#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60674	uniprotkb:P40238	intact:EBI-518647|uniprotkb:O14636|uniprotkb:O75297|intact:EBI-28977715|ensembl:ENSP00000371067	intact:EBI-6511486|ensembl:ENSP00000361548|uniprotkb:Q5JUZ0	psi-mi:jak2_human(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:JAK2(gene name)|psi-mi:JAK2(display_short)	psi-mi:tpor_human(display_long)|uniprotkb:MPL(gene name)|psi-mi:MPL(display_short)|uniprotkb:TPOR(gene name synonym)|uniprotkb:Myeloproliferative leukemia protein(gene name synonym)|uniprotkb:Proto-oncogene c-Mpl(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cleyrat et al. (2014)	imex:IM-23848|pubmed:24931576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10636930|imex:IM-23848-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309133.1|ensembl:ENSG00000096968(gene)|ensembl:ENST00000381652(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSP00000371067|refseq:NP_004963.1|refseq:NP_001309123.1|refseq:NP_001309124.1|refseq:NP_001309125.1|dip:DIP-33880N|go:"GO:0005730"(nucleolus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031904"(endosome lumen)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070757"(interleukin-35-mediated signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:O60674|rcsb pdb:2B7A|rcsb pdb:2W1I|rcsb pdb:2XA4|rcsb pdb:3E62|rcsb pdb:3E63|rcsb pdb:3E64|rcsb pdb:3FUP|rcsb pdb:3IO7|rcsb pdb:3IOK|rcsb pdb:3JY9|rcsb pdb:3KCK|rcsb pdb:3KRR|rcsb pdb:3LPB|rcsb pdb:3Q32|rcsb pdb:3RVG|rcsb pdb:3TJC|rcsb pdb:3TJD|rcsb pdb:3UGC|rcsb pdb:3ZMM|rcsb pdb:4AQC|rcsb pdb:4BBE|rcsb pdb:4BBF|rcsb pdb:4C61|rcsb pdb:4C62|rcsb pdb:4D0W|rcsb pdb:4D0X|rcsb pdb:4D1S|rcsb pdb:4E4M|rcsb pdb:4E6D|rcsb pdb:4E6Q|rcsb pdb:4F08|rcsb pdb:4F09|rcsb pdb:4FVP|rcsb pdb:4FVQ|rcsb pdb:4FVR|rcsb pdb:4GFM|rcsb pdb:4GMY|rcsb pdb:4HGE|rcsb pdb:4IVA|rcsb pdb:4JI9|rcsb pdb:4JIA|rcsb pdb:4P7E|rcsb pdb:4YTC|rcsb pdb:4YTF|rcsb pdb:4YTH|rcsb pdb:4YTI|rcsb pdb:4Z32|rcsb pdb:4ZIM|rcsb pdb:5CF4|rcsb pdb:5CF5|rcsb pdb:5CF6|rcsb pdb:5CF8|rcsb pdb:5HEZ|rcsb pdb:5I4N|rcsb pdb:5L3A|rcsb pdb:5TQ3|rcsb pdb:5TQ4|rcsb pdb:5TQ5|rcsb pdb:5TQ6|rcsb pdb:5TQ7|rcsb pdb:5TQ8|rcsb pdb:5USY|rcsb pdb:5USZ|rcsb pdb:5UT0|rcsb pdb:5UT1|rcsb pdb:5UT2|rcsb pdb:5UT3|rcsb pdb:5UT4|rcsb pdb:5UT5|rcsb pdb:5UT6|rcsb pdb:5WEV|rcsb pdb:5WIJ|rcsb pdb:5WIK|rcsb pdb:5WIL|rcsb pdb:5WIM|rcsb pdb:5WIN|rcsb pdb:6AAJ|rcsb pdb:6BBV|rcsb pdb:6BRW|rcsb pdb:6BS0|rcsb pdb:6BSS|rcsb pdb:6D2I|rcsb pdb:6DRW|rcsb pdb:6E2P|rcsb pdb:6E2Q|rcsb pdb:6G3C|rcsb pdb:6M9H|rcsb pdb:6OAV|rcsb pdb:6OBB|rcsb pdb:6OBF|rcsb pdb:6OBL|rcsb pdb:6OCC|rcsb pdb:6TPD|rcsb pdb:6VGL|rcsb pdb:6VN8|rcsb pdb:6VNB|rcsb pdb:6VNC|rcsb pdb:6VNE|rcsb pdb:6VNF|rcsb pdb:6VNG|rcsb pdb:6VNH|rcsb pdb:6VNI|rcsb pdb:6VNJ|rcsb pdb:6VNK|rcsb pdb:6VNL|rcsb pdb:6VNM|rcsb pdb:6VS3|rcsb pdb:6VSN|rcsb pdb:6WTN|rcsb pdb:6WTO|rcsb pdb:6WTP|rcsb pdb:6WTQ|rcsb pdb:6X8E|rcsb pdb:6XJK|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1170546|reactome:R-HSA-1433557|reactome:R-HSA-2586552|reactome:R-HSA-3214858|reactome:R-HSA-512988|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-6802946|rcsb