#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5JVL4	uniprotkb:Q7Z569	intact:EBI-743105|ensembl:ENSP00000360107|uniprotkb:Q5XKM4|uniprotkb:Q6E1U7|uniprotkb:Q6E1U8|uniprotkb:Q8WUL2|uniprotkb:Q9NVW6|intact:EBI-11099619|uniprotkb:B4DMU3|uniprotkb:F5GZD8	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:efhc1_human(display_long)|uniprotkb:EFHC1(gene name)|psi-mi:EFHC1(display_short)|uniprotkb:Myoclonin-1(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818275|imex:IM-24158-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000371068(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051302"(regulation of cell division)|go:"GO:0060285"(cilium-dependent cell motility)|go:"GO:0072686"(mitotic spindle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006602(Region of unknown function DM10)|interpro:IPR011992(EF-Hand type)|interpro:IPR040193|mint:Q5JVL4|refseq:NP_001165891.1|refseq:NP_060570.2|ensembl:ENSG00000096093(gene)	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:l5I5K4Lgihe08j5BuPBk4uDY+qk9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:rAqIzZuElwqmp59wM7kT0IEDJ/Q	false	sufficient binding region:372-584	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0CG47	uniprotkb:Q7Z569	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818283|imex:IM-24158-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:qT6fT1VN7UACZPr9hDsvZZbnMGc	false	sufficient binding region:71-91	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0CG48	uniprotkb:Q7Z569	intact:EBI-3390054|ensembl:ENSP00000344818|ensembl:ENSP00000441543|uniprotkb:Q9BWD6|uniprotkb:P02249|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q9UPK7|uniprotkb:P62988|uniprotkb:P02250|uniprotkb:Q9UEK8|uniprotkb:Q6LDU5|uniprotkb:Q91888|uniprotkb:Q6LBL4|uniprotkb:Q9UEF2|uniprotkb:Q29120|uniprotkb:P02248|uniprotkb:Q9BX98|uniprotkb:Q9UEG1	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:ubc_human(display_long)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818291|imex:IM-24158-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5656121|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|reactome:R-HSA-983168|reactome:R-HSA-9613829|ensembl:ENSG00000150991(gene)|ensembl:ENST00000339647(transcript)|ensembl:ENST00000536769(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG48|rcsb pdb:1C3T|rcsb pdb:1CMX|rcsb pdb:1D3Z|rcsb pdb:1F9J|rcsb pdb:1FXT|rcsb pdb:1G6J|rcsb pdb:1GJZ|rcsb pdb:1NBF|rcsb pdb:1OGW|rcsb pdb:1Q5W|rcsb pdb:1S1Q|rcsb pdb:1SIF|rcsb pdb:1TBE|rcsb pdb:1UBI|rcsb pdb:1UBQ|rcsb pdb:1UD7|rcsb pdb:1XD3|rcsb pdb:1XQQ|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:1ZGU|rcsb pdb:1ZO6|rcsb pdb:2AYO|rcsb pdb:2BGF|rcsb pdb:2DEN|rcsb pdb:2FUH|rcsb pdb:2G45|rcsb pdb:2GBJ|rcsb pdb:2GBK|rcsb pdb:2GBM|rcsb pdb:2GBN|rcsb pdb:2GBR|rcsb pdb:2GMI|rcsb pdb:2HTH|rcsb pdb:2IBI|rcsb pdb:2J7Q|rcsb pdb:2JF5|rcsb pdb:2JRI|interpro:IPR000626(Ubiquitin)|rcsb pdb:2JY6|rcsb pdb:2JZZ|rcsb pdb:2K25|rcsb pdb:2K6D|rcsb pdb:2K8B|rcsb pdb:2K8C|rcsb pdb:2KDF|rcsb pdb:2KHW|rcsb pdb:2KJH|rcsb pdb:2KLG|rcsb pdb:2KN5|rcsb pdb:2KX0|rcsb pdb:2L3Z|rcsb pdb:2LD9|rcsb pdb:2LVO|rcsb pdb:2LVP|rcsb pdb:2LVQ|rcsb pdb:2LZ6|rcsb pdb:2MBO|rcsb pdb:2MBQ|rcsb pdb:2MCN|rcsb pdb:2MJ5|rcsb pdb:2MOR|rcsb pdb:2MRE|rcsb pdb:2MWS|rcsb pdb:2N2K|rcsb pdb:2NR2|rcsb pdb:2O6V|rcsb pdb:2OJR|rcsb pdb:2PE9|rcsb pdb:2PEA|rcsb pdb:2RR9|rcsb pdb:2RU6|rcsb pdb:2MI8|rcsb pdb:2W9N|rcsb pdb:2WDT|rcsb pdb:2XEW|rcsb pdb:2Y5B|rcsb pdb:2Z59|rcsb pdb:2ZCB|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3A33|rcsb pdb:3ALB|rcsb pdb:3AUL|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:3BY4|rcsb pdb:3C0R|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EEC|rcsb pdb:3EFU|rcsb pdb:3EHV|rcsb pdb:3H7P|rcsb pdb:3H7S|rcsb pdb:3HM3|rcsb pdb:3I3T|rcsb pdb:3IFW|rcsb pdb:3IHP|rcsb pdb:3JSV|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3K9O|rcsb pdb:3K9P|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:3LDZ|rcsb pdb:3MHS|rcsb pdb:3MTN|rcsb pdb:3N30|rcsb pdb:3N32|rcsb pdb:3N3K|rcsb pdb:3NS8|rcsb pdb:3O65|rcsb pdb:3OFI|rcsb pdb:3OJ3|rcsb pdb:3OJ4|rcsb pdb:3ONS|rcsb pdb:3PRM|rcsb pdb:3PT2|rcsb pdb:3Q3F|rcsb pdb:3RUL|rcsb pdb:3PTF|rcsb pdb:3TMP|rcsb pdb:3U30|rcsb pdb:3UGB|rcsb pdb:3V6C|rcsb pdb:3V6E|rcsb pdb:3VFK|rcsb pdb:3VUW|rcsb pdb:3VUX|rcsb pdb:3VUY|rcsb pdb:3WXE|rcsb pdb:3WXF|rcsb pdb:3ZLZ|rcsb pdb:3ZNH|rcsb pdb:3ZNI|rcsb pdb:3ZNZ|rcsb pdb:4AP4|rcsb pdb:4AUQ|rcsb pdb:4BOS|rcsb pdb:4BOZ|rcsb pdb:4BVU|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4FJV|rcsb pdb:4HK2|rcsb pdb:4HXD|rcsb pdb:4I6L|rcsb pdb:4I6N|rcsb pdb:4IG7|rcsb pdb:4IUM|rcsb pdb:4JQW|rcsb pdb:4K1R|rcsb pdb:4K7S|rcsb pdb:4K7U|rcsb pdb:4K7W|rcsb pdb:4KSK|rcsb pdb:4KSL|rcsb pdb:4LCD|rcsb pdb:4LDT|rcsb pdb:4MDK|rcsb pdb:4MM3|rcsb pdb:4MSM|rcsb pdb:4MSQ|rcsb pdb:4NQK|rcsb pdb:4UN2|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZP|rcsb pdb:4XOK|rcsb pdb:4XOL|rcsb pdb:4ZQS|rcsb pdb:5A5B|rcsb pdb:5AF4|rcsb pdb:5AF5|rcsb pdb:5AF6|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5B83|rcsb pdb:5C7J|rcsb pdb:5C7M|rcsb pdb:5E6J|rcsb pdb:5H07|rcsb pdb:5NL4|rcsb pdb:5NLF|rcsb pdb:5NLI|rcsb pdb:5NMC|rcsb pdb:5OE7|rcsb pdb:5OHV|rcsb pdb:5OXH|rcsb pdb:5OXI|rcsb pdb:5UDH|rcsb pdb:5WQ4|rcsb pdb:5ZQ3|rcsb pdb:5ZQ4|rcsb pdb:5ZQ5|rcsb pdb:5ZQ6|rcsb pdb:5ZQ7|rcsb pdb:6A43|rcsb pdb:6A44|rcsb pdb:6AQR|rcsb pdb:6B7M|rcsb pdb:6B7O|rcsb pdb:6K2U|rcsb pdb:6KBE|rcsb pdb:6N13|rcsb pdb:6N6R|rcsb pdb:6NQA|rcsb pdb:6NXK|rcsb pdb:6OI4|rcsb pdb:6P5B|rcsb pdb:6Q00|rcsb pdb:6QML|rcsb pdb:6RYA|rcsb pdb:6S53|rcsb pdb:6SQR|rcsb pdb:6T7F|rcsb pdb:6T9L|rcsb pdb:6TNF|rcsb pdb:6TTU|rcsb pdb:6TUV|rcsb pdb:6TXB|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6EQI|rcsb pdb:6UMS|rcsb pdb:6UPU|rcsb pdb:6V5D|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:6VEN|rcsb pdb:6W9D|rcsb pdb:6W9R|rcsb pdb:6W9S|rcsb pdb:6WJD|rcsb pdb:6WKR|rcsb pdb:6WTG|rcsb pdb:6Z7V|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|rcsb pdb:7K6P|rcsb pdb:7K6Q|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|refseq:NP_066289.3	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:BM+LHQXjMaUn8RZfq1h9jsAAqcs9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:6AlhQxRIys7KWlwI/BP2VGrZ5I4	false	sufficient binding region:1-137|sufficient binding region:309-321|sufficient binding region:452-475	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02647	uniprotkb:Q7Z569	intact:EBI-701692|uniprotkb:Q6LDN9|uniprotkb:Q6Q785|uniprotkb:A8K866|uniprotkb:Q9UCS8|uniprotkb:Q9UCT8|ensembl:ENSP00000236850|ensembl:ENSP00000352471|ensembl:ENSP00000364469|ensembl:ENSP00000364472	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:apoa1_human(display_long)|uniprotkb:APOA1(gene name)|psi-mi:APOA1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818303|imex:IM-24158-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000030.1|refseq:NP_001304946.1|refseq:NP_001304947.1|refseq:NP_001304950.1|dip:DIP-29619N|ensembl:ENSG00000118137(gene)|ensembl:ENST00000236850(transcript)|ensembl:ENST00000359492(transcript)|ensembl:ENST00000375320(transcript)|ensembl:ENST00000375323(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02647|rcsb pdb:1AV1|rcsb pdb:1GW3|rcsb pdb:1GW4|rcsb pdb:1ODP|rcsb pdb:1ODQ|rcsb pdb:1ODR|rcsb pdb:2MSC|rcsb pdb:2MSD|rcsb pdb:2MSE|rcsb pdb:2N5E|rcsb pdb:3K2S|rcsb pdb:3R2P|rcsb pdb:4V6M|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CLZ|rcsb pdb:6CM1|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:7KJR|reactome:R-HSA-114608|reactome:R-HSA-1369062|reactome:R-HSA-1989781|reactome:R-HSA-2168880|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-5682113|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963896|reactome:R-HSA-8963901|reactome:R-HSA-8964011|reactome:R-HSA-8964058|reactome:R-HSA-9707616|reactome:R-HSA-975634|reactome:R-HSA-977225	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:yEzPDeU8Uu/43dkLLOBAy6ey1vs9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:qTczZYK4Ew2+EUp7C8fsYAAaedg	false	sufficient binding region:85-228	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14980	uniprotkb:Q7Z569	intact:EBI-521611|intact:EBI-28985993|ensembl:ENSP00000377298|uniprotkb:Q14981|uniprotkb:H0YH75|uniprotkb:Q9BTE9	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:numa1_human(display_long)|uniprotkb:SP-H antigen(gene name synonym)|uniprotkb:NUMA1(gene name)|psi-mi:NUMA1(display_short)|uniprotkb:NUMA(gene name synonym)|uniprotkb:NMP22(gene name synonym)|uniprotkb:Nuclear matrix protein-22(gene name synonym)|uniprotkb:Nuclear mitotic apparatus protein(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818312|imex:IM-24158-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137497(gene)|ensembl:ENST00000393695(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_006176.2|refseq:NP_001273490.1|refseq:XP_006718627.1|dip:DIP-32937N|ensembl:ENST00000351960|ensembl:ENSP00000260051|ensembl:ENST00000358965|ensembl:ENSP00000351851|ensembl:ENSP00000377298|ensembl:ENST00000613205|ensembl:ENSP00000480172|ensembl:ENST00000620566|ensembl:ENSP00000478624|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0006997"(nucleus organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0055028"(cortical microtubule)|go:"GO:0055048"(anastral spindle assembly)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061673"(mitotic spindle astral microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097427"(microtubule bundle)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0099738"(cell cortex region)|go:"GO:1902365"(positive regulation of protein localization to spindle pole body)|go:"GO:1902846"(positive regulation of mitotic spindle elongation)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|go:"GO:1905720"(cytoplasmic microtubule bundle)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:1905832"(positive regulation of spindle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR026650|mint:Q14980|rcsb pdb:3RO2|rcsb pdb:5GXW|rcsb pdb:6HC2|rcsb pdb:6QJA|reactome:R-HSA-380320|reactome:R-HSA-68875	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:goAKbcTz6vzGy3T7RlpGPnTCbdk9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:fnOgA0saUWYUSagPQk0ZNwazZCA	false	sufficient binding region:857-923	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WXH0	uniprotkb:Q7Z569	intact:EBI-2372294|uniprotkb:Q540G1|uniprotkb:Q8N1S3|uniprotkb:Q8NF49|uniprotkb:Q8TER7|uniprotkb:Q8WWW3|uniprotkb:Q8WWW4|uniprotkb:Q8WWW5|uniprotkb:Q8WXH1|uniprotkb:Q9NU50|uniprotkb:Q9UFQ4|uniprotkb:Q9Y2L4|uniprotkb:Q9Y4R1|uniprotkb:Q86YP9|uniprotkb:B4DND7|uniprotkb:B4DPR6|uniprotkb:I6XXQ5|ensembl:ENSP00000341781	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:syne2_human(display_long)|uniprotkb:SYNE2(gene name)|psi-mi:SYNE2(display_short)|uniprotkb:KIAA1011(gene name synonym)|uniprotkb:NUA(gene name synonym)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818497|imex:IM-24158-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344528|ensembl:ENSP00000341781|ensembl:ENST00000358025|ensembl:ENSP00000350719|ensembl:ENST00000458046|ensembl:ENSP00000391937|ensembl:ENST00000555002|ensembl:ENSP00000450831|ensembl:ENST00000341472|refseq:NP_055995.4|refseq:NP_878914.1|refseq:NP_878917.1|refseq:NP_878918.2|dip:DIP-53409N|ensembl:ENSG00000054654(gene)|ensembl:ENST00000344113(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|interpro:IPR030266|interpro:IPR036872|rcsb pdb:4DXS|rcsb pdb:4FI9|rcsb pdb:6XF1|reactome:R-HSA-1221632	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:wLHWOXR+dUHkcs93g+F2av/9wm49606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:FMILnd7g+/CqbPm9TpSZeVxAbac	false	sufficient binding