#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62406	ensembl:ENSMUSG00000016529	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	intact:EBI-6398833	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:il10_mouse_gene(display_short)|psi-mi:ENSMUSG00000016529(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Inoue et al. (2014)	imex:IM-24633|pubmed:24706909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11327476|imex:IM-24633-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	-	-	-	-	figure legend:4C|causality statement:Q62406 increases the expression at protein level of ENSMUSG00000016529|causality statement:P18893   decreases the expression at the RNA level of  ENSMUSG00000024401|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2015/08/27	2015/12/14	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:P56477	uniprotkb:Q62406	intact:EBI-643408|ensembl:ENSMUSP00000004392|ensembl:ENSMUSP00000127021	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:irf5_mouse(display_long)|uniprotkb:Irf5(gene name)|psi-mi:Irf5(display_short)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Inoue et al. (2014)	imex:IM-24633|pubmed:24706909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11327503|imex:IM-24633-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036187.1|refseq:NP_001239311.1|refseq:XP_006505160.1|ensembl:ENSMUSG00000029771(gene)|ensembl:ENSMUST00000004392(transcript)|ensembl:ENSMUST00000163511(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR029838|interpro:IPR036388|interpro:IPR036390|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|dip:DIP-49382N	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	-	-	-	figure legend:4F, 5D|agonist:LPS plus CD40 antibody|agonist:LPS|antagonist:Traf2 shRNA|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2015/08/27	2015/10/22	rogid:Mdz1n0MUvYYjxamfbVAzdusN1M810090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rigid:JcbaIzTI57/ErcTtiQX6yFrbmIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:Q62406	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Inoue et al. (2014)	imex:IM-24633|pubmed:24706909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11327568|imex:IM-24633-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	go:"GO:0005634"(nucleus)	-	-	figure legend:5A|agonist:LPS plus CD40 antibody|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2015/08/27	2015/12/14	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rigid:lokT8Ta4QMZHd4exDcn8M1Feuw8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10923	uniprotkb:Q62406	intact:EBI-11327582|uniprotkb:P19008|uniprotkb:Q91VH4|ensembl:ENSMUSP00000031243|ensembl:ENSMUSP00000108367|ensembl:ENSMUSP00000108368	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:ostp_mouse(display_long)|uniprotkb:Spp1(gene name)|psi-mi:Spp1(display_short)|uniprotkb:Eta-1(gene name synonym)|uniprotkb:Op(gene name synonym)|uniprotkb:Spp-1(gene name synonym)|uniprotkb:2AR(gene name synonym)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Calcium oxalate crystal growth inhibitor protein(gene name synonym)|uniprotkb:Early T-lymphocyte activation 1 protein(gene name synonym)|uniprotkb:Minopontin(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Inoue et al. (2014)	imex:IM-24633|pubmed:24706909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11327613|imex:IM-24633-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191162.1|refseq:NP_033289.2|ensembl:ENSMUSG00000029304(gene)|ensembl:ENSMUST00000031243(transcript)|ensembl:ENSMUST00000112747(transcript)|ensembl:ENSMUST00000112748(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0010033"(response to organic substance)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031982"(vesicle)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072044"(collecting duct development)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|reactome:R-MMU-1474228|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-381426|reactome:R-MMU-8957275	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	go:"GO:0005737"(cytoplasm)	-	-	figure legend:6B|agonist:LPS plus CD40 antibody|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2015/08/27	2015/12/04	rogid:DthinzUUHBP9dLc4Z1l2SXzsU9Q10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rigid:Tbu5p6Em68MDYn6fe36zox18vfE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:Q62406	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Inoue et al. (2014)	imex:IM-24633|pubmed:24706909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11327619|imex:IM-24633-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	go:"GO:0005634"(nucleus)	-	-	figure legend:6A, 6D|agonist:LPS plus CD40 antibody|antagonist:OPN knockout.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2015/08/27	2015/12/14	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rigid:lokT8Ta4QMZHd4exDcn8M1Feuw8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P56477	uniprotkb:Q62406	intact:EBI-643408|ensembl:ENSMUSP00000004392|ensembl:ENSMUSP00000127021	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:irf5_mouse(display_long)|uniprotkb:Irf5(gene name)|psi-mi:Irf5(display_short)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Inoue et al. (2014)	imex:IM-24633|pubmed:24706909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11327538|imex:IM-24633-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036187.1|refseq:NP_001239311.1|refseq:XP_006505160.1|ensembl:ENSMUSG00000029771(gene)|ensembl:ENSMUST00000004392(transcript)|ensembl:ENSMUST00000163511(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR029838|interpro:IPR036388|interpro:IPR036390|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|dip:DIP-49382N	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	go:"GO:0005634"(nucleus)	-	-	figure legend:4G,  Supp Fig 6|agonist:"LPS alone (Supp fig 6) or LPS plus CD40 antibody"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2015/08/27	2015/10/22	rogid:Mdz1n0MUvYYjxamfbVAzdusN1M810090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rigid:JcbaIzTI57/ErcTtiQX6yFrbmIk	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P10923	uniprotkb:Q62406	intact:EBI-11327582|uniprotkb:P19008|uniprotkb:Q91VH4|ensembl:ENSMUSP00000031243|ensembl:ENSMUSP00000108367|ensembl:ENSMUSP00000108368	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:ostp_mouse(display_long)|uniprotkb:Spp1(gene name)|psi-mi:Spp1(display_short)|uniprotkb:Eta-1(gene name synonym)|uniprotkb:Op(gene name synonym)|uniprotkb:Spp-1(gene name synonym)|uniprotkb:2AR(gene name synonym)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Calcium oxalate crystal growth inhibitor protein(gene name synonym)|uniprotkb:Early T-lymphocyte activation 1 protein(gene name synonym)|uniprotkb:Minopontin(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Inoue et al. (2014)	imex:IM-24633|pubmed:24706909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11327576|imex:IM-24633-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191162.1|refseq:NP_033289.2|ensembl:ENSMUSG00000029304(gene)|ensembl:ENSMUST00000031243(transcript)|ensembl:ENSMUST00000112747(transcript)|ensembl:ENSMUST00000112748(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0010033"(response to organic substance)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031982"(vesicle)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072044"(collecting duct development)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|reactome:R-MMU-1474228|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-381426|reactome:R-MMU-8957275	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	go:"GO:0005737"(cytoplasm)	-	-	figure legend:6A|agonist:LPS plus CD40 antibody|comment:"Opn-i - an intracellular  isoform of OPN  with a deletion of the N-terminal 16-aa signal sequence, is stated to have been detected, but the antibody used (sc-21742)  would not appear to distinguish between isoforms."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2015/08/27	2015/10/22	rogid:DthinzUUHBP9dLc4Z1l2SXzsU9Q10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rigid:Tbu5p6Em68MDYn6fe36zox18vfE	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)