#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y6E7	uniprotkb:P07203	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-7209024|uniprotkb:E9PAS1|ensembl:ENSP00000407375|uniprotkb:Q7Z5H1|uniprotkb:Q9BW12|intact:UNK-5370138	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:gpx1_human(display_long)|uniprotkb:GPX1(gene name)|psi-mi:GPX1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000572.2|ensembl:ENSG00000233276(gene)|ensembl:ENST00000419783(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902905"(positive regulation of supramolecular fiber organization)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P07203|rcsb pdb:2F8A|reactome:R-HSA-2142688|reactome:R-HSA-2142712|reactome:R-HSA-2142770|reactome:R-HSA-3299685|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)	go:"GO:0005739"(mitochondrion)	-	comment:mint|comment:homomint|function:Protects the hemoglobin in erythrocytes from oxidative breakdown	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:1/6I8LekGumy+rLlaLFqCbl1gV09606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:A3KMH1	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-308657|uniprotkb:Q5JTP6|uniprotkb:Q5VW08|uniprotkb:Q7Z6I9|uniprotkb:Q86YC9|uniprotkb:Q8N3E4|uniprotkb:O60310|ensembl:ENSP00000368612	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:vwa8_human(display_long)|uniprotkb:VWA8(gene name)|psi-mi:VWA8(display_short)|uniprotkb:KIAA0564(gene name synonym)|uniprotkb:PEX7-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000102763(gene)|ensembl:ENST00000379310(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR027417|interpro:IPR036465|interpro:IPR039891|refseq:NP_001009814.1|refseq:NP_055873.1|refseq:XP_016875963.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:IOalBj68cHFF4BsViQ+eeXQZiRY9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P49411	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-359097|uniprotkb:O15276|ensembl:ENSP00000322439	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:eftu_human(display_long)|uniprotkb:TUFM(gene name)|psi-mi:TUFM(display_short)|uniprotkb:P43(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_003312.3|ensembl:ENSG00000178952(gene)|ensembl:ENST00000313511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004541(Translation elongation factor EFTu/EF1A, bacterial and organelle)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|interpro:IPR033720|interpro:IPR041709|mint:P49411|rcsb pdb:7A5G|rcsb pdb:7O9K|reactome:R-HSA-5389840|refseq:XP_016879108.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:pDRPUBUqvFqnh613N8bDTl4sFHc9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q12931	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O96008	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1057581|uniprotkb:Q86VW4|uniprotkb:Q8WY09|uniprotkb:Q8WY10|uniprotkb:Q8WY11|uniprotkb:Q9BR95|uniprotkb:A0A024R0P9|ensembl:ENSP00000252487|ensembl:ENSP00000385184|ensembl:ENSP00000410339	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:tom40_human(display_long)|uniprotkb:TOMM40(gene name)|psi-mi:TOMM40(display_short)|uniprotkb:PEREC1(gene name synonym)|uniprotkb:TOM40(gene name synonym)|uniprotkb:C19orf1(gene name synonym)|uniprotkb:Translocase of outer membrane 40 kDa subunit homolog(gene name synonym)|uniprotkb:Protein Haymaker(gene name synonym)|uniprotkb:p38.5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001122388.1|refseq:NP_001122389.1|refseq:NP_006105.1|ensembl:ENSG00000130204(gene)|ensembl:ENST00000252487(transcript)|ensembl:ENST00000405636(transcript)|ensembl:ENST00000426677(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006811"(ion transport)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015288"(porin activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0046930"(pore complex)|interpro:IPR023614|interpro:IPR027246|interpro:IPR037930|rcsb pdb:7CK6|rcsb pdb:7CP9|reactome:R-HSA-1268020|reactome:R-HSA-5205685|go:"GO:0005741"(mitochondrial outer membrane)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:BBV//Cb2ekmDNGHNrZuAXRgS++Y9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q8IYQ7	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2515422|ensembl:ENSP00000365534|ensembl:ENSP00000434887|uniprotkb:Q5VV21|uniprotkb:B3KWL1|uniprotkb:D3DRV3	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:thns1_human(display_long)|uniprotkb:THNSL1(gene name)|psi-mi:THNSL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000185875(gene)|ensembl:ENST00000376356(transcript)|ensembl:ENST00000524413(transcript)|interpro:IPR000623(Shikimate kinase)|interpro:IPR004450(Threonine synthase)|interpro:IPR027417|interpro:IPR029144|interpro:IPR031322|interpro:IPR036052|interpro:IPR037158|refseq:XP_016872154.1|refseq:NP_079114.3|refseq:XP_005252654.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:kAjeYzxUImucaliHBZD7OMlQAjQ9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q969Z0	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-702328|uniprotkb:O14710|uniprotkb:Q53GI8|uniprotkb:Q8NDM4|uniprotkb:Q9BUC6|uniprotkb:Q9Y2F6|uniprotkb:A4D2L2|uniprotkb:A4D2L3|uniprotkb:D3DVL5|uniprotkb:D3DVL6|ensembl:ENSP00000258770|ensembl:ENSP00000420597	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:fakd4_human(display_long)|uniprotkb:Transforming growth factor beta regulator 4(gene name synonym)|uniprotkb:Cell cycle progression restoration protein 2(gene name synonym)|uniprotkb:TBRG4(gene name)|psi-mi:TBRG4(display_short)|uniprotkb:CPR2(gene name synonym)|uniprotkb:FASTKD4(gene name synonym)|uniprotkb:KIAA0948(gene name synonym)|uniprotkb:Protein TBRG4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_004740.2|refseq:NP_112162.1|refseq:NP_954573.1|ensembl:ENSG00000136270(gene)|ensembl:ENST00000258770(transcript)|ensembl:ENST00000494076(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090615"(mitochondrial mRNA processing)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|mint:Q969Z0	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:2maj6VmOPUpSw5F+xJG2kfNKAc49606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q96I99	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2511878|ensembl:ENSP00000307432|uniprotkb:Q8WUQ1|uniprotkb:Q86VX8|uniprotkb:O95195|uniprotkb:Q6NUH7|uniprotkb:C9JVT2	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:sucb2_human(display_long)|uniprotkb:SUCLG2(gene name)|psi-mi:SUCLG2(display_short)|uniprotkb:GTP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-G chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000172340(gene)|ensembl:ENST00000307227(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034722|mint:Q96I99|rcsb pdb:6WCV|reactome:R-HSA-71403|refseq:NP_001171070.1|refseq:NP_003839.2|dip:DIP-53563N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:jxrFGuu3hFn2QAYfrPxTKhScM249606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9P2R7	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2269898|uniprotkb:O95194|uniprotkb:Q5T9Q4|uniprotkb:Q5T9Q6|uniprotkb:Q9NV21|uniprotkb:Q9NVP7|uniprotkb:B2RDE7|ensembl:ENSP00000494360|ensembl:ENSP00000494987	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:sucb1_human(display_long)|uniprotkb:SUCLA2(gene name)|psi-mi:SUCLA2(display_short)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_003841.1|ensembl:ENSG00000136143(gene)|ensembl:ENST00000643584(transcript)|ensembl:ENST00000646932(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006781"(succinyl-CoA pathway)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9P2R7|rcsb pdb:6G4Q|reactome:R-HSA-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:I/FQp3c8ckxpxoyftKge2B5lDmI9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9UJZ1	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1044428|ensembl:ENSP00000348886|uniprotkb:O60376|uniprotkb:Q53G29|uniprotkb:Q96FY2|uniprotkb:Q9P042|uniprotkb:D3DRN3|uniprotkb:B4E1K7	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:stml2_human(display_long)|uniprotkb:EPB72-like protein 2(gene name synonym)|uniprotkb:STOML2(gene name)|psi-mi:STOML2(display_short)|uniprotkb:SLP2(gene name synonym)|uniprotkb:HSPC108(orf name)|uniprotkb:Paraprotein target 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000165283(gene)|ensembl:ENST00000356493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q9UJZ1|reactome:R-HSA-8949664|refseq:NP_001273960.1|refseq:NP_038470.1|refseq:NP_001273961.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:VH6uT4ShPg3IpPHbQtaSVXjZAYg9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P34897	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P29353	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9NP81	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1049768|uniprotkb:A6NHW7|uniprotkb:Q9BVP3|uniprotkb:B4DE10|ensembl:ENSP00000221431|ensembl:ENSP00000489539	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:sysm_human(display_long)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)|uniprotkb:SerRSmt(gene name synonym)|uniprotkb:SARS2(gene name)|psi-mi:SARS2(display_short)|uniprotkb:SARSM(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001139373.1|refseq:NP_060297.1|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR033729|interpro:IPR042103|mint:Q9NP81|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|reactome:R-HSA-379726|ensembl:ENSG00000104835(gene)|ensembl:ENSG00000283104(gene)|ensembl:ENST00000221431(transcript)|ensembl:ENST00000634687(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0070158"(mitochondrial seryl-tRNA aminoacylation)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:xYa2ZQIifKicNHV/6vlcUGaN9q49606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q5T160	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1050546|uniprotkb:Q96FU5|uniprotkb:Q9H8K8|uniprotkb:B2RDT7|ensembl:ENSP00000358549	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:syrm_human(display_long)|uniprotkb:RARS2(gene name)|psi-mi:RARS2(display_short)|uniprotkb:RARSL(gene name synonym)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_064716.2|ensembl:ENSG00000146282(gene)|ensembl:ENST00000369536(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q5T160|reactome:R-HSA-379726	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:jslLCkjYCriiVlR94nHAhNIYVeY9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q96C36	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P32322	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q96EY7	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-721110|uniprotkb:A6NHD2|uniprotkb:Q597H0|uniprotkb:Q658Y9|uniprotkb:Q9BUZ8|uniprotkb:Q9NWL0|intact:EBI-2560120|uniprotkb:D6W5M1|ensembl:ENSP00000254630	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ptcd3_human(display_long)|uniprotkb:Transformation-related gene 15 protein(gene name synonym)|uniprotkb:TRG15(orf name)|uniprotkb:28S ribosomal protein S39, mitochondrial(gene name synonym)|uniprotkb:MRPS39(gene name synonym)|uniprotkb:PTCD3(gene name)|psi-mi:PTCD3(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS39(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_060422.4|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR037387|mint:Q96EY7|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|go:"GO:0019843"(rRNA binding)|rcsb pdb:6ZSC|ensembl:ENSG00000132300(gene)|ensembl:ENST00000254630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006417"(regulation of translation)|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSD	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:k9hyBtBrNbiBMJ5gtOQ9R6Grl9U9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P30044	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-722161|uniprotkb:Q14CK0|uniprotkb:Q6IAF2|uniprotkb:Q9UBU5|uniprotkb:Q9UJU4|uniprotkb:Q9UKX4|uniprotkb:A6NG06|uniprotkb:B7ZLJ4|uniprotkb:A6NC19|uniprotkb:B7ZVW3|ensembl:ENSP00000265462	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:prdx5_human(display_long)|uniprotkb:Peroxiredoxin V(gene name synonym)|uniprotkb:Peroxisomal antioxidant enzyme(gene name synonym)|uniprotkb:PLP(gene name synonym)|uniprotkb:Thioredoxin peroxidase PMP20(gene name synonym)|uniprotkb:Antioxidant enzyme B166(gene name synonym)|uniprotkb:TPx type VI(gene name synonym)|uniprotkb:Liver tissue 2D-page spot 71B(gene name synonym)|uniprotkb:Alu corepressor 1(gene name synonym)|uniprotkb:PRDX5(gene name)|psi-mi:PRDX5(display_short)|uniprotkb:ACR1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 5(gene name synonym)|uniprotkb:SBBI10(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_036226.1|refseq:NP_857634.1|refseq:NP_857635.1|ensembl:ENSG00000126432(gene)|ensembl:ENST00000265462(transcript)|go:"GO:0001016"(RNA polymerase III transcription regulatory region sequence-specific DNA binding)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016480"(negative regulation of transcription