#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y618 uniprotkb:Q13133 intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474540|imex:IM-24874-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564 refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1 E/F-1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increased the binding of Q9Y618 to Q13133"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/12/01 2018/09/18 rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 rigid:Db0iVIMTmAjjNUeCzzCAEEYUz08 false sufficient binding region:2332-2354|fluorescein label:n-n glutathione s tranferase tag:?-?|sufficient binding region:207-447(IPR000536) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O75376 uniprotkb:Q13133 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474554|imex:IM-24874-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1 E/F-2|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increased the binding of O75376 to Q13133"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/12/01 2016/01/06 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 rigid:jH56BfeCRFoQORz0f0kNkEh8mPw false sufficient binding region:2048-2061|fluorescein label:n-n glutathione s tranferase tag:?-?|sufficient binding region:207-447(IPR000536) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q15648 uniprotkb:Q13133 intact:EBI-394459|uniprotkb:A2RRQ6|uniprotkb:O43810|uniprotkb:O75447|uniprotkb:Q6P9H7|uniprotkb:Q6PK58|uniprotkb:Q9HD39|ensembl:ENSP00000300651 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:med1_human(display_long)|uniprotkb:TRIP2(gene name synonym)|uniprotkb:MED1(gene name)|psi-mi:MED1(display_short)|uniprotkb:ARC205(gene name synonym)|uniprotkb:DRIP205(gene name synonym)|uniprotkb:TRAP220(gene name synonym)|uniprotkb:Activator-recruited cofactor 205 kDa component(gene name synonym)|uniprotkb:Mediator complex subunit 1(gene name synonym)|uniprotkb:Peroxisome proliferator-activated receptor-binding protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 220 kDa component(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 2(gene name synonym)|uniprotkb:p53 regulatory protein RB18A(gene name synonym)|uniprotkb:Vitamin D receptor-interacting protein complex component DRIP205(gene name synonym)|uniprotkb:CRSP1(gene name synonym)|uniprotkb:CRSP200(gene name synonym)|uniprotkb:DRIP230(gene name synonym)|uniprotkb:PBP(gene name synonym)|uniprotkb:PPARBP(gene name synonym)|uniprotkb:PPARGBP(gene name synonym)|uniprotkb:RB18A(gene name synonym) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474643|imex:IM-24874-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004765.2|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060335"(positive regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR019680|mint:Q15648|rcsb pdb:1RJK|rcsb pdb:1RK3|rcsb pdb:1RKG|rcsb pdb:1RKH|rcsb pdb:2O4J|rcsb pdb:2O4R|rcsb pdb:2ZFX|rcsb pdb:3A2H|rcsb pdb:3AUN|rcsb pdb:3VJS|rcsb pdb:3VJT|rcsb pdb:3VRT|rcsb pdb:3VRU|rcsb pdb:3VRV|rcsb pdb:3VRW|rcsb pdb:3W0G|rcsb pdb:3W0H|rcsb pdb:3W0I|rcsb pdb:3W0J|rcsb pdb:3W5P|rcsb pdb:3W5Q|rcsb pdb:3W5R|rcsb pdb:3W5T|rcsb pdb:3WT5|rcsb pdb:3WT6|rcsb pdb:3WT7|rcsb pdb:3WTQ|rcsb pdb:4YNK|rcsb pdb:5AWJ|rcsb pdb:5AWK|rcsb pdb:5B41|rcsb pdb:5B5B|rcsb pdb:5GIC|rcsb pdb:5GID|rcsb pdb:5GIE|rcsb pdb:5XPM|rcsb pdb:5XPN|rcsb pdb:5XPO|rcsb pdb:5XPP|rcsb pdb:5XUQ|rcsb pdb:5XZF|rcsb pdb:5XZH|rcsb pdb:5ZWE|rcsb pdb:5ZWF|rcsb pdb:5ZWH|rcsb pdb:5ZWI|rcsb pdb:6D94|rcsb pdb:6JEZ|rcsb pdb:6K5O|rcsb pdb:6ONJ|rcsb pdb:7C7V|rcsb pdb:7C7W|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|ensembl:ENSG00000125686(gene)|ensembl:ENST00000300651(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002154"(thyroid hormone mediated signaling pathway)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048822"(enucleate erythrocyte development)|go:"GO:0050693"(LBD domain binding)|dip:DIP-24212N refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1 E/F-3|agonist:"T0901317 (CHEMBL62136 )"|causality statement:CHEMBL62136 increased the binding of Q15648 to Q13133|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/12/01 2016/01/06 rogid:A4EIAri9zYycSlTA7s6NzbOi9n49606 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 rigid:hOJJm2VEQ93qk1IgVSXxF3g1WdQ false sufficient binding region:638-656|fluorescein label:n-n glutathione s tranferase tag:?-?