#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8TCT9	uniprotkb:Q9BUN8	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	intact:EBI-398977|uniprotkb:B3KW41|uniprotkb:E9PH19|ensembl:ENSP00000259512	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:derl1_human(display_long)|uniprotkb:DERL1(gene name)|psi-mi:DERL1(display_short)|uniprotkb:UNQ243/PRO276(orf name)|uniprotkb:Der1-like protein 1(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 1(gene name synonym)|uniprotkb:DER1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636802|imex:IM-23851-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	refseq:NP_001128143.1|refseq:NP_077271.1|ensembl:ENSG00000136986(gene)|ensembl:ENST00000259512(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002020"(protease binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0036502"(Derlin-1-VIMP complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|rcsb pdb:5GLF|rcsb pdb:7CZB|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5678895|reactome:R-HSA-8866654	-	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/18	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	rogid:M35Ah+CuYuV7RP1edsda6vU7Bgo9606	intact-crc:A7749E763BB93601|rigid:nxKG3KQa6QFkUkgf99vc1x+1VTw	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17861-1	uniprotkb:Q8TCT9	intact:EBI-7631279|ensembl:ENSP00000216037|intact:MINT-268178	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	psi-mi:p17861-1(display_long)|uniprotkb:Unprocessed XBP-1(isoform synonym)|uniprotkb:XBP1u(isoform synonym)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:XBP-1U(isoform synonym)	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10638076|imex:IM-23851-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|intact:EBI-6942961(xbp1_human)	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	-	comment:mint	-	figure legend:f6b sf6b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/19	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	intact-crc:86D595DF68FD02D6|rigid:8Pf/OPaHhrgZEyKdQGmzmy8cS9A	false	-	ha tag:?-?|mutation increasing interaction:265-265	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8WU17	uniprotkb:Q8TCT9	intact:EBI-1551681|uniprotkb:O75485|uniprotkb:Q7LDL3|uniprotkb:B3KMD5|ensembl:ENSP00000304051	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	psi-mi:rn139_human(display_long)|uniprotkb:Translocation in renal carcinoma on chromosome 8 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF139(gene name synonym)|uniprotkb:RING finger protein 139(gene name synonym)|uniprotkb:RNF139(gene name)|psi-mi:RNF139(display_short)|uniprotkb:TRC8(gene name synonym)	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636816|imex:IM-23851-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009149.2|ensembl:ENSG00000170881(gene)|ensembl:ENST00000303545(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|reactome:R-HSA-901032	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/18	rogid:LjH3X0GbTdHrU+hvPbJKZ3Bu9Jg9606	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	intact-crc:CB081166CD87E471|rigid:PYkRqzbBFjzfRJZHCC3DyHC2KuM	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BUN8	uniprotkb:Q8TCT9	intact:EBI-398977|uniprotkb:B3KW41|uniprotkb:E9PH19|ensembl:ENSP00000259512	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	psi-mi:derl1_human(display_long)|uniprotkb:DERL1(gene name)|psi-mi:DERL1(display_short)|uniprotkb:UNQ243/PRO276(orf name)|uniprotkb:Der1-like protein 1(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 1(gene name synonym)|uniprotkb:DER1(gene name synonym)	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636680|imex:IM-23851-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128143.1|refseq:NP_077271.1|ensembl:ENSG00000136986(gene)|ensembl:ENST00000259512(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002020"(protease binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0036502"(Derlin-1-VIMP complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|rcsb pdb:5GLF|rcsb pdb:7CZB|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5678895|reactome:R-HSA-8866654	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	-	-	-	figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/18	rogid:M35Ah+CuYuV7RP1edsda6vU7Bgo9606	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	intact-crc:451A6537C93601A2|rigid:nxKG3KQa6QFkUkgf99vc1x+1VTw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TCT9	uniprotkb:Q9BUN8	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	intact:EBI-398977|uniprotkb:B3KW41|uniprotkb:E9PH19|ensembl:ENSP00000259512	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:derl1_human(display_long)|uniprotkb:DERL1(gene