pdb:5AEP|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-69231|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9006335|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912526|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983231	ensembl:ENSG00000117400(gene)|ensembl:ENST00000372470(transcript)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035702"(monocyte homeostasis)|go:"GO:0038164"(thrombopoietin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1905221"(positive regulation of platelet formation)|go:"GO:1990959"(eosinophil homeostasis)|go:"GO:1990960"(basophil homeostasis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|reactome:R-HSA-76009|refseq:NP_005364.1|dip:DIP-5730N	-	-	-	figure legend:1F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hel)|taxid:9606(Homo sapiens HEL erythroleukemia cell line)	-	2015/02/13	2015/02/18	rogid:s2LnvkFxriuFzkRSlP9PI0h/wYk9606	rogid:5O8xJKJHqJM+X4swjvXrAz5Fs0Y9606	intact-crc:088BD39D1C5F90FE|rigid:0YmVbPmKV4nKBOrdvZ2Fe7CDlFg	false	mutation:617-617	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60674	uniprotkb:P40238	intact:EBI-518647|uniprotkb:O14636|uniprotkb:O75297|intact:EBI-28977715|ensembl:ENSP00000371067	intact:EBI-6511486|ensembl:ENSP00000361548|uniprotkb:Q5JUZ0	psi-mi:jak2_human(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:JAK2(gene name)|psi-mi:JAK2(display_short)	psi-mi:tpor_human(display_long)|uniprotkb:MPL(gene name)|psi-mi:MPL(display_short)|uniprotkb:TPOR(gene name synonym)|uniprotkb:Myeloproliferative leukemia protein(gene name synonym)|uniprotkb:Proto-oncogene c-Mpl(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cleyrat et al. (2014)	imex:IM-23848|pubmed:24931576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637013|imex:IM-23848-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309133.1|ensembl:ENSG00000096968(gene)|ensembl:ENST00000381652(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSP00000371067|refseq:NP_004963.1|refseq:NP_001309123.1|refseq:NP_001309124.1|refseq:NP_001309125.1|dip:DIP-33880N|go:"GO:0005730"(nucleolus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031904"(endosome lumen)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070757"(interleukin-35-mediated signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:O60674|rcsb pdb:2B7A|rcsb pdb:2W1I|rcsb pdb:2XA4|rcsb pdb:3E62|rcsb pdb:3E63|rcsb pdb:3E64|rcsb pdb:3FUP|rcsb pdb:3IO7|rcsb pdb:3IOK|rcsb pdb:3JY9|rcsb pdb:3KCK|rcsb pdb:3KRR|rcsb pdb:3LPB|rcsb pdb:3Q32|rcsb pdb:3RVG|rcsb pdb:3TJC|rcsb pdb:3TJD|rcsb pdb:3UGC|rcsb pdb:3ZMM|rcsb pdb:4AQC|rcsb pdb:4BBE|rcsb pdb:4BBF|rcsb pdb:4C61|rcsb pdb:4C62|rcsb pdb:4D0W|rcsb pdb:4D0X|rcsb pdb:4D1S|rcsb pdb:4E4M|rcsb pdb:4E6D|rcsb pdb:4E6Q|rcsb pdb:4F08|rcsb pdb:4F09|rcsb pdb:4FVP|rcsb pdb:4FVQ|rcsb pdb:4FVR|rcsb pdb:4GFM|rcsb pdb:4GMY|rcsb pdb:4HGE|rcsb pdb:4IVA|rcsb pdb:4JI9|rcsb pdb:4JIA|rcsb pdb:4P7E|rcsb pdb:4YTC|rcsb pdb:4YTF|rcsb pdb:4YTH|rcsb pdb:4YTI|rcsb pdb:4Z32|rcsb pdb:4ZIM|rcsb pdb:5CF4|rcsb pdb:5CF5|rcsb pdb:5CF6|rcsb pdb:5CF8|rcsb pdb:5HEZ|rcsb pdb:5I4N|rcsb pdb:5L3A|rcsb pdb:5TQ3|rcsb pdb:5TQ4|rcsb pdb:5TQ5|rcsb pdb:5TQ6|rcsb