region:5986-6126	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WUW1	uniprotkb:Q7Z569	intact:EBI-2837444|uniprotkb:Q9P082|uniprotkb:B2R5E2|ensembl:ENSP00000432472	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:brk1_human(display_long)|uniprotkb:C3orf10(gene name synonym)|uniprotkb:BRK1(gene name)|psi-mi:BRK1(display_short)|uniprotkb:HSPC300(orf name)|uniprotkb:MDS027(orf name)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818505|imex:IM-24158-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060932.2|dip:DIP-41554N|ensembl:ENSG00000254999(gene)|ensembl:ENST00000530758(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:IZ0oK9Z3VxULlM+igusbB5mwyyo9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:NZinJSGHBMWBZPYP3gMUe6nJ4cg	false	sufficient binding region:24-75	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8IYK2	uniprotkb:Q7Z569	intact:EBI-10818513|uniprotkb:Q8N7T5|uniprotkb:Q8NDL5|ensembl:ENSP00000292574	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:cc105_human(display_long)|uniprotkb:CCDC105(gene name)|psi-mi:CCDC105(display_short)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818524|imex:IM-24158-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775753.2|ensembl:ENSG00000160994(gene)|ensembl:ENST00000292574(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR038949	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:P9jNykN9SwuauATnpu0dLT57gEg9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:Z8vek6mpZnHZiyN4ckTJBCADEZk	false	sufficient binding region:181-348	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BZQ2	uniprotkb:Q7Z569	intact:EBI-10818532|uniprotkb:Q4G195|uniprotkb:Q9BZQ3|uniprotkb:Q9H2B6|ensembl:ENSP00000356518	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:shp1l_human(display_long)|uniprotkb:SHCBP1L(gene name)|psi-mi:SHCBP1L(display_short)|uniprotkb:C1orf14(gene name synonym)|uniprotkb:SHC SH2 domain-binding protein 1-like protein(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818548|imex:IM-24158-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112195.2|ensembl:ENSG00000157060(gene)|ensembl:ENST00000367547(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0072687"(meiotic spindle)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR006633(Carbohydrate-binding and sugar hydrolysis)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448|refseq:NP_001332857.1	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2016/11/30	rogid:w3DH/+0ykQlTMqg2jVjzVcCMj9Y9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:WRiqTEOxAoy+HVcFLdzue8x2Y7o	false	sufficient binding region:?-?	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5T0J7	uniprotkb:Q7Z569	intact:EBI-8465719|intact:MINT-4725644|uniprotkb:Q5T0J8|uniprotkb:Q8IYU6|uniprotkb:Q8NA15|uniprotkb:Q8N7Z1|uniprotkb:Q5T0J9|uniprotkb:Q9H0Q7|ensembl:ENSP00000323795	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:tex35_human(display_long)|uniprotkb:TEX35(gene name)|psi-mi:TEX35(display_short)|uniprotkb:C1orf49(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818556|imex:IM-24158-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115502.2|refseq:NP_001164193.1|refseq:NP_001164195.1|refseq:NP_001164194.1|ensembl:ENSG00000240021(gene)|ensembl:ENST00000319416(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR027874|mint:Q5T0J7	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	comment:mint|comment:homomint	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/11	rogid:TA6VPdPzrbHVKewIwrXBdfZarTg9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:56vbdBwRlGh9Xjy8KmHdjMVMdhI	false	sufficient binding region:19-233	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:Q7Z569	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820449|imex:IM-24158-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:MNrg2i92zwiUkPfEK1ZUO0eZbos	false	sufficient binding region:699-833	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O60346	uniprotkb:Q7Z569	intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820458|imex:IM-24158-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:m3q9qJ1AP0hzYHZBaB24ZHbi0n4	false	sufficient binding region:1-137	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8NB25	uniprotkb:Q7Z569	intact:EBI-9917523|uniprotkb:B9DI75|uniprotkb:Q5TBS9|uniprotkb:Q96GY8|uniprotkb:Q9H851|uniprotkb:Q7Z323|uniprotkb:Q9H0J8|uniprotkb:F8W8D6|ensembl:ENSP00000342604	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:f184a_human(display_long)|uniprotkb:C6orf60(gene name synonym)|uniprotkb:FAM184A(gene name)|psi-mi:FAM184A(display_short)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820467|imex:IM-24158-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093881.1|refseq:NP_001275505.1|refseq:NP_078857.5|ensembl:ENSG00000111879(gene)|ensembl:ENST00000338891(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR029605|interpro:IPR029607|interpro:IPR039478	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:A9gX4FWK+lMGWE31zzMr1cszuHg9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:Kau2+QxIqbzYwxCwxcCp+0sloT4	false	sufficient binding region:483-612	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NVF7	uniprotkb:Q7Z569	intact:EBI-740282|uniprotkb:O75070|ensembl:ENSP00000355827|uniprotkb:E9PEM8	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:fbx28_human(display_long)|uniprotkb:FBXO28(gene name)|psi-mi:FBXO28(display_short)|uniprotkb:KIAA0483(gene name synonym)|uniprotkb:CENP-30(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820479|imex:IM-24158-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055991.1|ensembl:ENSG00000143756(gene)|ensembl:ENST00000366862(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0042802"(identical protein binding)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR039719|refseq:NP_001129587.1|dip:DIP-56683N	