|sufficient binding region:207-447(IPR000536) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q15648 uniprotkb:P55055 intact:EBI-394459|uniprotkb:A2RRQ6|uniprotkb:O43810|uniprotkb:O75447|uniprotkb:Q6P9H7|uniprotkb:Q6PK58|uniprotkb:Q9HD39|ensembl:ENSP00000300651 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:med1_human(display_long)|uniprotkb:TRIP2(gene name synonym)|uniprotkb:MED1(gene name)|psi-mi:MED1(display_short)|uniprotkb:ARC205(gene name synonym)|uniprotkb:DRIP205(gene name synonym)|uniprotkb:TRAP220(gene name synonym)|uniprotkb:Activator-recruited cofactor 205 kDa component(gene name synonym)|uniprotkb:Mediator complex subunit 1(gene name synonym)|uniprotkb:Peroxisome proliferator-activated receptor-binding protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 220 kDa component(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 2(gene name synonym)|uniprotkb:p53 regulatory protein RB18A(gene name synonym)|uniprotkb:Vitamin D receptor-interacting protein complex component DRIP205(gene name synonym)|uniprotkb:CRSP1(gene name synonym)|uniprotkb:CRSP200(gene name synonym)|uniprotkb:DRIP230(gene name synonym)|uniprotkb:PBP(gene name synonym)|uniprotkb:PPARBP(gene name synonym)|uniprotkb:PPARGBP(gene name synonym)|uniprotkb:RB18A(gene name synonym) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474715|imex:IM-24874-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004765.2|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060335"(positive regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR019680|mint:Q15648|rcsb pdb:1RJK|rcsb pdb:1RK3|rcsb pdb:1RKG|rcsb pdb:1RKH|rcsb pdb:2O4J|rcsb pdb:2O4R|rcsb pdb:2ZFX|rcsb pdb:3A2H|rcsb pdb:3AUN|rcsb pdb:3VJS|rcsb pdb:3VJT|rcsb pdb:3VRT|rcsb pdb:3VRU|rcsb pdb:3VRV|rcsb pdb:3VRW|rcsb pdb:3W0G|rcsb pdb:3W0H|rcsb pdb:3W0I|rcsb pdb:3W0J|rcsb pdb:3W5P|rcsb pdb:3W5Q|rcsb pdb:3W5R|rcsb pdb:3W5T|rcsb pdb:3WT5|rcsb pdb:3WT6|rcsb pdb:3WT7|rcsb pdb:3WTQ|rcsb pdb:4YNK|rcsb pdb:5AWJ|rcsb pdb:5AWK|rcsb pdb:5B41|rcsb pdb:5B5B|rcsb pdb:5GIC|rcsb pdb:5GID|rcsb pdb:5GIE|rcsb pdb:5XPM|rcsb pdb:5XPN|rcsb pdb:5XPO|rcsb pdb:5XPP|rcsb pdb:5XUQ|rcsb pdb:5XZF|rcsb pdb:5XZH|rcsb pdb:5ZWE|rcsb pdb:5ZWF|rcsb pdb:5ZWH|rcsb pdb:5ZWI|rcsb pdb:6D94|rcsb pdb:6JEZ|rcsb pdb:6K5O|rcsb pdb:6ONJ|rcsb pdb:7C7V|rcsb pdb:7C7W|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|ensembl:ENSG00000125686(gene)|ensembl:ENST00000300651(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002154"(thyroid hormone mediated signaling pathway)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048822"(enucleate erythrocyte development)|go:"GO:0050693"(LBD domain binding)|dip:DIP-24212N refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1 E/F-6|agonist:"T0901317 (CHEMBL62136 )"|causality statement:CHEMBL62136 increased the binding of Q15648 to P55055|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/12/01 2016/01/06 rogid:A4EIAri9zYycSlTA7s6NzbOi9n49606 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 rigid:jiCLCOtollnoLlGX7ndDLA3lvyQ false sufficient binding region:638-656|fluorescein label:n-n glutathione s tranferase tag:?-?|sufficient binding region:201-460(IPR000536) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O75376 uniprotkb:P55055 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474741|imex:IM-24874-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1 E/F-4|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increased the binding of O75376 to P55055"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/12/01 2016/01/06 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 rigid:QfOLIhzJ6hjZOEW6YiT+6eFozbw false sufficient binding region:2260-2273|fluorescein label:n-n glutathione s tranferase tag:?-?|sufficient binding region:201-460(IPR000536) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O75376 uniprotkb:P55055 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474773|imex:IM-24874-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1 E/F-5|agonist:"SR9243 (CHEBI:90842)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/12/01 2016/01/06 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 rigid:QfOLIhzJ6hjZOEW6YiT+6eFozbw false sufficient binding region:2048-2061|fluorescein label:n-n glutathione s tranferase tag:?-?|sufficient binding region:201-460(IPR000536) - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O75376 ensembl:ENSG00000158571 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-11475111 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)|ensembl:f261_human_gene(shortlabel)|psi-mi:ENSG00000158571(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11474986|imex:IM-24874-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001258733.1|refseq:NP_001258734.1|refseq:NP_002616.2 - - - figure legend:1H-3, Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and Q13133 to ENSG00000158571"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 - - false - sufficient binding region:?-? - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 uniprotkb:Q13133 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11474986|imex:IM-24874-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1H-3, Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and Q13133 to ENSG00000158571"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 - false - - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 ensembl:ENSG00000072310 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-11474993 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|ensembl:srbp1_human_gene(shortlabel)|psi-mi:ENSG00000072310(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475003|imex:IM-24874-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 - - - - figure legend:1H-1b,Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000072310"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 - - false - sufficient binding region:?-? - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 uniprotkb:P55055 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475003|imex:IM-24874-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-1b,Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000072310"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false - - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 ensembl:ENSG00000169710 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-2325482 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:fas_human_gene(display_short)|psi-mi:ENSG00000169710(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475219|imex:IM-24874-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 - - - - figure legend:1H-2b,Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000169710"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 - - false - sufficient binding region:?-? - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 uniprotkb:P55055 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475219|imex:IM-24874-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-2b,Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000169710"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false - - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 ensembl:ENSG00000158571 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-11475111 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)|ensembl:f261_human_gene(shortlabel)|psi-mi:ENSG00000158571(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475231|imex:IM-24874-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001258733.1|refseq:NP_001258734.1|refseq:NP_002616.2 - - - figure legend:1H-3b,Supp Fig 1|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000158571"|agonist:"SR9243 (CHEBI:90842)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 - - false - sufficient binding region:?-? - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 uniprotkb:P55055 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475231|imex:IM-24874-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-3b,Supp Fig 1|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000158571"|agonist:"SR9243 (CHEBI:90842)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false - - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 ensembl:ENSG00000156515 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-11475071 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) uniprotkb:HK1(gene name)|psi-mi:HK1(display_short)|ensembl:hxk1_human_gene(shortlabel)|psi-mi:ENSG00000156515(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475242|imex:IM-24874-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_000179.2|refseq:NP_277031.1|refseq:NP_277032.1|refseq:NP_277033.1|refseq:NP_277035.2|refseq:XP_005269793.1|refseq:XP_011538034.1 - - - figure legend:1H-4b,Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000156515"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 - - false - sufficient binding region:?-? - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O75376 uniprotkb:P55055 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475242|imex:IM-24874-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-4b,Supp Fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of O75376 and P55055 to ENSG00000156515"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false - - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000072310 uniprotkb:P55055 intact:EBI-11474993 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|ensembl:srbp1_human_gene(shortlabel)|psi-mi:ENSG00000072310(display_long) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475025|imex:IM-24874-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-1b,Supp fig 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000072310 uniprotkb:Q13133 intact:EBI-11474993 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|ensembl:srbp1_human_gene(shortlabel)|psi-mi:ENSG00000072310(display_long) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475018|imex:IM-24874-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1H-1,Supp fig 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000169710 uniprotkb:Q13133 intact:EBI-2325482 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:fas_human_gene(display_short)|psi-mi:ENSG00000169710(display_long) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475047|imex:IM-24874-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1H-2,Supp fig 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000169710 uniprotkb:P55055 intact:EBI-2325482 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 psi-mi:fas_human_gene(display_short)|psi-mi:ENSG00000169710(display_long) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475058|imex:IM-24874-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-2b, Supp fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of P55055 to ENSG00000169710"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000156515 uniprotkb:P55055 intact:EBI-11475071 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 uniprotkb:HK1(gene name)|psi-mi:HK1(display_short)|ensembl:hxk1_human_gene(shortlabel)|psi-mi:ENSG00000156515(display_long) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475064|imex:IM-24874-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_000179.2|refseq:NP_277031.1|refseq:NP_277032.1|refseq:NP_277033.1|refseq:NP_277035.2|refseq:XP_005269793.1|refseq:XP_011538034.1 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-3b,Supp fig 1|causality statement:"CHEBI:90842 increases the binding of P55055 to ENSG00000156515"|agonist:"SR9243 (CHEBI:90842)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000156515 uniprotkb:Q13133 intact:EBI-11475071 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 uniprotkb:HK1(gene name)|psi-mi:HK1(display_short)|ensembl:hxk1_human_gene(shortlabel)|psi-mi:ENSG00000156515(display_long) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475083|imex:IM-24874-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_000179.2|refseq:NP_277031.1|refseq:NP_277032.1|refseq:NP_277033.1|refseq:NP_277035.2|refseq:XP_005269793.1|refseq:XP_011538034.1 refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1H-3,Supp fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of Q13133 to ENSG00000156515"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000158571 uniprotkb:P55055 intact:EBI-11475111 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)|ensembl:f261_human_gene(shortlabel)|psi-mi:ENSG00000158571(display_long) psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475102|imex:IM-24874-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001258733.1|refseq:NP_001258734.1|refseq:NP_002616.2 refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N - - - figure legend:1H-4b,Supp fig 1|causality statement:"CHEBI:90842 increases the binding of P55055 to ENSG00000158571"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000158571 uniprotkb:Q13133 intact:EBI-11475111 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)|ensembl:f261_human_gene(shortlabel)|psi-mi:ENSG00000158571(display_long) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Flaveny et al. (2015) imex:IM-24874|pubmed:26120082 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11475122|imex:IM-24874-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001258733.1|refseq:NP_001258734.1|refseq:NP_002616.2 refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974 - - - figure legend:1H-4,Supp fig 1|agonist:"SR9243 (CHEBI:90842)"|causality statement:"CHEBI:90842 increases the binding of Q13133 to ENSG00000158571"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2015/12/01 2016/01/07 - rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr)