#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O88597 uniprotkb:Q8VCQ3 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815551|imex:IM-24463-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 - - - figure legend:1a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:zycZWhnTYSJddgPb0hHzeVsa0gw false enhanced green fluorescent protein tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O88597 uniprotkb:Q8CDJ3 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815551|imex:IM-24463-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N - - - figure legend:1a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rigid:zycZWhnTYSJddgPb0hHzeVsa0gw false enhanced green fluorescent protein tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O88597 uniprotkb:Q8K245 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-6678333|ensembl:ENSMUSP00000045297|intact:EBI-10689401|uniprotkb:Q8BVI8|uniprotkb:Q8C0K8 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:uvrag_mouse(display_long)|uniprotkb:Uvrag1(gene name synonym)|uniprotkb:Uvrag(gene name)|psi-mi:Uvrag(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815551|imex:IM-24463-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N ensembl:ENSMUSG00000035354(gene)|ensembl:ENSMUST00000037968(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0070418"(DNA-dependent protein kinase complex)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q8K245|rcsb pdb:5YR0|reactome:R-MMU-1632852|refseq:NP_848750.3 - - - figure legend:1a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:rzFzOhdqb0elqRBuF+JOh7I3AsI10090 rigid:zycZWhnTYSJddgPb0hHzeVsa0gw false enhanced green fluorescent protein tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O88597 uniprotkb:Q8VD65 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-6678184|ensembl:ENSMUSP00000067400|ensembl:ENSMUSP00000139427|uniprotkb:Q56A65|uniprotkb:Q8C948|uniprotkb:Q8C9D7|uniprotkb:Q9CVC5 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:pi3r4_mouse(display_long)|uniprotkb:Vps15(gene name synonym)|uniprotkb:Pik3r4(gene name)|psi-mi:Pik3r4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815551|imex:IM-24463-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N ensembl:ENSMUSG00000032571(gene)|ensembl:ENSMUST00000065778(transcript)|ensembl:ENSMUST00000191268(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q8VD65|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001074778.1|dip:DIP-57219N - - - figure legend:1a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:Z7LaqIZqtwpwdZAGpJ1e5gFHLT810090 rigid:zycZWhnTYSJddgPb0hHzeVsa0gw false enhanced green fluorescent protein tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O88597 uniprotkb:Q6PF93 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815551|imex:IM-24463-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N - - - figure legend:1a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rigid:zycZWhnTYSJddgPb0hHzeVsa0gw false enhanced green fluorescent protein tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O88597 uniprotkb:Q80U62 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-3506572|uniprotkb:Q3TAX3|uniprotkb:Q3TD96|uniprotkb:Q3TDF7|uniprotkb:Q3TDU2|uniprotkb:Q6NWW8|uniprotkb:Q6P9T7|uniprotkb:Q6PG18|uniprotkb:Q8BMP7|uniprotkb:Q8BY22|ensembl:ENSMUSP00000087114 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:rubic_mouse(display_long)|uniprotkb:Rubcn(gene name)|psi-mi:Rubcn(display_short)|uniprotkb:Kiaa0226(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815551|imex:IM-24463-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N refseq:NP_001186967.1|refseq:NP_766203.1|ensembl:ENSMUSG00000035629(gene)|ensembl:ENSMUST00000089684(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043553"(negative regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:1901097"(negative regulation of autophagosome maturation)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR004012(RUN)|interpro:IPR025258|interpro:IPR037213|mint:Q80U62 - - - figure legend:1a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:W9a7lLJWOl9czZuUTzBr+Nfyaqw10090 rigid:zycZWhnTYSJddgPb0hHzeVsa0gw false enhanced green fluorescent protein tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8VCQ3 uniprotkb:O88597 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815578|imex:IM-24463-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N - - - figure legend:1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/05/06 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:6u2SWnkCNo2iSeDqx445OiOdl1M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8VCQ3 uniprotkb:O88597 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815582|imex:IM-24463-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N - - - figure legend:1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/05/06 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:6u2SWnkCNo2iSeDqx445OiOdl1M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8VCQ3 uniprotkb:Q8CDJ3 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815586|imex:IM-24463-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N - - - figure legend:1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8VCQ3 uniprotkb:O88597 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815586|imex:IM-24463-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N - - - figure