by RNA polymerase III)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060785"(regulation of apoptosis involved in tissue homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0072541"(peroxynitrite reductase activity)|go:"GO:2001057"(reactive nitrogen species metabolic process)|interpro:IPR013740(Redoxin)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR037944|mint:P30044|rcsb pdb:1H4O|rcsb pdb:1HD2|rcsb pdb:1OC3|rcsb pdb:1URM|rcsb pdb:2VL2|rcsb pdb:2VL3|rcsb pdb:2VL9|rcsb pdb:3MNG|rcsb pdb:4K7I|rcsb pdb:4K7N|rcsb pdb:4K7O|rcsb pdb:4MMM|reactome:R-HSA-3299685|reactome:R-HSA-5628897	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Z1fs04RUXWI7z+s7Y+hzGige4mU9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P30048	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-748336|intact:EBI-10975142|uniprotkb:P35690|uniprotkb:Q0D2H1|uniprotkb:Q13776|uniprotkb:Q5T5V2|uniprotkb:Q96HK4|uniprotkb:B2R7Z0|uniprotkb:D3DRC9|uniprotkb:E9PH29|ensembl:ENSP00000298510	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:prdx3_human(display_long)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:Peroxiredoxin III(gene name synonym)|uniprotkb:Antioxidant protein 1(gene name synonym)|uniprotkb:Protein MER5 homolog(gene name synonym)|uniprotkb:HBC189(gene name synonym)|uniprotkb:PRDX3(gene name)|psi-mi:PRDX3(display_short)|uniprotkb:AOP1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001289201.1|refseq:NP_006784.1|ensembl:ENSG00000165672(gene)|ensembl:ENST00000298510(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008785"(alkyl hydroperoxide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:P30048|rcsb pdb:5JCG|rcsb pdb:5UCX|reactome:R-HSA-3299685|go:"GO:0005769"(early endosome)|dip:DIP-33600N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:+J/zV8u0jGCSzTGXafxgecTv/149606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9H2U2	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-3957115|uniprotkb:B4DLP7|uniprotkb:Q4W5E9|uniprotkb:Q6PG51|uniprotkb:Q8TBW0|uniprotkb:Q96E55|uniprotkb:Q9H0T0|uniprotkb:Q9NX37|uniprotkb:Q9P033|uniprotkb:Q9ULX0|uniprotkb:I6L9B6|uniprotkb:F8WDN9|ensembl:ENSP00000343885	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ipyr2_human(display_long)|uniprotkb:PPA2(gene name)|psi-mi:PPA2(display_short)|uniprotkb:Pyrophosphatase SID6-306(gene name synonym)|uniprotkb:Pyrophosphate phospho-hydrolase 2(gene name synonym)|uniprotkb:HSPC124(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_008834.3|refseq:NP_789842.2|refseq:NP_789843.2|refseq:NP_789845.1|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0071344"(diphosphate metabolic process)|interpro:IPR008162(Inorganic pyrophosphatase)|interpro:IPR036649|mint:Q9H2U2|reactome:R-HSA-379726|reactome:R-HSA-71737|ensembl:ENSG00000138777(gene)|ensembl:ENST00000341695(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:KrPc55Mf6MjN5tgxFagI03miOwY9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O75439	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-721199|uniprotkb:O60416|uniprotkb:Q96FV4|ensembl:ENSP00000249269	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:mppb_human(display_long)|uniprotkb:Beta-MPP(gene name synonym)|uniprotkb:P-52(gene name synonym)|uniprotkb:PMPCB(gene name)|psi-mi:PMPCB(display_short)|uniprotkb:MPPB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_004270.2|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0017087"(mitochondrial processing peptidase complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR037718|mint:O75439|reactome:R-HSA-1268020|reactome:R-HSA-8949664|ensembl:ENSG00000105819(gene)|ensembl:ENST00000249269(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:TMqHDYssMbBpUdw0HcGrMPaJd/89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q10713	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2514696|ensembl:ENSP00000360782|uniprotkb:Q8N513|uniprotkb:Q16639|uniprotkb:Q5SXM9|uniprotkb:B4DKL3|uniprotkb:E7ET61	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:mppa_human(display_long)|uniprotkb:PMPCA(gene name)|psi-mi:PMPCA(display_short)|uniprotkb:INPP5E(gene name synonym)|uniprotkb:KIAA0123(gene name synonym)|uniprotkb:MPPA(gene name synonym)|uniprotkb:Alpha-MPP(gene name synonym)|uniprotkb:P-55(gene name synonym)|uniprotkb:Inactive zinc metalloprotease alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001269875.1|ensembl:ENSG00000165688(gene)|ensembl:ENST00000371717(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|reactome:R-HSA-1268020|reactome:R-HSA-8949664|interpro:IPR037715|refseq:NP_001269873.1|refseq:NP_055975.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Kqz7qIyX2eUOcnNrfIsSPjc4Isw9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q5JRX3	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2432778|uniprotkb:B4E0J8|uniprotkb:E7ES23|uniprotkb:B3KMJ6|uniprotkb:O95204|uniprotkb:Q2M2G6|uniprotkb:Q4VBR1|uniprotkb:Q5JRW7|uniprotkb:Q7L5Z7|uniprotkb:Q9BSI6|uniprotkb:Q9BVJ5|uniprotkb:Q9UPP8|uniprotkb:C9JSL2|ensembl:ENSP00000224949	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:prep_human(display_long)|uniprotkb:PITRM1(gene name)|psi-mi:PITRM1(display_short)|uniprotkb:KIAA1104(gene name synonym)|uniprotkb:MP1(gene name synonym)|uniprotkb:Pitrilysin metalloproteinase 1(gene name synonym)|uniprotkb:PREP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001229236.1|refseq:NP_001229238.1|refseq:NP_055704.2|dip:DIP-52900N|ensembl:ENSG00000107959(gene)|ensembl:ENST00000224949(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006508"(proteolysis)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR013578(Peptidase M16C associated)|mint:Q5JRX3|rcsb pdb:4L3T|rcsb pdb:4NGE|rcsb pdb:4RPU|reactome:R-HSA-1268020	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:1kEY/XJB5fwgNRoM9u9ZGT+VrS09606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9P0J1	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2861634|uniprotkb:B3KX71|uniprotkb:Q5U5K1|uniprotkb:J3KPU0|ensembl:ENSP00000297598|ensembl:ENSP00000428317|ensembl:ENSP00000430380	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:pdp1_human(display_long)|uniprotkb:PDP1(gene name)|psi-mi:PDP1(display_short)|uniprotkb:PDP(gene name synonym)|uniprotkb:PPM2C(gene name synonym)|uniprotkb:Protein phosphatase 2C(gene name synonym)|uniprotkb:Pyruvate dehydrogenase phosphatase catalytic subunit 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:XP_011515438.1|refseq:NP_001155251.1|refseq:NP_001155252.1|refseq:NP_001155253.1|refseq:NP_060914.2|ensembl:ENSG00000164951(gene)|ensembl:ENST00000297598(transcript)|ensembl:ENST00000517764(transcript)|ensembl:ENST00000520728(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004741"("[pyruvate dehydrogenase (lipoamide)] phosphatase activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:1904184"(positive regulation of pyruvate dehydrogenase activity)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|reactome:R-HSA-204174|go:"GO:0005739"(mitochondrion)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:IXJq+qtJ0oAoODs/pXB1/NehhRY9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O00330	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-751566|uniprotkb:O60221|uniprotkb:Q96FV8|uniprotkb:Q99783|uniprotkb:D3DR11|uniprotkb:E9PB14|uniprotkb:B4DW62|uniprotkb:E9PBP7|ensembl:ENSP00000227868	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odpx_human(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Lipoyl-containing pyruvate dehydrogenase complex component X(gene name synonym)|uniprotkb:E3-binding protein(gene name synonym)|uniprotkb:proX(gene name synonym)|uniprotkb:PDHX(gene name)|psi-mi:PDHX(display_short)|uniprotkb:PDX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001128496.1|refseq:NP_001159630.1|refseq:NP_003468.2|dip:DIP-29026N|ensembl:ENSG00000110435(gene)|ensembl:ENST00000227868(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:O00330|rcsb pdb:1ZY8|rcsb pdb:2DNC|rcsb pdb:2F5Z|rcsb pdb:2F60|rcsb pdb:6H60|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:fcQCBKmyySLi0lr+SQKUkPy+rwE9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P11177	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1035872|uniprotkb:B2R7L0|uniprotkb:Q6FH45|uniprotkb:Q9BQ27|uniprotkb:Q9UFK3|ensembl:ENSP00000307241|uniprotkb:B4DDD7	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odpb_human(display_long)|uniprotkb:PDHB(gene name)|psi-mi:PDHB(display_short)|uniprotkb:PHE1B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000168291(gene)|ensembl:ENST00000302746(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR027110|interpro:IPR029061|interpro:IPR033248|mint:P11177|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|refseq:NP_000916.2|refseq:NP_001166939.1|refseq:NP_001302465.1|dip:DIP-37651N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:VnabVXgFi4b43Wl37PzUX3+j4A89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q6L8Q7	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2515865|ensembl:ENSP00000309142|uniprotkb:Q8IYU3|uniprotkb:Q8NDU2|uniprotkb:Q8TE78|uniprotkb:B4DTU8	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:pde12_human(display_long)|uniprotkb:PDE12(gene name)|psi-mi:PDE12(display_short)|uniprotkb:Mitochondrial deadenylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENST00000311180(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0004527"(exonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034611"(oligoribonucleotidase activity)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|ensembl:ENSG00000174840(gene)|interpro:IPR036691|mint:Q6L8Q7|rcsb pdb:4Z0V|rcsb pdb:4Z2B|rcsb pdb:4ZKF|reactome:R-HSA-8983711|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|refseq:NP_808881.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:P2ALFhSP4Qnqnd08vmkOcVoXe/I9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q16822	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2825219|uniprotkb:O43253|uniprotkb:Q9BV62|intact:EBI-3189808|uniprotkb:Q86U01|ensembl:ENSP00000216780|ensembl:ENSP00000494919|uniprotkb:B4DW73	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:pckgm_human(display_long)|uniprotkb:PCK2(gene name)|psi-mi:PCK2(display_short)|uniprotkb:PEPCK2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001278485.1|refseq:NP_001294983.1|refseq:NP_001018083.2|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033993"(response to lipid)|go:"GO:0042594"(response to starvation)|go:"GO:0046327"(glycerol biosynthetic process from pyruvate)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR008209(Phosphoenolpyruvate carboxykinase, GTP-utilising)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR018091|interpro:IPR035077|interpro:IPR035078|mint:Q16822|reactome:R-HSA-70263|go:"GO:0030145"(manganese ion binding)|ensembl:ENSG00000100889(gene)|ensembl:ENSG00000285241(gene)|ensembl:ENST00000216780(transcript)|ensembl:ENST00000645217(transcript)|go:"GO:0004611"(phosphoenolpyruvate carboxykinase activity)|go:"GO:0004613"("phosphoenolpyruvate carboxykinase (GTP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0019543"(propionate catabolic process)|refseq:NP_004554.