#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P60033	uniprotkb:P81605	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-395625|uniprotkb:P58461|uniprotkb:A5JHP2|uniprotkb:A5JHP3|uniprotkb:Q53YJ2|ensembl:ENSP00000293371	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:dcd_human(display_long)|uniprotkb:AIDD(gene name synonym)|uniprotkb:DSEP(gene name synonym)|uniprotkb:Preproteolysin(gene name synonym)|uniprotkb:DCD(gene name)|psi-mi:DCD(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_444513.1|refseq:NP_001287783.1|ensembl:ENSG00000161634(gene)|ensembl:ENST00000293371(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0008233"(peptidase activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028130|interpro:IPR043557|mint:P81605|rcsb pdb:2KSG|rcsb pdb:2NDK|rcsb pdb:2YMK|rcsb pdb:6SHK|reactome:R-HSA-6803157	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:M8PkKVWx98nhtd79ods05mqw8Ls9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P01040	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-724303|ensembl:ENSP00000264474|uniprotkb:Q6IB90	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:cyta_human(display_long)|uniprotkb:Cystatin-AS(gene name synonym)|uniprotkb:Stefin-A(gene name synonym)|uniprotkb:CSTA(gene name)|psi-mi:CSTA(display_short)|uniprotkb:STF1(gene name synonym)|uniprotkb:STFA(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_005204.1|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001713(Proteinase inhibitor I25A, stefin A)|mint:P01040|rcsb pdb:1CYU|rcsb pdb:1CYV|rcsb pdb:1DVC|rcsb pdb:1DVD|rcsb pdb:1GD3|rcsb pdb:1GD4|rcsb pdb:1N9J|rcsb pdb:1NB3|rcsb pdb:1NB5|rcsb pdb:3K9M|rcsb pdb:3KFQ|interpro:IPR018073|rcsb pdb:3KSE|reactome:R-HSA-6809371|ensembl:ENSG00000121552(gene)|ensembl:ENST00000264474(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002020"(protease binding)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0045861"(negative regulation of proteolysis)	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:SzbpyWUHlOtItIvffzuwhcqFsDI9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q05707	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-2528599|uniprotkb:B2RU07|uniprotkb:O00260|uniprotkb:O00261|uniprotkb:O00262|uniprotkb:Q05708|uniprotkb:Q5XJ18|uniprotkb:Q96C67|uniprotkb:Q9UDF6|ensembl:ENSP00000297848	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:coea1_human(display_long)|uniprotkb:COL14A1(gene name)|psi-mi:COL14A1(display_short)|uniprotkb:UND(gene name synonym)|uniprotkb:Undulin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:XP_016869298.1|refseq:NP_066933.1|refseq:XP_005251116.1|refseq:XP_006716714.1|ensembl:ENSG00000187955(gene)|ensembl:ENST00000297848(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005596"(collagen type XIV trimer)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001791(Laminin G)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036465|reactome:R-HSA-1442490|reactome:R-HSA-1650814|reactome:R-HSA-2022090|reactome:R-HSA-8948216	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:8eQ55YOi3IK4OWPI57s3ak2q4bg9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q02413	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-1045757|intact:EBI-28968615|ensembl:ENSP00000257192|uniprotkb:B7Z845	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:dsg1_human(display_long)|uniprotkb:CDHF4(gene name synonym)|uniprotkb:Desmosomal glycoprotein 1(gene name synonym)|uniprotkb:Pemphigus foliaceus antigen(gene name synonym)|uniprotkb:DSG1(gene name)|psi-mi:DSG1(display_short)|uniprotkb:Cadherin family member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	ensembl:ENSP00000257192|refseq:NP_001933.2|ensembl:ENSG00000134760(gene)|ensembl:ENST00000257192(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q02413|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:CiRFIJ9IWOol9bQpLJPxH8JArtE9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q5JTJ3	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-2874677|ensembl:ENSP00000355572|uniprotkb:Q8TA88|uniprotkb:Q5JTJ4|uniprotkb:Q5JTJ2	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:coa6_human(display_long)|uniprotkb:COA6(gene name)|psi-mi:COA6(display_short)|uniprotkb:C1orf31(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	