#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
ensembl:ENSMUSG00000054640	uniprotkb:P42225	intact:EBI-11362093	intact:EBI-647118	uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|ensembl:slc8a1_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000054640(display_long)	psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Radhakrishnan et al. (2015)	pubmed:25648899|imex:IM-24712	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11362090|imex:IM-24712-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_001106269.1|refseq:NP_035536.2|refseq:XP_006524002.1|uniprotkb:G3X9J1	dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295	-	-	-	figure legend:5D|agonist:"IFN-gamma (P01580 )"|causality statement:P01580 increases the binding of P42225 to ENSMUSG00000054640|causality statement:P01580  decreases the expression at RNA level of ENSMUSG00000054640|causality statement:P01580  decreases the expression at protein level of ENSMUSG00000054640|causality statement:P01580  increased the expression at protein level of P42225|causality statement:P42225  is required  for the P01580  induced decrease in expression at RNA level of  ENSMUSG00000054640|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mimcd_3)|taxid:10090(Mus musculus mIMDC-3 inner medullary collecting duct cells)	-	2015/09/30	2015/11/09	-	rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)