#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15127-PRO_0000016698	uniprotkb:O88900	intact:EBI-10768746	intact:EBI-7639197|intact:MINT-1347978	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:grb14_rat(display_long)|uniprotkb:Grb14(gene name)|psi-mi:Grb14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768744|imex:IM-24131-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:1904145"(negative regulation of meiotic cell cycle process involved in oocyte maturation)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|rgd:61869|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_113811.1|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|reactome:R-RNO-210993	-	chain-seq-start:764|chain-seq-end:1383	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	figure legend:Table 1|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:GMixEytYmFzuT6Kf3iYWl88a2xE10116	rigid:Q1+cGbEqEqnskBjiZCI0LWZ92eA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P15127-PRO_0000016698	uniprotkb:O35567	intact:EBI-10768746	intact:EBI-10768817|uniprotkb:Q6IN16|ensembl:ENSRNOP00000021105	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:pur9_rat(display_long)|uniprotkb:AICAR transformylase/inosine monophosphate cyclohydrolase(gene name synonym)|uniprotkb:Atic(gene name)|psi-mi:Atic(display_short)|uniprotkb:Purh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768744|imex:IM-24131-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	rgd:70879|refseq:NP_112276.2|go:"GO:0003360"(brainstem development)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|ensembl:ENSRNOG00000015511(gene)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0009259"(ribonucleotide metabolic process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|interpro:IPR036914|mint:O35567|reactome:R-RNO-73817|ensembl:ENSRNOT00000021105(transcript)	-	chain-seq-start:764|chain-seq-end:1383	-	figure legend:Table 1|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:o6Ga1fsJNW74MxIF2YKv6IDc/GQ10116	rigid:Q1+cGbEqEqnskBjiZCI0LWZ92eA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P15127-PRO_0000016698	uniprotkb:Q9WV78	intact:EBI-10768746	intact:EBI-10768752|ensembl:ENSRNOP00000023927	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:plvap_rat(display_long)|uniprotkb:Plasmalemma vesicle protein 1(gene name synonym)|uniprotkb:gp68(gene name synonym)|uniprotkb:Plvap(gene name)|psi-mi:Plvap(display_short)|uniprotkb:Pv1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768744|imex:IM-24131-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	rgd:619971|refseq:NP_064471.1|ensembl:ENSRNOG00000017676(gene)|ensembl:ENSRNOT00000023926(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005901"(caveola)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032502"(developmental process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR009538(PV-1)	-	chain-seq-start:764|chain-seq-end:1383	-	figure legend:Table 1|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:hkspWj/Q1M0DROHUubDjN+/a1zY10116	rigid:Q1+cGbEqEqnskBjiZCI0LWZ92eA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P15127-PRO_0000016698	uniprotkb:Q66H80	intact:EBI-10768746	intact:EBI-10768774|ensembl:ENSRNOP00000072654	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:copd_rat(display_long)|uniprotkb:Archain(gene name synonym)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:Arcn1(gene name)|psi-mi:Arcn1(display_short)|uniprotkb:Copd(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768744|imex:IM-24131-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	rgd:1359110|refseq:NP_001007663.1|ensembl:ENSRNOG00000061108(gene)|ensembl:ENSRNOT00000082687(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015031"(protein transport)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|reactome:R-RNO-6807878|reactome:R-RNO-6811434	-	chain-seq-start:764|chain-seq-end:1383	-	figure legend:Table 1|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:ymFteNg7dWpTOwp4+68/RLC2lA810116	rigid:Q1+cGbEqEqnskBjiZCI0LWZ92eA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P15127-PRO_0000016698	uniprotkb:D4ABI7	intact:EBI-10768746	intact:EBI-10768798|ensembl:ENSRNOP00000045049	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:d4abi7_rat(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:LOC100365676(gene