#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q16740 uniprotkb:Q16762 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-8463774|intact:UNK-5474760|uniprotkb:B3KRM1|intact:UNK-5393841|uniprotkb:Q6IB06|ensembl:ENSP00000249042|ensembl:ENSP00000385828|ensembl:ENSP00000478739 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:thtr_human(display_long)|uniprotkb:TST(gene name)|psi-mi:TST(display_short)|uniprotkb:Rhodanese(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001257412.1|refseq:NP_003303.2|ensembl:ENSG00000128311(gene)|ensembl:ENST00000249042(transcript)|ensembl:ENST00000403892(transcript)|ensembl:ENST00000622841(transcript)|go:"GO:0000098"(sulfur amino acid catabolic process)|go:"GO:0004792"(thiosulfate sulfurtransferase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0009440"(cyanate catabolic process)|go:"GO:0019346"(transsulfuration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035928"(rRNA import into mitochondrion)|go:"GO:0051029"(rRNA transport)|interpro:IPR001307(Thiosulphate sulphurtransferase, conserved site)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:Q16762|reactome:R-HSA-1614517|reactome:R-HSA-1614558 - - comment:mint|function:"Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity" figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:ZFzo21gbhPkIzH5aCGHRS1UoC0Y9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q99798 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2932893|ensembl:ENSP00000216254|uniprotkb:O75809|uniprotkb:Q5JZ41|uniprotkb:Q6FHX0|uniprotkb:Q8TAQ6 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:acon_human(display_long)|uniprotkb:ACO2(gene name)|psi-mi:ACO2(display_short)|uniprotkb:Citrate hydro-lyase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N ensembl:ENSG00000100412(gene)|ensembl:ENST00000216254(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003994"(aconitate hydratase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0035900"(response to isolation stress)|go:"GO:0047780"(citrate dehydratase activity)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000573(Aconitase A/isopropylmalate dehydratase small subunit, swivel)|interpro:IPR001030(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)|interpro:IPR006248(Aconitase, mitochondrial-like)|interpro:IPR015928(Aconitase/3-isopropylmalate dehydratase, swivel)|interpro:IPR015932(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2)|interpro:IPR018136|interpro:IPR036008|mint:Q99798|reactome:R-HSA-1268020|reactome:R-HSA-71403|interpro:IPR015931(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomains 1 and 3)|refseq:NP_001089.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:QpDlGJHSwqfCktMlwYXKTonXftA9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q96E11 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2855755|uniprotkb:Q5T7T3|uniprotkb:Q5T7T1|uniprotkb:A8K6Z4|uniprotkb:Q5T7T0|uniprotkb:Q5T7T4|uniprotkb:Q5T7T5|uniprotkb:Q5T7T2|uniprotkb:A8K6D8|uniprotkb:B7Z4X5|uniprotkb:Q5RKT1|uniprotkb:B7Z6P7|ensembl:ENSP00000343867 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:rrfm_human(display_long)|uniprotkb:MRRF(gene name)|psi-mi:MRRF(display_short)|uniprotkb:Ribosome-releasing factor, mitochondrial(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001166983.1|refseq:NP_620132.1|refseq:NP_954646.1|refseq:NP_001333270.1|refseq:NP_001333272.1|ensembl:ENSG00000148187(gene)|ensembl:ENST00000344641(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006412"(translation)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0043023"(ribosomal large subunit binding)|interpro:IPR002661(Ribosome recycling factor)|interpro:IPR023584|interpro:IPR036191|rcsb pdb:6NU2|rcsb pdb:6ZS9|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7NSH|rcsb pdb:7NSI|reactome:R-HSA-5419276 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:BKtDdDisxvo7PhTLScDC6mw62Ho9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q96IX5 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-954033|ensembl:ENSP00000311245|ensembl:ENSP00000337705|ensembl:ENSP00000358826|ensembl:ENSP00000358830|ensembl:ENSP00000358840|uniprotkb:B2R4N2|uniprotkb:D3DR92 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:atpmk_human(display_long)|uniprotkb:ATP5MK(gene name)|psi-mi:ATP5MK(display_short)|uniprotkb:ATP synthase membrane subunit DAPIT, mitochondrial(gene name synonym)|uniprotkb:ATP5MD(gene name synonym)|uniprotkb:DAPIT(gene name synonym)|uniprotkb:Diabetes-associated protein in insulin-sensitive tissues(gene name synonym)|uniprotkb:HCV F-transactivated protein 2(gene name synonym)|uniprotkb:HCVFTP2(gene name synonym)|uniprotkb:USMG5(gene name synonym)|uniprotkb:Up-regulated during skeletal muscle growth protein 5(gene name synonym)|uniprotkb:PD04912(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N ensembl:ENSG00000173915(gene)|ensembl:ENST00000309579(transcript)|ensembl:ENST00000337003(transcript)|ensembl:ENST00000369811(transcript)|ensembl:ENST00000369815(transcript)|ensembl:ENST00000369825(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009125(DAPIT)|mint:Q96IX5|refseq:NP_001193355.1|refseq:NP_001193356.1|refseq:NP_116136.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:7ClNWlgeH39kD7E6oiQdkuj7Hag9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9Y375 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-741874|uniprotkb:Q9BVZ5|ensembl:ENSP00000260361|ensembl:ENSP00000453944 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cia30_human(display_long)|uniprotkb:NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1(gene name synonym)|uniprotkb:NDUFAF1(gene name)|psi-mi:NDUFAF1(display_short)|uniprotkb:CIA30(gene name synonym)|uniprotkb:CGI-65(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_057097.2|ensembl:ENSG00000137806(gene)|ensembl:ENST00000260361(transcript)|ensembl:ENST00000560978(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0010257"(NADH dehydrogenase complex assembly)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013857("NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30")|interpro:IPR039131|mint:Q9Y375|reactome:R-HSA-6799198|refseq:XP_011519960.1|refseq:XP_006720618.