ensembl:ENSG00000168275(gene)|ensembl:ENST00000366613(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0042774"(plasma membrane ATP synthesis coupled electron transport)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|interpro:IPR042289|rcsb pdb:6NL3|rcsb pdb:6PCE|rcsb pdb:6PCF|reactome:R-HSA-1268020|refseq:NP_001013003.1|refseq:NP_001288662.1|refseq:NP_001193570.2	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:RhW1GWfW6148hd0Pa3uXIkRYkRY9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P15924	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-355041|uniprotkb:O75993|uniprotkb:Q14189|uniprotkb:Q9UHN4|uniprotkb:B2RTT2|uniprotkb:D7RX09|ensembl:ENSP00000369129	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:desp_human(display_long)|uniprotkb:DSP(gene name)|psi-mi:DSP(display_short)|uniprotkb:250/210 kDa paraneoplastic pemphigus antigen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_001305963.1|refseq:NP_001008844.1|refseq:NP_004406.2|go:"GO:0014704"(intercalated disc)|go:"GO:0005916"(fascia adherens)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|ensembl:ENSG00000096696(gene)|ensembl:ENST00000379802(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:P15924|rcsb pdb:1LM5|rcsb pdb:1LM7|rcsb pdb:3R6N|rcsb pdb:5DZZ|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696273|dip:DIP-109N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:enapEqSoyTSLfPEQUAopkGpdxbo9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P20073	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-2338704|uniprotkb:Q5F2H3|uniprotkb:Q5T0M6|uniprotkb:Q5T0M7|intact:EBI-28973842|ensembl:ENSP00000362010	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:anxa7_human(display_long)|uniprotkb:ANXA7(gene name)|psi-mi:ANXA7(display_short)|uniprotkb:ANX7(gene name synonym)|uniprotkb:SNX(gene name synonym)|uniprotkb:Annexin-7(gene name synonym)|uniprotkb:Annexin VII(gene name synonym)|uniprotkb:Synexin(gene name synonym)|uniprotkb:OK/SW-cl.95(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	ensembl:ENSP00000362010|ensembl:ENST00000372921|ensembl:ENSP00000362012|refseq:NP_001147.1|refseq:NP_004025.1|refseq:XP_016871651.1|refseq:XP_016871652.1|ensembl:ENSG00000138279(gene)|ensembl:ENST00000372919(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061025"(membrane fusion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:ad3I49rhRoZ0hG8ruDgSQWocVuw9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q15517	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-953708|ensembl:ENSP00000259726|ensembl:ENSP00000388386|ensembl:ENSP00000392863|ensembl:ENSP00000399604|uniprotkb:Q9NRH4|uniprotkb:Q9NRH5|uniprotkb:Q9NRH6|uniprotkb:Q9NRH7|uniprotkb:Q9NRH8|uniprotkb:Q9UBH8|uniprotkb:Q9UIN6|uniprotkb:Q9UIN7|uniprotkb:Q9UIN8|uniprotkb:Q9UIN9|uniprotkb:Q9UIP0|uniprotkb:O43509|uniprotkb:Q5SQ85|uniprotkb:Q5STD2|uniprotkb:Q7LA70|uniprotkb:Q7LA71|uniprotkb:Q86Z04|uniprotkb:Q8IZU4|uniprotkb:Q8IZU5|uniprotkb:Q8IZU6|uniprotkb:Q8N5P3|uniprotkb:Q95IF9|uniprotkb:Q9NP52|uniprotkb:Q9NPE0|uniprotkb:Q9NPG5|uniprotkb:B0S7V2|uniprotkb:B0UYZ7	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:cdsn_human(display_long)|uniprotkb:CDSN(gene name)|psi-mi:CDSN(display_short)|uniprotkb:S protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	ensembl:ENSG00000137197(gene)|ensembl:ENSG00000237114(gene)|ensembl:ENSG00000237123(gene)|ensembl:ENSG00000237165(gene)|ensembl:ENST00000259726(transcript)|ensembl:ENST00000418599(transcript)|ensembl:ENST00000445893(transcript)|ensembl:ENST00000457875(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003336"(corneocyte desquamation)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008544"(epidermis development)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1905716"(negative regulation of cornification)|interpro:IPR026087|mint:Q15517|reactome:R-HSA-6809371|refseq:NP_001255.3	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:2SaKSq9Py2cPLlytyEiH8znQcd49606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P31151	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-357520|uniprotkb:Q6FGE3|uniprotkb:Q5SY67|uniprotkb:Q9H1E2|ensembl:ENSP00000357711|ensembl:ENSP00000357712	