#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0096"(pull down) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688638|imex:IM-23971-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/06 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false glutathione s tranferase tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0096"(pull down) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688638|imex:IM-23971-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/06 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false glutathione s tranferase tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0096"(pull down) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688638|imex:IM-23971-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/06 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false glutathione s tranferase tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9P2Y5 uniprotkb:Q14457 intact:EBI-2952704|uniprotkb:B3KTC1|ensembl:ENSP00000348455|uniprotkb:O00392 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:uvrag_human(display_long)|uniprotkb:UVRAG(gene name)|psi-mi:UVRAG(display_short)|uniprotkb:p63(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0096"(pull down) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688903|imex:IM-23971-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q9P2Y5|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-9679504|reactome:R-HSA-9694676|ensembl:ENSG00000198382(gene)|ensembl:ENST00000356136(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|refseq:NP_003360.2|ensembl:ENSP00000348455|ensembl:ENST00000531818|ensembl:ENSP00000434082|ensembl:ENST00000532130|ensembl:ENSP00000436270|ensembl:ENST00000533454|ensembl:ENSP00000431256|dip:DIP-48652N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:Fig. 6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/09 rogid:TDc74eSYcSe2UJdNnKbFv5EBziE9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:MUCh1Xw/hFeGOhjQShfrFTNPDOE false glutathione s tranferase tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9P2Y5 uniprotkb:Q99570 intact:EBI-2952704|uniprotkb:B3KTC1|ensembl:ENSP00000348455|uniprotkb:O00392 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:uvrag_human(display_long)|uniprotkb:UVRAG(gene name)|psi-mi:UVRAG(display_short)|uniprotkb:p63(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0096"(pull down) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688903|imex:IM-23971-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q9P2Y5|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-9679504|reactome:R-HSA-9694676|ensembl:ENSG00000198382(gene)|ensembl:ENST00000356136(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|refseq:NP_003360.2|ensembl:ENSP00000348455|ensembl:ENST00000531818|ensembl:ENSP00000434082|ensembl:ENST00000532130|ensembl:ENSP00000436270|ensembl:ENST00000533454|ensembl:ENSP00000431256|dip:DIP-48652N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:Fig. 6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/09 rogid:TDc74eSYcSe2UJdNnKbFv5EBziE9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:MUCh1Xw/hFeGOhjQShfrFTNPDOE false glutathione s tranferase tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9P2Y5 uniprotkb:Q8NEB9 intact:EBI-2952704|uniprotkb:B3KTC1|ensembl:ENSP00000348455|uniprotkb:O00392 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:uvrag_human(display_long)|uniprotkb:UVRAG(gene name)|psi-mi:UVRAG(display_short)|uniprotkb:p63(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0096"(pull down) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688903|imex:IM-23971-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q9P2Y5|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-9679504|reactome:R-HSA-9694676|ensembl:ENSG00000198382(gene)|ensembl:ENST00000356136(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|refseq:NP_003360.2|ensembl:ENSP00000348455|ensembl:ENST00000531818|ensembl:ENSP00000434082|ensembl:ENST00000532130|ensembl:ENSP00000436270|ensembl:ENST00000533454|ensembl:ENSP00000431256|dip:DIP-48652N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:Fig. 6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/09 rogid:TDc74eSYcSe2UJdNnKbFv5EBziE9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:MUCh1Xw/hFeGOhjQShfrFTNPDOE false glutathione s tranferase tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688703|emdb:EMD-2846|imex:IM-23971-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:Fig. 1d, 3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688703|emdb:EMD-2846|imex:IM-23971-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:Fig. 1d, 3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688703|emdb:EMD-2846|imex:IM-23971-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:Fig. 1d, 3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688822|emdb:EMD-2846|imex:IM-23971-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:"Fig. 4a (line 1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688822|emdb:EMD-2846|imex:IM-23971-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:"Fig. 4a (line 1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688822|emdb:EMD-2846|imex:IM-23971-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:"Fig. 4a (line 1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - maltose binding protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688842|emdb:EMD-2846|imex:IM-23971-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:"Fig. 4a (line 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688842|emdb:EMD-2846|imex:IM-23971-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:"Fig. 4a (line 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688842|emdb:EMD-2846|imex:IM-23971-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:"Fig. 4a (line 2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - maltose binding protein tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688850|emdb:EMD-2846|imex:IM-23971-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:"Fig. 4a (line 3)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - maltose binding protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688850|emdb:EMD-2846|imex:IM-23971-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:"Fig. 4a (line 3)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688850|emdb:EMD-2846|imex:IM-23971-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:"Fig. 4a (line 3)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688860|emdb:EMD-2846|imex:IM-23971-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:"Fig. 4a (line 4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - maltose binding protein tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688860|emdb:EMD-2846|imex:IM-23971-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:"Fig. 4a (line 4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688860|emdb:EMD-2846|imex:IM-23971-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:"Fig. 4a (line 4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688868|emdb:EMD-2846|imex:IM-23971-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:"Fig. 4a (line 5)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false maltose binding protein tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688868|emdb:EMD-2846|imex:IM-23971-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:"Fig. 4a (line 5)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false maltose binding protein tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688868|emdb:EMD-2846|imex:IM-23971-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:"Fig. 4a (line 5)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false maltose binding protein tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688878|emdb:EMD-2846|imex:IM-23971-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:"Fig. 4a (line 6)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688878|emdb:EMD-2846|imex:IM-23971-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:"Fig. 4a (line 6)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - maltose binding protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688878|emdb:EMD-2846|imex:IM-23971-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:"Fig. 4a (line 6)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14457 uniprotkb:Q99570 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688923|imex:IM-23971-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:Fig. 6c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/09 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:MUCh1Xw/hFeGOhjQShfrFTNPDOE false strep tag:n-n|flag tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14457 uniprotkb:Q8NEB9 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688923|imex:IM-23971-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:Fig. 6c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/09 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:MUCh1Xw/hFeGOhjQShfrFTNPDOE false strep tag:n-n|flag tag:n-n strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14457 uniprotkb:Q9P2Y5 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 intact:EBI-2952704|uniprotkb:B3KTC1|ensembl:ENSP00000348455|uniprotkb:O00392 psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:uvrag_human(display_long)|uniprotkb:UVRAG(gene name)|psi-mi:UVRAG(display_short)|uniprotkb:p63(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688923|imex:IM-23971-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q9P2Y5|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-9679504|reactome:R-HSA-9694676|ensembl:ENSG00000198382(gene)|ensembl:ENST00000356136(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|refseq:NP_003360.2|ensembl:ENSP00000348455|ensembl:ENST00000531818|ensembl:ENSP00000434082|ensembl:ENST00000532130|ensembl:ENSP00000436270|ensembl:ENST00000533454|ensembl:ENSP00000431256|dip:DIP-48652N - - - figure legend:Fig. 6c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/09 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rogid:TDc74eSYcSe2UJdNnKbFv5EBziE9606 rigid:MUCh1Xw/hFeGOhjQShfrFTNPDOE false strep tag:n-n|flag tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688732|imex:IM-23971-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig 1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 - false - - - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) chebi:"CHEBI:28874" uniprotkb:Q6ZNE5 intact:EBI-2878872|chebi:"CHEBI:18877"|chebi:"CHEBI:494" intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 psi-mi:pi(display_short)|psi-mi:"CHEBI:28874"(display_long)|intact:phosphatidylinositols(synonym)|intact:PI(synonym)|intact:PtdIns(synonym) psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688732|imex:IM-23971-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig 1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 - rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 - false - - - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688732|imex:IM-23971-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:1343"(enzyme regulator) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig 1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 - false - - - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688732|imex:IM-23971-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig 1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 - false - - - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q6ZNE5 uniprotkb:Q14457 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688784|imex:IM-23971-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:Fig. 2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q99570 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688784|imex:IM-23971-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:Fig. 