#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15762 uniprotkb:Q15762 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Johnston et al. (2014) imex:IM-24166|pubmed:25465800 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10821192|imex:IM-24166-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) - - - figure legend:7 D/E|antagonist:"HA-TIGIT (T-cell immunoreceptor with Ig and ITIM domains)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/04/27 2015/06/08 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 rigid:8Rs4UJL+Y+0JRLAb2bk5zykbHsY false fluorophore:n-n|flag tag:?-? fluorophore:n-n|flag tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q495A1 uniprotkb:Q15762 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Johnston et al. (2014) imex:IM-24166|pubmed:25465800 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10821263|imex:IM-24166-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) - - - figure legend:7 F/H|antagonist:anti-TIGIT antibody|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/04/27 2015/06/08 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 rigid:fb1+jXQrO42qVSd+IbVYxphKNmU false ha tag:n-n flag tag:?-?|fluorophore:n-n - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q495A1 uniprotkb:Q15762 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Johnston et al. (2014) imex:IM-24166|pubmed:25465800 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10821253|imex:IM-24166-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) - - - figure legend:7G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2015/04/27 2015/05/19 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 rigid:fb1+jXQrO42qVSd+IbVYxphKNmU false ha tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q495A1 uniprotkb:Q15762 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Johnston et al. (2014) imex:IM-24166|pubmed:25465800 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10835985|imex:IM-24166-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) - - - figure legend:7Gi|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2015/04/27 2015/06/08 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 rigid:fb1+jXQrO42qVSd+IbVYxphKNmU false ha tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15762 uniprotkb:Q495A1 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Johnston et al. (2014) imex:IM-24166|pubmed:25465800 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10821282|imex:IM-24166-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 - - - figure legend:7 I|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-t-cell)|taxid:9606(Homo sapiens) - 2015/04/27 2015/05/19 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rigid:fb1+jXQrO42qVSd+IbVYxphKNmU false flag tag:n-n ha tag:n-n - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)