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:cZmtaAs6upui/PVTTBGQBEOcWvk9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P49448 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-720168|uniprotkb:Q9UDQ4|uniprotkb:B2R8G0|ensembl:ENSP00000327589|ensembl:ENSP00000500546 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:dhe4_human(display_long)|uniprotkb:GLUD2(gene name)|psi-mi:GLUD2(display_short)|uniprotkb:GLUDP1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_036216.2|ensembl:ENSG00000182890(gene)|ensembl:ENSG00000288118(gene)|ensembl:ENST00000328078(transcript)|ensembl:ENST00000673493(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0043531"(ADP binding)|go:"GO:0070728"(leucine binding)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|rcsb pdb:6G2U|reactome:R-HSA-2151201|reactome:R-HSA-8964539 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:F6sq5B69eoiIC2y3eOtEy029WQQ9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9UHN1 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-852642|uniprotkb:O00419|uniprotkb:Q0IJ81|uniprotkb:Q96GW2|uniprotkb:Q9UK35|uniprotkb:Q9UK94|ensembl:ENSP00000442563 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:dpog2_human(display_long)|uniprotkb:Mitochondrial DNA polymerase accessory subunit(gene name synonym)|uniprotkb:PolG-beta(gene name synonym)|uniprotkb:MtPolB(gene name synonym)|uniprotkb:DNA polymerase gamma accessory 55 kDa subunit(gene name synonym)|uniprotkb:POLG2(gene name)|psi-mi:POLG2(display_short)|uniprotkb:MTPOLB(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_009146.2|ensembl:ENSG00000256525(gene)|ensembl:ENST00000539111(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR004154(Anticodon-binding)|interpro:IPR027030|interpro:IPR027031|interpro:IPR036621|interpro:IPR042064|mint:Q9UHN1|rcsb pdb:2G4C|rcsb pdb:3IKL|rcsb pdb:3IKM|rcsb pdb:4ZTU|rcsb pdb:4ZTZ|rcsb pdb:5C51|rcsb pdb:5C52|rcsb pdb:5C53|reactome:R-HSA-2151201 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:41rQkZKot9P54MT7OJ7nGHer8BI9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9NZJ6 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-10897372|uniprotkb:B3KPX0|uniprotkb:Q5T061|uniprotkb:Q6P4F0|uniprotkb:Q8IXG6|uniprotkb:Q96BG1|uniprotkb:Q9H0N1|ensembl:ENSP00000254759 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:coq3_human(display_long)|uniprotkb:COQ3(gene name)|psi-mi:COQ3(display_short)|uniprotkb:3-demethylubiquinol 3-O-methyltransferase(gene name synonym)|uniprotkb:Polyprenyldihydroxybenzoate methyltransferase(gene name synonym)|uniprotkb:UG0215E05(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_059117.3|ensembl:ENSG00000132423(gene)|ensembl:ENST00000254759(transcript)|go:"GO:0004395"(hexaprenyldihydroxybenzoate methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008425"(2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity)|go:"GO:0008689"(3-demethylubiquinone-9 3-O-methyltransferase activity)|go:"GO:0010795"(regulation of ubiquinone biosynthetic process)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0032259"(methylation)|go:"GO:0044595"(decaprenyldihydroxybenzoate methyltransferase activity)|go:"GO:0044596"(3-demethylubiquinol-10 3-O-methyltransferase activity)|interpro:IPR010233(Ubiquinone biosynthesis O-methyltransferase)|interpro:IPR029063|reactome:R-HSA-2142789 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:l1QMK60WTofUGaffZWZsWFFe3bs9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P15954 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2606678|uniprotkb:Q6NR81|ensembl:ENSP00000247655|ensembl:ENSP00000425759 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cox7c_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide VIIc(gene name synonym)|uniprotkb:COX7C(gene name)|psi-mi:COX7C(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001858.1|ensembl:ENST00000247655(transcript)|ensembl:ENST00000509578(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004202(Cytochrome c oxidase subunit VIIc)|interpro:IPR036636|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|ensembl:ENSG00000127184(gene) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:hBYR7f5I8aE5H8JreIvHF8tg1HU9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:O75570 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-3957130|uniprotkb:Q5T6Y5|uniprotkb:Q8IUQ6|ensembl:ENSP00000368790|ensembl:ENSP00000368793|uniprotkb:B4DG01 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:rf1m_human(display_long)|uniprotkb:MTRF1(gene name)|psi-mi:MTRF1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:XP_011533620.1|refseq:XP_011533622.1|refseq:XP_011533623.1|refseq:XP_011533625.1|refseq:XP_011533627.1|refseq:NP_004285.2|ensembl:ENSG00000120662(gene)|ensembl:ENST00000379477(transcript)|ensembl:ENST00000379480(transcript)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0070126"(mitochondrial translational termination)|interpro:IPR000352(Class I peptide chain release factor)|interpro:IPR005139(PCRF)|refseq:XP_006719960.1|refseq:XP_006719961.1|refseq:XP_006719963.1|refseq:XP_005266656.1|refseq:XP_016876351.1|refseq:XP_016876352.1|refseq:XP_016876353.1|refseq:XP_016876354.1|refseq:XP_016876355.1|refseq:XP_016876356.1|refseq:XP_016876357.1|refseq:XP_016876358.1|refseq:XP_016876362.1|refseq:XP_016876363.1|refseq:XP_016876364.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:KlZ7evnGgblqFmqdIOxNnNy5u4Q9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q92947 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1236978|uniprotkb:O14719|uniprotkb:A8K2Z2|ensembl:ENSP00000222214|ensembl:ENSP00000466845 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:gcdh_human(display_long)|uniprotkb:GCDH(gene name)|psi-mi:GCDH(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_000150.1|refseq:NP_039663.1|ensembl:ENSG00000105607(gene)|ensembl:ENST00000222214(transcript)|ensembl:ENST00000591470(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004361"(glutaryl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:Q92947|rcsb pdb:1SIQ|rcsb pdb:1SIR|rcsb pdb:2R0M|rcsb pdb:2R0N|reactome:R-HSA-71064|go:"GO:0050660"(flavin adenine dinucleotide binding) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:W192IQEAyP1SdNxhI62Fh8C2UPU9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P12074 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2115950|uniprotkb:O43714|uniprotkb:Q32Q37|uniprotkb:B2R500|ensembl:ENSP00000229379 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cx6a1_human(display_long)|uniprotkb:COX6A1(gene name)|psi-mi:COX6A1(display_short)|uniprotkb:COX6AL(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-liver(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-liver(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_004364.2|ensembl:ENSG00000111775(gene)|ensembl:ENST00000229379(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:SJwbdw75pRCMcoPV/Mb98DrT1WM9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q15120 