pdb:5TQ7|rcsb pdb:5TQ8|rcsb pdb:5USY|rcsb pdb:5USZ|rcsb pdb:5UT0|rcsb pdb:5UT1|rcsb pdb:5UT2|rcsb pdb:5UT3|rcsb pdb:5UT4|rcsb pdb:5UT5|rcsb pdb:5UT6|rcsb pdb:5WEV|rcsb pdb:5WIJ|rcsb pdb:5WIK|rcsb pdb:5WIL|rcsb pdb:5WIM|rcsb pdb:5WIN|rcsb pdb:6AAJ|rcsb pdb:6BBV|rcsb pdb:6BRW|rcsb pdb:6BS0|rcsb pdb:6BSS|rcsb pdb:6D2I|rcsb pdb:6DRW|rcsb pdb:6E2P|rcsb pdb:6E2Q|rcsb pdb:6G3C|rcsb pdb:6M9H|rcsb pdb:6OAV|rcsb pdb:6OBB|rcsb pdb:6OBF|rcsb pdb:6OBL|rcsb pdb:6OCC|rcsb pdb:6TPD|rcsb pdb:6VGL|rcsb pdb:6VN8|rcsb pdb:6VNB|rcsb pdb:6VNC|rcsb pdb:6VNE|rcsb pdb:6VNF|rcsb pdb:6VNG|rcsb pdb:6VNH|rcsb pdb:6VNI|rcsb pdb:6VNJ|rcsb pdb:6VNK|rcsb pdb:6VNL|rcsb pdb:6VNM|rcsb pdb:6VS3|rcsb pdb:6VSN|rcsb pdb:6WTN|rcsb pdb:6WTO|rcsb pdb:6WTP|rcsb pdb:6WTQ|rcsb pdb:6X8E|rcsb pdb:6XJK|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1170546|reactome:R-HSA-1433557|reactome:R-HSA-2586552|reactome:R-HSA-3214858|reactome:R-HSA-512988|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-6802946|rcsb pdb:5AEP|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-69231|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9006335|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912526|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983231	ensembl:ENSG00000117400(gene)|ensembl:ENST00000372470(transcript)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035702"(monocyte homeostasis)|go:"GO:0038164"(thrombopoietin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1905221"(positive regulation of platelet formation)|go:"GO:1990959"(eosinophil homeostasis)|go:"GO:1990960"(basophil homeostasis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|reactome:R-HSA-76009|refseq:NP_005364.1|dip:DIP-5730N	-	-	-	figure legend:1F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2015/02/13	2015/02/18	rogid:s2LnvkFxriuFzkRSlP9PI0h/wYk9606	rogid:5O8xJKJHqJM+X4swjvXrAz5Fs0Y9606	intact-crc:0FAB9724958B3853|rigid:0YmVbPmKV4nKBOrdvZ2Fe7CDlFg	false	fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60674	uniprotkb:P40238	intact:EBI-518647|uniprotkb:O14636|uniprotkb:O75297|intact:EBI-28977715|ensembl:ENSP00000371067	intact:EBI-6511486|ensembl:ENSP00000361548|uniprotkb:Q5JUZ0	psi-mi:jak2_human(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:JAK2(gene name)|psi-mi:JAK2(display_short)	psi-mi:tpor_human(display_long)|uniprotkb:MPL(gene name)|psi-mi:MPL(display_short)|uniprotkb:TPOR(gene name synonym)|uniprotkb:Myeloproliferative leukemia protein(gene name synonym)|uniprotkb:Proto-oncogene c-Mpl(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Cleyrat et al. (2014)	imex:IM-23848|pubmed:24931576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637046|imex:IM-23848-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309133.1|ensembl:ENSG00000096968(gene)|ensembl:ENST00000381652(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSP00000371067|refseq:NP_004963.1|refseq:NP_001309123.1|refseq:NP_001309124.1|refseq:NP_001309125.1|dip:DIP-33880N|go:"GO:0005730"(nucleolus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031904"(endosome lumen)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070757"(interleukin-35-mediated signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:O60674|rcsb pdb:2B7A|rcsb pdb:2W1I|rcsb pdb:2XA4|rcsb pdb:3E62|rcsb pdb:3E63|rcsb pdb:3E64|rcsb pdb:3FUP|rcsb pdb:3IO7|rcsb pdb:3IOK|rcsb pdb:3JY9|rcsb pdb:3KCK|rcsb pdb:3KRR|rcsb pdb:3LPB|rcsb pdb:3Q32|rcsb pdb:3RVG|rcsb pdb:3TJC|rcsb pdb:3TJD|rcsb pdb:3UGC|rcsb pdb:3ZMM|rcsb pdb:4AQC|rcsb pdb:4BBE|rcsb pdb:4BBF|rcsb pdb:4C61|rcsb pdb:4C62|rcsb pdb:4D0W|rcsb pdb:4D0X|rcsb pdb:4D1S|rcsb pdb:4E4M|rcsb pdb:4E6D|rcsb pdb:4E6Q|rcsb pdb:4F08|rcsb pdb:4F09|rcsb pdb:4FVP|rcsb pdb:4FVQ|rcsb pdb:4FVR|rcsb pdb:4GFM|rcsb pdb:4GMY|rcsb pdb:4HGE|rcsb pdb:4IVA|rcsb pdb:4JI9|rcsb pdb:4JIA|rcsb pdb:4P7E|rcsb pdb:4YTC|rcsb pdb:4YTF|rcsb pdb:4YTH|rcsb pdb:4YTI|rcsb pdb:4Z32|rcsb pdb:4ZIM|rcsb pdb:5CF4|rcsb pdb:5CF5|rcsb pdb:5CF6|rcsb pdb:5CF8|rcsb pdb:5HEZ|rcsb pdb:5I4N|rcsb pdb:5L3A|rcsb pdb:5TQ3|rcsb pdb:5TQ4|rcsb pdb:5TQ5|rcsb pdb:5TQ6|rcsb pdb:5TQ7|rcsb pdb:5TQ8|rcsb pdb:5USY|rcsb pdb:5USZ|rcsb pdb:5UT0|rcsb pdb:5UT1|rcsb pdb:5UT2|rcsb pdb:5UT3|rcsb pdb:5UT4|rcsb pdb:5UT5|rcsb pdb:5UT6|rcsb pdb:5WEV|rcsb pdb:5WIJ|rcsb pdb:5WIK|rcsb pdb:5WIL|rcsb pdb:5WIM|rcsb pdb:5WIN|rcsb pdb:6AAJ|rcsb pdb:6BBV|rcsb pdb:6BRW|rcsb pdb:6BS0|rcsb pdb:6BSS|rcsb pdb:6D2I|rcsb pdb:6DRW|rcsb pdb:6E2P|rcsb pdb:6E2Q|rcsb pdb:6G3C|rcsb pdb:6M9H|rcsb pdb:6OAV|rcsb pdb:6OBB|rcsb pdb:6OBF|rcsb pdb:6OBL|rcsb pdb:6OCC|rcsb pdb:6TPD|rcsb pdb:6VGL|rcsb pdb:6VN8|rcsb pdb:6VNB|rcsb pdb:6VNC|rcsb pdb:6VNE|rcsb pdb:6VNF|rcsb pdb:6VNG|rcsb pdb:6VNH|rcsb pdb:6VNI|rcsb pdb:6VNJ|rcsb pdb:6VNK|rcsb pdb:6VNL|rcsb pdb:6VNM|rcsb pdb:6VS3|rcsb pdb:6VSN|rcsb pdb:6WTN|rcsb pdb:6WTO|rcsb pdb:6WTP|rcsb pdb:6WTQ|rcsb pdb:6X8E|rcsb pdb:6XJK|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1170546|reactome:R-HSA-1433557|reactome:R-HSA-2586552|reactome:R-HSA-3214858|reactome:R-HSA-512988|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-6802946|rcsb pdb:5AEP|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-69231|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9006335|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912526|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983231	ensembl:ENSG00000117400(gene)|ensembl:ENST00000372470(transcript)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035702"(monocyte homeostasis)|go:"GO:0038164"(thrombopoietin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1905221"(positive regulation of platelet formation)|go:"GO:1990959"(eosinophil homeostasis)|go:"GO:1990960"(basophil homeostasis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|reactome:R-HSA-76009|refseq:NP_005364.1|dip:DIP-5730N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:2D|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2015/02/13	2015/02/18	rogid:s2LnvkFxriuFzkRSlP9PI0h/wYk9606	rogid:5O8xJKJHqJM+X4swjvXrAz5Fs0Y9606	intact-crc:00FD41CF21B57304|rigid:0YmVbPmKV4nKBOrdvZ2Fe7CDlFg	false	-	fluorescent protein tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O60674	uniprotkb:P40238	intact:EBI-518647|uniprotkb:O14636|uniprotkb:O75297|intact:EBI-28977715|ensembl:ENSP00000371067	