legend:1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8VCQ3 uniprotkb:Q8K245 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-6678333|ensembl:ENSMUSP00000045297|intact:EBI-10689401|uniprotkb:Q8BVI8|uniprotkb:Q8C0K8 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:uvrag_mouse(display_long)|uniprotkb:Uvrag1(gene name synonym)|uniprotkb:Uvrag(gene name)|psi-mi:Uvrag(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815586|imex:IM-24463-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 ensembl:ENSMUSG00000035354(gene)|ensembl:ENSMUST00000037968(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0070418"(DNA-dependent protein kinase complex)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q8K245|rcsb pdb:5YR0|reactome:R-MMU-1632852|refseq:NP_848750.3 - - - figure legend:1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:rzFzOhdqb0elqRBuF+JOh7I3AsI10090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8VCQ3 uniprotkb:Q6PF93 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815586|imex:IM-24463-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N - - - figure legend:1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8VCQ3 uniprotkb:Q8VD65 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-6678184|ensembl:ENSMUSP00000067400|ensembl:ENSMUSP00000139427|uniprotkb:Q56A65|uniprotkb:Q8C948|uniprotkb:Q8C9D7|uniprotkb:Q9CVC5 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:pi3r4_mouse(display_long)|uniprotkb:Vps15(gene name synonym)|uniprotkb:Pik3r4(gene name)|psi-mi:Pik3r4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815586|imex:IM-24463-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 ensembl:ENSMUSG00000032571(gene)|ensembl:ENSMUST00000065778(transcript)|ensembl:ENSMUST00000191268(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q8VD65|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001074778.1|dip:DIP-57219N - - - figure legend:1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/07/18 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:Z7LaqIZqtwpwdZAGpJ1e5gFHLT810090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PF93 uniprotkb:Q8VCQ3 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990963|imex:IM-24463-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 - - - figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PF93 uniprotkb:Q8CDJ3 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990963|imex:IM-24463-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N - - - figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PF93 uniprotkb:O88597 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990963|imex:IM-24463-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N - - - figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PF93 uniprotkb:Q8K245 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 intact:EBI-6678333|ensembl:ENSMUSP00000045297|intact:EBI-10689401|uniprotkb:Q8BVI8|uniprotkb:Q8C0K8 psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:uvrag_mouse(display_long)|uniprotkb:Uvrag1(gene name synonym)|uniprotkb:Uvrag(gene name)|psi-mi:Uvrag(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990963|imex:IM-24463-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N ensembl:ENSMUSG00000035354(gene)|ensembl:ENSMUST00000037968(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0070418"(DNA-dependent protein kinase complex)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q8K245|rcsb pdb:5YR0|reactome:R-MMU-1632852|refseq:NP_848750.3 - - - figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rogid:rzFzOhdqb0elqRBuF+JOh7I3AsI10090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PF93 uniprotkb:Q8VD65 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 intact:EBI-6678184|ensembl:ENSMUSP00000067400|ensembl:ENSMUSP00000139427|uniprotkb:Q56A65|uniprotkb:Q8C948|uniprotkb:Q8C9D7|uniprotkb:Q9CVC5 psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:pi3r4_mouse(display_long)|uniprotkb:Vps15(gene name synonym)|uniprotkb:Pik3r4(gene name)|psi-mi:Pik3r4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990963|imex:IM-24463-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N ensembl:ENSMUSG00000032571(gene)|ensembl:ENSMUST00000065778(transcript)|ensembl:ENSMUST00000191268(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q8VD65|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001074778.1|dip:DIP-57219N - - - figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rogid:Z7LaqIZqtwpwdZAGpJ1e5gFHLT810090 rigid:eIMJUm+wFzHn+fMXoeo9802xCws false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8VCQ3 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990972|imex:IM-24463-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 - - - figure legend:8A|comment:Association of VPS15 and VPS34 is decreased in Nrbf2 KO mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:O88597 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990972|imex:IM-24463-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N - - - figure legend:8A|comment:Association of VPS15 and VPS34 is decreased in Nrbf2 KO mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8VD65 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678184|ensembl:ENSMUSP00000067400|ensembl:ENSMUSP00000139427|uniprotkb:Q56A65|uniprotkb:Q8C948|uniprotkb:Q8C9D7|uniprotkb:Q9CVC5 