#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P21555 uniprotkb:O08726 intact:EBI-10634242 intact:EBI-10634192|ensembl:ENSRNOP00000012523|ensembl:ENSRNOP00000067445|ensembl:ENSRNOP00000073780 psi-mi:npy1r_rat(display_long)|uniprotkb:Npy1r(gene name)|psi-mi:Npy1r(display_short)|uniprotkb:FC5(gene name synonym) psi-mi:galr2_rat(display_long)|uniprotkb:Galr2(gene name)|psi-mi:Galr2(display_short)|uniprotkb:Galnr2(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Narváez et al. (2014) imex:IM-23838|pubmed:24841617 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10634174|imex:IM-23838-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-RNO-375276|reactome:R-RNO-418594|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR000351(Neuropeptide Y1 receptor)|interpro:IPR000611(Neuropeptide Y receptor)|rgd:3198|go:"GO:0001601"(peptide YY receptor activity)|go:"GO:0001602"(pancreatic polypeptide receptor activity)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030432"(peristalsis)|go:"GO:0032355"(response to estradiol)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration) rgd:2657|refseq:NP_062045.1|refseq:XP_008766654.1|ensembl:ENSRNOG00000061733(gene)|ensembl:ENSRNOT00000012523(transcript)|ensembl:ENSRNOT00000075548(transcript)|ensembl:ENSRNOT00000086288(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0090663"(galanin-activated signaling pathway)|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|interpro:IPR003907(Galanin 2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-375276|reactome:R-RNO-418594|refseq:XP_017459673.1 - - - figure legend:Figure 3|comment:"Positive results were seen in cells of the ITC nucleus;the intercalated (ITC) cells of the amygdala are a group of GABAergic neurons situated between the basolateral and central nuclei of the amygdala that are important for inhibitory control over the amygdala."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain) - 2015/02/13 2015/02/16 rogid:3kiGMF6tE/DIRjwWLHMVxbYgKmE10116 rogid:lSddtwCAd54RLCIb8hRFyj1zYeQ10116 intact-crc:B3CB30B01AC51C5D|rigid:SENnsAa/EYL8h/H21xH/Vve/xcY false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O43603 uniprotkb:P25929 intact:EBI-6624855|ensembl:ENSP00000329684|uniprotkb:A5JUU4|uniprotkb:Q32MN8 intact:EBI-372227|uniprotkb:B2R6H5|ensembl:ENSP00000354652 psi-mi:galr2_human(display_long)|uniprotkb:GALR2(gene name)|psi-mi:GALR2(display_short)|uniprotkb:GALNR2(gene name synonym) psi-mi:npy1r_human(display_long)|uniprotkb:NPY1R(gene name)|psi-mi:NPY1R(display_short)|uniprotkb:NPYR(gene name synonym)|uniprotkb:NPYY1(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Narváez et al. (2014) imex:IM-23838|pubmed:24841617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-10634305|imex:IM-23838-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000182687(gene)|ensembl:ENST00000329003(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007611"(learning or memory)|go:"GO:0005929"(cilium)|go:"GO:0007631"(feeding behavior)|go:"GO:0006936"(muscle contraction)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0090663"(galanin-activated signaling pathway)|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|go:"GO:0007218"(neuropeptide signaling pathway)|interpro:IPR003907(Galanin 2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_003848.1 refseq:XP_011530312.1|refseq:NP_000900.1|refseq:XP_005263088.1|ensembl:ENSG00000164128(gene)|ensembl:ENST00000296533(transcript)|go:"GO:0001602"(pancreatic polypeptide receptor activity)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000351(Neuropeptide Y1 receptor)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2F1U|rcsb pdb:2IIL|rcsb pdb:5ZBQ|reactome:R-HSA-375276|reactome:R-HSA-418594 - - - figure legend:Supp Figure 5|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/02/13 2015/02/16 rogid:oOMJXr3SMk2TzwRk4CHvuTPCpeQ9606 rogid:Znnr1wafoTgjDhpe9OWZ1aBOa/s9606 intact-crc:8BCFC7A6A306F32C|rigid:5WLRIYtpiKvNJHrZFN+q3os+iQk false - ha tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P21555 uniprotkb:O08726 intact:EBI-10634242 intact:EBI-10634192|ensembl:ENSRNOP00000012523|ensembl:ENSRNOP00000067445|ensembl:ENSRNOP00000073780 psi-mi:npy1r_rat(display_long)|uniprotkb:Npy1r(gene name)|psi-mi:Npy1r(display_short)|uniprotkb:FC5(gene name synonym) psi-mi:galr2_rat(display_long)|uniprotkb:Galr2(gene name)|psi-mi:Galr2(display_short)|uniprotkb:Galnr2(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Narváez et al. (2014) imex:IM-23838|pubmed:24841617 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10634284|imex:IM-23838-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-RNO-375276|reactome:R-RNO-418594|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR000351(Neuropeptide Y1 receptor)|interpro:IPR000611(Neuropeptide Y receptor)|rgd:3198|go:"GO:0001601"(peptide YY receptor activity)|go:"GO:0001602"(pancreatic polypeptide receptor activity)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030432"(peristalsis)|go:"GO:0032355"(response to estradiol)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration) rgd:2657|refseq:NP_062045.1|refseq:XP_008766654.1|ensembl:ENSRNOG00000061733(gene)|ensembl:ENSRNOT00000012523(transcript)|ensembl:ENSRNOT00000075548(transcript)|ensembl:ENSRNOT00000086288(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0090663"(galanin-activated signaling pathway)|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|interpro:IPR003907(Galanin 2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-375276|reactome:R-RNO-418594|refseq:XP_017459673.1 - - - figure legend:Supp Figure 4|comment:"Positive results were seen in cells of the ITC nucleus;the intercalated (ITC) cells of the amygdala are a group of GABAergic neurons situated between the basolateral and central nuclei of the amygdala that are important for inhibitory control over the amygdala."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-amygdala)|taxid:10116(Rattus norvegicus) - 2015/02/13 2015/02/16 rogid:3kiGMF6tE/DIRjwWLHMVxbYgKmE10116 rogid:lSddtwCAd54RLCIb8hRFyj1zYeQ10116 intact-crc:6B87BB20E82CA4EA|rigid:SENnsAa/EYL8h/H21xH/Vve/xcY false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)