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:Iz7yI5ugv60KqYH7MAdBjXjw2vs9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:2esKxk+pknZy+HxzRq5fJtW2HHE	false	sufficient binding region:51-338	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q969G3	uniprotkb:Q7Z569	intact:EBI-455078|uniprotkb:O43539|uniprotkb:C0IMW4|uniprotkb:B3KMC1|uniprotkb:B4DFR4|uniprotkb:C0IMW5|uniprotkb:C0IMW7|uniprotkb:H7C3F6|ensembl:ENSP00000323967|ensembl:ENSP00000496094	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:smce1_human(display_long)|uniprotkb:BRG1-associated factor 57(gene name synonym)|uniprotkb:SMARCE1(gene name)|psi-mi:SMARCE1(display_short)|uniprotkb:BAF57(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820488|imex:IM-24158-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003070.3|dip:DIP-27614N|dip:DIP-33041N|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR030089|interpro:IPR036910|mint:Q969G3|rcsb pdb:6LTH|rcsb pdb:6LTJ|rcsb pdb:7CYU|reactome:R-HSA-3214858|reactome:R-HSA-8939243|ensembl:ENSG00000073584(gene)|ensembl:ENST00000348513(transcript)|ensembl:ENST00000643683(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/10/08	rogid:wf7PrAelShE+8xAwb/UdWKWDkyE9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:Q+05ouSbpxg1svumi1GGo0e11NU	false	sufficient binding region:36-277	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H799	uniprotkb:Q7Z569	intact:EBI-2811541|uniprotkb:Q9H5T1|uniprotkb:Q8N8L4|uniprotkb:Q4G174|uniprotkb:Q9H8T9|ensembl:ENSP00000421690|intact:EBI-3261532|uniprotkb:A8MUB7|uniprotkb:B7ZLV7|uniprotkb:Q6DK46	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:cpln1_human(display_long)|uniprotkb:C5orf42(gene name synonym)|uniprotkb:JBTS17(gene name synonym)|uniprotkb:Protein JBTS17(gene name synonym)|uniprotkb:CPLANE1(gene name)|psi-mi:CPLANE1(display_short)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820497|imex:IM-24158-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197603(gene)|ensembl:ENST00000508244(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0060271"(cilium assembly)|interpro:IPR028236|interpro:IPR036322|mint:Q9H799|refseq:NP_075561.3	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:8zhawWxiqpQM34EraNekNaz/N/o9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:AHkHZEPWO9rY4EZIdufDRuPq8H0	false	sufficient binding region:2000-2043	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96SR6	uniprotkb:Q7Z569	intact:EBI-10820535|uniprotkb:A3KMP6|uniprotkb:A8MT55|uniprotkb:C9K0V5|uniprotkb:Q53ZY8|uniprotkb:Q5JPJ2|ensembl:ENSP00000292928	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:zn382_human(display_long)|uniprotkb:KRAB/zinc finger suppressor protein 1(gene name synonym)|uniprotkb:Multiple zinc finger and krueppel-associated box protein KS1(gene name synonym)|uniprotkb:ZNF382(gene name)|psi-mi:ZNF382(display_short)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820563|imex:IM-24158-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243767.1|refseq:NP_116214.2|ensembl:ENSG00000161298(gene)|ensembl:ENST00000292928(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:FysnX8DD5JWhzNkZ4nV+F2QpnIg9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:pHdNxq3gD4lz4fBBD5wuIUT4R8k	false	sufficient binding region:161-365	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96JC4	uniprotkb:Q7Z569	intact:EBI-10820574|ensembl:ENSP00000324518|ensembl:ENSP00000333776	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:zn479_human(display_long)|uniprotkb:Zinc finger protein Kr19(gene name synonym)|uniprotkb:ZNF479(gene name)|psi-mi:ZNF479(display_short)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820595|imex:IM-24158-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150376.1|refseq:XP_011513906.1|refseq:XP_011513910.1|ensembl:ENSG00000185177(gene)|ensembl:ENST00000319636(transcript)|ensembl:ENST00000331162(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436|refseq:XP_016868266.1	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:pGRl8FXTfmfJGPNYJ9EUiBVW69U9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:lg2xzNPFDexs+MMYoeZEftUgIFk	false	sufficient binding region:248-458	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75969	uniprotkb:Q7Z569	intact:EBI-9033101|uniprotkb:O75945|uniprotkb:Q86X01|uniprotkb:Q9UM61|ensembl:ENSP00000228850|ensembl:ENSP00000440994	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:akap3_human(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:SOB1(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Cancer/testis antigen 82(gene name synonym)|uniprotkb:Fibrous sheath protein of 95 kDa(gene name synonym)|uniprotkb:Fibrousheathin I(gene name synonym)|uniprotkb:Fibrousheathin-1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:Sperm oocyte-binding protein(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820646|imex:IM-24158-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519210.1|refseq:XP_011519211.1|refseq:XP_011519212.1|refseq:NP_001265238.1|refseq:NP_006413.3|refseq:XP_005253721.1|ensembl:ENSG00000111254(gene)|ensembl:ENST00000228850(transcript)|ensembl:ENST00000545990(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008104"(protein localization)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:EInmydTsabZBmiDEYQRofcg4zy49606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:FaHhg3uU0Z4+4yIuCOTzXCtaAGE	false	sufficient binding region:772-853	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z569	uniprotkb:Q7Z569	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820655|imex:IM-24158-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:bBR6h+EPAdpvASL/gXJRelHpdn0	false	sufficient binding region:107-350|sufficient binding region:454-592	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9HCD6	