#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15061	uniprotkb:Q8WZ42	intact:EBI-7843148|intact:EBI-28977600|ensembl:ENSP00000336775|intact:MINT-198289|uniprotkb:Q2TBJ4|uniprotkb:Q5NJJ9|uniprotkb:Q8TE62|uniprotkb:A7E2Y2|uniprotkb:Q8TE61	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:synem_human(display_long)|uniprotkb:KIAA0353(gene name synonym)|uniprotkb:DMN(gene name synonym)|uniprotkb:SYN(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)|uniprotkb:SYNM(gene name)|psi-mi:SYNM(display_short)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108446|imex:IM-23816-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000336775|ensembl:ENSG00000182253(gene)|ensembl:ENST00000336292(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|rcsb pdb:6EWO|refseq:NP_056101.5|refseq:NP_663780.2	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N	-	comment:mint|function:"Desmuslin is a type-VI intermediate filament which may function as a mechanical support to the muscle fibers by making a linkage between the extracellular matrix via the dystrophin-associated protein complex (DAPC) and the Z-disk"	-	figure legend:f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/02/09	2015/02/09	rogid:rzVhqnzGeDs2F13p1f2TSKoradM9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:D7C69BF2724EACDD|rigid:LiEkV7I59bJUqvnnErFs0ymi670	false	binding-associated region:1359-1462	binding-associated region:34281-34350	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15061	uniprotkb:Q8WZ42	intact:EBI-7843148|intact:EBI-28977600|ensembl:ENSP00000336775|intact:MINT-198289|uniprotkb:Q2TBJ4|uniprotkb:Q5NJJ9|uniprotkb:Q8TE62|uniprotkb:A7E2Y2|uniprotkb:Q8TE61	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:synem_human(display_long)|uniprotkb:KIAA0353(gene name synonym)|uniprotkb:DMN(gene name synonym)|uniprotkb:SYN(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)|uniprotkb:SYNM(gene name)|psi-mi:SYNM(display_short)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108461|imex:IM-23816-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000336775|ensembl:ENSG00000182253(gene)|ensembl:ENST00000336292(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|rcsb pdb:6EWO|refseq:NP_056101.5|refseq:NP_663780.2	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N	-	comment:mint|function:"Desmuslin is a type-VI intermediate filament which may function as a mechanical support to the muscle fibers by making a linkage between the extracellular matrix via the dystrophin-associated protein complex (DAPC) and the Z-disk"	-	figure legend:st1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/02/09	2015/02/09	rogid:rzVhqnzGeDs2F13p1f2TSKoradM9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:D0376F30AA938F6B|rigid:LiEkV7I59bJUqvnnErFs0ymi670	false	binding-associated region:1152-1462	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15061	uniprotkb:Q14315	intact:EBI-7843148|intact:EBI-28977600|ensembl:ENSP00000336775|intact:MINT-198289|uniprotkb:Q2TBJ4|uniprotkb:Q5NJJ9|uniprotkb:Q8TE62|uniprotkb:A7E2Y2|uniprotkb:Q8TE61	intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145	psi-mi:synem_human(display_long)|uniprotkb:KIAA0353(gene name synonym)|uniprotkb:DMN(gene name synonym)|uniprotkb:SYN(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)|uniprotkb:SYNM(gene name)|psi-mi:SYNM(display_short)	psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108470|imex:IM-23816-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000336775|ensembl:ENSG00000182253(gene)|ensembl:ENST00000336292(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|rcsb pdb:6EWO|refseq:NP_056101.5|refseq:NP_663780.2	refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N	-	comment:mint|function:"Desmuslin is a type-VI intermediate filament which may function as a mechanical support to the muscle fibers by making a linkage between the extracellular matrix via the dystrophin-associated protein complex (DAPC) and the Z-disk"	-	figure legend:st1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/02/09	2015/02/09	rogid:rzVhqnzGeDs2F13p1f2TSKoradM9606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	intact-crc:9298297A82A5E9DD|rigid:Mx8PuemDz2RG13lirsJjKIqzcSk	false	binding-associated region:1152-1462	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15061	uniprotkb:Q9NRI5	intact:EBI-7843148|intact:EBI-28977600|ensembl:ENSP00000336775|intact:MINT-198289|uniprotkb:Q2TBJ4|uniprotkb:Q5NJJ9|uniprotkb:Q8TE62|uniprotkb:A7E2Y2|uniprotkb:Q8TE61	intact:EBI-529989|uniprotkb:O75045|uniprotkb:Q5VT44|uniprotkb:Q5VT45|uniprotkb:Q8IXJ0|uniprotkb:Q8IXJ1|uniprotkb:Q9BX19|uniprotkb:Q9NRI3|uniprotkb:Q9NRI4|uniprotkb:C9J6D0|intact:EBI-28977396|ensembl:ENSP00000403888|uniprotkb:A6NLH2|uniprotkb:C4P095|uniprotkb:C4P0A1|uniprotkb:C4P0A3|uniprotkb:C4P0B3|uniprotkb:C4P091|uniprotkb:C4P0B6|uniprotkb:C4P0C1	