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1383915|uniprotkb:B4DXG6|ensembl:ENSP00000368460|ensembl:ENSP00000497727 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:pdk3_human(display_long)|uniprotkb:Pyruvate dehydrogenase kinase isoform 3(gene name synonym)|uniprotkb:PDK3(gene name)|psi-mi:PDK3(display_short)|uniprotkb:PDHK3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_005382.1|refseq:NP_001135858.1|dip:DIP-29498N|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q15120|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2PNR|rcsb pdb:2Q8I|reactome:R-HSA-204174|reactome:R-HSA-5362517|ensembl:ENSG00000067992(gene)|ensembl:ENST00000379162(transcript)|ensembl:ENST00000648777(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0071333"(cellular response to glucose stimulus) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:Q+/L48rFsQ7HDy8zDZWSfHzVghU9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9UDW1 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1224495|uniprotkb:B5MCM5|uniprotkb:Q9T2V6|ensembl:ENSP00000332887 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:qcr9_human(display_long)|uniprotkb:UQCR10(gene name)|psi-mi:UQCR10(display_short)|uniprotkb:HSPC119(orf name)|uniprotkb:UCRC(gene name synonym)|uniprotkb:Ubiquinol-cytochrome c reductase complex 7.2 kDa protein(gene name synonym)|uniprotkb:Cytochrome c1 non-heme 7 kDa protein(gene name synonym)|uniprotkb:Complex III subunit X(gene name synonym)|uniprotkb:Complex III subunit 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001003684.1|refseq:NP_037519.2|interpro:IPR036656|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|ensembl:ENSG00000184076(gene)|ensembl:ENST00000330029(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|interpro:IPR008027(Ubiquinol-cytochrome C reductase, UQCRX/QCR9-like) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:DDANQjwNz4ft+SVqOawiqaxueJk9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P13196 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-3905054|ensembl:ENSP00000309259|ensembl:ENSP00000378416|ensembl:ENSP00000417719|ensembl:ENSP00000418779 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:hem1_human(display_long)|uniprotkb:ALAS1(gene name)|psi-mi:ALAS1(display_short)|uniprotkb:ALAS3(gene name synonym)|uniprotkb:ALASH(gene name synonym)|uniprotkb:5-aminolevulinic acid synthase 1(gene name synonym)|uniprotkb:Delta-ALA synthase 1(gene name synonym)|uniprotkb:Delta-aminolevulinate synthase 1(gene name synonym)|uniprotkb:OK/SW-cl.121(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001291372.1|refseq:NP_001291373.1|refseq:NP_000679.1|refseq:NP_954635.1|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0048821"(erythrocyte development)|ensembl:ENSG00000023330(gene)|ensembl:ENST00000310271(transcript)|ensembl:ENST00000394965(transcript)|ensembl:ENST00000469224(transcript)|ensembl:ENST00000484952(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003870"(5-aminolevulinate synthase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR010961(Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase)|interpro:IPR015118(5-aminolevulinate synthase presequence)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P13196|reactome:R-HSA-189451|reactome:R-HSA-1989781|reactome:R-HSA-2151201|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:HFjJ6zrRF9UYD7LMB6A3CcxcS7c9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q8N4T8 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-10897344|uniprotkb:Q8WTW8|uniprotkb:Q96K93|ensembl:ENSP00000303525 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cbr4_human(display_long)|uniprotkb:CBR4(gene name)|psi-mi:CBR4(display_short)|uniprotkb:SDR45C1(gene name synonym)|uniprotkb:Quinone reductase CBR4(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 45C member 1(gene name synonym)|uniprotkb:3-ketoacyl-[acyl-carrier-protein] reductase beta subunit(gene name synonym)|uniprotkb:Carbonyl reductase family member 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_116172.2|rcsb pdb:4CQL|rcsb pdb:4CQM|reactome:R-HSA-75105|interpro:IPR036291|ensembl:ENSG00000145439(gene)|ensembl:ENST00000306193(transcript)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004316"("3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0044597"(daunorubicin metabolic process)|go:"GO:0044598"(doxorubicin metabolic process)|go:"GO:0048038"(quinone binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070402"(NADPH binding)|go:"GO:0102131"(obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity)|go:"GO:0102132"(obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity)|go:"GO:1990204"(oxidoreductase complex)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:90umrT5u3VndeVMkAoOe8iewIJg9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:O00483 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1049381|uniprotkb:Q6FHN5|uniprotkb:A4D109|ensembl:ENSP00000339720 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:ndua4_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase MLRQ subunit(gene name synonym)|uniprotkb:Complex I-MLRQ(gene name synonym)|uniprotkb:NDUFA4(gene name)|psi-mi:NDUFA4(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_002480.1|ensembl:ENSG00000189043(gene)|ensembl:ENST00000339600(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|interpro:IPR010530(B12D)|mint:O00483|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:TnrYlkH8abl42/yGsvfc8Bh6Mu09606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9NVH6 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-395312|uniprotkb:Q5TZB5|uniprotkb:Q6IA90|uniprotkb:Q8TBT0|ensembl:ENSP00000335261|uniprotkb:A8K6M9|uniprotkb:B4E3R3 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:tmlh_human(display_long)|uniprotkb:TMLHE(gene name)|psi-mi:TMLHE(display_short)|uniprotkb:TMLH(gene name synonym)|uniprotkb:Epsilon-trimethyllysine 2-oxoglutarate dioxygenase(gene name synonym)|uniprotkb:TML-alpha-ketoglutarate dioxygenase(gene name synonym)|uniprotkb:TML hydroxylase(gene name synonym)|uniprotkb:Epsilon-trimethyllysine hydroxylase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001171726.1|refseq:NP_060666.1|go:"GO:0051354"(negative regulation of oxidoreductase activity)|interpro:IPR003819(Taurine catabolism dioxygenase TauD/TfdA)|interpro:IPR010376(Protein of unknown function DUF971)|interpro:IPR012776(Trimethyllysine dioxygenase)|interpro:IPR038492|interpro:IPR042098|reactome:R-HSA-71262|ensembl:ENSG00000185973(gene)|ensembl:ENST00000334398(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050353"(trimethyllysine