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:s10a7_human(display_long)|uniprotkb:S100A7(gene name)|psi-mi:S100A7(display_short)|uniprotkb:PSOR1(gene name synonym)|uniprotkb:S100A7C(gene name synonym)|uniprotkb:S100 calcium-binding protein A7(gene name synonym)|uniprotkb:Psoriasin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	ensembl:ENSG00000143556(gene)|ensembl:ENST00000368722(transcript)|ensembl:ENST00000368723(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008544"(epidermis development)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051238"(sequestering of metal ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|mint:P31151|rcsb pdb:1PSR|rcsb pdb:2PSR|rcsb pdb:2WND|rcsb pdb:2WOR|rcsb pdb:2WOS|rcsb pdb:3PSR|rcsb pdb:4AQJ|reactome:R-HSA-6798695|reactome:R-HSA-6799990|refseq:NP_002954.2	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:/v8+XQ7rCMTYzq9k/KqjcSm/G0A9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q9NZT1	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-1051681|uniprotkb:Q8IXU8|uniprotkb:Q5SQI3|ensembl:ENSP00000369689	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:call5_human(display_long)|uniprotkb:Calmodulin-like skin protein(gene name synonym)|uniprotkb:CALML5(gene name)|psi-mi:CALML5(display_short)|uniprotkb:CLSP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_059118.2|ensembl:ENST00000380332(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9NZT1|rcsb pdb:2B1U|reactome:R-HSA-6798695|ensembl:ENSG00000178372(gene)	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:uPD/avsoqpiogqHCK5TGJQwvCX89606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P31944	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-2510738|ensembl:ENSP00000393417|uniprotkb:O95823|uniprotkb:Q3SYC9	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:caspe_human(display_long)|uniprotkb:CASP14(gene name)|psi-mi:CASP14(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033174|mint:P31944|reactome:R-HSA-6809371|ensembl:ENSG00000105141(gene)|ensembl:ENST00000427043(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0031424"(keratinization)|go:"GO:0045095"(keratin filament)|go:"GO:0070268"(cornification)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|refseq:NP_036246.1	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:e8QPsuebgXeKJEuMm/KU0WAOs3k9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P35579	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q13813	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q96CT7	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-5461329|ensembl:ENSP00000408730|ensembl:ENSP00000471455	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:cc124_human(display_long)|uniprotkb:CCDC124(gene name)|psi-mi:CCDC124(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_001129675.1|refseq:NP_612451.1|ensembl:ENSG00000007080(gene)|ensembl:ENST00000445755(transcript)|ensembl:ENST00000597436(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0030496"(midbody)|go:"GO:0051301"(cell division)|interpro:IPR010422(Protein of unknown function DUF1014)|mint:Q96CT7|rcsb pdb:6Z6L|rcsb pdb:6ZM7|rcsb pdb:6ZME	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:w3LqsScVHWABZgIwYZXS6Ly9CiM9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P13667	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P78527	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P12956	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P13010	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P09874	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:O75531	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-1055977|uniprotkb:O60558|uniprotkb:Q6FGG7|ensembl:ENSP00000310275|ensembl:ENSP00000416128|ensembl:ENSP00000432867|ensembl:ENSP00000433760	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:baf_human(display_long)|uniprotkb:BANF1(gene name)|psi-mi:BANF1(display_short)|uniprotkb:BAF(gene name synonym)|uniprotkb:BCRG1(gene name synonym)|uniprotkb:Breakpoint cluster region protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_001137457.1|refseq:NP_003851.1|ensembl:ENST00000445560(transcript)|ensembl:ENST00000527348(transcript)|ensembl:ENST00000533166(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0097726"(LEM domain