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:gbQbu8+tVa1xs/fKesefSJlpSaM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P05165	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2211679|uniprotkb:B4DPF9|uniprotkb:C9JPQ8|uniprotkb:B4DKY8|uniprotkb:Q15979|intact:EBI-2803938|uniprotkb:Q8WXQ7|ensembl:ENSP00000365462	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:pcca_human(display_long)|uniprotkb:PCCA(gene name)|psi-mi:PCCA(display_short)|uniprotkb:"Propanoyl-CoA:carbon dioxide ligase subunit alpha"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000273.2|refseq:NP_001121164.1|refseq:NP_001171475.1|dip:DIP-57493N|ensembl:ENSG00000175198(gene)|ensembl:ENST00000376285(transcript)|go:"GO:0004658"(propionyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0009374"(biotin binding)|go:"GO:0016421"(CoA carboxylase activity)|go:"GO:0019626"(short-chain fatty acid catabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR041265|mint:P05165|rcsb pdb:2CQY|rcsb pdb:2JKU|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-71032	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:IR3jXR6XjVwD8WRNlN4N5+AOk049606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P11498	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q02218	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-747213|intact:EBI-1210683|uniprotkb:Q9UDX0|uniprotkb:D3DVL0|uniprotkb:B4E2U9|uniprotkb:E9PBM1|uniprotkb:Q96DD3|ensembl:ENSP00000222673	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odo1_human(display_long)|uniprotkb:OGDH(gene name)|psi-mi:OGDH(display_short)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_002532.2|refseq:NP_001003941.1|refseq:NP_001158508.1|go:"GO:0021766"(hippocampus development)|go:"GO:0021794"(thalamus development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0021756"(striatum development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034602"("oxoglutarate dehydrogenase (NAD+) activity")|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0106077"(histone succinylation)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|rcsb pdb:3ERY|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403|ensembl:ENSG00000105953(gene)|ensembl:ENST00000222673(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006096"(glycolytic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0021695"(cerebellar cortex development)|dip:DIP-39353N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:B9CSRCmhDYg7n5jSpuDlr2mrxDg9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q86UY8	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2682594|uniprotkb:Q9P2T3|uniprotkb:Q9P2T2|uniprotkb:Q9NUM7|ensembl:ENSP00000376615	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:nt5d3_human(display_long)|uniprotkb:GNN(gene name synonym)|uniprotkb:TU12B1-TY(gene name synonym)|uniprotkb:GRP94-neighboring nucleotidase(gene name synonym)|uniprotkb:NT5DC3(gene name)|psi-mi:NT5DC3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001026871.1|interpro:IPR008380(HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase)|interpro:IPR016695(Purine 5'-nucleotidase)|interpro:IPR023214|interpro:IPR036412|ensembl:ENSG00000111696(gene)|ensembl:ENST00000392876(transcript)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0046872"(metal ion binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:RosGgCpFaCMvbM9Ukz2gDz0Kjxw9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9H857	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-359244|uniprotkb:O95888|uniprotkb:Q96C80|uniprotkb:Q9H9Z8|uniprotkb:C9JTZ6|uniprotkb:E9PAL9|intact:EBI-11044897|ensembl:ENSP00000302468	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:nt5d2_human(display_long)|uniprotkb:NT5DC2(gene name)|psi-mi:NT5DC2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001127703.1|refseq:NP_075059.1|refseq:XP_005265463.1|refseq:XP_006713368.1|ensembl:ENSG00000168268(gene)|ensembl:ENST00000307076(transcript)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR008380(HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase)|interpro:IPR016695(Purine 5'-nucleotidase)|interpro:IPR023214|interpro:IPR036412	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:nfT/9N1bWVadX70eY1G0GS9pS9U9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q86UT6	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-3893071|uniprotkb:A8K6Q1|uniprotkb:B3KPK2|uniprotkb:B3KTA2|uniprotkb:Q7RTR3|uniprotkb:Q96D51|uniprotkb:Q9H724|ensembl:ENSP00000292199|ensembl:ENSP00000386851|ensembl:ENSP00000386858|ensembl:ENSP00000387334	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:nlrx1_human(display_long)|uniprotkb:NLRX1(gene name)|psi-mi:NLRX1(display_short)|uniprotkb:NOD26(gene name synonym)|uniprotkb:NOD5(gene name synonym)|uniprotkb:NOD9(gene name synonym)|uniprotkb:Caterpiller protein 11.3(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 26(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 5(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:XP_006718967.1|refseq:XP_011541282.1|refseq:NP_078894.2|dip:DIP-60637N|refseq:NP_001269072.1|refseq:NP_001269073.1|refseq:NP_001269287.1|refseq:XP_005271726.1|ensembl:ENSG00000160703(gene)|ensembl:ENST00000292199(transcript)|ensembl:ENST00000409109(transcript)|ensembl:ENST00000409265(transcript)|ensembl:ENST00000409991(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR032675|rcsb pdb:3UN9|reactome:R-HSA-168928|reactome:R-HSA-936440|go:"GO:0030054"(cell junction)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:w+BOLVATt2ey/lEP6RY9zP2q/gc9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q86X76	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-716301|uniprotkb:O76091|uniprotkb:B1AQP3|uniprotkb:D3DVF4|ensembl:ENSP00000356988	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:nit1_human(display_long)|uniprotkb:Nitrilase homolog 1(gene name synonym)|uniprotkb:NIT1(gene name)|psi-mi:NIT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001172021.1|refseq:NP_001172022.1|refseq:NP_001172023.1|refseq:NP_005591.1|ensembl:ENST00000368007|ensembl:ENSP00000356986|ensembl:ENST00000368008|ensembl:ENSP00000356987|ensembl:ENSP00000356988|ensembl:ENST00000392190|ensembl:ENSP00000376028|refseq:XP_005245273.1|ensembl:ENSG00000158793(gene)|ensembl:ENST00000368009(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0043605"(cellular amide catabolic process)|go:"GO:0110050"(deaminated glutathione amidase activity)|interpro:IPR001110(Protein of unknown function UPF0012, conserved site)|interpro:IPR003010(Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase)|interpro:IPR036526	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Tt+RiYdwfe/+RD7509CdCMNHnvk9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P49821	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-748312|uniprotkb:Q6IBR3|uniprotkb:O60924|uniprotkb:O60940|uniprotkb:Q16104|uniprotkb:Q96BF8|uniprotkb:Q96HS7|ensembl:ENSP00000322450|ensembl:ENSP00000497587	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:nduv1_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 51 kDa subunit(gene name synonym)|uniprotkb:Complex I-51kD(gene name synonym)|uniprotkb:NADH dehydrogenase flavoprotein 1(gene name synonym)|uniprotkb:NDUFV1(gene name)|psi-mi:NDUFV1(display_short)|uniprotkb:UQOR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001159574.1|refseq:NP_009034.2|ensembl:ENSG00000167792(gene)|ensembl:ENST00000322776(transcript)|ensembl:ENST00000647561(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|mint:P49821|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:0pEd6isDBEamZQJ5QNo5yJ7rKu89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O75306	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P28331	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q4G0N4	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-10714975|uniprotkb:B5MC93|uniprotkb:Q6UTX5|uniprotkb:Q96NM0|ensembl:ENSP00000371362	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:nakd2_human(display_long)|uniprotkb:Mitochondrial NAD kinase(gene name synonym)|uniprotkb:NAD kinase domain-containing protein 1, mitochondrial(gene name synonym)|uniprotkb:NADK2(gene name)|psi-mi:NADK2(display_short)|uniprotkb:C5orf33(gene name synonym)|uniprotkb:MNADK(gene name synonym)|uniprotkb:NADKD1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001078880.1|refseq:NP_001274269.1|refseq:NP_001274270.1|refseq:NP_694558.1|ensembl:ENSG00000152620(gene)|ensembl:ENST00000381937(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR002504(ATP-NAD/AcoX kinase)|interpro:IPR012355(ATP-NAD kinase-like, eukaryotic)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|reactome:R-HSA-196807	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:FuMnD0CG7LLYTwuSzpavlen42iI9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q6UB35	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1046835|intact:EBI-28986171|ensembl:ENSP00000356290|uniprotkb:Q2TBF3|uniprotkb:Q8WVW0|uniprotkb:Q96HG8|uniprotkb:Q9H789|uniprotkb:Q9UFU8	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:c1tm_human(display_long)|uniprotkb:MTHFD1L(gene name)|psi-mi:MTHFD1L(display_short)|uniprotkb:FTHFSDC1(gene name synonym)|uniprotkb:Formyltetrahydrofolate synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000120254(gene)|ensembl:ENST00000367321(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006760"(folic acid-containing compound metabolic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0015942"(formate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR027417|interpro:IPR036291|reactome:R-HSA-196757|refseq:NP_001229696.1|refseq:NP_001229697.1|refseq:NP_001229698.1|refseq:NP_056255.2|ensembl:ENST00000367307|ensembl:ENSP00000356276|ensembl:ENSP00000356290	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:lJRND1kcMEF99+fT1b+X8hfuLHM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P82933	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-721385|intact:EBI-1049991|uniprotkb:Q6PG40|ensembl:ENSP00000258455	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rt09_human(display_long)|uniprotkb:MRPS9(gene name)|psi-mi:MRPS9(display_short)|uniprotkb:RPMS9(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein uS9m(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_872578.1|ensembl:ENSG00000135972(gene)|ensembl:ENST00000258455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P82933|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSE	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:XNB4GL84eYgYFEB3WxOtoD3Ub989606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9NP92	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-6393499|ensembl:ENSP00000424328|uniprotkb:Q96I91|uniprotkb:Q96Q19|uniprotkb:Q9H0P8|uniprotkb:Q9NSF9|uniprotkb:Q9NZ76	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rt30_human(display_long)|uniprotkb:MRPS30(gene name)|psi-mi:MRPS30(display_short)|uniprotkb:PDCD9(gene name synonym)|uniprotkb:Programmed cell death protein 9(gene name synonym)|uniprotkb:BM-047(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mS30(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein mL65(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000112996(gene)|ensembl:ENST00000507110(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|interpro:IPR010793(Ribosomal protein S30, mitochondrial)|interpro:IPR039982|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_057724.2	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:AyFqyCMR1Poix/xU7k195b8D+hw9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9Y3D9	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1054270|uniprotkb:Q96Q24|uniprotkb:Q9BWH8|uniprotkb:Q9P053|uniprotkb:B2R6V3|ensembl:ENSP00000320184	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rt23_human(display_long)|uniprotkb:MRPS23(gene name)|psi-mi:MRPS23(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS23(gene name synonym)|uniprotkb:CGI-138(orf name)|uniprotkb:HSPC329(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_057154.2|ensembl:ENSG00000181610(gene)|ensembl:ENST00000313608(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0031965"(nuclear membrane)|interpro:IPR019520|interpro:IPR023611|mint:Q9Y3D9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:6Iyu6KkT1Y0+n0LKWy5Gf0DkhHw9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P82650	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1050752|ensembl:ENSP00000418008|ensembl:ENSP00000505414|uniprotkb:Q9H3I1	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rt22_human(display_long)|uniprotkb:MRPS22(gene name)|psi-mi:MRPS22(display_short)|uniprotkb:C3orf5(gene name synonym)|uniprotkb:RPMS22(gene name synonym)|uniprotkb:GK002(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein mS22(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_064576.1|ensembl:ENSG00000175110(gene)|ensembl:ENST00000495075(transcript)|ensembl:ENST00000680020(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR019374|mint:P82650|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:T0htF4/rvOZUZ3RcuCjWvEg9iTE9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9Y676	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-750085|uniprotkb:Q9BS27|uniprotkb:A6NDQ0|uniprotkb:Q659G4|intact:EBI-1050511|ensembl:ENSP00000259873|ensembl:ENSP00000383438|ensembl:ENSP00000397790|ensembl:ENSP00000398494|ensembl:ENSP00000402718|ensembl:ENSP00000414972|ensembl:ENSP00000415703	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rt18b_human(display_long)|uniprotkb:28S ribosomal protein S18-2, mitochondrial(gene name synonym)|uniprotkb:C6orf14(gene name synonym)|uniprotkb:MRPS18B(gene name)|psi-mi:MRPS18B(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein bS18b(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS40(gene name synonym)|uniprotkb:HSPC183(orf name)|uniprotkb:PTD017(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_054765.1|dip:DIP-29894N|ensembl:ENSG00000203624(gene)|ensembl:ENSG00000204568(gene)|ensembl:ENSG00000223775(gene)|ensembl:ENSG00000226111(gene)|ensembl:ENSG00000227420(gene)|ensembl:ENSG00000229861(gene)|ensembl:ENSG00000233813(gene)|ensembl:ENST00000259873(transcript)|ensembl:ENST00000327800(transcript)|ensembl:ENST00000412451(transcript)|ensembl:ENST00000426945(transcript)|ensembl:ENST00000430402(transcript)|ensembl:ENST00000451032(transcript)|ensembl:ENST00000454427(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0030054"(cell junction)|go:"GO:0032543"(mitochondrial translation)|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|interpro:IPR001648(Ribosomal protein S18)|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|interpro:IPR036870|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|interpro:IPR040054|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|mint:Q9Y676	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:DFGekxKm74bAo8IWpOi8LDITWqc9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9H9J2	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-713619|uniprotkb:Q53S16|uniprotkb:Q6IA62|uniprotkb:Q9H821|ensembl:ENSP00000258383|intact:EBI-21356011	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rm44_human(display_long)|uniprotkb:MRPL44(gene name)|psi-mi:MRPL44(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL44(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000135900(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044444|mint:Q9H9J2|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|ensembl:ENST00000258383(transcript)|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_075066.