uniprotkb:Q7Z569	intact:EBI-7954108|uniprotkb:Q9NW88|uniprotkb:Q9HAC3|uniprotkb:Q9NXY9|intact:MINT-7945062|uniprotkb:Q9ULS2|ensembl:ENSP00000387593	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:tanc2_human(display_long)|uniprotkb:TANC2(gene name)|psi-mi:TANC2(display_short)|uniprotkb:KIAA1148(gene name synonym)|uniprotkb:KIAA1636(gene name synonym)|uniprotkb:Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820666|imex:IM-24158-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079461.2|refseq:XP_005257260.1|ensembl:ENSG00000170921(gene)|ensembl:ENST00000424789(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0099519"(dense core granule cytoskeletal transport)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	comment:mint|comment:homomint	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:S8hh+VooYXTnBPORuFNVVfh1YpQ9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:2KN/IA6hOYableOZD7C9IOapv9Y	false	sufficient binding region:1257-1450	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NTZ6	uniprotkb:Q7Z569	intact:EBI-310707|uniprotkb:E1P5R6|uniprotkb:B3KRU2|uniprotkb:O94865|uniprotkb:Q8N3B1|uniprotkb:Q9H196|ensembl:ENSP00000352668|ensembl:ENSP00000363217|ensembl:ENSP00000363228	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:rbm12_human(display_long)|uniprotkb:HRIHFB2091(orf name)|uniprotkb:RBM12(gene name)|psi-mi:RBM12(display_short)|uniprotkb:KIAA0765(gene name synonym)|uniprotkb:RNA-binding motif protein 12(gene name synonym)|uniprotkb:SH3/WW domain anchor protein in the nucleus(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820675|imex:IM-24158-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185767.1|refseq:NP_001185769.1|refseq:NP_006038.2|refseq:NP_690051.1|ensembl:ENSG00000244462(gene)|ensembl:ENST00000359646(transcript)|ensembl:ENST00000374104(transcript)|ensembl:ENST00000374114(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034591|interpro:IPR034594|interpro:IPR034854|interpro:IPR034855|interpro:IPR034856|interpro:IPR035979|mint:Q9NTZ6|rcsb pdb:1WEL|rcsb pdb:2CPY|rcsb pdb:2DNN|rcsb pdb:2EK1|rcsb pdb:2EK6	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:Hcz7OUumWYuRnRNMjwFYUZBquVo9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:lGygtpbYHvxvQbagVq8iAt7yg+0	false	sufficient binding region:826-924(IPR000504)	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43313	uniprotkb:Q7Z569	intact:EBI-7422202|uniprotkb:Q68DC9|intact:MINT-4979558|uniprotkb:A8K4H8|intact:EBI-28977639|ensembl:ENSP00000299575	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:atmin_human(display_long)|uniprotkb:ATMIN(gene name)|psi-mi:ATMIN(display_short)|uniprotkb:KIAA0431(gene name synonym)|uniprotkb:ZNF822(gene name synonym)|uniprotkb:ATM/ATR-substrate CHK2-interacting zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 822(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820685|imex:IM-24158-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287657.1|ensembl:ENSP00000299575|ensembl:ENST00000564241|ensembl:ENSP00000463478|ensembl:ENST00000566488|ensembl:ENSP00000455497|refseq:NP_056066.2|ensembl:ENSG00000166454(gene)|ensembl:ENST00000299575(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|mint:O43313	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	comment:mint	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:p99DnqqtJ+KEO7xudwlxSTkLwXM9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:IDAZJ4FJPnDsx9qukMMeCTtuuLU	false	sufficient binding region:59-206	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5VVM6	uniprotkb:Q7Z569	intact:EBI-10820694|uniprotkb:Q14F06|uniprotkb:Q5VVM5|ensembl:ENSP00000339280|ensembl:ENSP00000397035	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:ccd30_human(display_long)|uniprotkb:CCDC30(gene name)|psi-mi:CCDC30(display_short)|uniprotkb:PFDN6L(gene name synonym)|uniprotkb:Prefoldin subunit 6-like protein(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820712|imex:IM-24158-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074319.1|refseq:XP_011540369.1|refseq:XP_011540370.1|ensembl:ENSG00000186409(gene)|ensembl:ENST00000342022(transcript)|ensembl:ENST00000428554(transcript)|interpro:IPR031476|refseq:XP_016857714.1|refseq:XP_016857715.1	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/05/15	rogid:28dN0erHHMUcmTNDdAXuHWp10pM9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:oTqiOfDw7g3O7ctti5eLsX03D04	false	sufficient binding region:448-783	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96K83	uniprotkb:Q7Z569	intact:EBI-6597673|ensembl:ENSP00000354794|ensembl:ENSP00000440768|uniprotkb:A3QVP7|uniprotkb:B0YJB7|uniprotkb:Q8IXI0|uniprotkb:Q8TES6|uniprotkb:Q9C065|uniprotkb:Q9HAL5|uniprotkb:Q9UFK4	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:zn521_human(display_long)|uniprotkb:ZNF521(gene name)|psi-mi:ZNF521(display_short)|uniprotkb:EHZF(gene name synonym)|uniprotkb:LIP3(gene name synonym)|uniprotkb:Early hematopoietic zinc finger protein(gene name synonym)|uniprotkb:LYST-interacting protein 3(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11297295|imex:IM-24158-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-8940973|ensembl:ENST00000538137(transcript)|ensembl:ENSG00000198795(gene)|ensembl:ENST00000361524(transcript)|refseq:NP_001295154.1|refseq:NP_056276.1|refseq:XP_011524213.1|refseq:XP_016881187.1	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/10/08	rogid:fD/EObMotuA/LJSsMV7rjwNgZX09606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:jC2w1IHyLQZgcqAVns1nB+fR+e4	false	sufficient binding region:44-336	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NP66	uniprotkb:Q7Z569	intact:EBI-740641|ensembl:ENSP00000336856|ensembl:ENSP00000371133|uniprotkb:A6NHY3|uniprotkb:Q53G31|uniprotkb:Q9NSF6|uniprotkb:D3DW78	