binding)|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617|mint:O75531|rcsb pdb:1CI4|rcsb pdb:1QCK|rcsb pdb:2BZF|rcsb pdb:2EZX|rcsb pdb:2EZY|rcsb pdb:2EZZ|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:6UNT|rcsb pdb:6URE|rcsb pdb:6URJ|rcsb pdb:6URK|rcsb pdb:6URL|rcsb pdb:6URN|rcsb pdb:6URR|rcsb pdb:6URZ|rcsb pdb:6US0|rcsb pdb:6US1|rcsb pdb:6US7|rcsb pdb:6USB|rcsb pdb:6USD|rcsb pdb:6USI|rcsb pdb:7NDY|ensembl:ENSG00000175334(gene)|ensembl:ENST00000312175(transcript)|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|reactome:R-HSA-2980766|reactome:R-HSA-2995383|refseq:XP_016874003.1|refseq:XP_016874004.1|dip:DIP-50395N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:JSfPqQhIXIFEXNQn1+I8v5zG+Hw9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q5JSZ5	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-744891|uniprotkb:Q66VZ2|uniprotkb:Q9H683|uniprotkb:Q5JSZ7|uniprotkb:O60270|intact:EBI-2512629|intact:EBI-947989|uniprotkb:Q68CR0|intact:EBI-2559356|uniprotkb:Q96EI9|ensembl:ENSP00000508005|ensembl:ENSP00000508048	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:prc2b_human(display_long)|uniprotkb:PRRC2B(gene name)|psi-mi:PRRC2B(display_short)|uniprotkb:HLA-B-associated transcript 2-like 1(gene name synonym)|uniprotkb:KIAA0515(gene name synonym)|uniprotkb:BAT2L(gene name synonym)|uniprotkb:BAT2L1(gene name synonym)|uniprotkb:Proline-rich coiled-coil protein 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_037450.2|ensembl:ENST00000682501|ensembl:ENSP00000508073|ensembl:ENSP00000508048|ensembl:ENSP00000508005|ensembl:ENSG00000288701(gene)|ensembl:ENST00000683519(transcript)|ensembl:ENST00000684596(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q5JSZ5	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:N1MgJl3k+WJTF+XUf5VFIB06B909606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q9BUH6	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-2839993|uniprotkb:Q8IY19|ensembl:ENSP00000360682	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:paxx_human(display_long)|uniprotkb:PAXX(gene name)|psi-mi:PAXX(display_short)|uniprotkb:C9orf142(gene name synonym)|uniprotkb:Paralog of XRCC4 and XLF(gene name synonym)|uniprotkb:XLS(gene name synonym)|uniprotkb:XRCC4-like small protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_899064.1|ensembl:ENSG00000148362(gene)|ensembl:ENST00000371620(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR027873|rcsb pdb:3WTD|rcsb pdb:3WTF|rcsb pdb:4WJA|dip:DIP-61486N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:UMZ93NqWo4l2n0lySBKId8EFhZ49606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:P60903	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-717048|uniprotkb:P08206|uniprotkb:Q5T1C5|uniprotkb:A8K4V8|ensembl:ENSP00000357799|ensembl:ENSP00000357801	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:s10aa_human(display_long)|uniprotkb:S100 calcium-binding protein A10(gene name synonym)|uniprotkb:Calpactin-1 light chain(gene name synonym)|uniprotkb:Calpactin I light chain(gene name synonym)|uniprotkb:p10 protein(gene name synonym)|uniprotkb:p11(gene name synonym)|uniprotkb:Cellular ligand of annexin II(gene name synonym)|uniprotkb:S100A10(gene name)|psi-mi:S100A10(display_short)|uniprotkb:ANX2LG(gene name synonym)|uniprotkb:CAL1L(gene name synonym)|uniprotkb:CLP11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_002957.1|ensembl:ENSG00000197747(gene)|ensembl:ENST00000368809(transcript)|ensembl:ENST00000368811(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005576"(extracellular region)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990665"(AnxA2-p11 complex)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028476|rcsb pdb:1A4P|rcsb pdb:1BT6|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRE|rcsb pdb:4HRG|rcsb pdb:4HRH|reactome:R-HSA-75205	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:WlxwW4qaHp6tcyEAYvQ2ut9SyRA9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:O75146	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q01082	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-351561|intact:EBI-1642531|uniprotkb:O60837|uniprotkb:Q16057|uniprotkb:Q53R99|uniprotkb:Q59ER3|uniprotkb:Q8IX99|uniprotkb:B2RP63|ensembl:ENSP00000349259	