#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16144	uniprotkb:O95136	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-10634606|uniprotkb:Q86UN8|ensembl:ENSP00000496438	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:s1pr2_human(display_long)|uniprotkb:S1PR2(gene name)|psi-mi:S1PR2(display_short)|uniprotkb:EDG5(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ni et al. (2014)	imex:IM-23840|pubmed:24851274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10634604|imex:IM-23840-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	dip:DIP-60682N|refseq:NP_004221.3|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1ZTI|reactome:R-HSA-418594|reactome:R-HSA-419408|ensembl:ENSG00000267534(gene)|ensembl:ENST00000646641(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008528"(G protein-coupled peptide receptor activity)	-	-	-	figure legend:Figure 2 A, 4B|agonist:S1P -Sphingosine 1-phosphate|agonist:HGF -hepatocyte growth factor|antagonist:siRNA specific for S1PR1 significantly attenuated S1P-induced increases in this association.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2015/02/13	2015/02/16	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:ARaavcJykjiU7GQbZhgD1bnjNpI9606	intact-crc:93932A83A9B51620|rigid:Q4wBgIfS6Q1jTOsaNB0jxvZmyrI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16144	uniprotkb:O95136	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-10634606|uniprotkb:Q86UN8|ensembl:ENSP00000496438	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:s1pr2_human(display_long)|uniprotkb:S1PR2(gene name)|psi-mi:S1PR2(display_short)|uniprotkb:EDG5(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ni et al. (2014)	imex:IM-23840|pubmed:24851274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10634651|imex:IM-23840-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	dip:DIP-60682N|refseq:NP_004221.3|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1ZTI|reactome:R-HSA-418594|reactome:R-HSA-419408|ensembl:ENSG00000267534(gene)|ensembl:ENST00000646641(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008528"(G protein-coupled peptide receptor activity)	-	-	-	figure legend:Figure 2 B, 4B|agonist:S1P -Sphingosine 1-phosphate|agonist:HGF -hepatocyte growth factor|antagonist:siRNA specific for S1PR1 significantly attenuated S1P-induced increases in this association.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2015/02/13	2015/02/16	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:ARaavcJykjiU7GQbZhgD1bnjNpI9606	intact-crc:C7E1D4792834847F|rigid:Q4wBgIfS6Q1jTOsaNB0jxvZmyrI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16144	uniprotkb:Q99500	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-10634734|uniprotkb:Q5SQD8|uniprotkb:Q7Z5I2|ensembl:ENSP00000350878|ensembl:ENSP00000365006	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:s1pr3_human(display_long)|uniprotkb:S1PR3(gene name)|psi-mi:S1PR3(display_short)|uniprotkb:EDG3(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 3(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ni et al. (2014)	imex:IM-23840|pubmed:24851274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10634728|imex:IM-23840-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	refseq:NP_005217.2|ensembl:ENSG00000213694(gene)|ensembl:ENST00000358157(transcript)|ensembl:ENST00000375846(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004062(EDG-3 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7C4S|reactome:R-HSA-418594|reactome:R-HSA-419408|reactome:R-HSA-9009391	-	-	-	figure legend:Figure 2 D, 4C|agonist:S1P -Sphingosine 1-phosphate|agonist:HGF -hepatocyte growth factor|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2015/02/13	2015/02/16	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:FipzLBIPPrqK+JDvhvWWL5Kw9xM9606	intact-crc:941CDD6256C3FD6C|rigid:/rZXsTSj5tTy/AI9GaNHMVrlQMU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16144	uniprotkb:Q99500	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-10634734|uniprotkb:Q5SQD8|uniprotkb:Q7Z5I2|ensembl:ENSP00000350878|ensembl:ENSP00000365006	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:s1pr3_human(display_long)|uniprotkb:S1PR3(gene name)|psi-mi:S1PR3(display_short)|uniprotkb:EDG3(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 3(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ni et al. (2014)	