#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96DE0	uniprotkb:Q96DE0	intact:EBI-5464685|uniprotkb:Q96N82|uniprotkb:B4E3B4|uniprotkb:E9PED4|uniprotkb:F5GYJ1|ensembl:ENSP00000429274	intact:EBI-5464685|uniprotkb:Q96N82|uniprotkb:B4E3B4|uniprotkb:E9PED4|uniprotkb:F5GYJ1|ensembl:ENSP00000429274	psi-mi:nud16_human(display_long)|uniprotkb:NUDT16(gene name)|psi-mi:NUDT16(display_short)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 16(gene name synonym)|uniprotkb:U8 snoRNA-binding protein H29K(gene name synonym)|uniprotkb:m7GpppN-mRNA hydrolase(gene name synonym)|uniprotkb:IDP phosphatase(gene name synonym)|uniprotkb:Inosine diphosphate phosphatase(gene name synonym)|uniprotkb:Nudix hydrolase 16(gene name synonym)	psi-mi:nud16_human(display_long)|uniprotkb:NUDT16(gene name)|psi-mi:NUDT16(display_short)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 16(gene name synonym)|uniprotkb:U8 snoRNA-binding protein H29K(gene name synonym)|uniprotkb:m7GpppN-mRNA hydrolase(gene name synonym)|uniprotkb:IDP phosphatase(gene name synonym)|uniprotkb:Inosine diphosphate phosphatase(gene name synonym)|uniprotkb:Nudix hydrolase 16(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Trésaugues et al. (2014)	imex:IM-24377|pubmed:26121039	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10916501|imex:IM-24377-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689608.2|refseq:NP_001165376.1|refseq:NP_001165377.1|ensembl:ENSG00000198585(gene)|ensembl:ENST00000521288(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0016077"("sno(s)RNA catabolic process")|go:"GO:0030145"(manganese ion binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035863"(dITP catabolic process)|go:"GO:0035870"(dITP diphosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046709"(IDP catabolic process)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0050897"(cobalt ion binding)|go:"GO:1901640"(XTP binding)|go:"GO:1901641"(ITP binding)|go:"GO:1990003"(inosine-diphosphatase activity)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|go:"GO:2000233"(negative regulation of rRNA processing)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|rcsb pdb:2XSQ|rcsb pdb:3COU|rcsb pdb:3MGM|rcsb pdb:5VY2|rcsb pdb:5W6X|rcsb pdb:5W6Z|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0097383"(dIDP diphosphatase activity)|go:"GO:0098519"(nucleotide phosphatase activity, acting on free nucleotides)|go:"GO:0110155"(NAD-cap decapping)|rcsb pdb:5WJI|rcsb pdb:6B09|rcsb pdb:6CO2|rcsb pdb:6X7U|rcsb pdb:6X7V|reactome:R-HSA-2393930	refseq:NP_689608.2|refseq:NP_001165376.1|refseq:NP_001165377.1|ensembl:ENSG00000198585(gene)|ensembl:ENST00000521288(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0016077"("sno(s)RNA catabolic process")|go:"GO:0030145"(manganese ion binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035863"(dITP catabolic process)|go:"GO:0035870"(dITP diphosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046709"(IDP catabolic process)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0050897"(cobalt ion binding)|go:"GO:1901640"(XTP binding)|go:"GO:1901641"(ITP binding)|go:"GO:1990003"(inosine-diphosphatase activity)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|go:"GO:2000233"(negative regulation of rRNA processing)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|rcsb pdb:2XSQ|rcsb pdb:3COU|rcsb pdb:3MGM|rcsb pdb:5VY2|rcsb pdb:5W6X|rcsb pdb:5W6Z|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0097383"(dIDP diphosphatase activity)|go:"GO:0098519"(nucleotide phosphatase activity, acting on free nucleotides)|go:"GO:0110155"(NAD-cap decapping)|rcsb pdb:5WJI|rcsb pdb:6B09|rcsb pdb:6CO2|rcsb pdb:6X7U|rcsb pdb:6X7V|reactome:R-HSA-2393930	-	-	-	figure legend:Fig S1|figure legend:S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2015/07/20	2015/07/21	rogid:QpYwz7oqdUHTL5hEx+wPPA57Mt49606	rogid:QpYwz7oqdUHTL5hEx+wPPA57Mt49606	rigid:DBf8RKVZMFR+u5k+S/2PRJPQleU	false	his tag:n-n|mutation:22-22	his tag:n-n|mutation:22-22	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DE0	