name)|psi-mi:DERL1(display_short)|uniprotkb:UNQ243/PRO276(orf name)|uniprotkb:Der1-like protein 1(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 1(gene name synonym)|uniprotkb:DER1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636676|imex:IM-23851-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	refseq:NP_001128143.1|refseq:NP_077271.1|ensembl:ENSG00000136986(gene)|ensembl:ENST00000259512(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002020"(protease binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0036502"(Derlin-1-VIMP complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|rcsb pdb:5GLF|rcsb pdb:7CZB|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5678895|reactome:R-HSA-8866654	-	-	-	figure legend:f1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/18	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	rogid:M35Ah+CuYuV7RP1edsda6vU7Bgo9606	intact-crc:D2FC6A1A3999378B|rigid:nxKG3KQa6QFkUkgf99vc1x+1VTw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TCT9	uniprotkb:Q9BUN8	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	intact:EBI-398977|uniprotkb:B3KW41|uniprotkb:E9PH19|ensembl:ENSP00000259512	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:derl1_human(display_long)|uniprotkb:DERL1(gene name)|psi-mi:DERL1(display_short)|uniprotkb:UNQ243/PRO276(orf name)|uniprotkb:Der1-like protein 1(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 1(gene name synonym)|uniprotkb:DER1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636672|imex:IM-23851-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	refseq:NP_001128143.1|refseq:NP_077271.1|ensembl:ENSG00000136986(gene)|ensembl:ENST00000259512(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002020"(protease binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0036502"(Derlin-1-VIMP complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|rcsb pdb:5GLF|rcsb pdb:7CZB|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5678895|reactome:R-HSA-8866654	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/18	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	rogid:M35Ah+CuYuV7RP1edsda6vU7Bgo9606	intact-crc:D2FEBA1A3999378B|rigid:nxKG3KQa6QFkUkgf99vc1x+1VTw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17861-1	uniprotkb:Q8WU17	intact:EBI-7631279|ensembl:ENSP00000216037|intact:MINT-268178	intact:EBI-1551681|uniprotkb:O75485|uniprotkb:Q7LDL3|uniprotkb:B3KMD5|ensembl:ENSP00000304051	psi-mi:p17861-1(display_long)|uniprotkb:Unprocessed XBP-1(isoform synonym)|uniprotkb:XBP1u(isoform synonym)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:XBP-1U(isoform synonym)	psi-mi:rn139_human(display_long)|uniprotkb:Translocation in renal carcinoma on chromosome 8 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF139(gene name synonym)|uniprotkb:RING finger protein 139(gene name synonym)|uniprotkb:RNF139(gene name)|psi-mi:RNF139(display_short)|uniprotkb:TRC8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10638102|imex:IM-23851-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|intact:EBI-6942961(xbp1_human)	refseq:NP_009149.2|ensembl:ENSG00000170881(gene)|ensembl:ENST00000303545(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|reactome:R-HSA-901032	-	comment:mint	-	figure legend:sf7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2021/01/18	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:LjH3X0GbTdHrU+hvPbJKZ3Bu9Jg9606	intact-crc:6F630311A312B825|rigid:sY/ieZ0rmNF+gTlWGXYFV8KEeP4	false	flag tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P17861-1	uniprotkb:P17861-2	intact:EBI-7631279|ensembl:ENSP00000216037|intact:MINT-268178	intact:EBI-10638056|ensembl:ENSP00000343155|ensembl:ENSP00000481170	psi-mi:p17861-1(display_long)|uniprotkb:Unprocessed XBP-1(isoform synonym)|uniprotkb:XBP1u(isoform synonym)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:XBP-1U(isoform synonym)	psi-mi:p17861-2(display_long)|uniprotkb:Processed XBP-1(isoform synonym)|uniprotkb:XBP-1S(isoform synonym)|uniprotkb:XBP1s(isoform synonym)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10638068|imex:IM-23851-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|intact:EBI-6942961(xbp1_human)	intact:EBI-6942961(isoform-parent)|ensembl:ENSG00000100219(gene)|ensembl:ENST00000344347(transcript)|ensembl:ENST00000611155(transcript)|uniprotkb:P17861-2(isoform-parent)	-	comment:mint	isoform-comment:"Potent transcriptional activator. Induced by unconventional ERN1-dependent splicing in response to endoplasmic reticulum stress (Ref.4, Ref.18, Ref.19). ENR1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript (Ref.4)."	