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:YNUNu4UGyhAuaSChEzFXCw2k7wk9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9NYK5	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2513042|ensembl:ENSP00000284967|uniprotkb:Q9BZV6|uniprotkb:Q32Q74|uniprotkb:Q9BSQ7|uniprotkb:Q5QTR3|uniprotkb:Q96Q65|uniprotkb:Q9NX44|uniprotkb:C9JYA5	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rm39_human(display_long)|uniprotkb:MRPL39(gene name)|psi-mi:MRPL39(display_short)|uniprotkb:C21orf92(gene name synonym)|uniprotkb:MRPL5(gene name synonym)|uniprotkb:RPML5(gene name synonym)|uniprotkb:39S ribosomal protein L5, mitochondrial(gene name synonym)|uniprotkb:MSTP003(orf name)|uniprotkb:PRED22(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mL39(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000154719(gene)|ensembl:ENST00000352957(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR004095(TGS)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR018163|mint:Q9NYK5|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6NU3|refseq:NP_059142.2|refseq:NP_542984.2|refseq:XP_006724089.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:yolHEKnYRC1KwprZYyWZXZmjgr89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9BZE1	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-5325218|ensembl:ENSP00000354086|uniprotkb:Q96Q67|uniprotkb:Q9BWR1|uniprotkb:Q9P0P3	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rm37_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL37(gene name synonym)|uniprotkb:MRPL37(gene name)|psi-mi:MRPL37(display_short)|uniprotkb:MRPL2(gene name synonym)|uniprotkb:RPML2(gene name synonym)|uniprotkb:39S ribosomal protein L2, mitochondrial(gene name synonym)|uniprotkb:HSPC235(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000116221(gene)|ensembl:ENST00000360840(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR010793(Ribosomal protein S30, mitochondrial)|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:3J7Y|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:3J9M|rcsb pdb:7ODR|rcsb pdb:5OOL|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:5OOM|rcsb pdb:7OF0|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OG4|refseq:NP_057575.2|dip:DIP-59718N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:rYwNelB9BJA4STHaD5AlJjUxCpM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q13084	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-723426|uniprotkb:Q4TT39|uniprotkb:Q96S26|uniprotkb:Q9BQD8|uniprotkb:Q9BR04|ensembl:ENSP00000199706|ensembl:ENSP00000374326|ensembl:ENSP00000497004|uniprotkb:B2RCM4|uniprotkb:D3DU46	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rm28_human(display_long)|uniprotkb:Melanoma antigen p15(gene name synonym)|uniprotkb:MRPL28(gene name)|psi-mi:MRPL28(display_short)|uniprotkb:MAAT1(gene name synonym)|uniprotkb:Melanoma-associated antigen recognized by T-lymphocytes(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein bL28m(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_006419.2|rcsb pdb:3J7Y|ensembl:ENSG00000086504(gene)|ensembl:ENST00000199706(transcript)|ensembl:ENST00000389675(transcript)|ensembl:ENST00000648346(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|interpro:IPR026569|interpro:IPR034704|interpro:IPR037147|mint:Q13084|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_011520653.1|refseq:XP_005255098.1|dip:DIP-61135N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:rgjK24sQlABM210ZM7T9mT2wxKs9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9BYD6	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-5325394|ensembl:ENSP00000315017|uniprotkb:A6NG03|uniprotkb:Q4W5B8|uniprotkb:Q6IAG4|uniprotkb:Q96BW3|uniprotkb:Q9H793|uniprotkb:Q9NRL5	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rm01_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein uL1m(gene name synonym)|uniprotkb:BM-022(orf name)|uniprotkb:MRPL1(gene name)|psi-mi:MRPL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000169288(gene)|ensembl:ENST00000315567(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR005879(Ribosomal protein L1, mitochondrial)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023674|interpro:IPR028364|mint:Q9BYD6|rcsb pdb:7A5K|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_011530500.1|refseq:XP_011530501.1|refseq:NP_064621.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:S5t4UAM2nDToXMl6lV3gh6Ecef09606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q8IVH4	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O95822	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-10714916|uniprotkb:Q9UNU5|uniprotkb:Q9Y3F2|ensembl:ENSP00000262430	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:dcmc_human(display_long)|uniprotkb:MLYCD(gene name)|psi-mi:MLYCD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_036345.2|ensembl:ENSG00000103150(gene)|ensembl:ENST00000262430(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0050080"(malonyl-CoA decarboxylase activity)|go:"GO:2001294"(malonyl-CoA catabolic process)|interpro:IPR007956(Malonyl-CoA decarboxylase)|interpro:IPR035372|interpro:IPR038351|interpro:IPR038917|interpro:IPR042303|rcsb pdb:2YGW|rcsb pdb:4F0X|reactome:R-HSA-390247|reactome:R-HSA-9033241|dip:DIP-60405N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:8wCYyrLE10zXVn0GPBiZUsPUp2o9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q99797	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-3893060|uniprotkb:Q5JV15|uniprotkb:Q5T9Q9|uniprotkb:Q96G65|ensembl:ENSP00000371607	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:mipep_human(display_long)|uniprotkb:MIPEP(gene name)|psi-mi:MIPEP(display_short)|uniprotkb:MIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_005923.2|ensembl:ENSG00000027001(gene)|ensembl:ENST00000382172(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001567(Peptidase M3A and M3B, thimet/oligopeptidase F)|interpro:IPR024077|interpro:IPR024079	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:vAXeDaFEEGzQGvsfOQUknrfD74Q9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P23368	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1043318|uniprotkb:Q9H4B2|uniprotkb:Q9BYG1|ensembl:ENSP00000321070|uniprotkb:B2R8J2|uniprotkb:Q9BWL6	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:maom_human(display_long)|uniprotkb:Malic enzyme 2(gene name synonym)|uniprotkb:ME2(gene name)|psi-mi:ME2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001161807.1|rcsb pdb:1QR6|rcsb pdb:7BSJ|rcsb pdb:7BSK|rcsb pdb:7BSL|reactome:R-HSA-71403|ensembl:ENST00000321341(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|ensembl:ENSG00000082212(gene)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|mint:P23368|rcsb pdb:1DO8|rcsb pdb:1EFK|rcsb pdb:1EFL|rcsb pdb:1GZ3|rcsb pdb:1GZ4|rcsb pdb:1PJ2|rcsb pdb:1PJ3|rcsb pdb:1PJ4|rcsb pdb:1PJL|refseq:NP_002387.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:aJAm/VMhqHLF07K3FlystextLrc9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9HCC0	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2211296|uniprotkb:A6NIY9|uniprotkb:Q96C27|uniprotkb:Q9Y4L7|ensembl:ENSP00000343657	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:mccb_human(display_long)|uniprotkb:MCCC2(gene name)|psi-mi:MCCC2(display_short)|uniprotkb:MCCB(gene name synonym)|uniprotkb:"3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta"(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_071415.1|refseq:XP_005248624.1|ensembl:ENSG00000131844(gene)|ensembl:ENST00000340941(transcript)|go:"GO:0002169"(3-methylcrotonyl-CoA carboxylase complex, mitochondrial)|go:"GO:0004485"(methylcrotonoyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:1905202"(methylcrotonoyl-CoA carboxylase complex)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR029045|interpro:IPR034733|mint:Q9HCC0|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70895	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:5NkqDKqdX1wHsbqXW7v5+/Gld109606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q96RQ3	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2211703|uniprotkb:Q59ES4|uniprotkb:Q9H959|uniprotkb:Q9NS97|ensembl:ENSP00000265594	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:mcca_human(display_long)|uniprotkb:MCCC1(gene name)|psi-mi:MCCC1(display_short)|uniprotkb:MCCA(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase 1(gene name synonym)|uniprotkb:"3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha"(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase biotin-containing subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_064551.3|refseq:NP_001280202.1|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR016185(PreATP-grasp-like fold)|mint:Q96RQ3|rcsb pdb:2EJM|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70895|ensembl:ENSG00000078070(gene)|ensembl:ENST00000265594(transcript)|go:"GO:0002169"(3-methylcrotonyl-CoA carboxylase complex, mitochondrial)|go:"GO:0004075"(biotin carboxylase activity)|go:"GO:0004485"(methylcrotonoyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0016421"(CoA carboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:1905202"(methylcrotonoyl-CoA carboxylase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:obze7v7i2yTIIcJjd7laIriNFg89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P42704	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P36776	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P26440	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2866408|uniprotkb:J3KR54|uniprotkb:Q53XZ9|uniprotkb:Q96AF6|uniprotkb:B2RCV5|uniprotkb:B3KVI7|ensembl:ENSP00000499074	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ivd_human(display_long)|uniprotkb:IVD(gene name)|psi-mi:IVD(display_short)|uniprotkb:Butyryl-CoA dehydrogenase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_002216.2|refseq:NP_001152980.1|ensembl:ENSG00000128928(gene)|ensembl:ENST00000651168(transcript)|go:"GO:0004085"(butyryl-CoA dehydrogenase activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0008470"(isovaleryl-CoA dehydrogenase activity)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR034183|interpro:IPR036250|interpro:IPR037069|rcsb pdb:1IVH|reactome:R-HSA-70895	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:GewB1Yyc2EEVepN5e1H068xpjI09606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P48735	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-3931130|uniprotkb:Q96GT3|uniprotkb:B2R6L6|ensembl:ENSP00000331897|uniprotkb:B4DFL2	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:idhp_human(display_long)|uniprotkb:IDH2(gene name)|psi-mi:IDH2(display_short)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000182054(gene)|ensembl:ENST00000330062(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P48735|rcsb pdb:4JA8|rcsb pdb:5GIS|rcsb pdb:5I95|rcsb pdb:5I96|rcsb pdb:5SVN|rcsb pdb:5SVO|rcsb pdb:6ADI|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VFZ|reactome:R-HSA-2151201|reactome:R-HSA-71403|refseq:NP_002159.2|refseq:NP_001276839.1|refseq:NP_001277043.1|dip:DIP-61416N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:CeuTM4HmOk3+OKkWlOt9JfNlCIM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P14735	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q5T440	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-10714899|ensembl:ENSP00000355672	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:caf17_human(display_long)|uniprotkb:Iron-sulfur cluster assembly factor homolog(gene name synonym)|uniprotkb:IBA57(gene name)|psi-mi:IBA57(display_short)|uniprotkb:C1orf69(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001010867.1|ensembl:ENSG00000181873(gene)|ensembl:ENST00000366711(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016740"(transferase activity)|interpro:IPR017703(Folate-binding, YgfZ)|interpro:IPR027266|rcsb