:NP_000181.2|refseq:NP_001019553.1|refseq:NP_001245137.1|refseq:NP_001245138.1|refseq:XP_005271588.1|refseq:XP_005271589.1|refseq:XP_016873118.1|ensembl:ENSG00000256269(gene)|go:"GO:0004418"(hydroxymethylbilane synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0018160"(peptidyl-pyrromethane cofactor linkage)|interpro:IPR000860(Tetrapyrrole biosynthesis, hydroxymethylbilane synthase)|interpro:IPR022417|interpro:IPR022418|interpro:IPR022419|interpro:IPR036803|rcsb pdb:3ECR|ensembl:ENST00000652429(transcript)|rcsb pdb:5M6R|rcsb pdb:5M7F|rcsb pdb:7AAJ|rcsb pdb:7AAK|rcsb pdb:7CCX|rcsb pdb:7CCY|rcsb pdb:7CCZ|rcsb pdb:7CD0|reactome:R-HSA-189451|rcsb pdb:3EQ1	go:"GO:0005829"(cytosol)	comment:mint|function:Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/07/15	rogid:vn2nkrOKUsrRLdP5f5BaXWKbIL010090	rogid:aTjyl498kJtf2NyY0oQFyz00ogc9606	rigid:RwxWnidQhFSDeZvoFd3fQ5E/5Nw	false	-	flag tag:n-n	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P10518	uniprotkb:P13716	intact:EBI-1634066|uniprotkb:Q3THV6|ensembl:ENSMUSP00000030090|ensembl:ENSMUSP00000103068	intact:EBI-6917458|uniprotkb:A8K375|uniprotkb:B2R6F2|uniprotkb:Q16870|uniprotkb:Q16871|uniprotkb:Q9BVQ9|ensembl:ENSP00000386284	psi-mi:hem2_mouse(display_long)|uniprotkb:Alad(gene name)|psi-mi:Alad(display_short)|uniprotkb:Lv(gene name synonym)|uniprotkb:Porphobilinogen synthase(gene name synonym)	psi-mi:hem2_human(display_long)|uniprotkb:ALAD(gene name)|psi-mi:ALAD(display_short)|uniprotkb:Porphobilinogen synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767342|imex:IM-24072-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032551.3|refseq:XP_006537702.1|refseq:NP_001263375.1|ensembl:ENSMUSG00000028393(gene)|ensembl:ENSMUST00000030090(transcript)|ensembl:ENSMUST00000107444(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004655"(porphobilinogen synthase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007584"(response to nutrient)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009635"(response to herbicide)|go:"GO:0010033"(response to organic substance)|go:"GO:0010038"(response to metal ion)|go:"GO:0010039"(response to iron ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010266"(response to vitamin B1)|go:"GO:0010269"(response to selenium ion)|go:"GO:0014823"(response to activity)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033197"(response to vitamin E)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0045471"(response to ethanol)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904854"(proteasome core complex binding)|interpro:IPR001731(Tetrapyrrole biosynthesis, porphobilinogen synthase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR030656|mint:P10518|rcsb pdb:2Z0I|rcsb pdb:2Z1B|reactome:R-MMU-189451|reactome:R-MMU-6798695	refseq:NP_001003945.1|refseq:XP_011516666.1|refseq:NP_000022.3|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070541"(response to platinum ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904854"(proteasome core complex binding)|interpro:IPR001731(Tetrapyrrole biosynthesis, porphobilinogen synthase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR030656|rcsb pdb:1E51|rcsb pdb:1PV8|rcsb pdb:5HMS|rcsb pdb:5HNR|reactome:R-HSA-189451|reactome:R-HSA-6798695|go:"GO:0045471"(response to ethanol)|ensembl:ENSG00000148218(gene)|ensembl:ENST00000409155(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003824"(catalytic activity)|go:"GO:0004655"(porphobilinogen synthase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009635"(response to herbicide)|go:"GO:0010039"(response to iron ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010266"(response to vitamin B1)|go:"GO:0010269"(response to selenium ion)|go:"GO:0014823"(response to activity)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043200"(response to amino acid)	go:"GO:0005829"(cytosol)	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:NhU2SJjS9uO8bs14ufdf3+i8wTc10090	rogid:2545gfRH9UwPlIt863Ul/qY/2pY9606	rigid:hH2xvBA0hzODB0dJSQMNNI02tOQ	false	-	flag tag:n-n	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P70697	uniprotkb:P06132	intact:EBI-8376993|intact:MINT-4092930|uniprotkb:Q91VW4|ensembl:ENSMUSP00000030446	intact:EBI-2871776|uniprotkb:Q9BUZ0|uniprotkb:Q16863|uniprotkb:Q6IB28|uniprotkb:Q53YB8|uniprotkb:A8K762|uniprotkb:Q16883|uniprotkb:Q53ZP6|ensembl:ENSP00000246337	psi-mi:dcup_mouse(display_long)|uniprotkb:Urod(gene name)|psi-mi:Urod(display_short)	psi-mi:dcup_human(display_long)|uniprotkb:UROD(gene name)|psi-mi:UROD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767351|imex:IM-24072-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033504.2|ensembl:ENSMUSG00000028684(gene)|ensembl:ENSMUST00000030446(transcript)|go:"GO:0004853"(uroporphyrinogen decarboxylase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0042168"(heme metabolic process)|go:"GO:0046502"(uroporphyrinogen III metabolic process)|interpro:IPR000257("Uroporphyrinogen decarboxylase (URO-D)")|interpro:IPR006361(Uroporphyrinogen decarboxylase HemE)|interpro:IPR038071|mint:P70697|reactome:R-MMU-189451	refseq:NP_000365.3|ensembl:ENSG00000126088(gene)|ensembl:ENST00000246337(transcript)|go:"GO:0004853"(uroporphyrinogen decarboxylase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|interpro:IPR000257("Uroporphyrinogen decarboxylase (URO-D)")|interpro:IPR006361(Uroporphyrinogen decarboxylase HemE)|interpro:IPR038071|rcsb pdb:1JPH|rcsb pdb:1JPI|rcsb pdb:1JPK|rcsb pdb:1R3Q|rcsb pdb:1R3R|rcsb pdb:1R3S|rcsb pdb:1R3T|rcsb pdb:1R3V|rcsb pdb:1R3W|rcsb pdb:1R3Y|rcsb pdb:1URO|rcsb pdb:2Q6Z|rcsb pdb:2Q71|rcsb pdb:3GVQ|rcsb pdb:3GVR|rcsb pdb:3GVV|rcsb pdb:3GVW|rcsb pdb:3GW0|rcsb pdb:3GW3|reactome:R-HSA-189451	go:"GO:0005829"(cytosol)	function:Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen III to yield coproporphyrinogen III|comment:mint	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:pWo6b0YGWUM8tYHYaDATW2kVgGs10090	rogid:z7CP0Z1yVLMjDRwXMe4ENFXu1aM9606	rigid:95LG+fl1R0Ny5D90z9WaJZ0P+QA	false	-	flag tag:n-n	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:P22315	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-7174007|intact:MINT-1842883	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:P36552	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-8345447|uniprotkb:Q7TQ36|uniprotkb:Q8VD08|intact:MINT-1844590|ensembl:ENSMUSP00000055455	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:hem6_mouse(display_long)|uniprotkb:Cpox(gene name)|psi-mi:Cpox(display_short)|uniprotkb:Cpo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	refseq:NP_031783.2|ensembl:ENSMUSG00000022742(gene)|ensembl:ENSMUST00000060077(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0010039"(response to iron ion)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0017085"(response to insecticide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051597"(response to methylmercury)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|mint:P36552|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	comment:mint	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:GZqRcpZdHv5rZB0A5L3p74g1Wos10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:Q60930	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-444578|ensembl:ENSMUSP00000022293|uniprotkb:Q78MH6|uniprotkb:Q99L98	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:vdac2_mouse(display_long)|uniprotkb:Voltage-dependent anion-selective channel protein 6(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:Vdac2(gene name)|psi-mi:Vdac2(display_short)|uniprotkb:Vdac6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	refseq:NP_035825.1|ensembl:ENSMUSG00000021771(gene)|ensembl:ENSMUST00000022293(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:Q60930|reactome:R-MMU-5689880	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:ApSD4TVlagQ1QHePbOZw7J5rmzQ10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:Q9Z2I9	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:P51175	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-10767384|uniprotkb:P97344|uniprotkb:Q99M34|ensembl:ENSMUSP00000072863	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:ppox_mouse(display_long)|uniprotkb:Ppox(gene name)|psi-mi:Ppox(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	refseq:NP_032937.1|refseq:XP_006496770.1|ensembl:ENSMUSG00000062729(gene)|ensembl:ENSMUST00000073120(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:rcR25BoqGU+V9P5N30wFKolChiU10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:Q9CR62	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-299894|ensembl:ENSMUSP00000014750	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:m2om_mouse(display_long)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	ensembl:ENSMUSG00000014606(gene)|ensembl:ENSMUST00000014750(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q9CR62|reactome:R-MMU-70263|refseq:NP_077173.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:fYdym44Y2a8dI7c6hjpN4ADNRgA10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:Q80Y14	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-645575|uniprotkb:Q3YML1|uniprotkb:Q9D6E9|ensembl:ENSMUSP00000021522	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:glrx5_mouse(display_long)|uniprotkb:Glrx5(gene name)|psi-mi:Glrx5(display_short)|uniprotkb:Monothiol glutaredoxin-5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	refseq:NP_082695.1|ensembl:ENSMUSG00000021102(gene)|ensembl:ENSMUST00000021522(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR033658|interpro:IPR036249|reactome:R-MMU-1362409|go:"GO:0044571"([2Fe-2S] cluster assembly)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:qKMGEJ5oYXg0R4AfyNqzR5pIg0o10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:P51881	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-445370|uniprotkb:Q61311|ensembl:ENSMUSP00000016463	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:adt2_mouse(display_long)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Aac2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	refseq:NP_031477.1|dip:DIP-31399N|ensembl:ENSMUSG00000016319(gene)|ensembl:ENSMUST00000016463(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P51881|reactome:R-MMU-83936|go:"GO:0031625"(ubiquitin protein ligase binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:146+I0bORlUf6z9chvmdXwUCtOs10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:P48962	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-299469|ensembl:ENSMUSP00000034049|uniprotkb:Q62164	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:adt1_mouse(display_long)|uniprotkb:Slc25a4(gene name)|psi-mi:Slc25a4(display_short)|uniprotkb:Anc1(gene name synonym)|uniprotkb:Ant1(gene name synonym)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:ADP,ATP carrier protein, heart/skeletal muscle isoform T1(gene name synonym)|uniprotkb:Aac1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	ensembl:ENSMUST00000034049(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P48962|reactome:R-MMU-83936|ensembl:ENSMUSG00000031633(gene)|refseq:NP_031476.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:WHXVn/8emywvVfEH5dZ7KrUTiC810090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:Q61102	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P36551	uniprotkb:Q9JI39	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767410|imex:IM-24072-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:Olk89LAiCGq8J5fdjKPr3ZyIPq0	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:P22315	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-7174007|intact:MINT-1842883	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:P36552	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-8345447|uniprotkb:Q7TQ36|uniprotkb:Q8VD08|intact:MINT-1844590|ensembl:ENSMUSP00000055455	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:hem6_mouse(display_long)|uniprotkb:Cpox(gene name)|psi-mi:Cpox(display_short)|uniprotkb:Cpo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_031783.2|ensembl:ENSMUSG00000022742(gene)|ensembl:ENSMUST00000060077(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0010039"(response to iron ion)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0017085"(response to insecticide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051597"(response to methylmercury)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|mint:P36552|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	comment:mint	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:GZqRcpZdHv5rZB0A5L3p74g1Wos10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q60930	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-444578|ensembl:ENSMUSP00000022293|uniprotkb:Q78MH6|uniprotkb:Q99L98	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:vdac2_mouse(display_long)|uniprotkb:Voltage-dependent anion-selective channel protein 6(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:Vdac2(gene name)|psi-mi:Vdac2(display_short)|uniprotkb:Vdac6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_035825.1|ensembl:ENSMUSG00000021771(gene)|ensembl:ENSMUST00000022293(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:Q60930|reactome:R-MMU-5689880	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:ApSD4TVlagQ1QHePbOZw7J5rmzQ10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q62351	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q9Z2I9	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q8CI59	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767480|uniprotkb:Q3TKE4|uniprotkb:Q80ZF3|uniprotkb:Q8C5F0|uniprotkb:Q924Z1	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:stea3_mouse(display_long)|uniprotkb:Dudulin-2(gene name synonym)|uniprotkb:Protein nm1054(gene name synonym)|uniprotkb:Six-transmembrane epithelial antigen of prostate 3(gene name synonym)|uniprotkb:Tumor suppressor-activated pathway protein 