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pi3r4_mouse(display_long)|uniprotkb:Vps15(gene name synonym)|uniprotkb:Pik3r4(gene name)|psi-mi:Pik3r4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990972|imex:IM-24463-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000032571(gene)|ensembl:ENSMUST00000065778(transcript)|ensembl:ENSMUST00000191268(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q8VD65|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001074778.1|dip:DIP-57219N - - - figure legend:8A|comment:Association of VPS15 and VPS34 is decreased in Nrbf2 KO mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:Z7LaqIZqtwpwdZAGpJ1e5gFHLT810090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q6PF93 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990972|imex:IM-24463-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N - - - figure legend:8A|comment:Association of VPS15 and VPS34 is decreased in Nrbf2 KO mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:O88597 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0071"(molecular sieving) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-10815606|imex:IM-24463-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N - - - figure legend:1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/05/06 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:oL6D/DvEaqElC4vZjQNKDx7JW58 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8VCQ3 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0071"(molecular sieving) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-10815606|imex:IM-24463-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 - - - figure legend:1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2015/05/06 2015/05/06 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:oL6D/DvEaqElC4vZjQNKDx7JW58 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O88597 uniprotkb:Q8VCQ3 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815620|imex:IM-24463-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 - - - figure legend:1e|comment:"Association not affected by Nrbf2 knockdown (RNAi). ATG14L KO decreased the interaction between becn1 and nrbf2"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2015/05/06 2015/08/13 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:oL6D/DvEaqElC4vZjQNKDx7JW58 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O88597 uniprotkb:Q8CDJ3 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815620|imex:IM-24463-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N - - - figure legend:1e|comment:"Association not affected by Nrbf2 knockdown (RNAi). ATG14L KO decreased the interaction between becn1 and nrbf2"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2015/05/06 2015/08/13 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rigid:oL6D/DvEaqElC4vZjQNKDx7JW58 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8VCQ3 uniprotkb:Q8CDJ3 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:"MI:0096"(pull down) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10815645|imex:IM-24463-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N - - - figure legend:1f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/05/06 2015/05/06 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rigid:Nz9+y2eF9Jn8yqfcvDzClWzdCm4 false glutathione s tranferase tag:?-? flag tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q96F24 uniprotkb:Q8CDJ3 intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym) psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815691|imex:IM-24463-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280 refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N - - - figure legend:S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/05/06 2015/05/06 rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rigid:qnT+8H3U8i4OQq7ZvTiq9V0agUk false - enhanced green fluorescent protein tag:c-c|necessary binding region:1-95 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q14457 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-10815721|imex:IM-24463-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:S2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2015/05/06 2015/05/06 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:XlZMWAGY58Ewh4c4gbcTMsu8WAw false fluorescent protein tag:?-? myc tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q8CDJ3 uniprotkb:Q8VCQ3 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0663"(confocal microscopy) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-10815721|imex:IM-24463-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 - - - figure legend:S2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2015/05/06 2015/05/06 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:XlZMWAGY58Ewh4c4gbcTMsu8WAw false fluorescent protein tag:?-? enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q96F24 uniprotkb:Q8NEB9 intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815788|imex:IM-24463-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280 refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N - - - figure legend:1g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/05/06 2015/05/06 rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:KiBaur+ZJtuA2lfhGT7qy8Ta0rY false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96F24 uniprotkb:Q14457 intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746 intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7 psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym) psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815788|imex:IM-24463-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280 ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1 - - - figure legend:1g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/05/06 2015/05/06 rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606 rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606 rigid:KiBaur+ZJtuA2lfhGT7qy8Ta0rY false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96F24 uniprotkb:Q99570 intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815788|imex:IM-24463-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280 refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:1g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/05/06 2015/05/06 rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:KiBaur+ZJtuA2lfhGT7qy8Ta0rY false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96F24 uniprotkb:Q6ZNE5 intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746 intact:EBI-2690371|uniprotkb:Q32MK7|uniprotkb:A6NJE4|uniprotkb:Q32MK8|uniprotkb:O94920|uniprotkb:A8K9U5|uniprotkb:B7ZWP5|ensembl:ENSP00000247178 psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym) psi-mi:bakor_human(display_long)|uniprotkb:KIAA0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:ATG14(gene name)|psi-mi:ATG14(display_short)|uniprotkb:ATG14L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10815788|imex:IM-24463-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280 refseq:XP_011534865.1|refseq:NP_055739.2|ensembl:ENSG00000126775(gene)|ensembl:ENST00000247178(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|rcsb pdb:6HOL|reactome:R-HSA-1632852|dip:DIP-48651N - - - figure legend:1g|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/05/06 2015/05/06 rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606 rogid:hAzH6syRuwo7HuR/MOXekHPrkJc9606 rigid:KiBaur+ZJtuA2lfhGT7qy8Ta0rY false ha tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8CDJ3 uniprotkb:Q8VCQ3 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816228|imex:IM-24463-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 go:"GO:0001727"(lipid kinase activity) - - figure legend:2b|comment:In mock-transfected NRBF2 KO MEFS no Vps15/Pik3r4 and no lipid kinase activity of the precipitate detected|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/05/06 2015/05/07 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - cyan fluorescent protein tag:c-c|necessary binding region:8-52 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8CDJ3 uniprotkb:O88597 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816228|imex:IM-24463-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N go:"GO:0001727"(lipid kinase activity) - - figure legend:2b|comment:In mock-transfected NRBF2 KO MEFS no Vps15/Pik3r4 and no lipid kinase activity of the precipitate detected|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/05/06 2015/05/07 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q6PF93 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816228|imex:IM-24463-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N go:"GO:0001727"(lipid kinase activity) - - figure legend:2b|comment:In mock-transfected NRBF2 KO MEFS no Vps15/Pik3r4 and no lipid kinase activity of the precipitate detected|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/05/06 2015/05/07 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8VD65 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678184|ensembl:ENSMUSP00000067400|ensembl:ENSMUSP00000139427|uniprotkb:Q56A65|uniprotkb:Q8C948|uniprotkb:Q8C9D7|uniprotkb:Q9CVC5 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pi3r4_mouse(display_long)|uniprotkb:Vps15(gene name synonym)|uniprotkb:Pik3r4(gene name)|psi-mi:Pik3r4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816228|imex:IM-24463-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000032571(gene)|ensembl:ENSMUST00000065778(transcript)|ensembl:ENSMUST00000191268(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q8VD65|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001074778.1|dip:DIP-57219N go:"GO:0001727"(lipid kinase activity) - - figure legend:2b|comment:In mock-transfected NRBF2 KO MEFS no Vps15/Pik3r4 and no lipid kinase activity of the precipitate detected|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/05/06 2015/05/07 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:Z7LaqIZqtwpwdZAGpJ1e5gFHLT810090 rigid:4BVTyrP2UNNXS+YPUpoImipObKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:O88597 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816241|imex:IM-24463-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N go:"GO:0001727"(lipid kinase activity) - - figure legend:2b|comment:in wildtype MEFs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/05/06 2015/05/07 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090 rigid:kQ04hMSsDJ/SXnK2/XrYrAXBhcc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q6PF93 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816241|imex:IM-24463-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N go:"GO:0001727"(lipid kinase activity) - - figure legend:2b|comment:in wildtype MEFs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/05/06 