#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04912	uniprotkb:P26927	intact:EBI-2637518|uniprotkb:B5A944|uniprotkb:B5A945|uniprotkb:B5A946|uniprotkb:B5A947|ensembl:ENSP00000296474|uniprotkb:A0A087WZG2	intact:EBI-6929133|uniprotkb:Q6GTN4|uniprotkb:A8MSX3|uniprotkb:Q14870|uniprotkb:Q13350|uniprotkb:A6NLA3	psi-mi:ron_human(display_long)|uniprotkb:MST1R(gene name)|psi-mi:MST1R(display_short)|uniprotkb:PTK8(gene name synonym)|uniprotkb:RON(gene name synonym)|uniprotkb:p185-Ron(gene name synonym)|uniprotkb:Protein-tyrosine kinase 8(gene name synonym)|uniprotkb:CDw136(gene name synonym)	psi-mi:hgfl_human(display_long)|uniprotkb:D3F15S2(gene name synonym)|uniprotkb:DNF15S2(gene name synonym)|uniprotkb:HGFL(gene name synonym)|uniprotkb:Macrophage stimulatory protein(gene name synonym)|uniprotkb:Macrophage-stimulating protein(gene name synonym)|uniprotkb:MST1(gene name)|psi-mi:MST1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Chao et al. (2014)	imex:IM-24509|pubmed:25193665	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10959273|pdbe:4qt8|imex:IM-24509-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001231866.1|refseq:NP_002438.2|ensembl:ENSG00000164078(gene)|ensembl:ENST00000296474(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036352|interpro:IPR039413|mint:Q04912|rcsb pdb:3PLS|rcsb pdb:4FWW|rcsb pdb:4QT8|reactome:R-HSA-8852405|dip:DIP-6029N	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035978"(histone H2A-S139 phosphorylation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR024174|interpro:IPR038178|interpro:IPR043504|interpro:IPR043575|rcsb pdb:2ASU|rcsb pdb:4QT8|reactome:R-HSA-8852405|refseq:NP_066278.3|mint:P26927|dip:DIP-6028N|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)	-	-	-	figure legend:Table 1|3d-resolution:3.0 A|3d-r-factors:Rworking 23.4%, Rfree 29.1%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/15	2018/04/06	rogid:qwF0CoIEkkzk0ETJxoUnwwKDHho9606	rogid:CdkibLlWSzABgjln1RQ0/wPVfTc9606	rigid:TrW3PQ4Kkn+pKY+JKq0C9DCu3k4	false	ha tag:?-?|his tag:c-c|sufficient binding region:25-683|variant:322-322	mutation:672-672|sufficient binding region:465-711|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26927	uniprotkb:Q04912	intact:EBI-6929133|uniprotkb:Q6GTN4|uniprotkb:A8MSX3|uniprotkb:Q14870|uniprotkb:Q13350|uniprotkb:A6NLA3	intact:EBI-2637518|uniprotkb:B5A944|uniprotkb:B5A945|uniprotkb:B5A946|uniprotkb:B5A947|ensembl:ENSP00000296474|uniprotkb:A0A087WZG2	psi-mi:hgfl_human(display_long)|uniprotkb:D3F15S2(gene name synonym)|uniprotkb:DNF15S2(gene name synonym)|uniprotkb:HGFL(gene name synonym)|uniprotkb:Macrophage stimulatory protein(gene name synonym)|uniprotkb:Macrophage-stimulating protein(gene name synonym)|uniprotkb:MST1(gene name)|psi-mi:MST1(display_short)	psi-mi:ron_human(display_long)|uniprotkb:MST1R(gene name)|psi-mi:MST1R(display_short)|uniprotkb:PTK8(gene name synonym)|uniprotkb:RON(gene name synonym)|uniprotkb:p185-Ron(gene name synonym)|uniprotkb:Protein-tyrosine kinase 8(gene name synonym)|uniprotkb:CDw136(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Chao et al. (2014)	imex:IM-24509|pubmed:25193665	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10959498|imex:IM-24509-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035978"(histone