#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-11292207	uniprotkb:O88942	-	intact:EBI-8073353|uniprotkb:O70345|intact:MINT-6612506	psi-mi:putative_cns2_intronic_region_probe_nfat_binding_motif(display_short)|psi-mi:EBI-11292207(display_long)	psi-mi:nfac1_mouse(display_long)|uniprotkb:Nfatc1(gene name)|psi-mi:Nfatc1(display_short)|uniprotkb:Nfat2(gene name synonym)|uniprotkb:Nfatc(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292205|imex:IM-24543-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	interpro:IPR032397|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR011539(Rel homology)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR037059|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002337"(B-1a B cell differentiation)|go:"GO:0003170"(heart valve development)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000647"(negative regulation of stem cell proliferation)|go:"GO:0014883"(transition between fast and slow fiber)|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763	-	-	comment:mint|function:Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells	figure legend:7C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/09/28	2015/09/29	-	rogid:jZN9fTzBdPNHxfb7e6nFy1AGnd410090	-	false	biotin tag:?-?|mutation disrupting interaction strength:18-22,10-13	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11292207	uniprotkb:Q60591	-	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:putative_cns2_intronic_region_probe_nfat_binding_motif(display_short)|psi-mi:EBI-11292207(display_long)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292205|imex:IM-24543-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	figure legend:7C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/09/28	2015/09/29	-	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	false	biotin tag:?-?|mutation disrupting interaction strength:18-22,10-13	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11292228	uniprotkb:O88942	-	intact:EBI-8073353|uniprotkb:O70345|intact:MINT-6612506	psi-mi:il2_arre_mouse(display_short)|psi-mi:EBI-11292228(display_long)	psi-mi:nfac1_mouse(display_long)|uniprotkb:Nfatc1(gene name)|psi-mi:Nfatc1(display_short)|uniprotkb:Nfat2(gene name synonym)|uniprotkb:Nfatc(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292218|imex:IM-24543-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	interpro:IPR032397|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR011539(Rel homology)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR037059|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002337"(B-1a B cell differentiation)|go:"GO:0003170"(heart valve development)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000647"(negative regulation of stem cell proliferation)|go:"GO:0014883"(transition between fast and slow fiber)|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763	-	-	comment:mint|function:Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells	figure legend:7Ci|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/09/28	2015/09/29	-	rogid:jZN9fTzBdPNHxfb7e6nFy1AGnd410090	-	false	biotin tag:?-?|mutation disrupting interaction strength:18-22,10-13	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11292228	uniprotkb:Q60591	-	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:il2_arre_mouse(display_short)|psi-mi:EBI-11292228(display_long)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292218|imex:IM-24543-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	figure legend:7Ci|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/09/28	2015/09/29	-	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	false	biotin tag:?-?|mutation disrupting interaction strength:18-22,10-13	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60591	ensembl:ENSMUSG00000039521	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	intact:EBI-10899641	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292679|imex:IM-24543-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:7F|causality statement:P08505  causes no change to  expression at protein level  of ENSMUSG00000039521|causality statement:P07750 causes no change to  expression at protein level  of ENSMUSG00000039521|causality statement:"CHEBI:50131 increases expression at protein level  of ENSMUSG00000039521"|comment:Aza did not increase Foxp3 expression in CNS2 -/- cells.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/28	2015/09/29	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:O88942	ensembl:ENSMUSG00000039521	intact:EBI-8073353|uniprotkb:O70345|intact:MINT-6612506	intact:EBI-10899641	psi-mi:nfac1_mouse(display_long)|uniprotkb:Nfatc1(gene name)|psi-mi:Nfatc1(display_short)|uniprotkb:Nfat2(gene name synonym)|uniprotkb:Nfatc(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292695|imex:IM-24543-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	interpro:IPR032397|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR011539(Rel homology)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR037059|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002337"(B-1a B cell differentiation)|go:"GO:0003170"(heart valve development)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000647"(negative regulation of stem cell proliferation)|go:"GO:0014883"(transition between fast and slow fiber)|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	comment:mint|function:Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells	-	figure legend:7F|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/28	2015/09/29	rogid:jZN9fTzBdPNHxfb7e6nFy1AGnd410090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q6KCD5	ensembl:ENSMUSG00000039521	intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6	intact:EBI-10899641	psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292755|imex:IM-24543-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:7I|comment:Binding is greater to the CNS2 region than the Foxp3 promoter region.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/28	2015/09/29	rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:A2AGH6	ensembl:ENSMUSG00000039521	intact:EBI-5744969|uniprotkb:A2AGH7|uniprotkb:O88542|uniprotkb:Q571H3|uniprotkb:Q6PGB4|uniprotkb:Q6PGD8|ensembl:ENSMUSP00000085260	intact:EBI-10899641	psi-mi:med12_mouse(display_long)|uniprotkb:Med12(gene name)|psi-mi:Med12(display_short)|uniprotkb:Kiaa0192(gene name synonym)|uniprotkb:Mopa(gene name synonym)|uniprotkb:Tnrc11(gene name synonym)|uniprotkb:Trap230(gene name synonym)|uniprotkb:Mediator complex subunit 12(gene name synonym)|uniprotkb:OPA-containing protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 230 kDa component(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 11 protein(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292764|imex:IM-24543-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_067496.2|go:"GO:0048568"(embryonic organ development)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR019035|interpro:IPR021989|interpro:IPR021990|mint:A2AGH6|reactome:R-MMU-212436|ensembl:ENSMUSG00000079487(gene)|ensembl:ENSMUST00000087948(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|dip:DIP-59233N	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:7K|comment:Binding is much greater to the CNS2 region than the Foxp3 promoter region.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/28	2015/09/29	rogid:9l10cOqNn+PIwL7gQq/WsgiZnLE10090	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000039521	ensembl:ENSMUSG00000039521	intact:EBI-10899641	intact:EBI-10899641	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:1218"(chromosome conformation capture assay)	Li et al. (2014)	pubmed:25126782|imex:IM-24543	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11292743|imex:IM-24543-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0250"(gene)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:7 G/H|agonist:"Ionomycin -CHEBI:63954"|antagonist:"Cyclosporin A -CHEBI:4031"|causality statement:"CHEBI:4031 reduces the binding of ENSMUSG00000039521 (cns2 region) to ENSMUSG00000039521 (proximal promoter region)"|causality statement:"CHEBI:63954 increases the binding of ENSMUSG00000039521 (cns2 region) to ENSMUSG00000039521 (proximal promoter region)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/28	2015/09/29	-	-	-	false	sufficient binding region:?-?	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)