intact:EBI-6511486|ensembl:ENSP00000361548|uniprotkb:Q5JUZ0	psi-mi:jak2_human(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:JAK2(gene name)|psi-mi:JAK2(display_short)	psi-mi:tpor_human(display_long)|uniprotkb:MPL(gene name)|psi-mi:MPL(display_short)|uniprotkb:TPOR(gene name synonym)|uniprotkb:Myeloproliferative leukemia protein(gene name synonym)|uniprotkb:Proto-oncogene c-Mpl(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Cleyrat et al. (2014)	imex:IM-23848|pubmed:24931576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637090|imex:IM-23848-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309133.1|ensembl:ENSG00000096968(gene)|ensembl:ENST00000381652(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSP00000371067|refseq:NP_004963.1|refseq:NP_001309123.1|refseq:NP_001309124.1|refseq:NP_001309125.1|dip:DIP-33880N|go:"GO:0005730"(nucleolus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031904"(endosome lumen)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070757"(interleukin-35-mediated signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:O60674|rcsb pdb:2B7A|rcsb pdb:2W1I|rcsb pdb:2XA4|rcsb pdb:3E62|rcsb pdb:3E63|rcsb pdb:3E64|rcsb pdb:3FUP|rcsb pdb:3IO7|rcsb pdb:3IOK|rcsb pdb:3JY9|rcsb pdb:3KCK|rcsb pdb:3KRR|rcsb pdb:3LPB|rcsb pdb:3Q32|rcsb pdb:3RVG|rcsb pdb:3TJC|rcsb pdb:3TJD|rcsb pdb:3UGC|rcsb pdb:3ZMM|rcsb pdb:4AQC|rcsb pdb:4BBE|rcsb pdb:4BBF|rcsb pdb:4C61|rcsb pdb:4C62|rcsb pdb:4D0W|rcsb pdb:4D0X|rcsb pdb:4D1S|rcsb pdb:4E4M|rcsb pdb:4E6D|rcsb pdb:4E6Q|rcsb pdb:4F08|rcsb pdb:4F09|rcsb pdb:4FVP|rcsb pdb:4FVQ|rcsb pdb:4FVR|rcsb pdb:4GFM|rcsb pdb:4GMY|rcsb pdb:4HGE|rcsb pdb:4IVA|rcsb pdb:4JI9|rcsb pdb:4JIA|rcsb pdb:4P7E|rcsb pdb:4YTC|rcsb pdb:4YTF|rcsb pdb:4YTH|rcsb pdb:4YTI|rcsb pdb:4Z32|rcsb pdb:4ZIM|rcsb pdb:5CF4|rcsb pdb:5CF5|rcsb pdb:5CF6|rcsb pdb:5CF8|rcsb pdb:5HEZ|rcsb pdb:5I4N|rcsb pdb:5L3A|rcsb pdb:5TQ3|rcsb pdb:5TQ4|rcsb pdb:5TQ5|rcsb pdb:5TQ6|rcsb pdb:5TQ7|rcsb pdb:5TQ8|rcsb pdb:5USY|rcsb pdb:5USZ|rcsb pdb:5UT0|rcsb pdb:5UT1|rcsb pdb:5UT2|rcsb pdb:5UT3|rcsb pdb:5UT4|rcsb pdb:5UT5|rcsb pdb:5UT6|rcsb pdb:5WEV|rcsb pdb:5WIJ|rcsb pdb:5WIK|rcsb pdb:5WIL|rcsb pdb:5WIM|rcsb pdb:5WIN|rcsb pdb:6AAJ|rcsb pdb:6BBV|rcsb pdb:6BRW|rcsb pdb:6BS0|rcsb pdb:6BSS|rcsb pdb:6D2I|rcsb pdb:6DRW|rcsb pdb:6E2P|rcsb pdb:6E2Q|rcsb pdb:6G3C|rcsb pdb:6M9H|rcsb pdb:6OAV|rcsb pdb:6OBB|rcsb pdb:6OBF|rcsb pdb:6OBL|rcsb pdb:6OCC|rcsb pdb:6TPD|rcsb pdb:6VGL|rcsb pdb:6VN8|rcsb pdb:6VNB|rcsb pdb:6VNC|rcsb pdb:6VNE|rcsb pdb:6VNF|rcsb pdb:6VNG|rcsb pdb:6VNH|rcsb pdb:6VNI|rcsb pdb:6VNJ|rcsb pdb:6VNK|rcsb pdb:6VNL|rcsb pdb:6VNM|rcsb pdb:6VS3|rcsb pdb:6VSN|rcsb pdb:6WTN|rcsb pdb:6WTO|rcsb pdb:6WTP|rcsb pdb:6WTQ|rcsb pdb:6X8E|rcsb pdb:6XJK|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1170546|reactome:R-HSA-1433557|reactome:R-HSA-2586552|reactome:R-HSA-3214858|reactome:R-HSA-512988|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-6802946|rcsb pdb:5AEP|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-69231|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9006335|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912526|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983231	