6(gene name synonym)|uniprotkb:Steap3(gene name)|psi-mi:Steap3(display_short)|uniprotkb:Tsap6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	reactome:R-MMU-6803204|reactome:R-MMU-917977|reactome:R-MMU-9013148|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9035034|refseq:NP_001078878.1|refseq:NP_573449.2|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR028939|go:"GO:0000293"(ferric-chelate reductase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008823"(cupric reductase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0015677"(copper ion import)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033212"(iron import into cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0052851"("ferric-chelate reductase (NADPH) activity")|go:"GO:0098706"(iron ion import across cell outer membrane)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1990182"(exosomal secretion)|interpro:IPR036291	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:8p8Tf/zr3ZSGWgNriaa01NC6yXE10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q99JR1	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-775916|uniprotkb:Q3UB44|uniprotkb:Q9CZG4|ensembl:ENSMUSP00000021930	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:sfxn1_mouse(display_long)|uniprotkb:Sfxn1(gene name)|psi-mi:Sfxn1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_081600.1|refseq:XP_006516912.2|refseq:XP_006516913.1|ensembl:ENSMUSG00000021474(gene)|ensembl:ENSMUST00000021930(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006826"(iron ion transport)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015825"(L-serine transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042942"(D-serine transport)|go:"GO:0042945"(D-serine transmembrane transporter activity)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q99JR1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:Fw53Bii/EOp13qU53qI4/06lIaE10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:P51175	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767384|uniprotkb:P97344|uniprotkb:Q99M34|ensembl:ENSMUSP00000072863	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:ppox_mouse(display_long)|uniprotkb:Ppox(gene name)|psi-mi:Ppox(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_032937.1|refseq:XP_006496770.1|ensembl:ENSMUSG00000062729(gene)|ensembl:ENSMUST00000073120(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:rcR25BoqGU+V9P5N30wFKolChiU10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q9CR62	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-299894|ensembl:ENSMUSP00000014750	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:m2om_mouse(display_long)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	ensembl:ENSMUSG00000014606(gene)|ensembl:ENSMUST00000014750(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q9CR62|reactome:R-MMU-70263|refseq:NP_077173.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:fYdym44Y2a8dI7c6hjpN4ADNRgA10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q80Y14	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-645575|uniprotkb:Q3YML1|uniprotkb:Q9D6E9|ensembl:ENSMUSP00000021522	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:glrx5_mouse(display_long)|uniprotkb:Glrx5(gene name)|psi-mi:Glrx5(display_short)|uniprotkb:Monothiol glutaredoxin-5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_082695.1|ensembl:ENSMUSG00000021102(gene)|ensembl:ENSMUST00000021522(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR033658|interpro:IPR036249|reactome:R-MMU-1362409|go:"GO:0044571"([2Fe-2S] cluster assembly)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:qKMGEJ5oYXg0R4AfyNqzR5pIg0o10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:P51881	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-445370|uniprotkb:Q61311|ensembl:ENSMUSP00000016463	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:adt2_mouse(display_long)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Aac2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_031477.1|dip:DIP-31399N|ensembl:ENSMUSG00000016319(gene)|ensembl:ENSMUST00000016463(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P51881|reactome:R-MMU-83936|go:"GO:0031625"(ubiquitin protein ligase binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:146+I0bORlUf6z9chvmdXwUCtOs10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:P48962	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-299469|ensembl:ENSMUSP00000034049|uniprotkb:Q62164	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:adt1_mouse(display_long)|uniprotkb:Slc25a4(gene name)|psi-mi:Slc25a4(display_short)|uniprotkb:Anc1(gene name synonym)|uniprotkb:Ant1(gene name synonym)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:ADP,ATP carrier protein, heart/skeletal muscle isoform T1(gene name synonym)|uniprotkb:Aac1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	ensembl:ENSMUST00000034049(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P48962|reactome:R-MMU-83936|ensembl:ENSMUSG00000031633(gene)|refseq:NP_031476.