2015/05/07 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rigid:kQ04hMSsDJ/SXnK2/XrYrAXBhcc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8VD65 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678184|ensembl:ENSMUSP00000067400|ensembl:ENSMUSP00000139427|uniprotkb:Q56A65|uniprotkb:Q8C948|uniprotkb:Q8C9D7|uniprotkb:Q9CVC5 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pi3r4_mouse(display_long)|uniprotkb:Vps15(gene name synonym)|uniprotkb:Pik3r4(gene name)|psi-mi:Pik3r4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816241|imex:IM-24463-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000032571(gene)|ensembl:ENSMUST00000065778(transcript)|ensembl:ENSMUST00000191268(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q8VD65|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001074778.1|dip:DIP-57219N go:"GO:0001727"(lipid kinase activity) - - figure legend:2b|comment:in wildtype MEFs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/05/06 2015/05/07 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:Z7LaqIZqtwpwdZAGpJ1e5gFHLT810090 rigid:kQ04hMSsDJ/SXnK2/XrYrAXBhcc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8VCQ3 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816259|imex:IM-24463-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 go:"GO:0001727"(lipid kinase activity) - - figure legend:2d|comment:NRBF2 cotransfection increases lipid kinase activity of the precipitate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:hFC8f/62MmnjvWvRRR6tXT/2mVA false flag tag:?-? cyan fluorescent protein tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8NEB9 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816259|imex:IM-24463-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N go:"GO:0001727"(lipid kinase activity) - - figure legend:2d|comment:NRBF2 cotransfection increases lipid kinase activity of the precipitate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:hFC8f/62MmnjvWvRRR6tXT/2mVA false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P2Y5 uniprotkb:Q8VCQ3 intact:EBI-2952704|uniprotkb:B3KTC1|ensembl:ENSP00000348455|uniprotkb:O00392 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:uvrag_human(display_long)|uniprotkb:UVRAG(gene name)|psi-mi:UVRAG(display_short)|uniprotkb:p63(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816282|imex:IM-24463-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q9P2Y5|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-9679504|reactome:R-HSA-9694676|ensembl:ENSG00000198382(gene)|ensembl:ENST00000356136(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|refseq:NP_003360.2|ensembl:ENSP00000348455|ensembl:ENST00000531818|ensembl:ENSP00000434082|ensembl:ENST00000532130|ensembl:ENSP00000436270|ensembl:ENST00000533454|ensembl:ENSP00000431256|dip:DIP-48652N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 go:"GO:0001727"(lipid kinase activity) - - figure legend:4d|comment:NRBF2 cotransfection increases lipid kinase activity of the precipitate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/05/06 2015/08/13 rogid:TDc74eSYcSe2UJdNnKbFv5EBziE9606 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:tXslJ0FGXK+KID5qDR1ypvpRUeQ false flag tag:?-? cyan fluorescent protein tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P2Y5 uniprotkb:Q8NEB9 intact:EBI-2952704|uniprotkb:B3KTC1|ensembl:ENSP00000348455|uniprotkb:O00392 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 psi-mi:uvrag_human(display_long)|uniprotkb:UVRAG(gene name)|psi-mi:UVRAG(display_short)|uniprotkb:p63(gene name synonym) psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816282|imex:IM-24463-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0017124"(SH3 domain binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051684"(maintenance of Golgi location)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR018791|interpro:IPR035892|mint:Q9P2Y5|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-9679504|reactome:R-HSA-9694676|ensembl:ENSG00000198382(gene)|ensembl:ENST00000356136(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000323"(lytic vacuole)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007098"(centrosome cycle)|refseq:NP_003360.2|ensembl:ENSP00000348455|ensembl:ENST00000531818|ensembl:ENSP00000434082|ensembl:ENST00000532130|ensembl:ENSP00000436270|ensembl:ENST00000533454|ensembl:ENSP00000431256|dip:DIP-48652N refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N go:"GO:0001727"(lipid kinase activity) - - figure legend:4d|comment:NRBF2 cotransfection increases lipid kinase activity of the precipitate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/05/06 2015/08/13 rogid:TDc74eSYcSe2UJdNnKbFv5EBziE9606 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rigid:tXslJ0FGXK+KID5qDR1ypvpRUeQ false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NEB9 uniprotkb:Q8VCQ3 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 intact:EBI-2365563|uniprotkb:Q9DCG3|ensembl:ENSMUSP00000097254 psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:nrbf2_mouse(display_long)|uniprotkb:Nrbf2(gene name)|psi-mi:Nrbf2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816298|imex:IM-24463-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N refseq:NP_001031370.1|ensembl:ENSMUSG00000075000(gene)|ensembl:ENSMUST00000077839(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:2CRB|reactome:R-MMU-383280 go:"GO:0001727"(lipid kinase activity) - - figure legend:8d|comment:NRBF2 cotransfection increases lipid kinase activity of the precipitate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/05/06 2015/05/07 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rogid:cHhf0gkdE7geEOeyn/SAXBPCt2g10090 rigid:KL7WrQ33pH/4ICgakIsBZlcreBA false myc tag:?