#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07602	uniprotkb:P31944	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2510738|ensembl:ENSP00000393417|uniprotkb:O95823|uniprotkb:Q3SYC9	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:caspe_human(display_long)|uniprotkb:CASP14(gene name)|psi-mi:CASP14(display_short)	psi-mi:"MI:0096"(pull down)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635204|imex:IM-23849-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033174|mint:P31944|reactome:R-HSA-6809371|ensembl:ENSG00000105141(gene)|ensembl:ENST00000427043(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0031424"(keratinization)|go:"GO:0045095"(keratin filament)|go:"GO:0070268"(cornification)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|refseq:NP_036246.1	-	-	-	figure legend:Table 1 -1|comment:"This interaction  was detected using an extract from differentiated cells - cells 2 days post confluence followed by 1.2 mm calcium treatment  and after air exposure.   A \"growth\" phase extract (cells at 80% confluuence)  gave no interactors with Pro-caspase-14."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/13	2015/02/16	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:e8QPsuebgXeKJEuMm/KU0WAOs3k9606	intact-crc:8069BF2D3F4CA465|rigid:Q3XroSrdwyof0FQjp3t6eDwV5Is	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P07602	uniprotkb:P31944	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2510738|ensembl:ENSP00000393417|uniprotkb:O95823|uniprotkb:Q3SYC9	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:caspe_human(display_long)|uniprotkb:CASP14(gene name)|psi-mi:CASP14(display_short)	psi-mi:"MI:0096"(pull down)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635257|imex:IM-23849-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033174|mint:P31944|reactome:R-HSA-6809371|ensembl:ENSG00000105141(gene)|ensembl:ENST00000427043(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0031424"(keratinization)|go:"GO:0045095"(keratin filament)|go:"GO:0070268"(cornification)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|refseq:NP_036246.1	-	-	-	figure legend:Table 1 -2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/13	2015/02/16	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:e8QPsuebgXeKJEuMm/KU0WAOs3k9606	intact-crc:8849E131EF3A9BDA|rigid:Q3XroSrdwyof0FQjp3t6eDwV5Is	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P07602-1	uniprotkb:P35030-3	intact:EBI-10635648|ensembl:ENSP00000378394	intact:EBI-10635575|ensembl:ENSP00000368715	psi-mi:p07602-1(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:p35030-3(display_long)|uniprotkb:Mesotrypsin(gene name synonym)|uniprotkb:C(isoform synonym)|uniprotkb:PRSS3(gene name)|psi-mi:PRSS3(display_short)|uniprotkb:PRSS4(gene name synonym)|uniprotkb:TRY3(gene name synonym)|uniprotkb:TRY4(gene name synonym)|uniprotkb:Brain trypsinogen(gene name synonym)|uniprotkb:Mesotrypsinogen(gene name synonym)|uniprotkb:Serine protease 3(gene name synonym)|uniprotkb:Serine protease 4(gene name synonym)|uniprotkb:Trypsin III(gene name synonym)|uniprotkb:Trypsin IV(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635639|imex:IM-23849-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-716699(isoform-parent)|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)	intact:EBI-1221209(isoform-parent)|ensembl:ENSG00000010438(gene)|ensembl:ENST00000379405(transcript)	-	-	-	figure legend:2F-1|comment:"Saposin A-related products were formed by mesotrypsin digestion;other saposin bands were also formed, as were bands from \"putative intermediate fragments of higher molecular weight.