name synonym)|uniprotkb:RGD1565496_predicted(gene name synonym)|uniprotkb:rCG_58140(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768744|imex:IM-24131-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	rgd:1565496|refseq:NP_001100301.1|ensembl:ENSRNOG00000030232(gene)|ensembl:ENSRNOT00000041915(transcript)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|reactome:R-RNO-75876	-	chain-seq-start:764|chain-seq-end:1383	-	figure legend:Table 1|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:xIABaImrR/3ubIB4U/n+TI80T1g10116	rigid:Q1+cGbEqEqnskBjiZCI0LWZ92eA	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P15127-PRO_0000016698	uniprotkb:Q09137	intact:EBI-10768746	intact:EBI-10768927	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:aapk2_rat(display_long)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Prkaa2(gene name)|psi-mi:Prkaa2(display_short)|uniprotkb:Ampk(gene name synonym)|uniprotkb:Ampk2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768861|imex:IM-24131-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	interpro:IPR028783|reactome:R-RNO-1632852|reactome:R-RNO-163680|reactome:R-RNO-200425|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756|rgd:620893|refseq:NP_076481.1|interpro:IPR028375|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR032270|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR039148	go:"GO:0005886"(plasma membrane)|go:"GO:0005768"(endosome)	chain-seq-start:764|chain-seq-end:1383	-	figure legend:2E, 3A|comment:"IR is stated to be auto-phosphorylated as shown by the use of a non-specific anti-phospho-tyrosine antibody (PY20); however no molecular weight markers are shown to confirm the molecular weight (and presumed identity) of the  band.  In the Plasma Membrane fraction IR phosphorylation was greatest at ~30 seconds post Insulin  injection, and then decreased.   For the Golgi/Endosome fraction the peak was at  2 minutes post injection and then declined; however ATIC and a protein tyrosine phosphatase (PTP) inhibitor inhibited  this decline."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:CVIN69R0cm+lg4hn+MoE1csKtdw10116	rigid:nASrUgr4GGm9Vhb3glXSiOHc+hY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15127-PRO_0000016698	uniprotkb:O35567	intact:EBI-10768746	intact:EBI-10768817|uniprotkb:Q6IN16|ensembl:ENSRNOP00000021105	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:pur9_rat(display_long)|uniprotkb:AICAR transformylase/inosine monophosphate cyclohydrolase(gene name synonym)|uniprotkb:Atic(gene name)|psi-mi:Atic(display_short)|uniprotkb:Purh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768861|imex:IM-24131-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	rgd:70879|refseq:NP_112276.2|go:"GO:0003360"(brainstem development)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|ensembl:ENSRNOG00000015511(gene)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0009259"(ribonucleotide metabolic process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|interpro:IPR036914|mint:O35567|reactome:R-RNO-73817|ensembl:ENSRNOT00000021105(transcript)	go:"GO:0005886"(plasma membrane)|go:"GO:0005768"(endosome)	chain-seq-start:764|chain-seq-end:1383	-	figure legend:2E, 3A|comment:"IR is stated to be auto-phosphorylated as shown by the use of a non-specific anti-phospho-tyrosine antibody (PY20); however no molecular weight markers are shown to confirm the molecular weight (and presumed identity) of the  band.  In the Plasma Membrane fraction IR phosphorylation was greatest at ~30 seconds post Insulin  injection, and then decreased.   For the Golgi/Endosome fraction the peak was at  2 minutes post injection and then declined; however ATIC and a protein tyrosine phosphatase (PTP) inhibitor inhibited  this decline."