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:sptb2_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	refseq:NP_003119.2|refseq:NP_842565.2|ensembl:ENSG00000115306(gene)|ensembl:ENST00000356805(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q01082|rcsb pdb:1AA2|rcsb pdb:1BKR|rcsb pdb:3EDV|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9703465|reactome:R-HSA-373753|refseq:XP_005264574.1|refseq:XP_006712150.1|refseq:XP_016860268.1|refseq:XP_016860269.1|refseq:XP_016860270.1|dip:DIP-33182N	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:rQJxsoEirg87umLjsEwHcQ0/blQ9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P60033	uniprotkb:Q8NEF9	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	intact:EBI-2824681|uniprotkb:Q5QFI2|uniprotkb:Q96AH4|uniprotkb:Q96DK2|ensembl:ENSP00000341324	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:srfb1_human(display_long)|uniprotkb:SRFBP1(gene name)|psi-mi:SRFBP1(display_short)|uniprotkb:SRF-dependent transcription regulation-associated protein(gene name synonym)|uniprotkb:p49/STRAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766934|imex:IM-24070-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	ensembl:ENSG00000151304(gene)|ensembl:ENST00000339397(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030686"(90S preribosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR015158(Bud-site selection protein, BUD22)|interpro:IPR037393|refseq:NP_689759.2	-	-	-	figure legend:1B, 1C, table S2|author-identifiers:"Internal tracker: GG2015-CD81-SILAC-HCV"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2015/04/20	2015/04/20	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rogid:MQv9j4+l9h+7z05X/bRJAompesc9606	rigid:6eX6LPaKa2z01v7vVHnyMYKPMYI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NEF9	uniprotkb:P60033	intact:EBI-2824681|uniprotkb:Q5QFI2|uniprotkb:Q96AH4|uniprotkb:Q96DK2|ensembl:ENSP00000341324	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	psi-mi:srfb1_human(display_long)|uniprotkb:SRFBP1(gene name)|psi-mi:SRFBP1(display_short)|uniprotkb:SRF-dependent transcription regulation-associated protein(gene name synonym)|uniprotkb:p49/STRAP(gene name synonym)	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10766999|imex:IM-24070-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000151304(gene)|ensembl:ENST00000339397(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030686"(90S preribosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR015158(Bud-site selection protein, BUD22)|interpro:IPR037393|refseq:NP_689759.2	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)	-	-	figure legend:4A, 5A, 5F, S5E|agonist:HCV exposure|agonist:Purified ectodomain of the HCV E2 glycoprotein|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells)	-	2015/04/20	2015/04/20	rogid:MQv9j4+l9h+7z05X/bRJAompesc9606	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rigid:51AulNEEgidZGiyiQ0bOSNTYrPs	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8NEF9	uniprotkb:P60033	intact:EBI-2824681|uniprotkb:Q5QFI2|uniprotkb:Q96AH4|uniprotkb:Q96DK2|ensembl:ENSP00000341324	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	psi-mi:srfb1_human(display_long)|uniprotkb:SRFBP1(gene name)|psi-mi:SRFBP1(display_short)|uniprotkb:SRF-dependent transcription regulation-associated protein(gene name synonym)|uniprotkb:p49/STRAP(gene name synonym)	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Gerold et al. (2015)	imex:IM-24070|pubmed:26212323	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10767011|imex:IM-24070-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000151304(gene)|ensembl:ENST00000339397(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030686"(90S preribosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR015158(Bud-site selection protein, BUD22)|interpro:IPR037393|refseq:NP_689759.2	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	-	-	-	figure legend:S5C, S5D|agonist:"HCV E2 glycoprotein (eE2)"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hepatocytes)|taxid:9606(Human-hepatocytes)	-	2015/04/20	2015/04/20	rogid:MQv9j4+l9h+7z05X/bRJAompesc9606	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rigid:51AulNEEgidZGiyiQ0bOSNTYrPs	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)