\""|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/13	2015/02/17	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:PnB4gOaHa3JJYKETpweoMhTl/fU9606	intact-crc:457551DC21D470A0|rigid:O1P9GGnBASSYCDdnHpVlcbjgmHQ	false	glutathione s tranferase tag:n-n|sufficient binding region:1..16-524	sufficient binding region:24-247|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49862-1	uniprotkb:P07602-1	intact:EBI-10635674|ensembl:ENSP00000375683|ensembl:ENSP00000470538	intact:EBI-10635648|ensembl:ENSP00000378394	psi-mi:p49862-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:KLK7(gene name)|psi-mi:KLK7(display_short)|uniprotkb:PRSS6(gene name synonym)|uniprotkb:SCCE(gene name synonym)|uniprotkb:Serine protease 6(gene name synonym)|uniprotkb:Stratum corneum chymotryptic enzyme(gene name synonym)	psi-mi:p07602-1(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635661|imex:IM-23849-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-9057886(isoform-parent)|ensembl:ENSG00000169035(gene)|ensembl:ENST00000391807(transcript)|ensembl:ENST00000595820(transcript)	intact:EBI-716699(isoform-parent)|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)	-	-	-	figure legend:2F-2|comment:KLK7 generated several intermediate products from prosaposin.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/13	2015/02/23	rogid:p17WCO5mmwMxspYS5x0rrNCdSH49606	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	intact-crc:9BAB1A72D30B2711|rigid:+ghn3xGebD6xWPAuPqvdKeoCEzg	false	his tag:c-c|sufficient binding region:23-252	glutathione s tranferase tag:n-n|sufficient binding region:1..16-524	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:84832"	uniprotkb:P35030-3	intact:EBI-10635571	intact:EBI-10635575|ensembl:ENSP00000368715	psi-mi:boc-gln-ala-arg-methylcoumarin(display_short)|psi-mi:"CHEBI:84832"(display_long)	psi-mi:p35030-3(display_long)|uniprotkb:Mesotrypsin(gene name synonym)|uniprotkb:C(isoform synonym)|uniprotkb:PRSS3(gene name)|psi-mi:PRSS3(display_short)|uniprotkb:PRSS4(gene name synonym)|uniprotkb:TRY3(gene name synonym)|uniprotkb:TRY4(gene name synonym)|uniprotkb:Brain trypsinogen(gene name synonym)|uniprotkb:Mesotrypsinogen(gene name synonym)|uniprotkb:Serine protease 3(gene name synonym)|uniprotkb:Serine protease 4(gene name synonym)|uniprotkb:Trypsin III(gene name synonym)|uniprotkb:Trypsin IV(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635569|imex:IM-23849-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-1221209(isoform-parent)|ensembl:ENSG00000010438(gene)|ensembl:ENST00000379405(transcript)	-	-	-	figure legend:2E|agonist:"Enterokinase (of unknown origin)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/13	2015/02/17	-	rogid:PnB4gOaHa3JJYKETpweoMhTl/fU9606	intact-crc:011AA81A287C3EE1	false	-	sufficient binding region:24-247|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35030	uniprotkb:P07602	intact:EBI-1221209|uniprotkb:Q5VXV0|intact:EBI-2825937|uniprotkb:A8CED3|uniprotkb:F8W7P3|uniprotkb:Q6ISJ4|uniprotkb:P15951|uniprotkb:Q15665|uniprotkb:Q9UQV3|uniprotkb:A9Z1Y4|uniprotkb:E7ES07|uniprotkb:A8CED1	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	psi-mi:try3_human(display_long)|uniprotkb:PRSS3(gene name)|psi-mi:PRSS3(display_short)|uniprotkb:PRSS4(gene name synonym)|uniprotkb:TRY3(gene name synonym)|uniprotkb:TRY4(gene name synonym)|uniprotkb:Trypsin III(gene name synonym)|uniprotkb:Brain trypsinogen(gene name synonym)|uniprotkb:Mesotrypsinogen(gene name synonym)|uniprotkb:Trypsin IV(gene name synonym)|uniprotkb:Serine protease 3(gene name synonym)|uniprotkb:Serine protease 4(gene name synonym)|uniprotkb:Mesotrypsin(gene name synonym)	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635869|imex:IM-23849-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002762.2|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|refseq:NP_001184026.2|refseq:NP_031369.2|refseq:NP_001184027.1|mint:P35030|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007586"(digestion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0031638"(zymogen activation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:1904724"(tertiary granule lumen)|rcsb pdb:1H4W|rcsb pdb:2R9P|rcsb pdb:3L33|rcsb pdb:3L3T|rcsb pdb:3P92|rcsb pdb:3P95|rcsb pdb:4DG4|rcsb pdb:4U30|rcsb pdb:4U32|rcsb pdb:5C67|rcsb pdb:5JBT|rcsb pdb:5TP0|rcsb pdb:6BX8|rcsb pdb:6GFI|reactome:R-HSA-1462054|reactome:R-HSA-196741|reactome:R-HSA-6798695|reactome:R-HSA-6803157|interpro:IPR043504	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	-	-	-	figure legend:3C-1|comment:Positive reactions  were seen from the lower to upper epidermis, and with a punctuate pattern especially at the stratum granulosum.