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:o6Ga1fsJNW74MxIF2YKv6IDc/GQ10116	rigid:nASrUgr4GGm9Vhb3glXSiOHc+hY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15127-PRO_0000016698	uniprotkb:D4ABI7	intact:EBI-10768746	intact:EBI-10768798|ensembl:ENSRNOP00000045049	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:d4abi7_rat(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:LOC100365676(gene name synonym)|uniprotkb:RGD1565496_predicted(gene name synonym)|uniprotkb:rCG_58140(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768861|imex:IM-24131-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	rgd:1565496|refseq:NP_001100301.1|ensembl:ENSRNOG00000030232(gene)|ensembl:ENSRNOT00000041915(transcript)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|reactome:R-RNO-75876	go:"GO:0005886"(plasma membrane)|go:"GO:0005768"(endosome)	chain-seq-start:764|chain-seq-end:1383	-	figure legend:2E, 3A|comment:"IR is stated to be auto-phosphorylated as shown by the use of a non-specific anti-phospho-tyrosine antibody (PY20); however no molecular weight markers are shown to confirm the molecular weight (and presumed identity) of the  band.  In the Plasma Membrane fraction IR phosphorylation was greatest at ~30 seconds post Insulin  injection, and then decreased.   For the Golgi/Endosome fraction the peak was at  2 minutes post injection and then declined; however ATIC and a protein tyrosine phosphatase (PTP) inhibitor inhibited  this decline."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:xIABaImrR/3ubIB4U/n+TI80T1g10116	rigid:nASrUgr4GGm9Vhb3glXSiOHc+hY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15127-PRO_0000016698	uniprotkb:O35567	intact:EBI-10768746	intact:EBI-10768817|uniprotkb:Q6IN16|ensembl:ENSRNOP00000021105	psi-mi:p15127-pro_0000016698(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:pur9_rat(display_long)|uniprotkb:AICAR transformylase/inosine monophosphate cyclohydrolase(gene name synonym)|uniprotkb:Atic(gene name)|psi-mi:Atic(display_short)|uniprotkb:Purh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10768994|imex:IM-24131-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7472166(chain-parent)	rgd:70879|refseq:NP_112276.2|go:"GO:0003360"(brainstem development)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|ensembl:ENSRNOG00000015511(gene)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0009259"(ribonucleotide metabolic process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|interpro:IPR036914|mint:O35567|reactome:R-RNO-73817|ensembl:ENSRNOT00000021105(transcript)	go:"GO:0005829"(cytosol)	chain-seq-start:764|chain-seq-end:1383	-	figure legend:3B|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2015/04/27	2015/04/27	rogid:YwQCH37K+m0YjaBA4Kpq+0YV5VM10116	rogid:o6Ga1fsJNW74MxIF2YKv6IDc/GQ10116	rigid:/CMLs9aLswPiO9PHKgycyvHfwS4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:P31939	intact:EBI-10818032	intact:EBI-1048599|uniprotkb:Q13856|uniprotkb:Q53S28|uniprotkb:A8K202|uniprotkb:E9PBU3|ensembl:ENSP00000236959	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:pur9_human(display_long)|uniprotkb:ATIC(gene name)|psi-mi:ATIC(display_short)|uniprotkb:PURH(gene name synonym)|uniprotkb:OK/SW-cl.86(orf name)|uniprotkb:AICAR transformylase/inosine monophosphate cyclohydrolase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10769013|imex:IM-24131-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	refseq:NP_004035.2|ensembl:ENSG00000138363(gene)|ensembl:ENST00000236959(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|interpro:IPR036914|rcsb pdb:1P4R|rcsb pdb:1PKX|rcsb pdb:1PL0|rcsb pdb:5UY8|rcsb pdb:5UZ0|reactome:R-HSA-73817	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B+C|comment:Shown here are the results from the  IP of the Insulin Receptor using scrambled siRNA. Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:Xe3388w/LOBYgag9P8Gp3IGo9wU9606	rigid:T02mHT2njHyvIuWIfbYcnkT5Nxg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:P60709	intact:EBI-10818032	intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10769013|imex:IM-24131-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B+C|comment:Shown here are the results from the  IP of the Insulin Receptor using scrambled siRNA. Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606	rigid:T02mHT2njHyvIuWIfbYcnkT5Nxg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:Q12840	intact:EBI-10818032	intact:EBI-713468|uniprotkb:Q4LE26|ensembl:ENSP00000408979|uniprotkb:A6H8M5	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:kif5a_human(display_long)|uniprotkb:Neuronal kinesin heavy chain(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 1(gene name synonym)|uniprotkb:KIF5A(gene name)|psi-mi:KIF5A(display_short)|uniprotkb:NKHC1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10769013|imex:IM-24131-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	ensembl:ENST00000455537(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043204"(perikaryon)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q12840|rcsb pdb:4UXT|rcsb pdb:4UXY|rcsb pdb:4UY0|reactome:R-HSA-2132295|reactome:R-HSA-264876|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|ensembl:ENSG00000155980(gene)|refseq:NP_004975.2|dip:DIP-37584N	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B+C|comment:Shown here are the results from the  IP of the Insulin Receptor using scrambled siRNA. Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:fvhe2vZFe1vN8SS4IPCMA5Nr7j09606	rigid:T02mHT2njHyvIuWIfbYcnkT5Nxg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:Q9P035	intact:EBI-10818032	intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10769013|imex:IM-24131-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B+C|comment:Shown here are the results from the  IP of the Insulin Receptor using scrambled siRNA. Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606	rigid:T02mHT2njHyvIuWIfbYcnkT5Nxg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:P54646	intact:EBI-10818032	intact:EBI-1383852|uniprotkb:Q9H1E8|uniprotkb:Q9UD43|ensembl:ENSP00000360290	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:aapk2_human(display_long)|uniprotkb:PRKAA2(gene name)|psi-mi:PRKAA2(display_short)|uniprotkb:AMPK(gene name synonym)|uniprotkb:AMPK2(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10769013|imex:IM-24131-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	refseq:NP_006243.2|dip:DIP-39796N|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0030424"(axon)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028783|interpro:IPR032270|interpro:IPR039148|mint:P54646|rcsb pdb:2H6D|rcsb pdb:3AQV|rcsb pdb:2LTU|rcsb pdb:2YZA|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6BX6|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|ensembl:ENSG00000162409(gene)|ensembl:ENST00000371244(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B+C|comment:Shown here are the results from the  IP of the Insulin Receptor using scrambled siRNA. Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:2t/qHlT6HwqoLLbMjjbhOaCZ1Ow9606	rigid:T02mHT2njHyvIuWIfbYcnkT5Nxg	false	-	O-phospho-L-threonine:172-172	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:Q12840	intact:EBI-10818032	intact:EBI-713468|uniprotkb:Q4LE26|ensembl:ENSP00000408979|uniprotkb:A6H8M5	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:kif5a_human(display_long)|uniprotkb:Neuronal kinesin heavy chain(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 1(gene name synonym)|uniprotkb:KIF5A(gene name)|psi-mi:KIF5A(display_short)|uniprotkb:NKHC1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818039|imex:IM-24131-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	ensembl:ENST00000455537(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043204"(perikaryon)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q12840|rcsb pdb:4UXT|rcsb pdb:4UXY|rcsb pdb:4UY0|reactome:R-HSA-2132295|reactome:R-HSA-264876|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|ensembl:ENSG00000155980(gene)|refseq:NP_004975.2|dip:DIP-37584N	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B|comment:Shown here are the results from the  IP of the Insulin Receptor using ATIC siRNA.|comment:"ATIC depletion increased levels of  phosphorylated AMPKA and KIF5A detected,   but reduced levels of phosphorylated IR (in the presence of Insulin)."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:fvhe2vZFe1vN8SS4IPCMA5Nr7j09606	rigid:T5lqiOMZjnj0GZscy0yHZ4Y1Gas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:Q9P035	intact:EBI-10818032	intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818039|imex:IM-24131-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B|comment:Shown here are the results from the  IP of the Insulin Receptor using ATIC siRNA.|comment:"ATIC depletion increased levels of  phosphorylated AMPKA and KIF5A detected,   but reduced levels of phosphorylated IR (in the presence of Insulin)."