#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:E9Q401	uniprotkb:G5E8J6	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	intact:EBI-10216723|ensembl:ENSMUSP00000082459	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:g5e8j6_mouse(display_long)|uniprotkb:Hrc(gene name)|psi-mi:Hrc(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Zhang et al. (2014)	pubmed:24805197|imex:IM-23853	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10210525|imex:IM-23853-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	refseq:NP_034603.2|ensembl:ENSMUSG00000038239(gene)|ensembl:ENSMUST00000085351(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901899"(positive regulation of relaxation of cardiac muscle)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR015666(Histidine-rich calcium-binding protein)|interpro:IPR019552|reactome:R-MMU-381426|reactome:R-MMU-8957275	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Supp Fig 4|antagonist:Calcium 2mM|antagonist:caffeine 20mM|comment:"Both high (2mM)  and depleted store Ca2 + levels (addition of caffeine) reduce the association between RyR2 and HRC WT."|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-myocytes)|taxid:10090(Mouse Myocytes)	-	2015/02/13	2015/02/16	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	rogid:zoGQiiRQCgtn1DdnyyzfGoHpfKw10090	intact-crc:08CFA00975329C22|rigid:KR4EqYbgMGAQrvnaaoaquTRToVY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:E9Q401	uniprotkb:P23327	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	intact:EBI-9639760|uniprotkb:Q504Y6|ensembl:ENSP00000252825	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:srch_human(display_long)|uniprotkb:HRC(gene name)|psi-mi:HRC(display_short)|uniprotkb:HCP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2014)	pubmed:24805197|imex:IM-23853	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10634068|imex:IM-23853-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	refseq:NP_002143.1|ensembl:ENSG00000130528(gene)|ensembl:ENST00000252825(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006936"(muscle contraction)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030018"(Z disc)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901899"(positive regulation of relaxation of cardiac muscle)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|interpro:IPR015666(Histidine-rich calcium-binding protein)|interpro:IPR019552|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Supp Fig 5|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/02/13	2015/02/16	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	rogid:0MaUpv/EsS+BOJ7Nv3HAtl6T/yQ9606	intact-crc:9A636447EF9F4E39|rigid:cui6BzEpGzVHbJXHO0RGd3g73wk	false	-	mutation decreasing interaction strength:96-96	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:E9Q401	uniprotkb:P23327	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	intact:EBI-9639760|uniprotkb:Q504Y6|ensembl:ENSP00000252825	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:srch_human(display_long)|uniprotkb:HRC(gene name)|psi-mi:HRC(display_short)|uniprotkb:HCP(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Zhang et al. (2014)	pubmed:24805197|imex:IM-23853	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10205233|imex:IM-23853-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	refseq:NP_002143.1|ensembl:ENSG00000130528(gene)|ensembl:ENST00000252825(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006936"(muscle contraction)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030018"(Z disc)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901899"(positive regulation of relaxation of cardiac muscle)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|interpro:IPR015666(Histidine-rich calcium-binding protein)|interpro:IPR019552|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Fig 5|antagonist:Calcium 2mM|antagonist:caffeine 20mM|comment:"Both high (2mM)  and depleted store Ca2 + levels (addition of caffeine) reduce the association between RyR2 and HRC WT."|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/02/13	2015/02/13	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	rogid:0MaUpv/EsS+BOJ7Nv3HAtl6T/yQ9606	intact-crc:8B931A3D6155A8DD|rigid:cui6BzEpGzVHbJXHO0RGd3g73wk	false	-	mutation decreasing interaction strength:96-96	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:E9Q401	uniprotkb:P23327	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	intact:EBI-9639760|uniprotkb:Q504Y6|ensembl:ENSP00000252825	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:srch_human(display_long)|uniprotkb:HRC(gene name)|psi-mi:HRC(display_short)|uniprotkb:HCP(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2014)	pubmed:24805197|imex:IM-23853	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10205346|imex:IM-23853-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	refseq:NP_002143.1|ensembl:ENSG00000130528(gene)|ensembl:ENST00000252825(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006936"(muscle contraction)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030018"(Z disc)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901899"(positive regulation of relaxation of cardiac muscle)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|interpro:IPR015666(Histidine-rich calcium-binding protein)|interpro:IPR019552|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Supp fig 2|antagonist:Calcium 2mM|antagonist:caffeine 20mM|comment:"Both high (2mM)  and depleted store Ca2 + levels (addition of caffeine) reduce the association between RyR2 and HRC WT."|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/02/13	2015/02/13	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	rogid:0MaUpv/EsS+BOJ7Nv3HAtl6T/yQ9606	intact-crc:5B857DCABE8542E2|rigid:cui6BzEpGzVHbJXHO0RGd3g73wk	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)