pdb:6GEU|rcsb pdb:6QE3|rcsb pdb:6QE4	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:20ToUTe4EoBuv31juWsDvsuyQY89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9NSE4	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P10809	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q99714	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-79964|ensembl:ENSP00000168216|uniprotkb:Q8TCV9|uniprotkb:Q96HD5|uniprotkb:Q5H927|uniprotkb:Q6IBS9	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:hcd2_human(display_long)|uniprotkb:HSD17B10(gene name)|psi-mi:HSD17B10(display_short)|uniprotkb:SCHAD(gene name synonym)|uniprotkb:XH98G2(gene name synonym)|uniprotkb:HADH2(gene name synonym)|uniprotkb:3-hydroxyacyl-CoA dehydrogenase type II(gene name synonym)|uniprotkb:Type II HADH(gene name synonym)|uniprotkb:3-hydroxy-2-methylbutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:Endoplasmic reticulum-associated amyloid beta-peptide-binding protein(gene name synonym)|uniprotkb:Short-chain type dehydrogenase/reductase XH98G2(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 2(gene name synonym)|uniprotkb:2-methyl-3-hydroxybutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:ERAB(gene name synonym)|uniprotkb:MRPP2(gene name synonym)|uniprotkb:SDR5C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 5C member 1(gene name synonym)|uniprotkb:17-beta-estradiol 17-dehydrogenase(gene name synonym)|uniprotkb:"3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))"(gene name synonym)|uniprotkb:"3alpha(or 20beta)-hydroxysteroid dehydrogenase"(gene name synonym)|uniprotkb:7-alpha-hydroxysteroid dehydrogenase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	rcsb pdb:2O23|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-70895|reactome:R-HSA-8868766|ensembl:ENSG00000072506(gene)|ensembl:ENST00000168216(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008207"(C21-steroid hormone metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008709"(cholate 7-alpha-dehydrogenase activity)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0047015"(3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity)|go:"GO:0047035"("testosterone dehydrogenase (NAD+) activity")|go:"GO:0047044"(androstan-3-alpha,17-beta-diol dehydrogenase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0062173"(brexanolone metabolic process)|go:"GO:0070901"(mitochondrial tRNA methylation)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:0106281"("chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity")|go:"GO:0106282"("isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:0106283"("ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q99714|rcsb pdb:1F67|rcsb pdb:1SO8|rcsb pdb:1U7T|refseq:NP_001032900.1|refseq:NP_004484.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:q6/pRFyay7gQ6bb2rzvKYgfkeaE9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P35914	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-721399|uniprotkb:B7UCC6|uniprotkb:D3Y5K7|uniprotkb:Q6IBC0|uniprotkb:Q96FP8|uniprotkb:B4DUP4|ensembl:ENSP00000363614	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:hmgcl_human(display_long)|uniprotkb:3-hydroxy-3-methylglutarate-CoA lyase(gene name synonym)|uniprotkb:HMGCL(gene name)|psi-mi:HMGCL(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000182.2|refseq:NP_001159531.1|ensembl:ENSG00000117305(gene)|ensembl:ENST00000374490(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0004419"(hydroxymethylglutaryl-CoA lyase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007584"(response to nutrient)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042594"(response to starvation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046951"(ketone body biosynthetic process)|go:"GO:0070542"(response to fatty acid)|interpro:IPR000138(Hydroxymethylglutaryl-CoA lyase, active site)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR043594|rcsb pdb:2CW6|rcsb pdb:3MP3|rcsb pdb:3MP4|rcsb pdb:3MP5|reactome:R-HSA-77111|reactome:R-HSA-9033241	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:5MeWxi06/Ygl18C8UpZKlf9tJc09606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9UBN7	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P40939	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q8TD30	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2512017|ensembl:ENSP00000345282|uniprotkb:Q8N9E2	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:alat2_human(display_long)|uniprotkb:GPT2(gene name)|psi-mi:GPT2(display_short)|uniprotkb:AAT2(gene name synonym)|uniprotkb:ALT2(gene name synonym)|uniprotkb:Glutamic--pyruvic transaminase 2(gene name synonym)|uniprotkb:Glutamate pyruvate transaminase 2(gene name synonym)|uniprotkb:Glutamic--alanine transaminase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000166123(gene)|ensembl:ENST00000340124(transcript)|go:"GO:0004021"("L-alanine:2-oxoglutarate aminotransferase activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042851"(L-alanine metabolic process)|go:"GO:0042853"(L-alanine catabolic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:3IHJ|reactome:R-HSA-8964540|refseq:NP_001135938.1|refseq:NP_597700.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:y1b6AvLMwS7WNYKP9r2gwU2BeR49606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P00367	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-356544|uniprotkb:Q5TBU3|ensembl:ENSP00000277865|uniprotkb:B3KV55|uniprotkb:B4DGN5	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:dhe3_human(display_long)|uniprotkb:GLUD1(gene name)|psi-mi:GLUD1(display_short)|uniprotkb:GLUD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000148672(gene)|ensembl:ENST00000277865(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0042802"(identical protein binding)|refseq:NP_005262.1|refseq:NP_001305829.1|refseq:NP_001305830.1|refseq:NP_001305831.1|refseq:NP_001305833.1|refseq:NP_001305834.1|refseq:NP_001305835.1|go:"GO:0043531"(ADP binding)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070728"(leucine binding)|go:"GO:0072350"(tricarboxylic acid metabolic process)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|mint:P00367|rcsb pdb:1L1F|rcsb pdb:1NR1|rcsb pdb:6DQG|reactome:R-HSA-2151201|reactome:R-HSA-8964539	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:rWYi7otiOLlUvfEl7Vy6ELkY+BM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q92947	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1236978|uniprotkb:O14719|uniprotkb:A8K2Z2|ensembl:ENSP00000222214|ensembl:ENSP00000466845	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:gcdh_human(display_long)|uniprotkb:GCDH(gene name)|psi-mi:GCDH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000150.1|refseq:NP_039663.1|ensembl:ENSG00000105607(gene)|ensembl:ENST00000222214(transcript)|ensembl:ENST00000591470(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004361"(glutaryl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:Q92947|rcsb pdb:1SIQ|rcsb pdb:1SIR|rcsb pdb:2R0M|rcsb pdb:2R0N|reactome:R-HSA-71064|go:"GO:0050660"(flavin adenine dinucleotide binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:W192IQEAyP1SdNxhI62Fh8C2UPU9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P41250	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-724143|uniprotkb:B3KQA2|uniprotkb:B4DIA0|ensembl:ENSP00000373918|uniprotkb:Q969Y1|intact:EBI-25629666|uniprotkb:A0A090N8G0	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:gars_human(display_long)|uniprotkb:GARS1(gene name)|psi-mi:GARS1(display_short)|uniprotkb:Diadenosine tetraphosphate synthetase(gene name synonym)|uniprotkb:GARS(gene name synonym)|uniprotkb:Glycyl-tRNA synthetase(gene name synonym)|uniprotkb:Glycyl-tRNA synthetase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_002038.2|rcsb pdb:4KQE|rcsb pdb:4KR2|rcsb pdb:2ZT6|rcsb pdb:4KR3|rcsb pdb:4QEI|rcsb pdb:5E6M|reactome:R-HSA-379716|rcsb pdb:2ZT7|reactome:R-HSA-379726|rcsb pdb:2ZT8|rcsb pdb:2ZXF|ensembl:ENSG00000106105(gene)|ensembl:ENST00000389266(transcript)|go:"GO:0004081"("bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity")|go:"GO:0004820"(glycine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006426"(glycyl-tRNA aminoacylation)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016740"(transferase activity)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070150"(mitochondrial glycyl-tRNA aminoacylation)|interpro:IPR000738(WHEP-TRS)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002315(Glycyl-tRNA synthetase, alpha2 dimer)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR027031|interpro:IPR033731|interpro:IPR036621|mint:P41250|rcsb pdb:2PME|rcsb pdb:2PMF|rcsb pdb:2Q5H|rcsb pdb:2Q5I|rcsb pdb:2ZT5|refseq:NP_001303701.1|dip:DIP-50471N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:bBlAPOMGXKsEvu0DxGKJJLjDI1s9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q8NFF5	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-742815|uniprotkb:Q8N5J1|uniprotkb:Q8N686|uniprotkb:Q8WU93|uniprotkb:Q8WUJ4|uniprotkb:Q96CR8|uniprotkb:Q99764|uniprotkb:Q9HBN6|ensembl:ENSP00000292180	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:fad1_human(display_long)|uniprotkb:FMN adenylyltransferase(gene name synonym)|uniprotkb:FAD pyrophosphorylase(gene name synonym)|uniprotkb:Flavin adenine dinucleotide synthase(gene name synonym)|uniprotkb:FLAD1(gene name)|psi-mi:FLAD1(display_short)|uniprotkb:PP591(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001171820.1|refseq:NP_001171821.1|refseq:NP_079483.3|refseq:NP_958800.1|ensembl:ENSG00000160688(gene)|ensembl:ENST00000292180(transcript)|go:"GO:0003919"(FMN adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006747"(FAD biosynthetic process)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR002500(Phosphoadenosine phosphosulphate reductase)|interpro:IPR012183(FAD synthetase, molybdopterin binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036425|mint:Q8NFF5|reactome:R-HSA-196843	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:XIktrF0PkC+W6/1cHF4l/WWtGUs9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q7L8L6	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-747570|uniprotkb:Q96JN3|uniprotkb:Q9H5D1|uniprotkb:Q9H8Y3|ensembl:ENSP00000369618	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:fakd5_human(display_long)|uniprotkb:FASTKD5(gene name)|psi-mi:FASTKD5(display_short)|uniprotkb:KIAA1792(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_068598.1|ensembl:ENSG00000215251(gene)|ensembl:ENST00000380266(transcript)|go:"GO:0000963"(mitochondrial RNA processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:i48wNX7cmBCPpWXkXfnZhGnrse89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O95571	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-715318|uniprotkb:Q96HR0|uniprotkb:Q9H001|ensembl:ENSP00000292147	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ethe1_human(display_long)|uniprotkb:Ethylmalonic encephalopathy protein 1(gene name synonym)|uniprotkb:Hepatoma subtracted clone one protein(gene name synonym)|uniprotkb:ETHE1(gene name)|psi-mi:ETHE1(display_short)|uniprotkb:HSCO(gene name synonym)|uniprotkb:Sulfur dioxygenase ETHE1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_055112.2|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0042802"(identical protein binding)|go:"GO:0050313"(sulfur dioxygenase activity)|go:"GO:0070813"(hydrogen sulfide metabolic process)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR036866|interpro:IPR044528|rcsb pdb:4CHL|reactome:R-HSA-1614517|ensembl:ENSG00000105755(gene)|ensembl:ENST00000292147(transcript)|go:"GO:0005506"(iron ion binding)|refseq:XP_005258744.1|refseq:NP_001307796.1|refseq:NP_001307797.1|refseq:NP_001307798.