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606	rigid:T5lqiOMZjnj0GZscy0yHZ4Y1Gas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:P54646	intact:EBI-10818032	intact:EBI-1383852|uniprotkb:Q9H1E8|uniprotkb:Q9UD43|ensembl:ENSP00000360290	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:aapk2_human(display_long)|uniprotkb:PRKAA2(gene name)|psi-mi:PRKAA2(display_short)|uniprotkb:AMPK(gene name synonym)|uniprotkb:AMPK2(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818039|imex:IM-24131-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	refseq:NP_006243.2|dip:DIP-39796N|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0030424"(axon)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028783|interpro:IPR032270|interpro:IPR039148|mint:P54646|rcsb pdb:2H6D|rcsb pdb:3AQV|rcsb pdb:2LTU|rcsb pdb:2YZA|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6BX6|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|ensembl:ENSG00000162409(gene)|ensembl:ENST00000371244(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 B|comment:Shown here are the results from the  IP of the Insulin Receptor using ATIC siRNA.|comment:"ATIC depletion increased levels of  phosphorylated AMPKA and KIF5A detected,   but reduced levels of phosphorylated IR (in the presence of Insulin)."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:2t/qHlT6HwqoLLbMjjbhOaCZ1Ow9606	rigid:T5lqiOMZjnj0GZscy0yHZ4Y1Gas	false	-	O-phospho-L-threonine:172-172	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:P31939	intact:EBI-10818032	intact:EBI-1048599|uniprotkb:Q13856|uniprotkb:Q53S28|uniprotkb:A8K202|uniprotkb:E9PBU3|ensembl:ENSP00000236959	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:pur9_human(display_long)|uniprotkb:ATIC(gene name)|psi-mi:ATIC(display_short)|uniprotkb:PURH(gene name synonym)|uniprotkb:OK/SW-cl.86(orf name)|uniprotkb:AICAR transformylase/inosine monophosphate cyclohydrolase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818051|imex:IM-24131-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	refseq:NP_004035.2|ensembl:ENSG00000138363(gene)|ensembl:ENST00000236959(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016020"(membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR024050|interpro:IPR024051|interpro:IPR036914|rcsb pdb:1P4R|rcsb pdb:1PKX|rcsb pdb:1PL0|rcsb pdb:5UY8|rcsb pdb:5UZ0|reactome:R-HSA-73817	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 C|comment:"Shown here are the results from the  IP of the Insulin Receptor using   PTPLAD1 (HACD3)   siRNA.  Levels of this molecule were decreased, but not absent.      Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:Xe3388w/LOBYgag9P8Gp3IGo9wU9606	rigid:ZFy6iNQjhbaIJCNN68ZDa6lavhg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:P60709	intact:EBI-10818032	intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818051|imex:IM-24131-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 C|comment:"Shown here are the results from the  IP of the Insulin Receptor using   PTPLAD1 (HACD3)   siRNA.  Levels of this molecule were decreased, but not absent.      Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606	rigid:ZFy6iNQjhbaIJCNN68ZDa6lavhg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06213-PRO_0000016689	uniprotkb:Q9P035	intact:EBI-10818032	intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875	psi-mi:p06213-pro_0000016689(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boutchueng-Djidjou et al. (2015)	pubmed:25687571|imex:IM-24131	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10818051|imex:IM-24131-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(chain-parent)	ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876	-	chain-seq-start:763|chain-seq-end:1382	-	figure legend:4 C|comment:"Shown here are the results from the  IP of the Insulin Receptor using   PTPLAD1 (HACD3)   siRNA.  Levels of this molecule were decreased, but not absent.      Insulin administration appeared to increase the phosphorylation of the IR as shown by use of a non-specific phosphotyrosine antibody."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/04/27	2015/05/11	rogid:tcJK0KIXRvwCm7IhJvGm84Gyu249606	rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606	rigid:ZFy6iNQjhbaIJCNN68ZDa6lavhg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)