2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZNE5 uniprotkb:Q8NEB9 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10688784|imex:IM-23971-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:Fig. 2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/03/06 2015/03/08 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:ADTyCKtRsfCOLt15wMJJT7786KU false - strep tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:11750" uniprotkb:Q14457 intact:EBI-10689708|chebi:"CHEBI:64388" intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:3-sn-phosphatidyl-l-serine(display_short)|psi-mi:"CHEBI:11750"(display_long)|intact:1,2-diacyl-sn-glycero-3-phospho-L-serine(synonym)|intact:1,2-diacyl-sn-glycerol 3-phospho-L-serine(synonym)|intact:1-D-phosphatidyl-L-serine(synonym)|intact:3-L-phosphatidyl-L-serine(synonym)|intact:3-O-sn-phosphatidyl-L-serine(synonym)|intact:3-sn-phosphatidyl-L-serines(synonym)|intact:L-alpha-phosphatidylserine(synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688804|imex:IM-23971-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 - rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:11750" chebi:"CHEBI:28874" intact:EBI-10689708|chebi:"CHEBI:64388" intact:EBI-2878872|chebi:"CHEBI:18877"|chebi:"CHEBI:494" psi-mi:3-sn-phosphatidyl-l-serine(display_short)|psi-mi:"CHEBI:11750"(display_long)|intact:1,2-diacyl-sn-glycero-3-phospho-L-serine(synonym)|intact:1,2-diacyl-sn-glycerol 3-phospho-L-serine(synonym)|intact:1-D-phosphatidyl-L-serine(synonym)|intact:3-L-phosphatidyl-L-serine(synonym)|intact:3-O-sn-phosphatidyl-L-serine(synonym)|intact:3-sn-phosphatidyl-L-serines(synonym)|intact:L-alpha-phosphatidylserine(synonym) psi-mi:pi(display_short)|psi-mi:"CHEBI:28874"(display_long)|intact:phosphatidylinositols(synonym)|intact:PI(synonym)|intact:PtdIns(synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688804|imex:IM-23971-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:11750" uniprotkb:Q99570 intact:EBI-10689708|chebi:"CHEBI:64388" intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:3-sn-phosphatidyl-l-serine(display_short)|psi-mi:"CHEBI:11750"(display_long)|intact:1,2-diacyl-sn-glycero-3-phospho-L-serine(synonym)|intact:1,2-diacyl-sn-glycerol 3-phospho-L-serine(synonym)|intact:1-D-phosphatidyl-L-serine(synonym)|intact:3-L-phosphatidyl-L-serine(synonym)|intact:3-O-sn-phosphatidyl-L-serine(synonym)|intact:3-sn-phosphatidyl-L-serines(synonym)|intact:L-alpha-phosphatidylserine(synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688804|imex:IM-23971-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:1343"(enzyme regulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 - rogid:CjToF5FvjyANBQtA1wuWQxC82889606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:11750" uniprotkb:Q8NEB9 intact:EBI-10689708|chebi:"CHEBI:64388" intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:3-sn-phosphatidyl-l-serine(display_short)|psi-mi:"CHEBI:11750"(display_long)|intact:1,2-diacyl-sn-glycero-3-phospho-L-serine(synonym)|intact:1,2-diacyl-sn-glycerol 3-phospho-L-serine(synonym)|intact:1-D-phosphatidyl-L-serine(synonym)|intact:3-L-phosphatidyl-L-serine(synonym)|intact:3-O-sn-phosphatidyl-L-serine(synonym)|intact:3-sn-phosphatidyl-L-serines(synonym)|intact:L-alpha-phosphatidylserine(synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688804|imex:IM-23971-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 - rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:11750" uniprotkb:Q9P2Y5 intact:EBI-10689708|chebi:"CHEBI:64388" intact:EBI-2952704|uniprotkb:B3KTC1|ensembl:ENSP00000348455|uniprotkb:O00392 psi-mi:3-sn-phosphatidyl-l-serine(display_short)|psi-mi:"CHEBI:11750"(display_long)|intact:1,2-diacyl-sn-glycero-3-phospho-L-serine(synonym)|intact:1,2-diacyl-sn-glycerol 3-phospho-L-serine(synonym)|intact:1-D-phosphatidyl-L-serine(synonym)|intact:3-L-phosphatidyl-L-serine(synonym)|intact:3-O-sn-phosphatidyl-L-serine(synonym)|intact:3-sn-phosphatidyl-L-serines(synonym)|intact:L-alpha-phosphatidylserine(synonym) psi-mi:uvrag_human(display_long)|uniprotkb:UVRAG(gene name)|psi-mi:UVRAG(display_short)|uniprotkb:p63(gene name synonym) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688804|imex:IM-23971-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q9P2Y5|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-9679504|reactome:R-HSA-9694676|ensembl:ENSG00000198382(gene)|ensembl:ENST00000356136(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|refseq:NP_003360.2|ensembl:ENSP00000348455|ensembl:ENST00000531818|ensembl:ENSP00000434082|ensembl:ENST00000532130|ensembl:ENSP00000436270|ensembl:ENST00000533454|ensembl:ENSP00000431256|dip:DIP-48652N go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 - rogid:TDc74eSYcSe2UJdNnKbFv5EBziE9606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:11750" chebi:"CHEBI:52289" intact:EBI-10689708|chebi:"CHEBI:64388" intact:EBI-2307860 psi-mi:3-sn-phosphatidyl-l-serine(display_short)|psi-mi:"CHEBI:11750"(display_long)|intact:1,2-diacyl-sn-glycero-3-phospho-L-serine(synonym)|intact:1,2-diacyl-sn-glycerol 3-phospho-L-serine(synonym)|intact:1-D-phosphatidyl-L-serine(synonym)|intact:3-L-phosphatidyl-L-serine(synonym)|intact:3-O-sn-phosphatidyl-L-serine(synonym)|intact:3-sn-phosphatidyl-L-serines(synonym)|intact:L-alpha-phosphatidylserine(synonym) psi-mi:wortmannin(display_short)|psi-mi:"CHEBI:52289"(display_long)|intact:Wartmannin(synonym)|intact:"(1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate"(iupac name) psi-mi:"MI:0841"(phosphotransferase assay) Baskaran et al. (2013) pubmed:25490155|imex:IM-23971 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10688804|imex:IM-23971-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) - - figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/06 2015/03/23 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)