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:WHXVn/8emywvVfEH5dZ7KrUTiC810090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:P08680	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767448|uniprotkb:Q64452|uniprotkb:Q9DCN0|ensembl:ENSMUSP00000066040	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:hem0_mouse(display_long)|uniprotkb:5-aminolevulinic acid synthase 2(gene name synonym)|uniprotkb:Delta-ALA synthase 2(gene name synonym)|uniprotkb:Delta-aminolevulinate synthase 2(gene name synonym)|uniprotkb:Alas2(gene name)|psi-mi:Alas2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_001095916.1|refseq:NP_033783.1|ensembl:ENSMUST00000066337(transcript)|go:"GO:0001666"(response to hypoxia)|ensembl:ENSMUSG00000025270(gene)|go:"GO:0003870"(5-aminolevulinate synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0120225"(coenzyme A binding)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR010961(Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase)|interpro:IPR015118(5-aminolevulinate synthase presequence)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1H7D|rcsb pdb:1H7J|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:u2FJSJbEuyk+eU2flF2jrD+2Q7g10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q61102	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q9JI39	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767442|imex:IM-24072-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:MEwOPCPwnQAUN4N5aT7xD80fz/c	false	flag tag:61-62	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:P22315	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-7174007|intact:MINT-1842883	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:P36552	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-8345447|uniprotkb:Q7TQ36|uniprotkb:Q8VD08|intact:MINT-1844590|ensembl:ENSMUSP00000055455	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:hem6_mouse(display_long)|uniprotkb:Cpox(gene name)|psi-mi:Cpox(display_short)|uniprotkb:Cpo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_031783.2|ensembl:ENSMUSG00000022742(gene)|ensembl:ENSMUST00000060077(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0010039"(response to iron ion)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0017085"(response to insecticide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051597"(response to methylmercury)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|mint:P36552|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	comment:mint	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:GZqRcpZdHv5rZB0A5L3p74g1Wos10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q60930	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-444578|ensembl:ENSMUSP00000022293|uniprotkb:Q78MH6|uniprotkb:Q99L98	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:vdac2_mouse(display_long)|uniprotkb:Voltage-dependent anion-selective channel protein 6(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:Vdac2(gene name)|psi-mi:Vdac2(display_short)|uniprotkb:Vdac6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_035825.1|ensembl:ENSMUSG00000021771(gene)|ensembl:ENSMUST00000022293(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:Q60930|reactome:R-MMU-5689880	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:ApSD4TVlagQ1QHePbOZw7J5rmzQ10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q9CQN6	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-10767568|uniprotkb:Q543H6|uniprotkb:Q9D849|ensembl:ENSMUSP00000021790	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:tm14c_mouse(display_long)|uniprotkb:Tmem14c(gene name)|psi-mi:Tmem14c(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_079663.1|refseq:XP_006517001.1|ensembl:ENSMUSG00000021361(gene)|ensembl:ENSMUST00000021790(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0070453"(regulation of heme biosynthetic process)|interpro:IPR005349(Protein of unknown function UPF0136, Transmembrane)|interpro:IPR044890|refseq:XP_006517000.2|refseq:XP_006517002.