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:a7+fXdb2iEny5lCHBrJu+zRvyLs9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P13804	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1052886|uniprotkb:B4DT43|uniprotkb:Q53XN3|ensembl:ENSP00000452762	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:etfa_human(display_long)|uniprotkb:ETFA(gene name)|psi-mi:ETFA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000117.1|refseq:NP_001121188.1|dip:DIP-6161N|ensembl:ENSG00000140374(gene)|ensembl:ENST00000557943(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001308(Electron transfer flavoprotein, alpha subunit)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014730(Electron transfer flavoprotein, alpha/beta-subunit, N-terminal)|interpro:IPR014731(Electron transfer flavoprotein, alpha subunit, C-terminal)|interpro:IPR018206|interpro:IPR029035|interpro:IPR033947|mint:P13804|rcsb pdb:1EFV|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:2A1U|reactome:R-HSA-611105	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:J2PUTTVN+nd8eHe6TXga+37CiPw9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P30084	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-719602|uniprotkb:O00739|uniprotkb:Q5VWY1|uniprotkb:Q96H54|ensembl:ENSP00000357535	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:echm_human(display_long)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:ECHS1(gene name)|psi-mi:ECHS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_004083.3|ensembl:ENSG00000127884(gene)|ensembl:ENST00000368547(transcript)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:P30084|rcsb pdb:2HW5|reactome:R-HSA-70895|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|reactome:R-HSA-77352|go:"GO:0120092"(crotonyl-CoA hydratase activity)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:zXekfKfyCbjaTVLTdDdAuMgiDco9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q13011	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-711968|ensembl:ENSP00000221418|ensembl:ENSP00000489530|uniprotkb:Q8WVX0|uniprotkb:Q96EZ9|uniprotkb:A8K745	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ech1_human(display_long)|uniprotkb:ECH1(gene name)|psi-mi:ECH1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000104823(gene)|ensembl:ENSG00000282853(gene)|ensembl:ENST00000221418(transcript)|ensembl:ENST00000634245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016020"(membrane)|go:"GO:0051750"("delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:Q13011|rcsb pdb:2VRE|reactome:R-HSA-9033241|refseq:NP_001389.2	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:gh0bwdUu9tkSTHWuySCaTXIQGzI9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9ULA0	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-748356|uniprotkb:Q9BW44|uniprotkb:Q9NUV5|uniprotkb:Q9NV55|ensembl:ENSP00000273075	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:dnpep_human(display_long)|uniprotkb:ASPEP(gene name synonym)|uniprotkb:DAP(gene name synonym)|uniprotkb:DNPEP(gene name)|psi-mi:DNPEP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001306049.1|refseq:NP_036232.2|ensembl:ENSG00000123992(gene)|ensembl:ENST00000273075(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR001948(Peptidase M18, aminopeptidase I)|interpro:IPR023358|rcsb pdb:4DYO	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:xG06vZosglPmA5ktZd8A8EH9h0g9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P36957	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-351007|uniprotkb:Q9BQ32|uniprotkb:Q7LDY7|intact:EBI-2511564|uniprotkb:B7Z5W8|uniprotkb:E7ESY5|ensembl:ENSP00000335304	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odo2_human(display_long)|uniprotkb:DLST(gene name)|psi-mi:DLST(display_short)|uniprotkb:DLTS(gene name synonym)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:E2K(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001924.2|ensembl:ENSG00000119689(gene)|ensembl:ENST00000334220(transcript)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0106077"(histone succinylation)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|mint:P36957|rcsb pdb:6H05|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:lZLUcTHB/dxXBTI/IXnSjyuVmBo9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P09622	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-353366|uniprotkb:Q14131|uniprotkb:Q14167|uniprotkb:Q59EV8|uniprotkb:Q8WTS4|uniprotkb:B2R5X0|ensembl:ENSP00000205402|ensembl:ENSP00000390667|uniprotkb:B4DHG0|uniprotkb:B4DT69	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:dldh_human(display_long)|uniprotkb:DLD(gene name)|psi-mi:DLD(display_short)|uniprotkb:GCSL(gene name synonym)|uniprotkb:LAD(gene name synonym)|uniprotkb:PHE3(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Glycine cleavage system L protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001276679.1|refseq:NP_000099.2|rcsb pdb:6I4Z|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006508"(proteolysis)|go:"GO:0007369"(gastrulation)|go:"GO:0007568"(aging)|go:"GO:0009106"(lipoate metabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0043544"(lipoamide binding)|ensembl:ENSG00000091140(gene)|ensembl:ENST00000205402(transcript)|ensembl:ENST00000417551(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-6783984|reactome:R-HSA-70268|reactome:R-HSA-70895|reactome:R-HSA-71064|reactome:R-HSA-71403|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051068"(dihydrolipoamide metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0106077"(histone succinylation)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|mint:P09622|rcsb pdb:1ZMC|rcsb pdb:1ZMD|rcsb pdb:1ZY8|rcsb pdb:2F5Z|rcsb pdb:3RNM|rcsb pdb:5J5Z|rcsb pdb:5NHG|rcsb pdb:6HG8|rcsb pdb:6I4P|rcsb pdb:6I4Q|rcsb pdb:6I4R|rcsb pdb:6I4S|rcsb pdb:6I4T|rcsb pdb:6I4U|refseq:NP_001276680.1|refseq:NP_001276681.1|dip:DIP-29027N	go:"GO:0005739"(mitochondrion)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:7613492C516F3835	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:7Yf9KyBWf18686aOXVUwab65rl89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P10515	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q7L2E3	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1211456|uniprotkb:O94965|uniprotkb:Q7Z753|uniprotkb:Q96CH4|uniprotkb:Q9NUQ0|uniprotkb:A8K5F1|ensembl:ENSP00000392601|ensembl:ENSP00000405620|intact:EBI-21350949	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:dhx30_human(display_long)|uniprotkb:DHX30(gene name)|psi-mi:DHX30(display_short)|uniprotkb:KIAA0890(gene name synonym)|uniprotkb:DDX30(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_055781.2|refseq:NP_619520.1|refseq:XP_011531796.1|refseq:XP_011531797.1|refseq:XP_016861406.1|ensembl:ENSG00000132153(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007417"(central nervous system development)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q7L2E3|rcsb pdb:2DB2|ensembl:ENST00000445061(transcript)|ensembl:ENST00000446256(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:tb4GzZKLycraXS0NlVqj8reV3IQ9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P11182	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-359002|uniprotkb:Q5VVL8|uniprotkb:B2R811|intact:EBI-1058407|ensembl:ENSP00000359151	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odb2_human(display_long)|uniprotkb:DBT(gene name)|psi-mi:DBT(display_short)|uniprotkb:BCATE2(gene name synonym)|uniprotkb:"Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase"(gene name synonym)|uniprotkb:Dihydrolipoamide branched chain transacylase(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex(gene name synonym)|uniprotkb:Branched-chain alpha-keto acid dehydrogenase complex component E2(gene name synonym)|uniprotkb:52 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Branched chain 2-oxo-acid dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001909.3|ensembl:ENSG00000137992(gene)|ensembl:ENST00000370132(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043754"("dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity")|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P11182|rcsb pdb:1K8M|rcsb pdb:1K8O|rcsb pdb:1ZWV|rcsb pdb:2COO|rcsb pdb:3RNM|reactome:R-HSA-389661|reactome:R-HSA-70895|reactome:R-HSA-9013407	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Q+c6k43BrkvtPPFCOW5pfJltPsU9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P51398	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-355912|uniprotkb:Q13044|uniprotkb:Q96Q20|uniprotkb:Q68CT7|uniprotkb:B4DP59|uniprotkb:E7EM60|uniprotkb:B4DY62|ensembl:ENSP00000341692|ensembl:ENSP00000357320	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rt29_human(display_long)|uniprotkb:DAP3(gene name)|psi-mi:DAP3(display_short)|uniprotkb:MRPS29(gene name synonym)|uniprotkb:Death-associated protein 3(gene name synonym)|uniprotkb:Ionizing radiation resistance conferring protein(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS29(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001186778.1|refseq:NP_004623.1|refseq:NP_387506.1|refseq:NP_001186779.1|refseq:NP_001186780.1|refseq:XP_005245537.1|refseq:XP_005245538.1|ensembl:ENSG00000132676(gene)|ensembl:ENST00000343043(transcript)|ensembl:ENST00000368336(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR008092(Death associated protein 3)|interpro:IPR019368|interpro:IPR027417|mint:P51398|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_016857780.1|refseq:XP_016857781.1|refseq:XP_016857782.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:xSIyqKH4F49Iu+AVuVThJWsi9EA9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9UHQ9	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-953870|ensembl:ENSP00000356218|uniprotkb:A0PK21|uniprotkb:O95329|uniprotkb:Q53F73|uniprotkb:Q8NCL5|uniprotkb:Q9UHJ1|uniprotkb:B2R8E0	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:nb5r1_human(display_long)|uniprotkb:"NAD(P)H:quinone oxidoreductase type 3 polypeptide A2"(gene name synonym)|uniprotkb:Humb5R2(gene name synonym)|uniprotkb:CYB5R1(gene name)|psi-mi:CYB5R1(display_short)|uniprotkb:NQO3A2(gene name synonym)|uniprotkb:UNQ3049/PRO9865(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000159348(gene)|ensembl:ENST00000367249(transcript)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071949"(FAD binding)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001834("NADH:cytochrome b5 reductase (CBR)")|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-HSA-114608|reactome:R-HSA-1237044|go:"GO:0016020"(membrane)|refseq:NP_057327.2	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:TOvJYSyfYu73Ac/SYjup+ABu74g9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P36551	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P09543	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1059219|intact:EBI-1188262|ensembl:ENSP00000377470	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:cn37_human(display_long)|uniprotkb:CNP(gene name)|psi-mi:CNP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_149124.3|refseq:XP_011522642.1|ensembl:ENSG00000173786(gene)|ensembl:ENST00000393892(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004113"(2',3'-cyclic-nucleotide 3'-phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009214"(cyclic nucleotide catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031143"(pseudopodium)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042470"(melanosome)|go:"GO:0045202"(synapse)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008431(Cyclic nucleotide phosphodiesterase)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR027417|mint:P09543|rcsb pdb:1WOJ|go:"GO:0003723"(RNA binding)|refseq:NP_001317145.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:TpzVM789s3qQKK7B00Vo92s31bY9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O76031	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1052667|uniprotkb:A1L428|uniprotkb:A8K8F1|uniprotkb:Q9H4D9|uniprotkb:B9EGI8|ensembl:ENSP00000300107	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:clpx_human(display_long)|uniprotkb:CLPX(gene name)|psi-mi:CLPX(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_006651.2|ensembl:ENSG00000166855(gene)|ensembl:ENST00000300107(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004487(ClpX, ATPase regulatory subunit)|interpro:IPR010603(Zinc finger, C4-type)|interpro:IPR019489|interpro:IPR027417|go:"GO:0009841"(mitochondrial endopeptidase Clp complex)|mint:O76031|dip:DIP-50293N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:+SOis7raPEZqqeel6Y6dOWJcLj49606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9BXW7	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-4399500|uniprotkb:B2RCK5|uniprotkb:Q9BXW8|uniprotkb:Q9NWA8|uniprotkb:Q9NX41|ensembl:ENSP00000337358	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:hdhd5_human(display_long)|uniprotkb:HDHD5(gene name)|psi-mi:HDHD5(display_short)|uniprotkb:CECR5(gene name synonym)|uniprotkb:Cat eye syndrome critical region protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_060299.4|refseq:NP_149061.1|ensembl:ENSG00000069998(gene)|ensembl:ENST00000336737(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|interpro:IPR006353(HAD-superfamily hydrolase, subfamily IIA, CECR5)|interpro:IPR006357(HAD-superfamily hydrolase, subfamily IIA)|interpro:IPR023214|interpro:IPR029621|interpro:IPR036412|mint:Q9BXW7	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:INkCPE3PGW5PVO8j4245B1F99HU9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9BSJ5	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2872520|uniprotkb:A8K9X3|uniprotkb:Q9H0L9|uniprotkb:Q9NWN5|uniprotkb:Q9H5E6|uniprotkb:Q5JB45|uniprotkb:Q6YAU3|ensembl:ENSP00000351937|ensembl:ENSP00000440551	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:cq080_human(display_long)|uniprotkb:C17orf80(gene name)|psi-mi:C17orf80(display_short)|uniprotkb:Cell migration-inducing gene 3 protein(gene name synonym)|uniprotkb:Human lung cancer oncogene 8 protein(gene name synonym)|uniprotkb:HLC8(orf name)|uniprotkb:MIG3(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:XP_011523263.1|refseq:XP_011523264.1|refseq:NP_001094091.1|refseq:NP_060411.2|refseq:XP_016880295.1|refseq:XP_005257544.1|ensembl:ENSG00000141219(gene)|ensembl:ENST00000359042(transcript)|ensembl:ENST00000535032(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR037694|refseq:NP_001275699.