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:hm20a_human(display_long)|uniprotkb:HMG box-containing protein 20A(gene name synonym)|uniprotkb:HMG domain-containing protein HMGX1(gene name synonym)|uniprotkb:HMG20A(gene name)|psi-mi:HMG20A(display_short)|uniprotkb:HMGX1(gene name synonym)|uniprotkb:HMGXB1(gene name synonym)|uniprotkb:HMG domain-containing protein 1(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11297304|imex:IM-24158-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060670.1|ensembl:ENSG00000140382(gene)|ensembl:ENST00000336216(transcript)|ensembl:ENST00000381714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q9NP66|refseq:NP_001291433.1|refseq:NP_001291434.1|refseq:XP_011519460.1	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/11	2015/10/08	rogid:LhilayeP+xv97pbYzIA8yMvwUbc9606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:1g7NKh1RwmSk+4SdkSCLRiGLFHU	false	sufficient binding region:6-314	sufficient binding region:343-592	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHE4	uniprotkb:Q99MP8	intact:EBI-8039777|intact:MINT-5315081|uniprotkb:Q6PCN0|uniprotkb:Q8QZU8|uniprotkb:Q8R5E5|uniprotkb:Q99KL6|ensembl:ENSMUSP00000056530	intact:EBI-10818333|ensembl:ENSMUSP00000031414|uniprotkb:Q8CC00|uniprotkb:Q8CHX1|uniprotkb:Q99MP7|uniprotkb:Q9CXX8	psi-mi:phlp1_mouse(display_long)|uniprotkb:Phlpp1(gene name)|psi-mi:Phlpp1(display_short)|uniprotkb:Kiaa0606(gene name synonym)|uniprotkb:Phlpp(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Plekhe1(gene name synonym)|uniprotkb:Scop(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym)	psi-mi:brap_mouse(display_long)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:Brap(gene name)|psi-mi:Brap(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818370|imex:IM-24158-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598582.3|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|reactome:R-MMU-199418|go:"GO:1900744"(regulation of p38MAPK cascade)|ensembl:ENSMUSG00000044340(gene)|ensembl:ENSMUST00000061047(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0090038"(negative regulation of protein kinase C signaling)|go:"GO:0106306"|go:"GO:0106307"	ensembl:ENSMUSG00000029458(gene)|ensembl:ENSMUST00000031414(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-MMU-5673000|reactome:R-MMU-5675221|refseq:NP_001276473.1|refseq:NP_082503.2|refseq:XP_006530532.1	-	function:Protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. May act as a negative regulator of K-Ras signaling in the membrane rafts|comment:mint	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2015/05/11	2015/05/11	rogid:HZtxUA76RTTwKVkcfzlH8RSv7vo10090	rogid:byVqFwRh4Meqr8/1Du0FznKaK/Y10090	rigid:jB6oiDGFfoxCDSmxeLx+29yUfso	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88987	uniprotkb:Q99MP8	intact:EBI-9033539|uniprotkb:Q497M9|ensembl:ENSMUSP00000093091|ensembl:ENSMUSP00000143794|ensembl:ENSMUSP00000144405	intact:EBI-10818333|ensembl:ENSMUSP00000031414|uniprotkb:Q8CC00|uniprotkb:Q8CHX1|uniprotkb:Q99MP7|uniprotkb:Q9CXX8	psi-mi:akap3_mouse(display_long)|uniprotkb:Akap3(gene name)|psi-mi:Akap3(display_short)|uniprotkb:Akap110(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)	psi-mi:brap_mouse(display_long)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:Brap(gene name)|psi-mi:Brap(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818376|imex:IM-24158-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033780.2|ensembl:ENSMUSG00000030344(gene)|ensembl:ENSMUST00000095440(transcript)|ensembl:ENSMUST00000202574(transcript)|ensembl:ENSMUST00000202878(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0008104"(protein localization)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	ensembl:ENSMUSG00000029458(gene)|ensembl:ENSMUST00000031414(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-MMU-5673000|reactome:R-MMU-5675221|refseq:NP_001276473.1|refseq:NP_082503.2|refseq:XP_006530532.1	-	-	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2015/05/11	2015/05/11	rogid:jG+5Gjkz6rF8vIz3hr1dnHzhjOI10090	rogid:byVqFwRh4Meqr8/1Du0FznKaK/Y10090	rigid:WJn4MdXHjYJXEmDtI1wZZ8MOf04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13864	uniprotkb:Q99MP8	intact:EBI-301927|uniprotkb:Q80ZU3|uniprotkb:Q9CSC6|uniprotkb:P97413|uniprotkb:Q9QXX6|ensembl:ENSMUSP00000004202	intact:EBI-10818333|ensembl:ENSMUSP00000031414|uniprotkb:Q8CC00|uniprotkb:Q8CHX1|uniprotkb:Q99MP7|uniprotkb:Q9CXX8	psi-mi:dnmt1_mouse(display_long)|uniprotkb:Dnmt1(gene name)|psi-mi:Dnmt1(display_short)|uniprotkb:Dnmt(gene name synonym)|uniprotkb:Met1(gene name synonym)|uniprotkb:Uim(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase MmuI(gene name synonym)	psi-mi:brap_mouse(display_long)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:Brap(gene name)|psi-mi:Brap(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818380|imex:IM-24158-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186360.2|refseq:NP_001186361.1|refseq:NP_001186362.1|refseq:NP_034196.5|interpro:IPR031303|interpro:IPR043151|mint:P13864|rcsb pdb:3AV4|rcsb pdb:3AV5|rcsb pdb:3AV6|rcsb pdb:3PT6|rcsb pdb:3PT9|rcsb pdb:4DA4|rcsb pdb:5GUT|rcsb pdb:5GUV|rcsb pdb:5WY1|rcsb pdb:6W8V|rcsb pdb:6W8W|reactome:R-MMU-212300|reactome:R-MMU-4655427|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|ensembl:ENSMUST00000004202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0044026"(DNA hypermethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046500"(S-adenosylmethionine metabolic process)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:0016458"(obsolete gene silencing)|ensembl:ENSMUSG00000004099(gene)|refseq:NP_001300940.1	ensembl:ENSMUSG00000029458(gene)|ensembl:ENSMUST00000031414(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-MMU-5673000|reactome:R-MMU-5675221|refseq:NP_001276473.1|refseq:NP_082503.2|refseq:XP_006530532.1	