#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02730	uniprotkb:P05026	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10819700|imex:IM-24344-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/14	2015/06/26	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:bsciETEaRGANBX1paLWhUi9X4wA	false	sufficient binding region:876-911	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P05026	uniprotkb:P02730	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10888423|imex:IM-24344-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	-	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	figure legend:Fig 1C left panel|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kidney)|taxid:9606(Human kidney)	-	2015/05/14	2015/07/02	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rigid:8TkaMMrob1HW27NVy9WzpcLYBok	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05026	uniprotkb:P05023	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	intact:EBI-358778|uniprotkb:Q16689|uniprotkb:Q6LDM4|uniprotkb:Q9UJ20|uniprotkb:Q9UJ21|uniprotkb:B2RBR6|uniprotkb:Q9UCN1|ensembl:ENSP00000295598|uniprotkb:B7Z3U6|uniprotkb:B7Z2T5|uniprotkb:F5H3A1|intact:EBI-10963133	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:at1a1_human(display_long)|uniprotkb:ATP1A1(gene name)|psi-mi:ATP1A1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10888423|imex:IM-24344-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	refseq:NP_000692.2|refseq:NP_001153705.1|refseq:NP_001153706.1|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016791"(phosphatase activity)|ensembl:ENSG00000163399(gene)|ensembl:ENST00000295598(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031090"(organelle membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031947"(negative regulation of glucocorticoid biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036126"(sperm flagellum)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0043531"(ADP binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903416"(response to glycoside)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P05023|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|refseq:XP_016856849.1|refseq:XP_016856850.1|dip:DIP-38196N	-	-	-	figure legend:Fig 1C left panel|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kidney)|taxid:9606(Human kidney)	-	2015/05/14	2015/07/02	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rogid:uZf9iX38kcZh0Q+apz8uB17EtJw9606	rigid:8TkaMMrob1HW27NVy9WzpcLYBok	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P05023	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-358778|uniprotkb:Q16689|uniprotkb:Q6LDM4|uniprotkb:Q9UJ20|uniprotkb:Q9UJ21|uniprotkb:B2RBR6|uniprotkb:Q9UCN1|ensembl:ENSP00000295598|uniprotkb:B7Z3U6|uniprotkb:B7Z2T5|uniprotkb:F5H3A1|intact:EBI-10963133	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1a1_human(display_long)|uniprotkb:ATP1A1(gene name)|psi-mi:ATP1A1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10888427|imex:IM-24344-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_000692.2|refseq:NP_001153705.1|refseq:NP_001153706.1|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016791"(phosphatase activity)|ensembl:ENSG00000163399(gene)|ensembl:ENST00000295598(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031090"(organelle membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031947"(negative regulation of glucocorticoid biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036126"(sperm flagellum)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0043531"(ADP binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903416"(response to glycoside)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P05023|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|refseq:XP_016856849.1|refseq:XP_016856850.1|dip:DIP-38196N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Fig 1C 3rd and 4th IB|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kidney)|taxid:9606(Human kidney)	-	2015/05/14	2015/07/02	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:uZf9iX38kcZh0Q+apz8uB17EtJw9606	rigid:8TkaMMrob1HW27NVy9WzpcLYBok	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P05026	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10888427|imex:IM-24344-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Fig 1C 3rd and 4th IB|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kidney)|taxid:9606(Human kidney)	-	2015/05/14	2015/07/02	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:8TkaMMrob1HW27NVy9WzpcLYBok	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P05026	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10888882|imex:IM-24344-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	go:"GO:0016323"(basolateral plasma membrane)	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:"Fig 1B  (c and f)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kidney_cortex)|taxid:9606(human kidney cortex)	-	2015/05/14	2015/06/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:bsciETEaRGANBX1paLWhUi9X4wA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02730	uniprotkb:P05026	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10891594|imex:IM-24344-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Fig 2C upper blot|comment:The C-terminal 11 residues of SLC4A1 are essential for a complete binding site for ATP1B1, and/or form part of that site|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/05/14	2015/06/26	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:bsciETEaRGANBX1paLWhUi9X4wA	false	sufficient binding region:876-911|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P05026	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10892355|imex:IM-24344-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/14	2015/06/19	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:bsciETEaRGANBX1paLWhUi9X4wA	false	sufficient binding region:876-911	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02730	uniprotkb:P05026	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10893113|imex:IM-24344-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/05/14	2015/06/22	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:bsciETEaRGANBX1paLWhUi9X4wA	false	glutathione s tranferase tag:n-n|sufficient binding region:876-911	glutathione s tranferase tag:n-n|sufficient binding region:1-31	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P02730	uniprotkb:P05026	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Su et al. (2015)	imex:IM-24344|pubmed:25012180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10893222|imex:IM-24344-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.1x10^-5(molar)	2015/05/14	2015/06/22	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:bsciETEaRGANBX1paLWhUi9X4wA	false	glutathione s tranferase tag:n-n|sufficient binding region:876-911	sufficient binding region:1-31	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)