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:3+ewuNKkHdb53Ik8mxkO/1VECuI10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q62351	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q9Z2I9	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q8CI59	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-10767480|uniprotkb:Q3TKE4|uniprotkb:Q80ZF3|uniprotkb:Q8C5F0|uniprotkb:Q924Z1	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:stea3_mouse(display_long)|uniprotkb:Dudulin-2(gene name synonym)|uniprotkb:Protein nm1054(gene name synonym)|uniprotkb:Six-transmembrane epithelial antigen of prostate 3(gene name synonym)|uniprotkb:Tumor suppressor-activated pathway protein 6(gene name synonym)|uniprotkb:Steap3(gene name)|psi-mi:Steap3(display_short)|uniprotkb:Tsap6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	reactome:R-MMU-6803204|reactome:R-MMU-917977|reactome:R-MMU-9013148|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9035034|refseq:NP_001078878.1|refseq:NP_573449.2|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR028939|go:"GO:0000293"(ferric-chelate reductase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008823"(cupric reductase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0015677"(copper ion import)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033212"(iron import into cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0052851"("ferric-chelate reductase (NADPH) activity")|go:"GO:0098706"(iron ion import across cell outer membrane)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1990182"(exosomal secretion)|interpro:IPR036291	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:8p8Tf/zr3ZSGWgNriaa01NC6yXE10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q99JR1	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-775916|uniprotkb:Q3UB44|uniprotkb:Q9CZG4|ensembl:ENSMUSP00000021930	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:sfxn1_mouse(display_long)|uniprotkb:Sfxn1(gene name)|psi-mi:Sfxn1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_081600.1|refseq:XP_006516912.2|refseq:XP_006516913.1|ensembl:ENSMUSG00000021474(gene)|ensembl:ENSMUST00000021930(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006826"(iron ion transport)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015825"(L-serine transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042942"(D-serine transport)|go:"GO:0042945"(D-serine transmembrane transporter activity)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q99JR1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:Fw53Bii/EOp13qU53qI4/06lIaE10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:P51175	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-10767384|uniprotkb:P97344|uniprotkb:Q99M34|ensembl:ENSMUSP00000072863	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:ppox_mouse(display_long)|uniprotkb:Ppox(gene name)|psi-mi:Ppox(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_032937.1|refseq:XP_006496770.1|ensembl:ENSMUSG00000062729(gene)|ensembl:ENSMUST00000073120(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:rcR25BoqGU+V9P5N30wFKolChiU10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q9CR62	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-299894|ensembl:ENSMUSP00000014750	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:m2om_mouse(display_long)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	ensembl:ENSMUSG00000014606(gene)|ensembl:ENSMUST00000014750(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q9CR62|reactome:R-MMU-70263|refseq:NP_077173.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:fYdym44Y2a8dI7c6hjpN4ADNRgA10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q80Y14	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-645575|uniprotkb:Q3YML1|uniprotkb:Q9D6E9|ensembl:ENSMUSP00000021522	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:glrx5_mouse(display_long)|uniprotkb:Glrx5(gene name)|psi-mi:Glrx5(display_short)|uniprotkb:Monothiol glutaredoxin-5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_082695.1|ensembl:ENSMUSG00000021102(gene)|ensembl:ENSMUST00000021522(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR033658|interpro:IPR036249|reactome:R-MMU-1362409|go:"GO:0044571"([2Fe-2S] cluster assembly)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:qKMGEJ5oYXg0R4AfyNqzR5pIg0o10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:P51881	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-445370|uniprotkb:Q61311|ensembl:ENSMUSP00000016463	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:adt2_mouse(display_long)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Aac2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_031477.1|dip:DIP-31399N|ensembl:ENSMUSG00000016319(gene)|ensembl:ENSMUST00000016463(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P51881|reactome:R-MMU-83936|go:"GO:0031625"(ubiquitin