imex:IM-23840|pubmed:24851274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10634771|imex:IM-23840-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	refseq:NP_005217.2|ensembl:ENSG00000213694(gene)|ensembl:ENST00000358157(transcript)|ensembl:ENST00000375846(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004062(EDG-3 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7C4S|reactome:R-HSA-418594|reactome:R-HSA-419408|reactome:R-HSA-9009391	-	-	-	figure legend:Figure 2C, 4C|agonist:S1P -Sphingosine 1-phosphate|agonist:HGF -hepatocyte growth factor|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2015/02/13	2015/02/16	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:FipzLBIPPrqK+JDvhvWWL5Kw9xM9606	intact-crc:F38BE5B176697C4E|rigid:/rZXsTSj5tTy/AI9GaNHMVrlQMU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95136	uniprotkb:P21453	intact:EBI-10634606|uniprotkb:Q86UN8|ensembl:ENSP00000496438	intact:EBI-2681920|uniprotkb:Q9BYY4|uniprotkb:Q9NYN8|uniprotkb:D3DT66|ensembl:ENSP00000305416|ensembl:ENSP00000497175|ensembl:ENSP00000497478|ensembl:ENSP00000498038	psi-mi:s1pr2_human(display_long)|uniprotkb:S1PR2(gene name)|psi-mi:S1PR2(display_short)|uniprotkb:EDG5(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:s1pr1_human(display_long)|uniprotkb:S1PR1(gene name)|psi-mi:S1PR1(display_short)|uniprotkb:CHEDG1(gene name synonym)|uniprotkb:EDG1(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 1(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Ni et al. (2014)	imex:IM-23840|pubmed:24851274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10634824|imex:IM-23840-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60682N|refseq:NP_004221.3|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1ZTI|reactome:R-HSA-418594|reactome:R-HSA-419408|ensembl:ENSG00000267534(gene)|ensembl:ENST00000646641(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008528"(G protein-coupled peptide receptor activity)	refseq:NP_001307659.1|refseq:NP_001391.2|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0072678"(T cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000987(EDG-1 sphingosine 1-phosphate receptor)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3V2W|rcsb pdb:3V2Y|reactome:R-HSA-419408|reactome:R-HSA-6785807|ensembl:ENSG00000170989(gene)|ensembl:ENST00000305352(transcript)|ensembl:ENST00000475289(transcript)|ensembl:ENST00000648480(transcript)|ensembl:ENST00000649383(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003245"(cardiac muscle tissue growth involved in heart morphogenesis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-9679191|dip:DIP-60427N	-	-	-	figure legend:Figure 5|agonist:S1P -Sphingosine 1-phosphate|agonist:HGF -hepatocyte growth factor|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2015/02/13	2015/02/16	rogid:ARaavcJykjiU7GQbZhgD1bnjNpI9606	rogid:LVtMWT8CaCKezjGOwXuQugL/8NA9606	intact-crc:113AEEE4F556301C|rigid:EpWOlg/edYyDC6dsE6bc0RfcyFw	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q99500	uniprotkb:P16144	intact:EBI-10634734|uniprotkb:Q5SQD8|uniprotkb:Q7Z5I2|ensembl:ENSP00000350878|ensembl:ENSP00000365006	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:s1pr3_human(display_long)|uniprotkb:S1PR3(gene name)|psi-mi:S1PR3(display_short)|uniprotkb:EDG3(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 3(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-3(gene name synonym)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Ni et al. (2014)	imex:IM-23840|pubmed:24851274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10634797|imex:IM-23840-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005217.2|ensembl:ENSG00000213694(gene)|ensembl:ENST00000358157(transcript)|ensembl:ENST00000375846(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004062(EDG-3 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7C4S|reactome:R-HSA-418594|reactome:R-HSA-419408|reactome:R-HSA-9009391	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:Figure3|agonist:S1P -Sphingosine 1-phosphate|agonist:HGF -hepatocyte growth factor|antagonist:siRNA specific for S1PR3|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium)	-	2015/02/13	2015/02/16	rogid:FipzLBIPPrqK+JDvhvWWL5Kw9xM9606	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	intact-crc:3B1C43873521878D|rigid:/rZXsTSj5tTy/AI9GaNHMVrlQMU	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)