ensembl:ENSG00000117400(gene)|ensembl:ENST00000372470(transcript)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035702"(monocyte homeostasis)|go:"GO:0038164"(thrombopoietin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1905221"(positive regulation of platelet formation)|go:"GO:1990959"(eosinophil homeostasis)|go:"GO:1990960"(basophil homeostasis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|reactome:R-HSA-76009|refseq:NP_005364.1|dip:DIP-5730N	go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005886"(plasma membrane)	-	-	figure legend:2 F/G|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2015/02/13	2015/02/18	rogid:s2LnvkFxriuFzkRSlP9PI0h/wYk9606	rogid:5O8xJKJHqJM+X4swjvXrAz5Fs0Y9606	intact-crc:0574965B24447AC2|rigid:0YmVbPmKV4nKBOrdvZ2Fe7CDlFg	false	fluorescent protein tag:?-?|mutation decreasing interaction strength:617-617	fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P40238	uniprotkb:O60674	intact:EBI-6511486|ensembl:ENSP00000361548|uniprotkb:Q5JUZ0	intact:EBI-518647|uniprotkb:O14636|uniprotkb:O75297|intact:EBI-28977715|ensembl:ENSP00000371067	psi-mi:tpor_human(display_long)|uniprotkb:MPL(gene name)|psi-mi:MPL(display_short)|uniprotkb:TPOR(gene name synonym)|uniprotkb:Myeloproliferative leukemia protein(gene name synonym)|uniprotkb:Proto-oncogene c-Mpl(gene name synonym)	psi-mi:jak2_human(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:JAK2(gene name)|psi-mi:JAK2(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Cleyrat et al. (2014)	imex:IM-23848|pubmed:24931576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637350|imex:IM-23848-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000117400(gene)|ensembl:ENST00000372470(transcript)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035702"(monocyte homeostasis)|go:"GO:0038164"(thrombopoietin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1905221"(positive regulation of platelet formation)|go:"GO:1990959"(eosinophil homeostasis)|go:"GO:1990960"(basophil homeostasis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|reactome:R-HSA-76009|refseq:NP_005364.1|dip:DIP-5730N	refseq:NP_001309133.1|ensembl:ENSG00000096968(gene)|ensembl:ENST00000381652(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSP00000371067|refseq:NP_004963.1|refseq:NP_001309123.1|refseq:NP_001309124.1|refseq:NP_001309125.1|dip:DIP-33880N|go:"GO:0005730"(nucleolus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031904"(endosome lumen)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070757"(interleukin-35-mediated signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:O60674|rcsb pdb:2B7A|rcsb pdb:2W1I|rcsb pdb:2XA4|rcsb pdb:3E62|rcsb pdb:3E63|rcsb pdb:3E64|rcsb pdb:3FUP|rcsb pdb:3IO7|rcsb pdb:3IOK|rcsb pdb:3JY9|rcsb pdb:3KCK|rcsb pdb:3KRR|rcsb pdb:3LPB|rcsb pdb:3Q32|rcsb pdb:3RVG|rcsb pdb:3TJC|rcsb pdb:3TJD|rcsb pdb:3UGC|rcsb pdb:3ZMM|rcsb pdb:4AQC|rcsb pdb:4BBE|rcsb pdb:4BBF|rcsb pdb:4C61|rcsb pdb:4C62|rcsb pdb:4D0W|rcsb pdb:4D0X|rcsb pdb:4D1S|rcsb pdb:4E4M|rcsb pdb:4E6D|rcsb pdb:4E6Q|rcsb pdb:4F08|rcsb pdb:4F09|rcsb pdb:4FVP|rcsb