psi-mi:synem_human(display_long)|uniprotkb:KIAA0353(gene name synonym)|uniprotkb:DMN(gene name synonym)|uniprotkb:SYN(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)|uniprotkb:SYNM(gene name)|psi-mi:SYNM(display_short)	psi-mi:disc1_human(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108476|imex:IM-23816-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000336775|ensembl:ENSG00000182253(gene)|ensembl:ENST00000336292(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|rcsb pdb:6EWO|refseq:NP_056101.5|refseq:NP_663780.2	ensembl:ENST00000317586|ensembl:ENSP00000320784|ensembl:ENST00000366633|ensembl:ENSP00000355593|ensembl:ENST00000366636|ensembl:ENSP00000355596|ensembl:ENST00000366637|ensembl:ENSP00000355597|ensembl:ENSP00000403888|ensembl:ENST00000535983|ensembl:ENSP00000443996|ensembl:ENST00000539444|ensembl:ENSP00000440953|ensembl:ENST00000602281|ensembl:ENSP00000473425|ensembl:ENST00000602700|ensembl:ENSP00000473417|ensembl:ENST00000602713|ensembl:ENSP00000473261|ensembl:ENST00000602822|ensembl:ENSP00000473586|ensembl:ENST00000602873|ensembl:ENSP00000473386|ensembl:ENST00000628350|ensembl:ENSP00000487190|ensembl:ENSG00000162946(gene)|ensembl:ENST00000439617(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|mint:Q9NRI5|rcsb pdb:5V4B|refseq:NP_001012975.1|refseq:NP_001012976.1|refseq:NP_001012977.1|refseq:NP_061132.2|refseq:NP_001158011.1|refseq:NP_001158013.1|refseq:NP_001158017.1|refseq:NP_001158018.1|refseq:NP_001158019.1|refseq:NP_001158016.1|refseq:NP_001158027.1|refseq:NP_001158028.1|dip:DIP-33828N	-	comment:mint|function:"Desmuslin is a type-VI intermediate filament which may function as a mechanical support to the muscle fibers by making a linkage between the extracellular matrix via the dystrophin-associated protein complex (DAPC) and the Z-disk"	-	figure legend:st1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/02/09	2015/02/09	rogid:rzVhqnzGeDs2F13p1f2TSKoradM9606	rogid:m8e3Nji5GtYKa5m5lcFJDAUnh/89606	intact-crc:929285E9673CFA4C|rigid:YJ0EmaDxFVXx2dnUfTtqDGmVuU0	false	binding-associated region:1152-1462	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15061	uniprotkb:Q8WZ42	intact:EBI-7843148|intact:EBI-28977600|ensembl:ENSP00000336775|intact:MINT-198289|uniprotkb:Q2TBJ4|uniprotkb:Q5NJJ9|uniprotkb:Q8TE62|uniprotkb:A7E2Y2|uniprotkb:Q8TE61	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:synem_human(display_long)|uniprotkb:KIAA0353(gene name synonym)|uniprotkb:DMN(gene name synonym)|uniprotkb:SYN(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)|uniprotkb:SYNM(gene name)|psi-mi:SYNM(display_short)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108501|imex:IM-23816-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000336775|ensembl:ENSG00000182253(gene)|ensembl:ENST00000336292(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|rcsb pdb:6EWO|refseq:NP_056101.5|refseq:NP_663780.2	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N	-	comment:mint|function:"Desmuslin is a type-VI intermediate filament which may function as a mechanical support to the muscle fibers by making a linkage between the extracellular matrix via the dystrophin-associated protein complex (DAPC) and the Z-disk"	-	figure legend:f3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/09	2015/02/12	rogid:rzVhqnzGeDs2F13p1f2TSKoradM9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:9E757B2831ADA792|rigid:LiEkV7I59bJUqvnnErFs0ymi670	false	maltose binding protein tag:?-?|binding-associated region:1359-1462	binding-associated region:34281-34350|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A2ASS6	uniprotkb:Q70IV5	intact:EBI-9672947|uniprotkb:A2ASS5|uniprotkb:A2ASS7	intact:EBI-9989763|uniprotkb:Q3UPZ4|uniprotkb:Q6A081|uniprotkb:Q70IV3|uniprotkb:Q70IV4|ensembl:ENSMUSP00000073855	psi-mi:titin_mouse(display_long)|uniprotkb:Ttn(gene name)|psi-mi:Ttn(display_short)|uniprotkb:Connectin(gene name synonym)	psi-mi:synem_mouse(display_long)|uniprotkb:Synm(gene name)|psi-mi:Synm(display_short)|uniprotkb:Dmn(gene name synonym)|uniprotkb:Kiaa0353(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108532|imex:IM-23816-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR040849|rcsb pdb:6YJ0|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR004168(PPAK motif)|interpro:IPR000719(Protein kinase, core)|interpro:IPR015129(Titin Z)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR036116|interpro:IPR036179|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021591"(ventricular system development)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031672"(A band)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043056"(forward