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:5nHOYiWQzPdq69Zgy3moyewfalc9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P12694	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1029053|uniprotkb:Q16034|uniprotkb:Q16472|uniprotkb:B4DP47|uniprotkb:E7EW46|ensembl:ENSP00000269980	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odba_human(display_long)|uniprotkb:BCKDHA(gene name)|psi-mi:BCKDHA(display_short)|uniprotkb:Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000700.1|ensembl:ENSG00000248098(gene)|ensembl:ENST00000269980(transcript)|go:"GO:0003863"("3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0016831"(carboxy-lyase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR029061|interpro:IPR034616|rcsb pdb:1DTW|rcsb pdb:1OLS|rcsb pdb:1OLU|rcsb pdb:1OLX|rcsb pdb:1U5B|rcsb pdb:1V11|rcsb pdb:1V16|rcsb pdb:1V1M|rcsb pdb:1V1R|rcsb pdb:1WCI|rcsb pdb:1X7W|rcsb pdb:1X7X|rcsb pdb:1X7Y|rcsb pdb:1X7Z|rcsb pdb:1X80|rcsb pdb:2BEU|rcsb pdb:2BEV|rcsb pdb:2BEW|rcsb pdb:2BFB|rcsb pdb:2BFC|rcsb pdb:2BFD|rcsb pdb:2BFE|rcsb pdb:2BFF|rcsb pdb:2J9F|reactome:R-HSA-389661|reactome:R-HSA-70895|refseq:NP_001158255.1|dip:DIP-6146N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:dfjLnS4YI8gwCQljkXL3W24I/DY9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P05091	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-711703|uniprotkb:Q03639|uniprotkb:Q6IB13|uniprotkb:Q6IV71|uniprotkb:B4DW54|uniprotkb:E7EUE5|ensembl:ENSP00000261733	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:aldh2_human(display_long)|uniprotkb:ALDH class 2(gene name synonym)|uniprotkb:ALDHI(gene name synonym)|uniprotkb:ALDH-E2(gene name synonym)|uniprotkb:ALDH2(gene name)|psi-mi:ALDH2(display_short)|uniprotkb:ALDM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000681.2|refseq:NP_001191818.1|dip:DIP-40262N|ensembl:ENSG00000111275(gene)|ensembl:ENST00000261733(transcript)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0004030"("aldehyde dehydrogenase [NAD(P)+] activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006066"(alcohol metabolic process)|go:"GO:0006068"(ethanol catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P05091|rcsb pdb:1CW3|rcsb pdb:1NZW|rcsb pdb:1NZX|rcsb pdb:1NZZ|rcsb pdb:1O00|rcsb pdb:1O01|rcsb pdb:1O02|rcsb pdb:1O04|rcsb pdb:1O05|rcsb pdb:1ZUM|rcsb pdb:2ONM|rcsb pdb:2ONN|rcsb pdb:2ONO|rcsb pdb:2ONP|rcsb pdb:2VLE|rcsb pdb:3INJ|rcsb pdb:3INL|rcsb pdb:3N80|rcsb pdb:3N81|rcsb pdb:3N82|rcsb pdb:3N83|rcsb pdb:3SZ9|rcsb pdb:4FQF|rcsb pdb:4FR8|rcsb pdb:4KWF|rcsb pdb:4KWG|rcsb pdb:5L13|reactome:R-HSA-380612|reactome:R-HSA-71384	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:XvszkFUJP4cXHCYokY16c+LeDEI9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q3SY69	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-6916128|ensembl:ENSP00000258494|uniprotkb:Q3SY68|uniprotkb:Q68D62|uniprotkb:Q6AI55|uniprotkb:Q8N922	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:al1l2_human(display_long)|uniprotkb:ALDH1L2(gene name)|psi-mi:ALDH1L2(display_short)|uniprotkb:Aldehyde dehydrogenase family 1 member L2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:XP_011536291.1|ensembl:ENST00000258494(transcript)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0009258"(10-formyltetrahydrofolate catabolic process)|go:"GO:0016155"(formyltetrahydrofolate dehydrogenase activity)|go:"GO:0016742"(hydroxymethyl-, formyl- and related transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR005793(Formyl transferase, C-terminal)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011034(Formyl transferase, C-terminal-like)|interpro:IPR011407(10-formyltetrahydrofolate dehydrogenase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|ensembl:ENSG00000136010(gene)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|interpro:IPR036477|interpro:IPR036736|interpro:IPR037022|mint:Q3SY69|reactome:R-HSA-196757|refseq:NP_001029345.2	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Tfg9TJwXfyRvVxezABcOGaJrcas9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:O75891	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-10714847|uniprotkb:B4DG36|uniprotkb:E9PBX3|uniprotkb:Q68CS1|uniprotkb:Q8TBP8|ensembl:ENSP00000377083|ensembl:ENSP00000420293	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:al1l1_human(display_long)|uniprotkb:Aldehyde dehydrogenase family 1 member L1(gene name synonym)|uniprotkb:ALDH1L1(gene name)|psi-mi:ALDH1L1(display_short)|uniprotkb:FTHFD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001257293.1|refseq:NP_001257294.1|refseq:NP_036322.2|refseq:XP_006713544.1|refseq:XP_011510657.1|ensembl:ENSG00000144908(gene)|ensembl:ENST00000393434(transcript)|ensembl:ENST00000472186(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0009258"(10-formyltetrahydrofolate catabolic process)|go:"GO:0016155"(formyltetrahydrofolate dehydrogenase activity)|go:"GO:0016742"(hydroxymethyl-, formyl- and related transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR005793(Formyl transferase, C-terminal)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011034(Formyl transferase, C-terminal-like)|interpro:IPR011407(10-formyltetrahydrofolate dehydrogenase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|interpro:IPR036477|interpro:IPR036736|interpro:IPR037022|rcsb pdb:2BW0|rcsb pdb:2CFI|rcsb pdb:2CQ8|reactome:R-HSA-196757	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:8ixKith6JQNu3p5I1XqwgeRYfwc9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P54886	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1210304|ensembl:ENSP00000360268|uniprotkb:O95952|uniprotkb:Q5T566|uniprotkb:Q9UM72|uniprotkb:Q3KQU2|uniprotkb:B2R5Q4|uniprotkb:B7Z350|uniprotkb:B7Z5X8|uniprotkb:B7ZLP1|uniprotkb:Q5T567|uniprotkb:D3DR44	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:p5cs_human(display_long)|uniprotkb:ALDH18A1(gene name)|psi-mi:ALDH18A1(display_short)|uniprotkb:P5CS(gene name synonym)|uniprotkb:PYCS(gene name synonym)|uniprotkb:GSAS(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 18 member A1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000059573(gene)|ensembl:ENST00000371224(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004349"(glutamate 5-kinase activity)|go:"GO:0004350"(glutamate-5-semialdehyde dehydrogenase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0006592"(ornithine biosynthetic process)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000965(Gamma-glutamyl phosphate reductase GPR)|interpro:IPR001048(Aspartate/glutamate/uridylate kinase)|refseq:NP_001017423.1|refseq:NP_002851.2|refseq:NP_001310341.1|refseq:NP_001310342.1|refseq:NP_001310343.1|refseq:NP_001310344.1|refseq:NP_001310345.1|refseq:NP_001310348.1|interpro:IPR001057(Glutamate 5-kinase)|interpro:IPR005715(Glutamate 5-kinase, ProB-related)|interpro:IPR005766(delta l-pyrroline-5-carboxylate synthetase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR019797|interpro:IPR020593|interpro:IPR036393|interpro:IPR041744|mint:P54886|rcsb pdb:2H5G|reactome:R-HSA-8964539	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:NLYlqQhi3HebSXYBxkkSmKplRCM9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P13196	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-3905054|ensembl:ENSP00000309259|ensembl:ENSP00000378416|ensembl:ENSP00000417719|ensembl:ENSP00000418779	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:hem1_human(display_long)|uniprotkb:ALAS1(gene name)|psi-mi:ALAS1(display_short)|uniprotkb:ALAS3(gene name synonym)|uniprotkb:ALASH(gene name synonym)|uniprotkb:5-aminolevulinic acid synthase 1(gene name synonym)|uniprotkb:Delta-ALA synthase 1(gene name synonym)|uniprotkb:Delta-aminolevulinate synthase 1(gene name synonym)|uniprotkb:OK/SW-cl.121(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001291372.1|refseq:NP_001291373.1|refseq:NP_000679.1|refseq:NP_954635.1|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0048821"(erythrocyte development)|ensembl:ENSG00000023330(gene)|ensembl:ENST00000310271(transcript)|ensembl:ENST00000394965(transcript)|ensembl:ENST00000469224(transcript)|ensembl:ENST00000484952(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003870"(5-aminolevulinate synthase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR010961(Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase)|interpro:IPR015118(5-aminolevulinate synthase presequence)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P13196|reactome:R-HSA-189451|reactome:R-HSA-1989781|reactome:R-HSA-2151201|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:HFjJ6zrRF9UYD7LMB6A3CcxcS7c9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q4G176	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-10714818|uniprotkb:A8K4J8|uniprotkb:C9JQL6|uniprotkb:Q6INA0|uniprotkb:Q8N2F7|ensembl:ENSP00000320646|ensembl:ENSP00000384627|ensembl:ENSP00000479130	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:acsf3_human(display_long)|uniprotkb:ACSF3(gene name)|psi-mi:ACSF3(display_short)|uniprotkb:Acyl-CoA synthetase family member 3(gene name synonym)|uniprotkb:PSEC0197(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001120686.1|refseq:NP_001230208.1|refseq:NP_777577.2|ensembl:ENSG00000176715(gene)|ensembl:ENST00000317447(transcript)|ensembl:ENST00000406948(transcript)|ensembl:ENST00000614302(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0016405"(CoA-ligase activity)|go:"GO:0016878"(acid-thiol ligase activity)|go:"GO:0031957"(very long-chain fatty acid-CoA ligase activity)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0090409"(malonyl-CoA synthetase activity)|go:"GO:0090410"(malonate catabolic process)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR042099|reactome:R-HSA-75876	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:TSI6vfO7BHesTLbilpyoIeKy7oE9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q96DV4	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-720441|uniprotkb:Q96Q66|uniprotkb:Q9P0B9|uniprotkb:B3KN96|ensembl:ENSP00000308275	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:rm38_human(display_long)|uniprotkb:MRPL38(gene name)|psi-mi:MRPL38(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL38(gene name synonym)|uniprotkb:HSPC262(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_115867.2|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|rcsb pdb:6ZSC|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000204316(gene)|ensembl:ENST00000309352(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR008914(Phosphatidylethanolamine-binding protein PEBP)|interpro:IPR035810|interpro:IPR036610|mint:Q96DV4|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:U9R8ZJYdURLjkBNd5LZOt4wsWD89606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q96CM8	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2876502|ensembl:ENSP00000300441|uniprotkb:Q9H7G2|uniprotkb:B4DFQ6|uniprotkb:B4DHT5|uniprotkb:B4DUF5	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:acsf2_human(display_long)|uniprotkb:ACSF2(gene name)|psi-mi:ACSF2(display_short)|uniprotkb:UNQ493/PRO1009(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000167107(gene)|ensembl:ENST00000300441(transcript)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0031956"(medium-chain fatty acid-CoA ligase activity)|go:"GO:0047760"(butyrate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|mint:Q96CM8|reactome:R-HSA-77289|go:"GO:0006631"(fatty acid metabolic process)|refseq:NP_001275897.1|refseq:NP_001275898.1|refseq:NP_001275899.1|refseq:NP_001275900.1|refseq:NP_079425.3|refseq:NP_001275901.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:yn41ilnswMEfm0Y8mmbhKneGJdU9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9Y305	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2548214|ensembl:ENSP00000336580|uniprotkb:B3KNC9|uniprotkb:B7ZM94	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:acot9_human(display_long)|uniprotkb:ACOT9(gene name)|psi-mi:ACOT9(display_short)|uniprotkb:Acyl-CoA thioester hydrolase 9(gene name synonym)|uniprotkb:CGI-16(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000123130(gene)|ensembl:ENST00000336430(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|interpro:IPR029069|interpro:IPR033120|mint:Q9Y305|reactome:R-HSA-77289|refseq:NP_001028755.2|refseq:NP_001032248.1|refseq:NP_001317188.