dioxygenase activity) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:QJwymZVdaxmMdea5RhA7vcPCla49606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:O95674 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-3913685|uniprotkb:Q5TDY5|uniprotkb:Q5TDY3|uniprotkb:Q5TDY2|uniprotkb:Q9NTT2|uniprotkb:Q9BYK5|uniprotkb:Q5TDY4|uniprotkb:D3DW04|uniprotkb:B2RDC6|ensembl:ENSP00000419879 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cds2_human(display_long)|uniprotkb:CDS2(gene name)|psi-mi:CDS2(display_short)|uniprotkb:CDP-DAG synthase 2(gene name synonym)|uniprotkb:CDP-DG synthase 2(gene name synonym)|uniprotkb:CDP-diacylglycerol synthase 2(gene name synonym)|uniprotkb:CDP-diglyceride pyrophosphorylase 2(gene name synonym)|uniprotkb:CDP-diglyceride synthase 2(gene name synonym)|uniprotkb:"CTP:phosphatidate cytidylyltransferase 2"(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_003809.1|ensembl:ENSG00000101290(gene)|ensembl:ENST00000460006(transcript)|go:"GO:0004605"(phosphatidate cytidylyltransferase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006655"(phosphatidylglycerol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016024"(CDP-diacylglycerol biosynthetic process)|go:"GO:0140042"(lipid droplet formation)|interpro:IPR000374(Phosphatidate cytidylyltransferase)|interpro:IPR016720(Phosphatidate cytidylyltransferase, eukaryota)|mint:O95674|reactome:R-HSA-1483148 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:tCRLIDMiesBx7QPKIycdX3Igz589606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P03886 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1246156|uniprotkb:Q37523|uniprotkb:C0JKH6|ensembl:ENSP00000354687 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:nu1m_human(display_long)|uniprotkb:MT-ND1(gene name)|psi-mi:MT-ND1(display_short)|uniprotkb:MTND1(gene name synonym)|uniprotkb:NADH1(gene name synonym)|uniprotkb:ND1(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:YP_003024026.1|ensembl:ENSG00000198888(gene)|ensembl:ENST00000361390(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|interpro:IPR001694(Respiratory-chain NADH dehydrogenase, subunit 1)|interpro:IPR018086|mint:P03886|rcsb pdb:5XTC|rcsb pdb:5XTD|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:AZoXs+VEdQPt/9D2lr+qBuwsZfA9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q99643 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1224539|uniprotkb:O75609|uniprotkb:Q3C259|uniprotkb:Q3C2D8|uniprotkb:Q3C2H4|uniprotkb:Q5VTH3|ensembl:ENSP00000356953 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:c560_human(display_long)|uniprotkb:SDHC(gene name)|psi-mi:SDHC(display_short)|uniprotkb:CYB560(gene name synonym)|uniprotkb:SDH3(gene name synonym)|uniprotkb:Succinate dehydrogenase complex subunit C(gene name synonym)|uniprotkb:Integral membrane protein CII-3(gene name synonym)|uniprotkb:QPs-1(gene name synonym)|uniprotkb:Succinate-ubiquinone oxidoreductase cytochrome B large subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001265101.1|refseq:NP_001030588.1|refseq:NP_001030589.1|refseq:NP_001030590.1|refseq:NP_002992.1|ensembl:ENSG00000143252(gene)|ensembl:ENST00000367975(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000701(Succinate dehydrogenase, cytochrome b subunit)|interpro:IPR014314(Succinate dehydrogenase, cytochrome b556 subunit)|interpro:IPR018495|interpro:IPR034804|reactome:R-HSA-611105|reactome:R-HSA-71403|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:Myyea7l/YcmutWGKKntH678ndcU9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P51659 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-358398|ensembl:ENSP00000424940|uniprotkb:B4DNV1|uniprotkb:B4DVS5|uniprotkb:E9PB82|uniprotkb:F5HE57 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:dhb4_human(display_long)|uniprotkb:HSD17B4(gene name)|psi-mi:HSD17B4(display_short)|uniprotkb:EDH17B4(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:SDR8C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 8C member 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_000405.1|refseq:NP_001186220.1|refseq:NP_001186221.1|refseq:NP_001278956.1|refseq:NP_001278957.1|ensembl:ENSG00000133835(gene)|ensembl:ENST00000510025(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|rcsb pdb:1IKT|rcsb pdb:1S9C|rcsb pdb:1ZBQ|rcsb pdb:6Z1W|rcsb pdb:6Z1X|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|reactome:R-HSA-9033500 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:i3A0dh9gAO2vfrCYXvo2U6+PwJQ9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P10109 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2694652|uniprotkb:B0YJ14|uniprotkb:Q53YD6|ensembl:ENSP00000260270 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:adx_human(display_long)|uniprotkb:ADX(gene name synonym)|uniprotkb:Adrenal ferredoxin(gene name synonym)|uniprotkb:Ferredoxin-1(gene name synonym)|uniprotkb:Hepatoredoxin(gene name synonym)|uniprotkb:FDX1(gene name)|psi-mi:FDX1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_004100.1|ensembl:ENSG00000137714(gene)|ensembl:ENST00000260270(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0042446"(hormone biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001041(Ferredoxin)|interpro:IPR001055(Adrenodoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR018298|interpro:IPR036010|rcsb pdb:3N9Y|rcsb pdb:3N9Z|rcsb pdb:3NA0|rcsb pdb:3NA1|rcsb pdb:3P1M|rcsb pdb:7M8I|reactome:R-HSA-1362409|reactome:R-HSA-196108|reactome:R-HSA-211976|reactome:R-HSA-2395516|reactome:R-HSA-5579026 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:C6uFdlyqNUgWMeNDQlPYS7MZ4Ho9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P03928 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-3439833|intact:EBI-3450125|uniprotkb:Q34771|ensembl:ENSP00000355265 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:atp8_human(display_long)|uniprotkb:MT-ATP8(gene name)|psi-mi:MT-ATP8(display_short)|uniprotkb:ATP8(gene name synonym)|uniprotkb:ATPASE8(gene name synonym)|uniprotkb:MTATP8(gene name synonym)|uniprotkb:A6L(gene name synonym)|uniprotkb:F-ATPase subunit 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:YP_003024030.1|ensembl:ENSG00000228253(gene)|ensembl:ENST00000361851(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001421(ATPase, F0 complex, subunit 8, mitochondrial, Metazoan)|interpro:IPR039017|mint:P03928|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:8LbAeHQBEFnML9W9QP2R2igsr0U9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:O75439 