locomotion)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060419"(heart growth)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)	refseq:NP_899135.3|refseq:NP_964001.2|refseq:NP_997546.2|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030018"(Z disc)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|go:"GO:0005200"(structural constituent of cytoskeleton)|ensembl:ENSMUSG00000030554(gene)|ensembl:ENSMUST00000074233(transcript)	-	-	-	figure legend:f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hl-1)|taxid:10090(Mus musculus)	-	2015/02/09	2015/02/09	rogid:xDsiEoYt/F9ZCvYym/wgnXdwYbU10090	rogid:Fgh1JpG9IDFBh3r1Sorb6NU+60c10090	intact-crc:08B841795C965A1C|rigid:2QihH0fBnrhC6ciMxCl3a8i4oYQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q70IV5	uniprotkb:A2ASS6	intact:EBI-9989763|uniprotkb:Q3UPZ4|uniprotkb:Q6A081|uniprotkb:Q70IV3|uniprotkb:Q70IV4|ensembl:ENSMUSP00000073855	intact:EBI-9672947|uniprotkb:A2ASS5|uniprotkb:A2ASS7	psi-mi:synem_mouse(display_long)|uniprotkb:Synm(gene name)|psi-mi:Synm(display_short)|uniprotkb:Dmn(gene name synonym)|uniprotkb:Kiaa0353(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)	psi-mi:titin_mouse(display_long)|uniprotkb:Ttn(gene name)|psi-mi:Ttn(display_short)|uniprotkb:Connectin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108528|imex:IM-23816-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_899135.3|refseq:NP_964001.2|refseq:NP_997546.2|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030018"(Z disc)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|go:"GO:0005200"(structural constituent of cytoskeleton)|ensembl:ENSMUSG00000030554(gene)|ensembl:ENSMUST00000074233(transcript)	interpro:IPR040849|rcsb pdb:6YJ0|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR004168(PPAK motif)|interpro:IPR000719(Protein kinase, core)|interpro:IPR015129(Titin Z)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR036116|interpro:IPR036179|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021591"(ventricular system development)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031672"(A band)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043056"(forward locomotion)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060419"(heart growth)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)	-	-	-	figure legend:f4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hl-1)|taxid:10090(Mus musculus)	-	2015/02/09	2015/02/09	rogid:Fgh1JpG9IDFBh3r1Sorb6NU+60c10090	rogid:xDsiEoYt/F9ZCvYym/wgnXdwYbU10090	intact-crc:2CEC99D178BCFFD3|rigid:2QihH0fBnrhC6ciMxCl3a8i4oYQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q70IV5	uniprotkb:A2ASS6	intact:EBI-9989763|uniprotkb:Q3UPZ4|uniprotkb:Q6A081|uniprotkb:Q70IV3|uniprotkb:Q70IV4|ensembl:ENSMUSP00000073855	intact:EBI-9672947|uniprotkb:A2ASS5|uniprotkb:A2ASS7	psi-mi:synem_mouse(display_long)|uniprotkb:Synm(gene name)|psi-mi:Synm(display_short)|uniprotkb:Dmn(gene name synonym)|uniprotkb:Kiaa0353(gene name synonym)|uniprotkb:Desmuslin(gene name synonym)	psi-mi:titin_mouse(display_long)|uniprotkb:Ttn(gene name)|psi-mi:Ttn(display_short)|uniprotkb:Connectin(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Prudner et al. (2014)	imex:IM-23816|pubmed:25447537	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-10108549|imex:IM-23816-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_899135.3|refseq:NP_964001.2|refseq:NP_997546.2|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030018"(Z disc)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031443"(fast-twitch skeletal muscle fiber contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0060053"(neurofilament cytoskeleton)|interpro:IPR018039|interpro:IPR030634|interpro:IPR039008|go:"GO:0005200"(structural constituent of cytoskeleton)|ensembl:ENSMUSG00000030554(gene)|ensembl:ENSMUST00000074233(transcript)	interpro:IPR040849|rcsb pdb:6YJ0|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR004168(PPAK motif)|interpro:IPR000719(Protein kinase, core)|interpro:IPR015129(Titin Z)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR036116|interpro:IPR036179|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021591"(ventricular system development)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031672"(A band)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043056"(forward locomotion)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060419"(heart growth)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)	go:"GO:0030017"(sarcomere)	-	-	figure legend:f5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2015/02/09	2015/02/09	rogid:Fgh1JpG9IDFBh3r1Sorb6NU+60c10090	rogid:xDsiEoYt/F9ZCvYym/wgnXdwYbU10090	intact-crc:39ECE6ED60C74465|rigid:2QihH0fBnrhC6ciMxCl3a8i4oYQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)