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:WbPOPMGV/9XQRxLufTKCXvYQH/Y9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P24752	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-1051459|uniprotkb:B2R6H1|uniprotkb:G3XAB4|uniprotkb:Q96FG8|ensembl:ENSP00000265838	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:thil_human(display_long)|uniprotkb:Acetoacetyl-CoA thiolase(gene name synonym)|uniprotkb:T2(gene name synonym)|uniprotkb:ACAT1(gene name)|psi-mi:ACAT1(display_short)|uniprotkb:ACAT(gene name synonym)|uniprotkb:MAT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000010.1|ensembl:ENSG00000075239(gene)|ensembl:ENST00000265838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007420"(brain development)|go:"GO:0009725"(response to hormone)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016453"(C-acetyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0034435"(cholesterol esterification)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046356"(acetyl-CoA catabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072229"(metanephric proximal convoluted tubule development)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1902860"(propionyl-CoA biosynthetic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2F2S|rcsb pdb:2IB7|rcsb pdb:2IB8|rcsb pdb:2IB9|rcsb pdb:2IBU|rcsb pdb:2IBW|rcsb pdb:2IBY|reactome:R-HSA-70895|reactome:R-HSA-77108|reactome:R-HSA-77111	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:UYAY+kDdcJqx/hrDFoXH9rgtm/E9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P49748	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-727618|intact:EBI-10981570|uniprotkb:O76056|uniprotkb:Q8WUL0|uniprotkb:B4DEB6|uniprotkb:F5H2A9|ensembl:ENSP00000349297	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:acadv_human(display_long)|uniprotkb:ACADVL(gene name)|psi-mi:ACADVL(display_short)|uniprotkb:VLCAD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_000009.1|refseq:NP_001029031.1|refseq:NP_001257376.1|ensembl:ENSG00000072778(gene)|ensembl:ENST00000356839(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:P49748|rcsb pdb:2UXW|rcsb pdb:3B96|reactome:R-HSA-381038|reactome:R-HSA-77305|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009409"(response to cold)|go:"GO:0015980"(energy derivation by oxidation of organic compounds)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0090181"(regulation of cholesterol metabolic process)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:3SR9FcNgkWFPGrRGTi8JaJtwiF49606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q9H845	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:Q5JTZ9	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-308736|uniprotkb:Q8N198|uniprotkb:Q96D02|uniprotkb:Q9ULF0|uniprotkb:A2RRN5|ensembl:ENSP00000244571	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:syam_human(display_long)|uniprotkb:KIAA1270(gene name synonym)|uniprotkb:AARS2(gene name)|psi-mi:AARS2(display_short)|uniprotkb:AARSL(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10715009|imex:IM-24062-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_065796.1|ensembl:ENSG00000124608(gene)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018162|interpro:IPR018163|interpro:IPR018164|interpro:IPR018165|interpro:IPR023033|mint:Q5JTZ9|rcsb pdb:6NLQ|rcsb pdb:6NLY|rcsb pdb:6NOW|reactome:R-HSA-379726|ensembl:ENST00000244571(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006400"(tRNA modification)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016597"(amino acid binding)|go:"GO:0070143"(mitochondrial alanyl-tRNA aminoacylation)|interpro:IPR002318(Alanyl-tRNA synthetase, class IIc)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2020/10/21	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:RzNZMsaNjWpD4eB5AdgpjhC3vP09606	rigid:DTcTwQc5x4hl6TEL8HvqHf5+sMk	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6E7	uniprotkb:P10515	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10728010|imex:IM-24062-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2015/03/25	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rigid:ChIoO/7W9BlzQwvTqXNHw7s6ieY	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O00330	uniprotkb:Q9Y6E7	intact:EBI-751566|uniprotkb:O60221|uniprotkb:Q96FV8|uniprotkb:Q99783|uniprotkb:D3DR11|uniprotkb:E9PB14|uniprotkb:B4DW62|uniprotkb:E9PBP7|ensembl:ENSP00000227868	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	psi-mi:odpx_human(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Lipoyl-containing pyruvate dehydrogenase complex component X(gene name synonym)|uniprotkb:E3-binding protein(gene name synonym)|uniprotkb:proX(gene name synonym)|uniprotkb:PDHX(gene name)|psi-mi:PDHX(display_short)|uniprotkb:PDX1(gene name synonym)	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10728148|imex:IM-24062-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128496.1|refseq:NP_001159630.1|refseq:NP_003468.2|dip:DIP-29026N|ensembl:ENSG00000110435(gene)|ensembl:ENST00000227868(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:O00330|rcsb pdb:1ZY8|rcsb pdb:2DNC|rcsb pdb:2F5Z|rcsb pdb:2F60|rcsb pdb:6H60|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2015/03/25	rogid:fcQCBKmyySLi0lr+SQKUkPy+rwE9606	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rigid:il+WaQSOxY31mqGUafQ9OB/VKmw	false	-	enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9Y6E7	uniprotkb:O00330	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-751566|uniprotkb:O60221|uniprotkb:Q96FV8|uniprotkb:Q99783|uniprotkb:D3DR11|uniprotkb:E9PB14|uniprotkb:B4DW62|uniprotkb:E9PBP7|ensembl:ENSP00000227868	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odpx_human(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Lipoyl-containing pyruvate dehydrogenase complex component X(gene name synonym)|uniprotkb:E3-binding protein(gene name synonym)|uniprotkb:proX(gene name synonym)|uniprotkb:PDHX(gene name)|psi-mi:PDHX(display_short)|uniprotkb:PDX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10728205|imex:IM-24062-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001128496.1|refseq:NP_001159630.1|refseq:NP_003468.2|dip:DIP-29026N|ensembl:ENSG00000110435(gene)|ensembl:ENST00000227868(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:O00330|rcsb pdb:1ZY8|rcsb pdb:2DNC|rcsb pdb:2F5Z|rcsb pdb:2F60|rcsb pdb:6H60|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2015/03/25	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:fcQCBKmyySLi0lr+SQKUkPy+rwE9606	rigid:UN/9htS+UfJ++7RgW+Wwfhc3+hI	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6E7	uniprotkb:P10515	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10728205|imex:IM-24062-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2015/03/25	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rigid:UN/9htS+UfJ++7RgW+Wwfhc3+hI	false	enhanced green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6E7	uniprotkb:P10515	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10728260|imex:IM-24062-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2015/03/24	2015/03/25	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rigid:ChIoO/7W9BlzQwvTqXNHw7s6ieY	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10515	uniprotkb:Q9Y6E7	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:"MI:0991"(lipoprotein cleavage assay)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0212"(lipoprotein cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10728723|imex:IM-24062-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	go:"GO:0042159"(lipoprotein catabolic process)	-	-	figure legend:Fig. 2B, 2D, Supp. Fig. 2B|comment:SIRT4 enzyme may be His-tagged.|comment:"Reaction is NAD+ (CHEBI:15846 ) -dependent"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/24	2015/03/26	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rigid:ChIoO/7W9BlzQwvTqXNHw7s6ieY	false	sufficient binding region:254-265|N6-lipoyl-L-lysine:259-259|mutation:264-265	enhanced green fluorescent protein tag:c-c|sufficient binding region:33-314	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O00330	uniprotkb:Q9Y6E7	intact:EBI-751566|uniprotkb:O60221|uniprotkb:Q96FV8|uniprotkb:Q99783|uniprotkb:D3DR11|uniprotkb:E9PB14|uniprotkb:B4DW62|uniprotkb:E9PBP7|ensembl:ENSP00000227868	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	psi-mi:odpx_human(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Lipoyl-containing pyruvate dehydrogenase complex component X(gene name synonym)|uniprotkb:E3-binding protein(gene name synonym)|uniprotkb:proX(gene name synonym)|uniprotkb:PDHX(gene name)|psi-mi:PDHX(display_short)|uniprotkb:PDX1(gene name synonym)	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:"MI:0991"(lipoprotein cleavage assay)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0212"(lipoprotein cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10758176|imex:IM-24062-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128496.1|refseq:NP_001159630.1|refseq:NP_003468.2|dip:DIP-29026N|ensembl:ENSG00000110435(gene)|ensembl:ENST00000227868(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:O00330|rcsb pdb:1ZY8|rcsb pdb:2DNC|rcsb pdb:2F5Z|rcsb pdb:2F60|rcsb pdb:6H60|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	go:"GO:0042159"(lipoprotein catabolic process)	-	-	figure legend:Fig. 2B, 2D, Supp. Fig. 2C|comment:SIRT4 enzyme may be His-tagged.|comment:"Reaction is NAD+ (CHEBI:15846 ) -dependent"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/24	2015/03/26	rogid:fcQCBKmyySLi0lr+SQKUkPy+rwE9606	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rigid:il+WaQSOxY31mqGUafQ9OB/VKmw	false	sufficient binding region:91-103|N6-lipoyl-L-lysine:97-97|mutation:101-102	enhanced green fluorescent protein tag:c-c|sufficient binding region:33-314	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P10515	uniprotkb:Q9Y6E7	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:"MI:0991"(lipoprotein cleavage assay)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0212"(lipoprotein cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10758230|imex:IM-24062-15	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	go:"GO:0042159"(lipoprotein catabolic process)	-	-	figure legend:Fig. 3D|comment:SIRT4 enzyme may be His-tagged.|comment:"Reaction is NAD+ (CHEBI:15846 ) -dependent"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/24	2015/03/26	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rigid:ChIoO/7W9BlzQwvTqXNHw7s6ieY	false	sufficient binding region:254-265|N6-lipoyl-L-lysine:259-259|mutation:264-265	enhanced green fluorescent protein tag:c-c|sufficient binding region:33-314	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9NTG7	uniprotkb:P10515	intact:EBI-724621|uniprotkb:Q9Y6E8|ensembl:ENSP00000372191|uniprotkb:B7Z5U6	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	psi-mi:sir3_human(display_long)|uniprotkb:SIRT3(gene name)|psi-mi:SIRT3(display_short)|uniprotkb:SIR2L3(gene name synonym)|uniprotkb:SIR2-like protein 3(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 3(gene name synonym)	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0406"(deacetylase assay)	Mathias et al. (2014)	pubmed:25525879|imex:IM-24062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10758707|imex:IM-24062-17	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017524.1|refseq:NP_036371.1|ensembl:ENSG00000142082(gene)|ensembl:ENST00000382743(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009060"(aerobic respiration)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070403"(NAD+ binding)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902553"(positive regulation of catalase activity)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|go:"GO:0043565"(sequence-specific DNA binding)|rcsb pdb:3GLR|rcsb pdb:3GLS|rcsb pdb:3GLT|rcsb pdb:3GLU|rcsb pdb:4BN4|rcsb pdb:4BN5|rcsb pdb:4BV3|rcsb pdb:4BVB|rcsb pdb:4BVF|rcsb pdb:4BVG|rcsb pdb:4BVH|rcsb pdb:4C78|rcsb pdb:4C7B|rcsb pdb:4FVT|rcsb pdb:4FZ3|rcsb pdb:4HD8|rcsb pdb:4JSR|rcsb pdb:4JT8|rcsb pdb:4JT9|rcsb pdb:4O8Z|rcsb pdb:5BWN|rcsb pdb:5BWO|rcsb pdb:5D7N|rcsb pdb:5H4D|rcsb pdb:5Y4H|rcsb pdb:5YTK|rcsb pdb:5Z93|rcsb pdb:5Z94|rcsb pdb:5ZGC|rcsb pdb:6ISO|reactome:R-HSA-2151201|reactome:R-HSA-9615017|reactome:R-HSA-9617629|rcsb pdb:4BVE|refseq:XP_016872919.1|dip:DIP-46861N	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	go:"GO:0034979"(NAD-dependent protein deacetylase activity)	-	-	figure legend:Fig. 3C|comment:"Reaction is NAD+ (CHEBI:15846 ) -dependent"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:2.4x10^-4(molar)	2015/03/24	2015/04/14	rogid:KGNwfCABi61filBQeIU5v5n51kE9606	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rigid:W8o/1TyzqXVzRdyHKKHoVOj4fPk	false	glutathione s tranferase tag:c-c|sufficient binding region:47-399	sufficient binding region:254-265|N6-acetyl-L-lysine:259-259|mutation:264-265	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0396"(predetermined participant)