figure legend:sf5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/19	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:W58bz1aqbXfTuSRwt63y7OIoJP89606	intact-crc:4E93E15B93BACAB2|rigid:lwMPbRvOrr60+EI/EHs6x+EyP9M	false	flag tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P17861-1	uniprotkb:Q9BUN8	intact:EBI-7631279|ensembl:ENSP00000216037|intact:MINT-268178	intact:EBI-398977|uniprotkb:B3KW41|uniprotkb:E9PH19|ensembl:ENSP00000259512	psi-mi:p17861-1(display_long)|uniprotkb:Unprocessed XBP-1(isoform synonym)|uniprotkb:XBP1u(isoform synonym)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:XBP-1U(isoform synonym)	psi-mi:derl1_human(display_long)|uniprotkb:DERL1(gene name)|psi-mi:DERL1(display_short)|uniprotkb:UNQ243/PRO276(orf name)|uniprotkb:Der1-like protein 1(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 1(gene name synonym)|uniprotkb:DER1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10638116|imex:IM-23851-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|intact:EBI-6942961(xbp1_human)	refseq:NP_001128143.1|refseq:NP_077271.1|ensembl:ENSG00000136986(gene)|ensembl:ENST00000259512(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002020"(protease binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0036502"(Derlin-1-VIMP complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|rcsb pdb:5GLF|rcsb pdb:7CZB|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5678895|reactome:R-HSA-8866654	-	comment:mint	-	figure legend:f7c sf8b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/18	2015/02/19	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:M35Ah+CuYuV7RP1edsda6vU7Bgo9606	intact-crc:0AB7E330AE790137|rigid:VJ5EcpRe/gYiMGLWv4M2HAH1Suc	false	flag tag:n-n|binding-associated region:207-261	mutation:180-180|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TCT9	uniprotkb:Q9BUN8	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	intact:EBI-398977|uniprotkb:B3KW41|uniprotkb:E9PH19|ensembl:ENSP00000259512	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:derl1_human(display_long)|uniprotkb:DERL1(gene name)|psi-mi:DERL1(display_short)|uniprotkb:UNQ243/PRO276(orf name)|uniprotkb:Der1-like protein 1(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 1(gene name synonym)|uniprotkb:DER1(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636738|imex:IM-23851-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	refseq:NP_001128143.1|refseq:NP_077271.1|ensembl:ENSG00000136986(gene)|ensembl:ENST00000259512(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002020"(protease binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0036502"(Derlin-1-VIMP complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|rcsb pdb:5GLF|rcsb pdb:7CZB|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5678895|reactome:R-HSA-8866654	-	-	-	figure legend:f1d sf7f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/18	2015/02/19	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	rogid:M35Ah+CuYuV7RP1edsda6vU7Bgo9606	intact-crc:356AB43078BC73C6|rigid:nxKG3KQa6QFkUkgf99vc1x+1VTw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17861-1	uniprotkb:Q8TCT9	intact:EBI-7631279|ensembl:ENSP00000216037|intact:MINT-268178	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	psi-mi:p17861-1(display_long)|uniprotkb:Unprocessed XBP-1(isoform synonym)|uniprotkb:XBP1u(isoform synonym)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:XBP-1U(isoform synonym)	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:"MI:0276"(blue native page)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10638084|imex:IM-23851-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|intact:EBI-6942961(xbp1_human)	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	-	comment:mint	-	figure legend:f6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/18	2015/02/19	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	intact-crc:7EF5F1C81A076294|rigid:8Pf/OPaHhrgZEyKdQGmzmy8cS9A	false	flag tag:?-?	ha tag:?-?|trapping mutant:265-265	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WU17	uniprotkb:Q8TCT9	intact:EBI-1551681|uniprotkb:O75485|uniprotkb:Q7LDL3|uniprotkb:B3KMD5|ensembl:ENSP00000304051	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	psi-mi:rn139_human(display_long)|uniprotkb:Translocation in renal carcinoma on chromosome 8 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF139(gene name synonym)|uniprotkb:RING finger protein 139(gene name synonym)|uniprotkb:RNF139(gene name)|psi-mi:RNF139(display_short)|uniprotkb:TRC8(gene name synonym)	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:"MI:0276"(blue native page)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636790|imex:IM-23851-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009149.2|ensembl:ENSG00000170881(gene)|ensembl:ENST00000303545(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|reactome:R-HSA-901032	