#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BUR4 uniprotkb:O60832 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-713091|ensembl:ENSP00000358563|uniprotkb:O43845|uniprotkb:Q96G67|uniprotkb:Q9Y505|uniprotkb:F5BSB3 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:dkc1_human(display_long)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:CBF5 homolog(gene name synonym)|uniprotkb:DKC1(gene name)|psi-mi:DKC1(display_short)|uniprotkb:NOLA4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR012960(DKCLD)|interpro:IPR015947(PUA-like)|interpro:IPR020103|interpro:IPR032819|interpro:IPR036974|mint:O60832|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-6790901|interpro:IPR002478(PUA)|ensembl:ENSG00000130826(gene)|ensembl:ENST00000369550(transcript)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis)|go:"GO:0006396"(RNA processing)|refseq:NP_001354.1|refseq:NP_001135935.1|refseq:NP_001275676.1|dip:DIP-40645N - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:njIdhtX9m37BslwxyAAV/JoRrHo9606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P50990 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:Q99832 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422 - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P40227 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P48643 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P50991 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998 - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P49368 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P78371 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P17987 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714290|imex:IM-24025-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 rigid:P7nUH74x8EmOTVtYppYNCxfPp9g false ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BUR4 uniprotkb:P49368 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714311|imex:IM-24025-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N - - - figure legend:Fig. 4D, 6H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606 rigid:XZ63bsJ2kox1rm8c3hLw0AB2Du4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 uniprotkb:P78371 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714311|imex:IM-24025-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Fig. 4D, 6H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 rigid:XZ63bsJ2kox1rm8c3hLw0AB2Du4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 uniprotkb:P17987 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714311|imex:IM-24025-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - figure legend:Fig. 4D, 6H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 rigid:XZ63bsJ2kox1rm8c3hLw0AB2Du4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 intact:EBI-1772365 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 rnacentral:URS00004A7003_9606 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:terc_human_rna(display_short)|psi-mi:EBI-1772365(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714374|imex:IM-24025-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N ensembl:ENST00000602385(see-also) - - - figure legend:Fig. 4E, 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9986(rabit-reticulocyte)|taxid:9986(Oryctolagus cuniculus reticulocyte) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 - - false flag tag:?-?|sufficient binding region:126-548 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0929"(northern blot) uniprotkb:Q9BUR4 uniprotkb:O77622 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-10714431|ensembl:ENSOCUP00000015180 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpz_rabit(display_long)|uniprotkb:CCT6(gene name)|psi-mi:CCT6(display_short)|uniprotkb:CCT-zeta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714374|imex:IM-24025-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001075508.1|ensembl:ENSOCUG00000017674(gene)|ensembl:ENSOCUT00000017675(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413 - - - figure legend:Fig. 4E, 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9986(rabit-reticulocyte)|taxid:9986(Oryctolagus cuniculus reticulocyte) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:vojvgjzeYqugtcw8cQDB1KBBW1s9986 - false flag tag:?-?|sufficient binding region:126-548 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 uniprotkb:O77622 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-10714431|ensembl:ENSOCUP00000015180 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpz_rabit(display_long)|uniprotkb:CCT6(gene name)|psi-mi:CCT6(display_short)|uniprotkb:CCT-zeta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714479|imex:IM-24025-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001075508.1|ensembl:ENSOCUG00000017674(gene)|ensembl:ENSOCUT00000017675(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413 - - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9986(rabit-reticulocyte)|taxid:9986(Oryctolagus cuniculus reticulocyte) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:vojvgjzeYqugtcw8cQDB1KBBW1s9986 rigid:VllRsM1MGMTdL+pUfJw79NM0P+4 false flag tag:?-?|sufficient binding region:126-509(IPR017986) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 uniprotkb:P40227 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714512|imex:IM-24025-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N - - - figure legend:Fig. 6G, Supp. Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606 rigid:Lq9+ybk1Cf5p8RBCpvtMfZDzHW4 false ha tag:n-n|sufficient binding region:151-548|mutation increasing interaction strength:164-164|mutation increasing interaction strength:376-376|mutation increasing interaction strength:435-435|mutation increasing interaction strength:398-398 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 uniprotkb:P49368 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714512|imex:IM-24025-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N - - - figure legend:Fig. 6G, Supp. Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606 rigid:Lq9+ybk1Cf5p8RBCpvtMfZDzHW4 false ha tag:n-n|sufficient binding region:151-548|mutation increasing interaction strength:164-164|mutation increasing interaction strength:376-376|mutation increasing interaction strength:435-435|mutation increasing interaction strength:398-398 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-1772365 uniprotkb:Q9BUR4 rnacentral:URS00004A7003_9606 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 psi-mi:terc_human_rna(display_short)|psi-mi:EBI-1772365(display_long) psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714470|imex:IM-24025-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) ensembl:ENST00000602385(see-also) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N - - - figure legend:Fig. 4E, 5F, 6F, Supp. Fig. 3F|comment:TCAB1 is an obligate TRiC substrate, requiring TRiC for folding and TERC binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/02/27 2015/03/24 - rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 - false mutation decreasing interaction strength:414-414|mutation decreasing interaction strength:412-412 flag tag:?-?|necessary binding region:510-548|mutation decreasing interaction strength:164-164|mutation decreasing interaction strength:376-376|mutation:435-435|mutation decreasing interaction strength:398-398 - - psi-mi:"MI:0929"(northern blot) psi-mi:"MI:0929"(northern blot) uniprotkb:Q9BUR4 uniprotkb:P49368 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714742|imex:IM-24025-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N - - - figure legend:Fig. 6H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lymphoblast)|taxid:9606(Homo sapiens, lymphoblast) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606 rigid:XZ63bsJ2kox1rm8c3hLw0AB2Du4 false ha tag:n-n|mutation increasing interaction strength:398-398,164-164|mutation increasing interaction strength:376-376,435-435 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 uniprotkb:P78371 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714742|imex:IM-24025-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Fig. 6H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lymphoblast)|taxid:9606(Homo sapiens, lymphoblast) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 rigid:XZ63bsJ2kox1rm8c3hLw0AB2Du4 false ha tag:n-n|mutation increasing interaction strength:398-398,164-164|mutation increasing interaction strength:376-376,435-435 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BUR4 uniprotkb:P17987 intact:EBI-2563542|uniprotkb:Q9NW09|uniprotkb:Q08ET9|uniprotkb:B3KPR9|uniprotkb:D3DTQ4|ensembl:ENSP00000324203|ensembl:ENSP00000379727|ensembl:ENSP00000397219|ensembl:ENSP00000411061 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:tcab1_human(display_long)|uniprotkb:TCAB1(gene name synonym)|uniprotkb:WDR79(gene name synonym)|uniprotkb:WD repeat-containing protein 79(gene name synonym)|uniprotkb:WRAP53(gene name)|psi-mi:WRAP53(display_short)|uniprotkb:WD40 repeat-containing protein antisense to TP53 gene(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Freund et al. (2014) imex:IM-24025|pubmed:25467444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10714742|imex:IM-24025-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137462.1|refseq:NP_001137463.1|refseq:NP_001137464.1|refseq:NP_060551.2|ensembl:ENSG00000141499(gene)|ensembl:ENST00000316024(transcript)|ensembl:ENST00000396463(transcript)|ensembl:ENST00000431639(transcript)|ensembl:ENST00000457584(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030576"(Cajal body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032203"(telomere formation via telomerase)|go:"GO:0034337"(RNA folding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051087"(chaperone binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090671"(telomerase RNA localization to Cajal body)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904867"(protein localization to Cajal body)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000781"(positive regulation of double-strand break repair)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-390471|dip:DIP-56796N refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - figure legend:Fig. 6H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lymphoblast)|taxid:9606(Homo sapiens, lymphoblast) - 2015/02/27 2015/03/24 rogid:/tnht4JqijEJpOj3elodNqbYeWg9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 rigid:XZ63bsJ2kox1rm8c3hLw0AB2Du4 false ha tag:n-n|mutation increasing interaction strength:398-398,164-164|mutation increasing interaction strength:376-376,435-435 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)