uniprotkb:Q96DE0	intact:EBI-5464685|uniprotkb:Q96N82|uniprotkb:B4E3B4|uniprotkb:E9PED4|uniprotkb:F5GYJ1|ensembl:ENSP00000429274	intact:EBI-5464685|uniprotkb:Q96N82|uniprotkb:B4E3B4|uniprotkb:E9PED4|uniprotkb:F5GYJ1|ensembl:ENSP00000429274	psi-mi:nud16_human(display_long)|uniprotkb:NUDT16(gene name)|psi-mi:NUDT16(display_short)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 16(gene name synonym)|uniprotkb:U8 snoRNA-binding protein H29K(gene name synonym)|uniprotkb:m7GpppN-mRNA hydrolase(gene name synonym)|uniprotkb:IDP phosphatase(gene name synonym)|uniprotkb:Inosine diphosphate phosphatase(gene name synonym)|uniprotkb:Nudix hydrolase 16(gene name synonym)	psi-mi:nud16_human(display_long)|uniprotkb:NUDT16(gene name)|psi-mi:NUDT16(display_short)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 16(gene name synonym)|uniprotkb:U8 snoRNA-binding protein H29K(gene name synonym)|uniprotkb:m7GpppN-mRNA hydrolase(gene name synonym)|uniprotkb:IDP phosphatase(gene name synonym)|uniprotkb:Inosine diphosphate phosphatase(gene name synonym)|uniprotkb:Nudix hydrolase 16(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Trésaugues et al. (2014)	imex:IM-24377|pubmed:26121039	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10916526|pdbe:2xsq|imex:IM-24377-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689608.2|refseq:NP_001165376.1|refseq:NP_001165377.1|ensembl:ENSG00000198585(gene)|ensembl:ENST00000521288(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0016077"("sno(s)RNA catabolic process")|go:"GO:0030145"(manganese ion binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035863"(dITP catabolic process)|go:"GO:0035870"(dITP diphosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046709"(IDP catabolic process)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0050897"(cobalt ion binding)|go:"GO:1901640"(XTP binding)|go:"GO:1901641"(ITP binding)|go:"GO:1990003"(inosine-diphosphatase activity)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|go:"GO:2000233"(negative regulation of rRNA processing)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|rcsb pdb:2XSQ|rcsb pdb:3COU|rcsb pdb:3MGM|rcsb pdb:5VY2|rcsb pdb:5W6X|rcsb pdb:5W6Z|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0097383"(dIDP diphosphatase activity)|go:"GO:0098519"(nucleotide phosphatase activity, acting on free nucleotides)|go:"GO:0110155"(NAD-cap decapping)|rcsb pdb:5WJI|rcsb pdb:6B09|rcsb pdb:6CO2|rcsb pdb:6X7U|rcsb pdb:6X7V|reactome:R-HSA-2393930	refseq:NP_689608.2|refseq:NP_001165376.1|refseq:NP_001165377.1|ensembl:ENSG00000198585(gene)|ensembl:ENST00000521288(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0016077"("sno(s)RNA catabolic process")|go:"GO:0030145"(manganese ion binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035863"(dITP catabolic process)|go:"GO:0035870"(dITP diphosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046709"(IDP catabolic process)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0050897"(cobalt ion binding)|go:"GO:1901640"(XTP binding)|go:"GO:1901641"(ITP binding)|go:"GO:1990003"(inosine-diphosphatase activity)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|go:"GO:2000233"(negative regulation of rRNA processing)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|rcsb pdb:2XSQ|rcsb pdb:3COU|rcsb pdb:3MGM|rcsb pdb:5VY2|rcsb pdb:5W6X|rcsb pdb:5W6Z|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0097383"(dIDP diphosphatase activity)|go:"GO:0098519"(nucleotide phosphatase activity, acting on free nucleotides)|go:"GO:0110155"(NAD-cap decapping)|rcsb pdb:5WJI|rcsb pdb:6B09|rcsb pdb:6CO2|rcsb pdb:6X7U|rcsb pdb:6X7V|reactome:R-HSA-2393930	-	-	-	figure legend:fig 2|3d-resolution:1.72 A|3d-r-factors:"R-factor:0.159 R-free:0.181."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/20	2015/07/20	rogid:QpYwz7oqdUHTL5hEx+wPPA57Mt49606	rogid:QpYwz7oqdUHTL5hEx+wPPA57Mt49606	rigid:DBf8RKVZMFR+u5k+S/2PRJPQleU	false	mutation:22-22|his tag:n-n	mutation:22-22|his tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)