#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70673	uniprotkb:Q63563	intact:EBI-9560239|uniprotkb:Q62906|uniprotkb:Q9JM48|ensembl:ENSRNOP00000028685	intact:EBI-8744493|uniprotkb:O89115	psi-mi:kcj11_rat(display_long)|uniprotkb:Kcnj11(gene name)|psi-mi:Kcnj11(display_short)|uniprotkb:BIR(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym)	psi-mi:abcc9_rat(display_long)|uniprotkb:Abcc9(gene name)|psi-mi:Abcc9(display_short)|uniprotkb:Sulfonylurea receptor 2(gene name synonym)|uniprotkb:Sur2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lodwick et al. (2014)	imex:IM-24380|pubmed:25236767	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10948788|imex:IM-24380-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69247|refseq:NP_112648.2|dip:DIP-58641N|ensembl:ENSRNOG00000021128(gene)|ensembl:ENSRNOT00000028685(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:5TWV|rcsb pdb:6BAA|rcsb pdb:6PZ9|rcsb pdb:6PZA|reactome:R-RNO-1296025|reactome:R-RNO-382556|reactome:R-RNO-422356|reactome:R-RNO-5578775	interpro:IPR000388(Sulphonylurea receptor, N-terminus)|interpro:IPR001475(Sulphonylurea receptor, type 2, N-terminus)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|refseq:NP_037172.2|rgd:3787|interpro:IPR036640|reactome:R-RNO-1296025|reactome:R-RNO-382556|reactome:R-RNO-5578775|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006932"(substrate-dependent cell migration, cell contraction)|go:"GO:0008281"(sulfonylurea receptor activity)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030315"(T-tubule)|go:"GO:0033198"(response to ATP)|go:"GO:0036094"(small molecule binding)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061337"(cardiac conduction)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)	-	-	-	figure legend:Fig.s 1b & c, 3b & c, 4b & c, 5d, e & f|comment:"Chimeric constructs (fusion constructs with rat MRP1 protein) suggest a minimal binding region of KCNJ11/Kir6.2 316-390 aa with SUR2 1294-1337 aa."|comment:"\"Single charge reversals in both full-length Kir6.2 and MBP-SUR2-(1294–1358) restored co-immunoprecipitation to at least WT levels from mixtures of Kir6.2-K338E - SUR2-E1318R, Kir6.2-D323K - SUR2-K1322D and Kir6.2-D323K - SUR2-Q1336E (Figures 5e and 5f).\" All single mutants caused a decrease in the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/28	2015/07/31	rogid:5ZUdreoVKRhgvPw3N3zwAId+2eg10116	rogid:9+2t8tAz+PwezsKIvDGfwW3VBSQ10116	rigid:hKg5un0LcJnhb/DW8Tqc4+PZdcE	false	35s radiolabel:?-?|mutation decreasing interaction:323-323|mutation decreasing interaction:338-338|mutation increasing interaction:323-323|mutation increasing interaction:323-323|mutation increasing interaction:338-338	mutation decreasing interaction:1318-1318|mutation increasing interaction:1336-1336|mutation increasing interaction:1318-1318|mutation decreasing interaction:1322-1322|mutation decreasing interaction:1336-1336|mutation increasing interaction:1322-1322|sufficient binding region:1294-1403|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)