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-721199|uniprotkb:O60416|uniprotkb:Q96FV4|ensembl:ENSP00000249269 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:mppb_human(display_long)|uniprotkb:Beta-MPP(gene name synonym)|uniprotkb:P-52(gene name synonym)|uniprotkb:PMPCB(gene name)|psi-mi:PMPCB(display_short)|uniprotkb:MPPB(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_004270.2|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0017087"(mitochondrial processing peptidase complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR037718|mint:O75439|reactome:R-HSA-1268020|reactome:R-HSA-8949664|ensembl:ENSG00000105819(gene)|ensembl:ENST00000249269(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:TMqHDYssMbBpUdw0HcGrMPaJd/89606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9NUB1 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-10313831|uniprotkb:B3KXL2|uniprotkb:Q96JX6|uniprotkb:D3DW48|uniprotkb:B4DJZ3|uniprotkb:Q9NU28|uniprotkb:Q96JI1|uniprotkb:Q8IV99|uniprotkb:Q8N234|uniprotkb:Q5TF42|uniprotkb:F8W7Y1|uniprotkb:F5H6F4|ensembl:ENSP00000316924 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:acs2l_human(display_long)|uniprotkb:ACSS1(gene name)|psi-mi:ACSS1(display_short)|uniprotkb:ACAS2L(gene name synonym)|uniprotkb:Acetate--CoA ligase 2(gene name synonym)|uniprotkb:Acetyl-CoA synthetase 2(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 1(gene name synonym)|uniprotkb:KIAA1846(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001239604.1|refseq:NP_001239605.1|refseq:NP_001239606.1|refseq:NP_115890.2|ensembl:ENSG00000154930(gene)|ensembl:ENST00000323482(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006069"(ethanol oxidation)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0019542"(propionate biosynthetic process)|go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR032387|interpro:IPR042099|rcsb pdb:3GLR|rcsb pdb:3GLT|rcsb pdb:3GLU|rcsb pdb:4BVE|rcsb pdb:4BVF|rcsb pdb:4BVG|rcsb pdb:4C78|rcsb pdb:5YTK|reactome:R-HSA-71384|rcsb pdb:5Y4H|dip:DIP-61208N - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:Z+A3/EcJ41rhi4xeOFci7YBP9u89606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P11310 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-514381|uniprotkb:Q9NYF1|uniprotkb:Q5T4U4|ensembl:ENSP00000359878 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:acadm_human(display_long)|uniprotkb:Medium chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:ACADM(gene name)|psi-mi:ACADM(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_000007.1|refseq:NP_001120800.1|dip:DIP-34281N|ensembl:ENSG00000117054(gene)|ensembl:ENST00000370841(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009409"(response to cold)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0030424"(axon)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0051793"(medium-chain fatty acid catabolic process)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR034180|interpro:IPR036250|interpro:IPR037069|mint:P11310|rcsb pdb:1EGC|rcsb pdb:1EGD|rcsb pdb:1EGE|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:4P13|reactome:R-HSA-1989781|reactome:R-HSA-77288|reactome:R-HSA-77346|reactome:R-HSA-77348 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:rfmTmYKNQr6R6ikvfYovZIctoz49606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q00059 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:O43837 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-725377|uniprotkb:O95106|uniprotkb:Q5JXS8|uniprotkb:Q9NQ06|uniprotkb:Q9NQ07|uniprotkb:Q9UEX0|uniprotkb:Q9UG99|uniprotkb:B2RDR1|uniprotkb:D3DVX2|uniprotkb:D3DVX3|uniprotkb:Q9NUZ0|ensembl:ENSP00000370223 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:idh3b_human(display_long)|uniprotkb:Isocitric dehydrogenase subunit beta(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit beta"(gene name synonym)|uniprotkb:IDH3B(gene name)|psi-mi:IDH3B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_008830.2|refseq:NP_777280.1|ensembl:ENSG00000101365(gene)|ensembl:ENST00000380843(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:O43837|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:7CE3|reactome:R-HSA-71403|refseq:NP_001317692.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:in3sFQUqN4ZtqBii7BotVro104A9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q96I59 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-5455236|uniprotkb:G3V178|ensembl:ENSP00000281038 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:synm_human(display_long)|uniprotkb:NARS2(gene name)|psi-mi:NARS2(display_short)|uniprotkb:Asparaginyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_078954.4|refseq:NP_001230180.1|refseq:XP_016873792.1|ensembl:ENSG00000137513(gene)|ensembl:ENST00000281038(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004816"(asparagine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006421"(asparaginyl-tRNA aminoacylation)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004522(Asparaginyl-tRNA synthetase, class IIb)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|reactome:R-HSA-379726 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:8r61DYTijthPntztWKOxzbklcPY9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P10606 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9Y2S7 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P22830 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9Y2Q3 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1053767|uniprotkb:Q7Z520|uniprotkb:Q6P4H0|uniprotkb:Q9P1S4|uniprotkb:B4DIH1|uniprotkb:B4DSY2|ensembl:ENSP00000351181 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:gstk1_human(display_long)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)|uniprotkb:GSTK1(gene name)|psi-mi:GSTK1(display_short)|uniprotkb:HDCMD47P(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001137151.1|refseq:NP_001137152.1|refseq:NP_001137153.1|refseq:NP_057001.1|ensembl:ENSG00000197448(gene)|ensembl:ENST00000358406(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|rcsb pdb:1YZX|rcsb pdb:3RPN|rcsb pdb:3RPP|reactome:R-HSA-156590|reactome:R-HSA-9033241|dip:DIP-46924N - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:aTjqqss32Y4bcsXg6gYlazahVCw9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P55809 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2687150|uniprotkb:B7Z528|uniprotkb:B2R5V2|ensembl:ENSP00000196371 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:scot1_human(display_long)|uniprotkb:OXCT(gene name