protein ligase binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:146+I0bORlUf6z9chvmdXwUCtOs10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:P48962	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-299469|ensembl:ENSMUSP00000034049|uniprotkb:Q62164	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:adt1_mouse(display_long)|uniprotkb:Slc25a4(gene name)|psi-mi:Slc25a4(display_short)|uniprotkb:Anc1(gene name synonym)|uniprotkb:Ant1(gene name synonym)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:ADP,ATP carrier protein, heart/skeletal muscle isoform T1(gene name synonym)|uniprotkb:Aac1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	ensembl:ENSMUST00000034049(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P48962|reactome:R-MMU-83936|ensembl:ENSMUSG00000031633(gene)|refseq:NP_031476.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:WHXVn/8emywvVfEH5dZ7KrUTiC810090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:P08680	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-10767448|uniprotkb:Q64452|uniprotkb:Q9DCN0|ensembl:ENSMUSP00000066040	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:hem0_mouse(display_long)|uniprotkb:5-aminolevulinic acid synthase 2(gene name synonym)|uniprotkb:Delta-ALA synthase 2(gene name synonym)|uniprotkb:Delta-aminolevulinate synthase 2(gene name synonym)|uniprotkb:Alas2(gene name)|psi-mi:Alas2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_001095916.1|refseq:NP_033783.1|ensembl:ENSMUST00000066337(transcript)|go:"GO:0001666"(response to hypoxia)|ensembl:ENSMUSG00000025270(gene)|go:"GO:0003870"(5-aminolevulinate synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0120225"(coenzyme A binding)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR010961(Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase)|interpro:IPR015118(5-aminolevulinate synthase presequence)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1H7D|rcsb pdb:1H7J|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:u2FJSJbEuyk+eU2flF2jrD+2Q7g10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q61102	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P50336	uniprotkb:Q9JI39	intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767560|imex:IM-24072-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:R0JZIkiTkZQP3iQyQoQ7MX0mGcw	false	flag tag:c-c	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P22830	uniprotkb:Q9Z2I9	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767625|imex:IM-24072-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Figure 2|comment:E343K FECH mutant shows decreased binding of abcb10 prey.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:ba7wKsQkoBz1km0FB6LgquZZg9M	false	flag tag:61-62,1-1,23-26	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:P51175	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767384|uniprotkb:P97344|uniprotkb:Q99M34|ensembl:ENSMUSP00000072863	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:ppox_mouse(display_long)|uniprotkb:Ppox(gene name)|psi-mi:Ppox(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767625|imex:IM-24072-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_032937.1|refseq:XP_006496770.1|ensembl:ENSMUSG00000062729(gene)|ensembl:ENSMUST00000073120(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Figure 2|comment:E343K FECH mutant shows decreased binding of abcb10 prey.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:rcR25BoqGU+V9P5N30wFKolChiU10090	rigid:ba7wKsQkoBz1km0FB6LgquZZg9M	false	flag tag:61-62,1-1,23-26	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:Q61102	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767625|imex:IM-24072-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Figure 2|comment:E343K FECH mutant shows decreased binding of abcb10 prey.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:ba7wKsQkoBz1km0FB6LgquZZg9M	false	flag tag:61-62,1-1,23-26	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:Q9JI39	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Medlock et al. (2014)	pubmed:26287972|imex:IM-24072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767625|imex:IM-24072-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Figure 2|comment:E343K FECH mutant shows decreased binding of abcb10 prey.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2015/04/22	2015/04/23	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:ba7wKsQkoBz1km0FB6LgquZZg9M	false	flag tag:61-62,1-1,23-26	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)