-? cyan fluorescent protein tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NEB9 uniprotkb:Q99570 intact:EBI-1056470|uniprotkb:Q15134|ensembl:ENSP00000262039 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:pk3c3_human(display_long)|uniprotkb:PIK3C3(gene name)|psi-mi:PIK3C3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase p100 subunit(gene name synonym)|uniprotkb:VPS34(gene name synonym)|uniprotkb:hVps34(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10816298|imex:IM-24463-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002638.2|ensembl:ENSG00000078142(gene)|ensembl:ENST00000262039(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043201"(response to leucine)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:3IHY|rcsb pdb:3LS8|rcsb pdb:4OYS|rcsb pdb:4PH4|rcsb pdb:4UWF|rcsb pdb:4UWG|rcsb pdb:4UWH|rcsb pdb:4UWK|rcsb pdb:4UWL|rcsb pdb:5ANL|rcsb pdb:5ENN|rcsb pdb:6I3U|rcsb pdb:6YKG|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-42272N refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N go:"GO:0001727"(lipid kinase activity) - - figure legend:8d|comment:NRBF2 cotransfection increases lipid kinase activity of the precipitate|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/05/06 2015/05/07 rogid:sF4quAbxXhvZQ/Ud6Ra0VSWgbNQ9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:KL7WrQ33pH/4ICgakIsBZlcreBA false myc tag:?-? v5 tag:?-?|his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8CDJ3 uniprotkb:Q6PF93 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678149|ensembl:ENSMUSP00000111479|uniprotkb:Q8R3S8 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pk3c3_mouse(display_long)|uniprotkb:Vps34(gene name synonym)|uniprotkb:Pik3c3(gene name)|psi-mi:Pik3c3(display_short)|uniprotkb:Phosphoinositide-3-kinase class 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990993|imex:IM-24463-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000033628(gene)|ensembl:ENSMUST00000115812(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006497"(protein lipidation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0044754"(autolysosome)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0052742"(phosphatidylinositol kinase activity)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR008290(Phosphatidylinositol 3-kinase, Vps34 type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|mint:Q6PF93|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043201"(response to leucine)|refseq:NP_852079.2|dip:DIP-57222N - - - figure legend:6D|comment:Association of VPS34 and VPS15 is decreased in Nrbf2 KO mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-liver)|taxid:10090(Mus musculus) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:8QWBEdCH+5OBLtAeItoPLiUPcD810090 rigid:3x3TgWr4FsRAH+P/Xj94EVbi82w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CDJ3 uniprotkb:Q8VD65 intact:EBI-3506699|uniprotkb:Q69ZY1|uniprotkb:Q6PFY6|uniprotkb:Q8C6N0|uniprotkb:Q8R3M3|ensembl:ENSMUSP00000039047|ensembl:ENSMUSP00000153718 intact:EBI-6678184|ensembl:ENSMUSP00000067400|ensembl:ENSMUSP00000139427|uniprotkb:Q56A65|uniprotkb:Q8C948|uniprotkb:Q8C9D7|uniprotkb:Q9CVC5 psi-mi:bakor_mouse(display_long)|uniprotkb:Atg14(gene name)|psi-mi:Atg14(display_short)|uniprotkb:D14Ertd436e(gene name synonym)|uniprotkb:Kiaa0831(gene name synonym)|uniprotkb:Autophagy-related protein 14-like protein(gene name synonym)|uniprotkb:Atg14L(gene name synonym) psi-mi:pi3r4_mouse(display_long)|uniprotkb:Vps15(gene name synonym)|uniprotkb:Pik3r4(gene name)|psi-mi:Pik3r4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lu et al. (2013) imex:IM-24463|pubmed:24849286 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10990993|imex:IM-24463-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766187.1|ensembl:ENSMUSG00000037526(gene)|ensembl:ENSMUST00000042988(transcript)|ensembl:ENSMUST00000226299(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000423"(mitophagy)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016236"(macroautophagy)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051020"(GTPase binding)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR018791|mint:Q8CDJ3|reactome:R-MMU-1632852|dip:DIP-60849N ensembl:ENSMUSG00000032571(gene)|ensembl:ENSMUST00000065778(transcript)|ensembl:ENSMUST00000191268(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q8VD65|reactome:R-MMU-109704|reactome:R-MMU-1632852|reactome:R-MMU-1660514|reactome:R-MMU-1660516|reactome:R-MMU-1660517|reactome:R-MMU-168138|reactome:R-MMU-5668599|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001074778.1|dip:DIP-57219N - - - figure legend:6D|comment:Association of VPS34 and VPS15 is decreased in Nrbf2 KO mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-liver)|taxid:10090(Mus musculus) - 2015/05/06 2015/08/13 rogid:Ha+zYY4aNPLZH0LQPz9s1SSK9R410090 rogid:Z7LaqIZqtwpwdZAGpJ1e5gFHLT810090 rigid:3x3TgWr4FsRAH+P/Xj94EVbi82w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)