synonym)|uniprotkb:SCOT(gene name synonym)|uniprotkb:OXCT1(gene name)|psi-mi:OXCT1(display_short)|uniprotkb:3-oxoacid CoA-transferase 1(gene name synonym)|uniprotkb:"Somatic-type succinyl-CoA:3-oxoacid CoA-transferase"(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_000427.1|ensembl:ENSG00000083720(gene)|ensembl:ENST00000196371(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008260"(3-oxoacid CoA-transferase activity)|go:"GO:0008410"(CoA-transferase activity)|go:"GO:0009725"(response to hormone)|go:"GO:0014823"(response to activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042182"(ketone catabolic process)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0046950"(cellular ketone body metabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|interpro:IPR004163(Coenzyme A transferase binding site)|interpro:IPR004164(Coenzyme A transferase active site)|interpro:IPR004165(Coenzyme A transferase)|interpro:IPR012791(3-oxoacid CoA-transferase, subunit B)|interpro:IPR012792(3-oxoacid CoA-transferase, subunit A)|interpro:IPR014388(3-oxoacid CoA-transferase)|interpro:IPR037171|rcsb pdb:3DLX|reactome:R-HSA-77108 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:9kyVQbY3sPBRAfJkkF5HhHZg31c9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9UIJ7 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-3916527|uniprotkb:Q5VYW6|uniprotkb:Q9NPB4|uniprotkb:Q9H576|uniprotkb:D3DRI1|uniprotkb:Q9HC01|uniprotkb:B4DP58|uniprotkb:E7ET30|ensembl:ENSP00000371230 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:kad3_human(display_long)|uniprotkb:AK3(gene name)|psi-mi:AK3(display_short)|uniprotkb:AK3L1(gene name synonym)|uniprotkb:AK6(gene name synonym)|uniprotkb:AKL3L(gene name synonym)|uniprotkb:Adenylate kinase 3(gene name synonym)|uniprotkb:Adenylate kinase 3 alpha-like 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001186781.1|refseq:NP_001186782.1|refseq:NP_001186784.1|refseq:NP_001186785.1|refseq:NP_057366.2|ensembl:ENSG00000147853(gene)|ensembl:ENST00000381809(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0007596"(blood coagulation)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046041"(ITP metabolic process)|go:"GO:0046051"(UTP metabolic process)|go:"GO:0046899"(nucleoside triphosphate adenylate kinase activity)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR028586|interpro:IPR033690|interpro:IPR036193|mint:Q9UIJ7|rcsb pdb:1ZD8|rcsb pdb:6ZJB|rcsb pdb:6ZJD|rcsb pdb:6ZJE|reactome:R-HSA-983231|interpro:IPR027417 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:NDt9xiBjW8L9uXYnyZhVYpVybfA9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P27144 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-3905025|uniprotkb:B2R927|uniprotkb:Q8IUU9|uniprotkb:Q6NXQ5|uniprotkb:Q6IBH4|uniprotkb:D3DQ62|ensembl:ENSP00000322175|ensembl:ENSP00000378743|ensembl:ENSP00000445912 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:kad4_human(display_long)|uniprotkb:AK4(gene name)|psi-mi:AK4(display_short)|uniprotkb:AK3(gene name synonym)|uniprotkb:AK3L1(gene name synonym)|uniprotkb:Adenylate kinase 3-like(gene name synonym)|uniprotkb:"GTP:AMP phosphotransferase AK4"(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001005353.1|refseq:NP_037542.1|refseq:NP_982289.1|ensembl:ENSG00000162433(gene)|ensembl:ENST00000327299(transcript)|ensembl:ENST00000395334(transcript)|ensembl:ENST00000545314(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042493"|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046899"(nucleoside triphosphate adenylate kinase activity)|go:"GO:0050145"(nucleoside monophosphate kinase activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:2001169"(regulation of ATP biosynthetic process)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028585|interpro:IPR028586|interpro:IPR033690|interpro:IPR036193|rcsb pdb:2AR7|rcsb pdb:2BBW|rcsb pdb:3NDP|reactome:R-HSA-499943|go:"GO:0006172"(ADP biosynthetic process) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:Yt5oLpkD4mw2eCmEbLox3W3R2hw9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P45954 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2511905|ensembl:ENSP00000357873|uniprotkb:Q96CX7|uniprotkb:B4DQ51|uniprotkb:Q5SQN6 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:acdsb_human(display_long)|uniprotkb:ACADSB(gene name)|psi-mi:ACADSB(display_short)|uniprotkb:2-methyl branched chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:2-methylbutyryl-coenzyme A dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N ensembl:ENSG00000196177(gene)|ensembl:ENST00000358776(transcript)|go:"GO:0003853"(2-methylacyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016937"(short-branched-chain-acyl-CoA dehydrogenase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0102035"("isobutyryl-CoA:FAD oxidoreductase activity")|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|rcsb pdb:2JIF|reactome:R-HSA-70895|refseq:NP_001600.1|refseq:NP_001317103.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:phnlWtZGT21VyKrhWj9a3Wjfijw9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P20674 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9UGM6 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-10897254|uniprotkb:B1ALR1|uniprotkb:B2R9D4|uniprotkb:Q53FT4|uniprotkb:Q5VUD2|uniprotkb:Q86TQ0|ensembl:ENSP00000235521 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:sywm_human(display_long)|uniprotkb:WARS2(gene name)|psi-mi:WARS2(display_short)|uniprotkb:"(Mt)TrpRS"(gene name synonym)|uniprotkb:Tryptophanyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_056651.1|refseq:NP_957715.1|ensembl:ENSG00000116874(gene)|ensembl:ENST00000235521(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004830"(tryptophan-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006436"(tryptophanyl-tRNA aminoacylation)|go:"GO:0070183"(mitochondrial tryptophanyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002306(Tryptophanyl-tRNA synthetase, class Ib)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR024109|rcsb pdb:5EKD|reactome:R-HSA-379726 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:a3ec+kKKGh4XiLJcUoBdk3B2uFs9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9BPW8 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-307125|uniprotkb:O43800|uniprotkb:B2RAY3|ensembl:ENSP00000216121 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:nips1_human(display_long)|uniprotkb:NIPSNAP1(gene name)|psi-mi:NIPSNAP1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001189431.1|refseq:NP_003625.2|ensembl:ENSG00000184117(gene)|ensembl:ENST00000216121(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|mint:Q9BPW8 