H2A-S139 phosphorylation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR024174|interpro:IPR038178|interpro:IPR043504|interpro:IPR043575|rcsb pdb:2ASU|rcsb pdb:4QT8|reactome:R-HSA-8852405|refseq:NP_066278.3|mint:P26927|dip:DIP-6028N|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)	refseq:NP_001231866.1|refseq:NP_002438.2|ensembl:ENSG00000164078(gene)|ensembl:ENST00000296474(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036352|interpro:IPR039413|mint:Q04912|rcsb pdb:3PLS|rcsb pdb:4FWW|rcsb pdb:4QT8|reactome:R-HSA-8852405|dip:DIP-6029N	-	-	-	figure legend:Fig. 4, table 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.15x10^-6(molar)	2015/07/15	2018/04/06	rogid:CdkibLlWSzABgjln1RQ0/wPVfTc9606	rogid:qwF0CoIEkkzk0ETJxoUnwwKDHho9606	rigid:TrW3PQ4Kkn+pKY+JKq0C9DCu3k4	false	sufficient binding region:465-711|his tag:c-c|mutation:672-672	variant:322-322|ha tag:?-?|his tag:c-c|sufficient binding region:25-683	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26927	uniprotkb:Q04912	intact:EBI-6929133|uniprotkb:Q6GTN4|uniprotkb:A8MSX3|uniprotkb:Q14870|uniprotkb:Q13350|uniprotkb:A6NLA3	intact:EBI-2637518|uniprotkb:B5A944|uniprotkb:B5A945|uniprotkb:B5A946|uniprotkb:B5A947|ensembl:ENSP00000296474|uniprotkb:A0A087WZG2	psi-mi:hgfl_human(display_long)|uniprotkb:D3F15S2(gene name synonym)|uniprotkb:DNF15S2(gene name synonym)|uniprotkb:HGFL(gene name synonym)|uniprotkb:Macrophage stimulatory protein(gene name synonym)|uniprotkb:Macrophage-stimulating protein(gene name synonym)|uniprotkb:MST1(gene name)|psi-mi:MST1(display_short)	psi-mi:ron_human(display_long)|uniprotkb:MST1R(gene name)|psi-mi:MST1R(display_short)|uniprotkb:PTK8(gene name synonym)|uniprotkb:RON(gene name synonym)|uniprotkb:p185-Ron(gene name synonym)|uniprotkb:Protein-tyrosine kinase 8(gene name synonym)|uniprotkb:CDw136(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Chao et al. (2014)	imex:IM-24509|pubmed:25193665	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11175650|imex:IM-24509-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035978"(histone H2A-S139 phosphorylation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR024174|interpro:IPR038178|interpro:IPR043504|interpro:IPR043575|rcsb pdb:2ASU|rcsb pdb:4QT8|reactome:R-HSA-8852405|refseq:NP_066278.3|mint:P26927|dip:DIP-6028N|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)	refseq:NP_001231866.1|refseq:NP_002438.2|ensembl:ENSG00000164078(gene)|ensembl:ENST00000296474(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036352|interpro:IPR039413|mint:Q04912|rcsb pdb:3PLS|rcsb pdb:4FWW|rcsb pdb:4QT8|reactome:R-HSA-8852405|dip:DIP-6029N	-	-	-	figure legend:Fig. 4, table 2.|comment:"The MSP_alpha_beta and SP1 complex shows a major species consistent  with 1:1 stoichiometry, but 3-8% of the total signal resolved as a higher molecular weight species,  which may correspond to a higher state of receptor-ligand association."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/15	2018/04/06	rogid:CdkibLlWSzABgjln1RQ0/wPVfTc9606	rogid:qwF0CoIEkkzk0ETJxoUnwwKDHho9606	rigid:TrW3PQ4Kkn+pKY+JKq0C9DCu3k4	false	his tag:c-c|mutation:672-672|sufficient binding region:19-711	variant:322-322|ha tag:?-?|his tag:c-c|direct binding region:25-683	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)