-	-	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2015/05/11	2015/05/11	rogid:JgHTnDhDn4nuU6ww3jXfDPq01xY10090	rogid:byVqFwRh4Meqr8/1Du0FznKaK/Y10090	rigid:6imCa15C/AwWHnS1rWnuY1C7uIg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99MP8	uniprotkb:Q8CHE4-1	intact:EBI-10818333|ensembl:ENSMUSP00000031414|uniprotkb:Q8CC00|uniprotkb:Q8CHX1|uniprotkb:Q99MP7|uniprotkb:Q9CXX8	intact:EBI-11297314|ensembl:ENSMUSP00000056530	psi-mi:brap_mouse(display_long)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:Brap(gene name)|psi-mi:Brap(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:q8che4-1(display_long)|uniprotkb:Phlpp1(gene name)|psi-mi:Phlpp1(display_short)|uniprotkb:Kiaa0606(gene name synonym)|uniprotkb:Phlpp(gene name synonym)|uniprotkb:Plekhe1(gene name synonym)|uniprotkb:Scop(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym)|uniprotkb:beta(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818384|imex:IM-24158-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029458(gene)|ensembl:ENSMUST00000031414(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-MMU-5673000|reactome:R-MMU-5675221|refseq:NP_001276473.1|refseq:NP_082503.2|refseq:XP_006530532.1	intact:EBI-8039777(isoform-parent)|ensembl:ENSMUSG00000044340(gene)|ensembl:ENSMUST00000061047(transcript)	-	-	-	figure legend:Fig 2A|comment:Isoforms of Phlpp1 are identified by molecular weight difference, following binding by a common antibody.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2015/05/11	2015/10/08	rogid:byVqFwRh4Meqr8/1Du0FznKaK/Y10090	rogid:HZtxUA76RTTwKVkcfzlH8RSv7vo10090	rigid:aPcR5RVMGjbn3TNItyXY11OfsJk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99MP8	uniprotkb:O88987	intact:EBI-10818333|ensembl:ENSMUSP00000031414|uniprotkb:Q8CC00|uniprotkb:Q8CHX1|uniprotkb:Q99MP7|uniprotkb:Q9CXX8	intact:EBI-9033539|uniprotkb:Q497M9|ensembl:ENSMUSP00000093091|ensembl:ENSMUSP00000143794|ensembl:ENSMUSP00000144405	psi-mi:brap_mouse(display_long)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:Brap(gene name)|psi-mi:Brap(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:akap3_mouse(display_long)|uniprotkb:Akap3(gene name)|psi-mi:Akap3(display_short)|uniprotkb:Akap110(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818384|imex:IM-24158-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029458(gene)|ensembl:ENSMUST00000031414(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-MMU-5673000|reactome:R-MMU-5675221|refseq:NP_001276473.1|refseq:NP_082503.2|refseq:XP_006530532.1	refseq:NP_033780.2|ensembl:ENSMUSG00000030344(gene)|ensembl:ENSMUST00000095440(transcript)|ensembl:ENSMUST00000202574(transcript)|ensembl:ENSMUST00000202878(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0008104"(protein localization)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	-	-	-	figure legend:Fig 2A|comment:Isoforms of Phlpp1 are identified by molecular weight difference, following binding by a common antibody.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2015/05/11	2015/10/08	rogid:byVqFwRh4Meqr8/1Du0FznKaK/Y10090	rogid:jG+5Gjkz6rF8vIz3hr1dnHzhjOI10090	rigid:aPcR5RVMGjbn3TNItyXY11OfsJk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99MP8	uniprotkb:Q8CHE4-2	intact:EBI-10818333|ensembl:ENSMUSP00000031414|uniprotkb:Q8CC00|uniprotkb:Q8CHX1|uniprotkb:Q99MP7|uniprotkb:Q9CXX8	intact:EBI-11297325	psi-mi:brap_mouse(display_long)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:Brap(gene name)|psi-mi:Brap(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:q8che4-2(display_long)|uniprotkb:Phlpp1(gene name)|psi-mi:Phlpp1(display_short)|uniprotkb:Kiaa0606(gene name synonym)|uniprotkb:Phlpp(gene name synonym)|uniprotkb:Plekhe1(gene name synonym)|uniprotkb:Scop(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym)|uniprotkb:alpha(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818384|imex:IM-24158-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029458(gene)|ensembl:ENSMUST00000031414(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-MMU-5673000|reactome:R-MMU-5675221|refseq:NP_001276473.1|refseq:NP_082503.2|refseq:XP_006530532.1	intact:EBI-8039777(isoform-parent)	-	-	-	figure legend:Fig 2A|comment:Isoforms of Phlpp1 are identified by molecular weight difference, following binding by a common antibody.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2015/05/11	2015/10/08	rogid:byVqFwRh4Meqr8/1Du0FznKaK/Y10090	rogid:Mwfps3zmJw0QFeK2hhTk9bdtKQM10090	rigid:aPcR5RVMGjbn3TNItyXY11OfsJk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z569	uniprotkb:O60346-1	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	intact:EBI-11297338|ensembl:ENSP00000262719	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:o60346-1(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym)|uniprotkb:beta(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818398|imex:IM-24158-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|intact:EBI-2511516(isoform-parent)	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/05/11	2015/10/08	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606	rigid:m3q9qJ1AP0hzYHZBaB24ZHbi0n4	false	sufficient binding region:343-592|green fluorescent protein tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75969	uniprotkb:Q7Z569	intact:EBI-9033101|uniprotkb:O75945|uniprotkb:Q86X01|uniprotkb:Q9UM61|ensembl:ENSP00000228850|ensembl:ENSP00000440994	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:akap3_human(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:SOB1(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Cancer/testis antigen 82(gene name synonym)|uniprotkb:Fibrous sheath protein of 95 kDa(gene name synonym)|uniprotkb:Fibrousheathin I(gene name synonym)|uniprotkb:Fibrousheathin-1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:Sperm oocyte-binding protein(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818418|imex:IM-24158-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519210.1|refseq:XP_011519211.1|refseq:XP_011519212.1|refseq:NP_001265238.1|refseq:NP_006413.3|refseq:XP_005253721.1|ensembl:ENSG00000111254(gene)|ensembl:ENST00000228850(transcript)|ensembl:ENST00000545990(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008104"(protein localization)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/05/11	2015/05/11	rogid:EInmydTsabZBmiDEYQRofcg4zy49606	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:FaHhg3uU0Z4+4yIuCOTzXCtaAGE	false	glutathione s tranferase tag:?