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:mOosuRNhEeYvVB5cUbkMzTJ7X7s9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q04837 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9H0R6 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2856796|uniprotkb:Q5VWJ4|uniprotkb:Q9HA60|uniprotkb:Q9NV19|ensembl:ENSP00000358042 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:gata_human(display_long)|uniprotkb:QRSL1(gene name)|psi-mi:QRSL1(display_short)|uniprotkb:Glutaminyl-tRNA synthase-like protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_060762.3|dip:DIP-48970N|ensembl:ENSG00000130348(gene)|ensembl:ENST00000369046(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030956"("glutamyl-tRNA(Gln) amidotransferase complex")|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0050567"("glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity")|go:"GO:0070681"(glutaminyl-tRNAGln biosynthesis via transamidation)|interpro:IPR000120(Amidase signature enzyme)|interpro:IPR004412("Glutamyl-tRNA(Gln) amidotransferase A subunit")|interpro:IPR023631|interpro:IPR036928 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:/RVDRYFvbHttKo9WEmryGNEBR+09606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P30038 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-3926971|uniprotkb:Q9UDI6|uniprotkb:Q53HU4|uniprotkb:A8K1Q7|uniprotkb:Q16882|uniprotkb:Q8IZ38|uniprotkb:Q5JNV6|uniprotkb:Q96IF0|ensembl:ENSP00000290597|ensembl:ENSP00000364490|uniprotkb:B4DGE4|uniprotkb:D2D4A3 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:al4a1_human(display_long)|uniprotkb:ALDH4A1(gene name)|psi-mi:ALDH4A1(display_short)|uniprotkb:ALDH4(gene name synonym)|uniprotkb:P5CDH(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 4 member A1(gene name synonym)|uniprotkb:L-glutamate gamma-semialdehyde dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001154976.1|refseq:NP_003739.2|refseq:NP_733844.1|ensembl:ENSG00000159423(gene)|ensembl:ENST00000290597(transcript)|ensembl:ENST00000375341(transcript)|go:"GO:0003842"(1-pyrroline-5-carboxylate dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006560"(proline metabolic process)|go:"GO:0006562"(proline catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010133"(proline catabolic process to glutamate)|go:"GO:0019470"(4-hydroxyproline catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR005931(Delta-1-pyrroline-5-carboxylate dehydrogenase 1)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|rcsb pdb:3V9H|rcsb pdb:3V9I|rcsb pdb:4OE5|reactome:R-HSA-389661|reactome:R-HSA-70688|rcsb pdb:3V9G|refseq:NP_001306147.1 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:EffeJikoazdZ3SwYfhTdzZJ3FDw9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9Y697 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1751791|uniprotkb:E1P5R8|uniprotkb:Q6P0L8|uniprotkb:Q9NTZ5|uniprotkb:Q9Y481|uniprotkb:B3KMA5|uniprotkb:B4DXK9|uniprotkb:F5GYK5|ensembl:ENSP00000363205 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:nfs1_human(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001185918.1|refseq:NP_066923.3|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374092(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR016454(Cysteine desulphurase, NifS)|interpro:IPR020578|rcsb pdb:5KZ5|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|reactome:R-HSA-947581 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:tSeWDc9Ch78CnCC2Co+vzC2CWvg9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:P31040 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:Q9HA77 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-2107262|uniprotkb:Q8NI84|uniprotkb:Q96IV4|ensembl:ENSP00000257347 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:sycm_human(display_long)|uniprotkb:CARS2(gene name)|psi-mi:CARS2(display_short)|uniprotkb:Cysteinyl-tRNA synthetase(gene name synonym)|uniprotkb:OK/SW-cl.10(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_078813.1|ensembl:ENSG00000134905(gene)|ensembl:ENST00000257347(transcript)|go:"GO:0004817"(cysteine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006423"(cysteinyl-tRNA aminoacylation)|go:"GO:0046872"(metal ion binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR015803(Cysteinyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR024909|interpro:IPR032678|reactome:R-HSA-379726 - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:1YjqTFtsp39awdgDtBTL3AgJrp49606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:O75390 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-487493|ensembl:ENSP00000342056|uniprotkb:Q71UT9|uniprotkb:Q7KZH0|uniprotkb:Q96FZ8|uniprotkb:Q9BWN8 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:cisy_human(display_long)|uniprotkb:CS(gene name)|psi-mi:CS(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N go:"GO:0006101"(citrate metabolic process)|refseq:NP_004068.2|ensembl:ENSG00000062485(gene)|go:"GO:0004108"("citrate (Si)-synthase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000351328(transcript)|rcsb pdb:5UZQ|rcsb pdb:5UZR|reactome:R-HSA-1268020|reactome:R-HSA-71403|go:"GO:0070062"(extracellular exosome)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|rcsb pdb:5UZP - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:XKpnEsGOlGRNIAXMk4tTBH2okzo9606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16740 uniprotkb:O76031 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 intact:EBI-1052667|uniprotkb:A1L428|uniprotkb:A8K8F1|uniprotkb:Q9H4D9|uniprotkb:B9EGI8|ensembl:ENSP00000300107 psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:clpx_human(display_long)|uniprotkb:CLPX(gene name)|psi-mi:CLPX(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10897112|imex:IM-24491-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N refseq:NP_006651.2|ensembl:ENSG00000166855(gene)|ensembl:ENST00000300107(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004487(ClpX, ATPase regulatory subunit)|interpro:IPR010603(Zinc finger, C4-type)|interpro:IPR019489|interpro:IPR027417|go:"GO:0009841"(mitochondrial endopeptidase Clp complex)|mint:O76031|dip:DIP-50293N - - - figure legend:Table S2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/09/14 2015/07/06 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rogid:+SOis7raPEZqqeel6Y6dOWJcLj49606 rigid:phx1ygUn62ah4GNNNw+/vDRoQuk false enzyme tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) chebi:"CHEBI:63170" uniprotkb:P0A6G7 intact:EBI-5260138 