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skin)|taxid:9606(Homo sapiens skin)	-	2015/02/13	2015/02/17	rogid:AEfz7orXeNoasizB5N76AkF4WMk9606	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	intact-crc:20C40B190A76EAF8|rigid:V0LhqQdwjjmMsGfKKxOAaC8Qn+w	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35030	uniprotkb:P31944	intact:EBI-1221209|uniprotkb:Q5VXV0|intact:EBI-2825937|uniprotkb:A8CED3|uniprotkb:F8W7P3|uniprotkb:Q6ISJ4|uniprotkb:P15951|uniprotkb:Q15665|uniprotkb:Q9UQV3|uniprotkb:A9Z1Y4|uniprotkb:E7ES07|uniprotkb:A8CED1	intact:EBI-2510738|ensembl:ENSP00000393417|uniprotkb:O95823|uniprotkb:Q3SYC9	psi-mi:try3_human(display_long)|uniprotkb:PRSS3(gene name)|psi-mi:PRSS3(display_short)|uniprotkb:PRSS4(gene name synonym)|uniprotkb:TRY3(gene name synonym)|uniprotkb:TRY4(gene name synonym)|uniprotkb:Trypsin III(gene name synonym)|uniprotkb:Brain trypsinogen(gene name synonym)|uniprotkb:Mesotrypsinogen(gene name synonym)|uniprotkb:Trypsin IV(gene name synonym)|uniprotkb:Serine protease 3(gene name synonym)|uniprotkb:Serine protease 4(gene name synonym)|uniprotkb:Mesotrypsin(gene name synonym)	psi-mi:caspe_human(display_long)|uniprotkb:CASP14(gene name)|psi-mi:CASP14(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635979|imex:IM-23849-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002762.2|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|refseq:NP_001184026.2|refseq:NP_031369.2|refseq:NP_001184027.1|mint:P35030|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007586"(digestion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0031638"(zymogen activation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:1904724"(tertiary granule lumen)|rcsb pdb:1H4W|rcsb pdb:2R9P|rcsb pdb:3L33|rcsb pdb:3L3T|rcsb pdb:3P92|rcsb pdb:3P95|rcsb pdb:4DG4|rcsb pdb:4U30|rcsb pdb:4U32|rcsb pdb:5C67|rcsb pdb:5JBT|rcsb pdb:5TP0|rcsb pdb:6BX8|rcsb pdb:6GFI|reactome:R-HSA-1462054|reactome:R-HSA-196741|reactome:R-HSA-6798695|reactome:R-HSA-6803157|interpro:IPR043504	interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033174|mint:P31944|reactome:R-HSA-6809371|ensembl:ENSG00000105141(gene)|ensembl:ENST00000427043(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0031424"(keratinization)|go:"GO:0045095"(keratin filament)|go:"GO:0070268"(cornification)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|refseq:NP_036246.1	-	-	-	figure legend:3C-2|comment:Positive reaction was  seen at the  stratum granulosum.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skin)|taxid:9606(Homo sapiens skin)	-	2015/02/13	2015/02/17	rogid:AEfz7orXeNoasizB5N76AkF4WMk9606	rogid:e8QPsuebgXeKJEuMm/KU0WAOs3k9606	intact-crc:DA4AC09CC55D08AA|rigid:0bem1cUcaFa7T4yYZ4nz4WuzIgw	false	-	sufficient binding region:6-146	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P07602	uniprotkb:P31944	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2510738|ensembl:ENSP00000393417|uniprotkb:O95823|uniprotkb:Q3SYC9	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:caspe_human(display_long)|uniprotkb:CASP14(gene name)|psi-mi:CASP14(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Yamamoto-Tanaka et al. (2014)	imex:IM-23849|pubmed:24872419	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10635987|imex:IM-23849-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033174|mint:P31944|reactome:R-HSA-6809371|ensembl:ENSG00000105141(gene)|ensembl:ENST00000427043(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0031424"(keratinization)|go:"GO:0045095"(keratin filament)|go:"GO:0070268"(cornification)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|refseq:NP_036246.1	-	-	-	figure legend:3C-3|comment:Positive reactions  were seen  at the stratum granulosum and stratum corneum.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skin)|taxid:9606(Homo sapiens skin)	-	2015/02/13	2015/02/17	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:e8QPsuebgXeKJEuMm/KU0WAOs3k9606	intact-crc:B2D77899017F97DA|rigid:Q3XroSrdwyof0FQjp3t6eDwV5Is	false	-	sufficient binding region:6-146	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)