pdb:4FVQ|rcsb pdb:4FVR|rcsb pdb:4GFM|rcsb pdb:4GMY|rcsb pdb:4HGE|rcsb pdb:4IVA|rcsb pdb:4JI9|rcsb pdb:4JIA|rcsb pdb:4P7E|rcsb pdb:4YTC|rcsb pdb:4YTF|rcsb pdb:4YTH|rcsb pdb:4YTI|rcsb pdb:4Z32|rcsb pdb:4ZIM|rcsb pdb:5CF4|rcsb pdb:5CF5|rcsb pdb:5CF6|rcsb pdb:5CF8|rcsb pdb:5HEZ|rcsb pdb:5I4N|rcsb pdb:5L3A|rcsb pdb:5TQ3|rcsb pdb:5TQ4|rcsb pdb:5TQ5|rcsb pdb:5TQ6|rcsb pdb:5TQ7|rcsb pdb:5TQ8|rcsb pdb:5USY|rcsb pdb:5USZ|rcsb pdb:5UT0|rcsb pdb:5UT1|rcsb pdb:5UT2|rcsb pdb:5UT3|rcsb pdb:5UT4|rcsb pdb:5UT5|rcsb pdb:5UT6|rcsb pdb:5WEV|rcsb pdb:5WIJ|rcsb pdb:5WIK|rcsb pdb:5WIL|rcsb pdb:5WIM|rcsb pdb:5WIN|rcsb pdb:6AAJ|rcsb pdb:6BBV|rcsb pdb:6BRW|rcsb pdb:6BS0|rcsb pdb:6BSS|rcsb pdb:6D2I|rcsb pdb:6DRW|rcsb pdb:6E2P|rcsb pdb:6E2Q|rcsb pdb:6G3C|rcsb pdb:6M9H|rcsb pdb:6OAV|rcsb pdb:6OBB|rcsb pdb:6OBF|rcsb pdb:6OBL|rcsb pdb:6OCC|rcsb pdb:6TPD|rcsb pdb:6VGL|rcsb pdb:6VN8|rcsb pdb:6VNB|rcsb pdb:6VNC|rcsb pdb:6VNE|rcsb pdb:6VNF|rcsb pdb:6VNG|rcsb pdb:6VNH|rcsb pdb:6VNI|rcsb pdb:6VNJ|rcsb pdb:6VNK|rcsb pdb:6VNL|rcsb pdb:6VNM|rcsb pdb:6VS3|rcsb pdb:6VSN|rcsb pdb:6WTN|rcsb pdb:6WTO|rcsb pdb:6WTP|rcsb pdb:6WTQ|rcsb pdb:6X8E|rcsb pdb:6XJK|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1170546|reactome:R-HSA-1433557|reactome:R-HSA-2586552|reactome:R-HSA-3214858|reactome:R-HSA-512988|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-6802946|rcsb pdb:5AEP|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-69231|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9006335|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912526|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983231	go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005886"(plasma membrane)	-	-	figure legend:3 E/F|comment:association was low|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2015/02/13	2015/02/18	rogid:5O8xJKJHqJM+X4swjvXrAz5Fs0Y9606	rogid:s2LnvkFxriuFzkRSlP9PI0h/wYk9606	intact-crc:ABC3E1CAE69EABAC|rigid:0YmVbPmKV4nKBOrdvZ2Fe7CDlFg	false	fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O60674	uniprotkb:P40238	intact:EBI-518647|uniprotkb:O14636|uniprotkb:O75297|intact:EBI-28977715|ensembl:ENSP00000371067	intact:EBI-6511486|ensembl:ENSP00000361548|uniprotkb:Q5JUZ0	psi-mi:jak2_human(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:JAK2(gene name)|psi-mi:JAK2(display_short)	psi-mi:tpor_human(display_long)|uniprotkb:MPL(gene name)|psi-mi:MPL(display_short)|uniprotkb:TPOR(gene name synonym)|uniprotkb:Myeloproliferative leukemia protein(gene name synonym)|uniprotkb:Proto-oncogene c-Mpl(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Cleyrat et al. (2014)	imex:IM-23848|pubmed:24931576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637333|imex:IM-23848-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309133.1|ensembl:ENSG00000096968(gene)|ensembl:ENST00000381652(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSP00000371067|refseq:NP_004963.1|refseq:NP_001309123.1|refseq:NP_001309124.1|refseq:NP_001309125.1|dip:DIP-33880N|go:"GO:0005730"(nucleolus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031904"(endosome lumen)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070757"(interleukin-35-mediated signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:O60674|rcsb pdb:2B7A|rcsb pdb:2W1I|rcsb pdb:2XA4|rcsb pdb:3E62|rcsb pdb:3E63|rcsb pdb:3E64|rcsb pdb:3FUP|rcsb pdb:3IO7|rcsb pdb:3IOK|rcsb pdb:3JY9|rcsb pdb:3KCK|rcsb pdb:3KRR|rcsb pdb:3LPB|rcsb pdb:3Q32|rcsb pdb:3RVG|rcsb pdb:3TJC|rcsb pdb:3TJD|rcsb pdb:3UGC|rcsb pdb:3ZMM|rcsb pdb:4AQC|rcsb pdb:4BBE|rcsb pdb:4BBF|rcsb pdb:4C61|rcsb pdb:4C62|rcsb pdb:4D0W|rcsb pdb:4D0X|rcsb pdb:4D1S|rcsb pdb:4E4M|rcsb pdb:4E6D|rcsb pdb:4E6Q|rcsb pdb:4F08|rcsb pdb:4F09|rcsb pdb:4FVP|rcsb pdb:4FVQ|rcsb pdb:4FVR|rcsb pdb:4GFM|rcsb pdb:4GMY|rcsb pdb:4HGE|rcsb pdb:4IVA|rcsb pdb:4JI9|rcsb pdb:4JIA|rcsb pdb:4P7E|rcsb pdb:4YTC|rcsb pdb:4YTF|rcsb pdb:4YTH|rcsb pdb:4YTI|rcsb pdb:4Z32|rcsb pdb:4ZIM|rcsb pdb:5CF4|rcsb pdb:5CF5|rcsb pdb:5CF6|rcsb pdb:5CF8|rcsb pdb:5HEZ|rcsb pdb:5I4N|rcsb pdb:5L3A|rcsb pdb:5TQ3|rcsb pdb:5TQ4|rcsb pdb:5TQ5|rcsb pdb:5TQ6|rcsb pdb:5TQ7|rcsb pdb:5TQ8|rcsb pdb:5USY|rcsb pdb:5USZ|rcsb pdb:5UT0|rcsb pdb:5UT1|rcsb pdb:5UT2|rcsb pdb:5UT3|rcsb pdb:5UT4|rcsb pdb:5UT5|rcsb pdb:5UT6|rcsb pdb:5WEV|rcsb pdb:5WIJ|rcsb pdb:5WIK|rcsb pdb:5WIL|rcsb pdb:5WIM|rcsb pdb:5WIN|rcsb pdb:6AAJ|rcsb pdb:6BBV|rcsb pdb:6BRW|rcsb pdb:6BS0|rcsb pdb:6BSS|rcsb pdb:6D2I|rcsb pdb:6DRW|rcsb pdb:6E2P|rcsb pdb:6E2Q|rcsb pdb:6G3C|rcsb pdb:6M9H|rcsb pdb:6OAV|rcsb pdb:6OBB|rcsb pdb:6OBF|rcsb pdb:6OBL|rcsb pdb:6OCC|rcsb pdb:6TPD|rcsb pdb:6VGL|rcsb pdb:6VN8|rcsb pdb:6VNB|rcsb pdb:6VNC|rcsb pdb:6VNE|rcsb pdb:6VNF|rcsb pdb:6VNG|rcsb pdb:6VNH|rcsb pdb:6VNI|rcsb pdb:6VNJ|rcsb pdb:6VNK|rcsb pdb:6VNL|rcsb pdb:6VNM|rcsb pdb:6VS3|rcsb pdb:6VSN|rcsb pdb:6WTN|rcsb pdb:6WTO|rcsb pdb:6WTP|rcsb pdb:6WTQ|rcsb pdb:6X8E|rcsb pdb:6XJK|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1170546|reactome:R-HSA-1433557|reactome:R-HSA-2586552|reactome:R-HSA-3214858|reactome:R-HSA-512988|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-6802946|rcsb pdb:5AEP|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-69231|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9006335|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912526|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983231	ensembl:ENSG00000117400(gene)|ensembl:ENST00000372470(transcript)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035702"(monocyte homeostasis)|go:"GO:0038164"(thrombopoietin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1905221"(positive regulation of platelet formation)|go:"GO:1990959"(eosinophil homeostasis)|go:"GO:1990960"(basophil homeostasis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|reactome:R-HSA-76009|refseq:NP_005364.1|dip:DIP-5730N	go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005886"(plasma membrane)	-	-	figure legend:3 C/D|comment:association was low|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hel)|taxid:9606(Homo sapiens HEL erythroleukemia cell line)	-	2015/02/13	2015/02/18	rogid:s2LnvkFxriuFzkRSlP9PI0h/wYk9606	rogid:5O8xJKJHqJM+X4swjvXrAz5Fs0Y9606	intact-crc:3C924595C288C786|rigid:0YmVbPmKV4nKBOrdvZ2Fe7CDlFg	false	mutation:617-617	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)