intact:EBI-370625|uniprotkb:P19245|uniprotkb:Q2MBY9|ensemblbacteria:AAC73540|ensemblbacteria:BAE76217 psi-mi:suc-ly-amc(display_short)|psi-mi:"CHEBI:63170"(display_long) psi-mi:clpp_ecoli(display_long)|uniprotkb:clpP(gene name)|psi-mi:clpP(display_short)|uniprotkb:lopP(gene name synonym)|uniprotkb:Endopeptidase Clp(gene name synonym)|uniprotkb:Caseinolytic protease(gene name synonym)|uniprotkb:Protease Ti(gene name synonym)|uniprotkb:Heat shock protein F21.5(gene name synonym)|uniprotkb:b0437(locus name)|uniprotkb:JW0427(locus name) psi-mi:"MI:0990"(cleavage assay) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10897837|imex:IM-24491-2 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_000122253.1|refseq:NP_414971.1|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009314"(response to radiation)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0009376"(HslUV protease complex)|go:"GO:0009408"(response to heat)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0051117"(ATPase binding)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TYF|rcsb pdb:1YG6|rcsb pdb:1YG8|rcsb pdb:2FZS|rcsb pdb:3HLN|rcsb pdb:3MT6|rcsb pdb:6NB1|rcsb pdb:6PO1|rcsb pdb:6PO3|rcsb pdb:6POD|rcsb pdb:6POS|rcsb pdb:6PPE|rcsb pdb:6UQE|rcsb pdb:6UQO|rcsb pdb:6W1Z|rcsb pdb:6W20|rcsb pdb:6W21|rcsb pdb:6WR2|rcsb pdb:6WRF|rcsb pdb:6WSG|ensemblbacteria:AAC73540(transcript)|ensemblbacteria:b0437(gene)|ensemblbacteria:BAE76217(gene)|ensemblbacteria:BAE76217(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|dip:DIP-31838N go:"GO:0004176"(ATP-dependent peptidase activity) - - figure legend:Supp 4B/F/G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/09/14 2015/07/07 - rogid:M9znviYWdujU3uleyh6186V2r7I83333 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:86341" uniprotkb:P0A6G7 intact:EBI-10897984 intact:EBI-370625|uniprotkb:P19245|uniprotkb:Q2MBY9|ensemblbacteria:AAC73540|ensemblbacteria:BAE76217 psi-mi:a2-32-01(display_short)|psi-mi:"CHEBI:86341"(display_long) psi-mi:clpp_ecoli(display_long)|uniprotkb:clpP(gene name)|psi-mi:clpP(display_short)|uniprotkb:lopP(gene name synonym)|uniprotkb:Endopeptidase Clp(gene name synonym)|uniprotkb:Caseinolytic protease(gene name synonym)|uniprotkb:Protease Ti(gene name synonym)|uniprotkb:Heat shock protein F21.5(gene name synonym)|uniprotkb:b0437(locus name)|uniprotkb:JW0427(locus name) psi-mi:"MI:0990"(cleavage assay) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10897843|imex:IM-24491-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_000122253.1|refseq:NP_414971.1|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009314"(response to radiation)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0009376"(HslUV protease complex)|go:"GO:0009408"(response to heat)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0051117"(ATPase binding)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TYF|rcsb pdb:1YG6|rcsb pdb:1YG8|rcsb pdb:2FZS|rcsb pdb:3HLN|rcsb pdb:3MT6|rcsb pdb:6NB1|rcsb pdb:6PO1|rcsb pdb:6PO3|rcsb pdb:6POD|rcsb pdb:6POS|rcsb pdb:6PPE|rcsb pdb:6UQE|rcsb pdb:6UQO|rcsb pdb:6W1Z|rcsb pdb:6W20|rcsb pdb:6W21|rcsb pdb:6WR2|rcsb pdb:6WRF|rcsb pdb:6WSG|ensemblbacteria:AAC73540(transcript)|ensemblbacteria:b0437(gene)|ensemblbacteria:BAE76217(gene)|ensemblbacteria:BAE76217(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|dip:DIP-31838N go:"GO:0004176"(ATP-dependent peptidase activity) - - figure legend:Supp 4B/Fi|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/09/14 2015/07/07 - rogid:M9znviYWdujU3uleyh6186V2r7I83333 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:86341" chebi:"CHEBI:63170" intact:EBI-10897984 intact:EBI-5260138 psi-mi:a2-32-01(display_short)|psi-mi:"CHEBI:86341"(display_long) psi-mi:suc-ly-amc(display_short)|psi-mi:"CHEBI:63170"(display_long) psi-mi:"MI:0990"(cleavage assay) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10897843|imex:IM-24491-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0004176"(ATP-dependent peptidase activity) - - figure legend:Supp 4B/Fi|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/09/14 2015/07/07 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:86342" uniprotkb:P0A6G7 intact:EBI-10898014 intact:EBI-370625|uniprotkb:P19245|uniprotkb:Q2MBY9|ensemblbacteria:AAC73540|ensemblbacteria:BAE76217 psi-mi:a2-58-06(display_short)|psi-mi:"CHEBI:86342"(display_long) psi-mi:clpp_ecoli(display_long)|uniprotkb:clpP(gene name)|psi-mi:clpP(display_short)|uniprotkb:lopP(gene name synonym)|uniprotkb:Endopeptidase Clp(gene name synonym)|uniprotkb:Caseinolytic protease(gene name synonym)|uniprotkb:Protease Ti(gene name synonym)|uniprotkb:Heat shock protein F21.5(gene name synonym)|uniprotkb:b0437(locus name)|uniprotkb:JW0427(locus name) psi-mi:"MI:0990"(cleavage assay) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10898006|imex:IM-24491-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_000122253.1|refseq:NP_414971.1|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009314"(response to radiation)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0009376"(HslUV protease complex)|go:"GO:0009408"(response to heat)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0051117"(ATPase binding)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TYF|rcsb pdb:1YG6|rcsb pdb:1YG8|rcsb pdb:2FZS|rcsb pdb:3HLN|rcsb pdb:3MT6|rcsb pdb:6NB1|rcsb pdb:6PO1|rcsb pdb:6PO3|rcsb pdb:6POD|rcsb pdb:6POS|rcsb pdb:6PPE|rcsb pdb:6UQE|rcsb pdb:6UQO|rcsb pdb:6W1Z|rcsb pdb:6W20|rcsb pdb:6W21|rcsb pdb:6WR2|rcsb pdb:6WRF|rcsb pdb:6WSG|ensemblbacteria:AAC73540(transcript)|ensemblbacteria:b0437(gene)|ensemblbacteria:BAE76217(gene)|ensemblbacteria:BAE76217(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|dip:DIP-31838N go:"GO:0004176"(ATP-dependent peptidase activity) - - figure legend:Supp 4G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/09/14 2015/07/07 - rogid:M9znviYWdujU3uleyh6186V2r7I83333 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:86342" chebi:"CHEBI:63170" intact:EBI-10898014 intact:EBI-5260138 psi-mi:a2-58-06(display_short)|psi-mi:"CHEBI:86342"(display_long) psi-mi:suc-ly-amc(display_short)|psi-mi:"CHEBI:63170"(display_long) psi-mi:"MI:0990"(cleavage assay) Cole et al. (2015) imex:IM-24491|pubmed:26058080 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10898006|imex:IM-24491-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0004176"(ATP-dependent peptidase activity) - - figure legend:Supp 4G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/09/14 2015/07/07 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)