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	-	-	-	figure legend:f1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/18	2015/02/19	rogid:LjH3X0GbTdHrU+hvPbJKZ3Bu9Jg9606	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	intact-crc:F3B53CE040C54776|rigid:PYkRqzbBFjzfRJZHCC3DyHC2KuM	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BUN8	uniprotkb:Q8TCT9	intact:EBI-398977|uniprotkb:B3KW41|uniprotkb:E9PH19|ensembl:ENSP00000259512	intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032	psi-mi:derl1_human(display_long)|uniprotkb:DERL1(gene name)|psi-mi:DERL1(display_short)|uniprotkb:UNQ243/PRO276(orf name)|uniprotkb:Der1-like protein 1(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 1(gene name synonym)|uniprotkb:DER1(gene name synonym)	psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name)	psi-mi:"MI:0276"(blue native page)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10638094|imex:IM-23851-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128143.1|refseq:NP_077271.1|ensembl:ENSG00000136986(gene)|ensembl:ENST00000259512(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002020"(protease binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0036502"(Derlin-1-VIMP complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|rcsb pdb:5GLF|rcsb pdb:7CZB|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5678895|reactome:R-HSA-8866654	refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587	-	-	-	figure legend:sf7a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/18	2015/02/19	rogid:M35Ah+CuYuV7RP1edsda6vU7Bgo9606	rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606	intact-crc:E141B665521B4199|rigid:nxKG3KQa6QFkUkgf99vc1x+1VTw	false	green fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17861	uniprotkb:P27824	intact:EBI-6942961|ensembl:ENSP00000216037|uniprotkb:Q969P1|intact:MINT-268152|uniprotkb:Q96BD7|uniprotkb:Q8WYK6	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	psi-mi:xbp1_human(display_long)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-10638110|imex:IM-23851-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903489"(positive regulation of lactation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|rcsb pdb:6R5Q|rcsb pdb:6R6G|rcsb pdb:6R6P|rcsb pdb:6R7Q|reactome:R-HSA-381038|reactome:R-HSA-381070|reactome:R-HSA-381183|go:"GO:0071499"(cellular response to laminar fluid shear stress)|refseq:NP_001073007.1|refseq:NP_005071.2|dip:DIP-41692N	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	go:"GO:0043231"(intracellular membrane-bounded organelle)	function:"Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I"|comment:mint	-	figure legend:sf7d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/18	2015/02/23	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	intact-crc:9209610A23A3E1AB|rigid:LQ/OboxefXttwC13p34LL5TR0ew	false	binding-associated region:1-194	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11021	uniprotkb:P27824	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636905|imex:IM-23851-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	go:"GO:0043231"(intracellular membrane-bounded organelle)	-	-	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/18	2015/02/18	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	intact-crc:209BFAD8B68913BC|rigid:10AZ93xI83ZRjVdSkRpMlJkd0X4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11021	uniprotkb:P17861	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	intact:EBI-6942961|ensembl:ENSP00000216037|uniprotkb:Q969P1|intact:MINT-268152|uniprotkb:Q96BD7|uniprotkb:Q8WYK6	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:xbp1_human(display_long)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Chen et al. (2014)	pubmed:25239945|imex:IM-23851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-10636905|imex:IM-23851-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903489"(positive regulation of lactation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|rcsb pdb:6R5Q|rcsb pdb:6R6G|rcsb pdb:6R6P|rcsb pdb:6R7Q|reactome:R-HSA-381038|reactome:R-HSA-381070|reactome:R-HSA-381183|go:"GO:0071499"(cellular response to laminar fluid shear stress)|refseq:NP_001073007.1|refseq:NP_005071.2|dip:DIP-41692N	go:"GO:0043231"(intracellular membrane-bounded organelle)	-	function:"Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I"|comment:mint	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/18	2015/02/18	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	intact-crc:209BFAD8B68913BC|rigid:10AZ93xI83ZRjVdSkRpMlJkd0X4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)