-?	sufficient binding region:343-592|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P13864	uniprotkb:Q7Z569	intact:EBI-301927|uniprotkb:Q80ZU3|uniprotkb:Q9CSC6|uniprotkb:P97413|uniprotkb:Q9QXX6|ensembl:ENSMUSP00000004202	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	psi-mi:dnmt1_mouse(display_long)|uniprotkb:Dnmt1(gene name)|psi-mi:Dnmt1(display_short)|uniprotkb:Dnmt(gene name synonym)|uniprotkb:Met1(gene name synonym)|uniprotkb:Uim(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase MmuI(gene name synonym)	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820726|imex:IM-24158-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186360.2|refseq:NP_001186361.1|refseq:NP_001186362.1|refseq:NP_034196.5|interpro:IPR031303|interpro:IPR043151|mint:P13864|rcsb pdb:3AV4|rcsb pdb:3AV5|rcsb pdb:3AV6|rcsb pdb:3PT6|rcsb pdb:3PT9|rcsb pdb:4DA4|rcsb pdb:5GUT|rcsb pdb:5GUV|rcsb pdb:5WY1|rcsb pdb:6W8V|rcsb pdb:6W8W|reactome:R-MMU-212300|reactome:R-MMU-4655427|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|ensembl:ENSMUST00000004202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0044026"(DNA hypermethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046500"(S-adenosylmethionine metabolic process)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:0016458"(obsolete gene silencing)|ensembl:ENSMUSG00000004099(gene)|refseq:NP_001300940.1	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/05/11	2015/05/15	rogid:JgHTnDhDn4nuU6ww3jXfDPq01xY10090	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rigid:glVpIOepbIG8ESNDlsRoTcFvupQ	false	myc tag:?-?	sufficient binding region:343-592|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z569	uniprotkb:O60346-2	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	intact:EBI-11165225	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:o60346-2(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym)|uniprotkb:alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11297349|imex:IM-24158-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	intact:EBI-2511516(isoform-parent)	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/05/11	2015/10/08	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rogid:eJcvp0jKrqrOdOcFtozARcGD7A09606	rigid:jvceOlP9OVFKWDT9yeHWOtGO0Ag	false	sufficient binding region:343-592|green fluorescent protein tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z569	uniprotkb:O60346	intact:EBI-349900|uniprotkb:O43238|uniprotkb:O75341|ensembl:ENSP00000403524|uniprotkb:B9EGS8|uniprotkb:B4DRM1	intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1	psi-mi:brap_human(display_long)|uniprotkb:BRAP(gene name)|psi-mi:BRAP(display_short)|uniprotkb:RNF52(gene name synonym)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:RING finger protein 52(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818438|imex:IM-24158-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006759.3|ensembl:ENSG00000089234(gene)|ensembl:ENST00000419234(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9649948	ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2	-	-	-	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2015/05/11	2015/05/11	rogid:hk+0eh6wL1csHtwCgLqmX44QSVI9606	rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606	rigid:m3q9qJ1AP0hzYHZBaB24ZHbi0n4	false	sufficient binding region:442-592|red fluorescent protein tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q99MP8	uniprotkb:O88987	intact:EBI-10818333|ensembl:ENSMUSP00000031414|uniprotkb:Q8CC00|uniprotkb:Q8CHX1|uniprotkb:Q99MP7|uniprotkb:Q9CXX8	intact:EBI-9033539|uniprotkb:Q497M9|ensembl:ENSMUSP00000093091|ensembl:ENSMUSP00000143794|ensembl:ENSMUSP00000144405	psi-mi:brap_mouse(display_long)|uniprotkb:BRAP2(gene name synonym)|uniprotkb:Impedes mitogenic signal propagation(gene name synonym)|uniprotkb:Brap(gene name)|psi-mi:Brap(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BRAP2(gene name synonym)	psi-mi:akap3_mouse(display_long)|uniprotkb:Akap3(gene name)|psi-mi:Akap3(display_short)|uniprotkb:Akap110(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Fatima et al. (2014)	pubmed:25820252|imex:IM-24158	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10820788|imex:IM-24158-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029458(gene)|ensembl:ENSMUST00000031414(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011422(BRCA1-associated 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034932|interpro:IPR035979|reactome:R-MMU-5673000|reactome:R-MMU-5675221|refseq:NP_001276473.1|refseq:NP_082503.2|refseq:XP_006530532.1	refseq:NP_033780.2|ensembl:ENSMUSG00000030344(gene)|ensembl:ENSMUST00000095440(transcript)|ensembl:ENSMUST00000202574(transcript)|ensembl:ENSMUST00000202878(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0008104"(protein localization)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-spermatocyte)|taxid:10090(Mus musculus)	-	2015/05/11	2015/05/15	rogid:byVqFwRh4Meqr8/1Du0FznKaK/Y10090	rogid:jG+5Gjkz6rF8vIz3hr1dnHzhjOI10090	rigid:WJn4MdXHjYJXEmDtI1wZZ8MOf04	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)