#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O70405 uniprotkb:Q9DB70 intact:EBI-8390771|intact:UNK-5365168|uniprotkb:Q6PGB2 intact:EBI-10106464|uniprotkb:A2BEA3|ensembl:ENSMUSP00000026016 psi-mi:ulk1_mouse(display_long)|uniprotkb:Ulk1(gene name)|psi-mi:Ulk1(display_short)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Unc51.1(gene name synonym) psi-mi:fund1_mouse(display_long)|uniprotkb:Fundc1(gene name)|psi-mi:Fundc1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-10106478|imex:IM-23792-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033495.2|dip:DIP-60541N|mint:O70405|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008104"(protein localization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010941"(regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021933"(radial glia guided migration of cerebellar granule cell)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0051386"(regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR022708|reactome:R-MMU-1632852|reactome:R-MMU-8854214|reactome:R-MMU-8876198|reactome:R-MMU-8934903|interpro:IPR017441(Protein kinase ATP binding, conserved site) refseq:NP_001300674.1|refseq:NP_082334.1|ensembl:ENSMUSG00000025040(gene)|ensembl:ENSMUST00000026016(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|reactome:R-MMU-8934903|interpro:IPR007014(FUN14) - comment:mint|comment:homomint|function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells - figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/02/03 2015/02/19 rogid:mLPj6Pp1VXGMixWyd7MygI4VgPo10090 rogid:aPTJQJtZKx69LTpyH69MzXY58Ug10090 intact-crc:7A00A84721894DB4|rigid:eApPBnbJXBOR+LS/Dm7YraGv6gk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O70405 uniprotkb:Q9WTQ8 intact:EBI-8390771|intact:UNK-5365168|uniprotkb:Q6PGB2 intact:EBI-10106224 psi-mi:ulk1_mouse(display_long)|uniprotkb:Ulk1(gene name)|psi-mi:Ulk1(display_short)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Unc51.1(gene name synonym) psi-mi:tim23_mouse(display_long)|uniprotkb:Timm23(gene name)|psi-mi:Timm23(display_short)|uniprotkb:Tim23(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-10106220|imex:IM-23792-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033495.2|dip:DIP-60541N|mint:O70405|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008104"(protein localization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010941"(regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021933"(radial glia guided migration of cerebellar granule cell)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0051386"(regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR022708|reactome:R-MMU-1632852|reactome:R-MMU-8854214|reactome:R-MMU-8876198|reactome:R-MMU-8934903|interpro:IPR017441(Protein kinase ATP binding, conserved site) interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane) go:"GO:0005739"(mitochondrion) comment:mint|comment:homomint|function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells - figure legend:f1f f1g|comment:"Subcellular fractionation assays further demonstrated that a propor- tion of ULK1 molecules are indeed co-fractionated with mitochon- dria in response to either hypoxia or FCCP (Fig 1F and G)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/02/03 2015/02/19 rogid:mLPj6Pp1VXGMixWyd7MygI4VgPo10090 rogid:m2+B2MBLLvMa/1yY5BJ6fV8zoAw10090 intact-crc:C22E8CC9069BFA79|rigid:+n2FgvQ+Jckyxs1QFIyFq5tc5jc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IVP5 uniprotkb:Q9GZQ8 intact:EBI-3059266|ensembl:ENSP00000367284 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 psi-mi:fund1_human(display_long)|uniprotkb:FUNDC1(gene name)|psi-mi:FUNDC1(display_short) psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-10106602|imex:IM-23792-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000069509(gene)|ensembl:ENST00000378045(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|interpro:IPR007014(FUN14)|rcsb pdb:2N9X|rcsb pdb:5GMV|reactome:R-HSA-8934903|refseq:NP_776155.1 ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N go:"GO:0005739"(mitochondrion) - - figure legend:f3g|comment:"Overex- pression of FUNDC1 (WT) induces extensive colocalization of mito- chondria with endogenous LC3 puncta in ULK1+/+ cells, which is largely suppressed in ULK1-deficient cells (Fig 3G)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/02/03 2015/02/05 rogid:ePb5LilgvHruy4JTvgfP43kWUao9606 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 intact-crc:1C98020D4CCEAAFA|rigid:YuRBfB9PFu2SwyRlFetTHRvWAhQ false myc tag:?-? - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:O70405 uniprotkb:Q9WTQ8 intact:EBI-8390771|intact:UNK-5365168|uniprotkb:Q6PGB2 intact:EBI-10106224 psi-mi:ulk1_mouse(display_long)|uniprotkb:Ulk1(gene name)|psi-mi:Ulk1(display_short)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Unc51.1(gene name synonym) psi-mi:tim23_mouse(display_long)|uniprotkb:Timm23(gene name)|psi-mi:Timm23(display_short)|uniprotkb:Tim23(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-10106152|imex:IM-23792-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033495.2|dip:DIP-60541N|mint:O70405|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008104"(protein localization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010941"(regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021933"(radial glia guided migration of cerebellar granule cell)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0051386"(regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR022708|reactome:R-MMU-1632852|reactome:R-MMU-8854214|reactome:R-MMU-8876198|reactome:R-MMU-8934903|interpro:IPR017441(Protein kinase ATP binding, conserved site) interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane) go:"GO:0005739"(mitochondrion) comment:mint|comment:homomint|function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells - figure legend:f1e sf1c|comment:"Immu- nofluorescence results show that hypoxia or FCCP not only exten- sively induces mitochondrial fragmentation but also significantly enhances the number and size of ULK1-positive puncta (Fig 1E). A large number of ULK1-positive puncta translocate to fragmented mitochondria in both conditions compared with untreated control or with starvation condition (Fig 1E and Supplementary Fig S1)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/02/03 2015/02/19 rogid:mLPj6Pp1VXGMixWyd7MygI4VgPo10090 rogid:m2+B2MBLLvMa/1yY5BJ6fV8zoAw10090 intact-crc:56C186CA11A87340|rigid:+n2FgvQ+Jckyxs1QFIyFq5tc5jc false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:O70405 uniprotkb:Q8IVP5 intact:EBI-8390771|intact:UNK-5365168|uniprotkb:Q6PGB2 intact:EBI-3059266|ensembl:ENSP00000367284 psi-mi:ulk1_mouse(display_long)|uniprotkb:Ulk1(gene name)|psi-mi:Ulk1(display_short)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Unc51.1(gene name synonym) psi-mi:fund1_human(display_long)|uniprotkb:FUNDC1(gene name)|psi-mi:FUNDC1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-10106413|imex:IM-23792-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033495.2|dip:DIP-60541N|mint:O70405|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008104"(protein localization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010941"(regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021933"(radial glia guided migration of cerebellar granule cell)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0051386"(regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR022708|reactome:R-MMU-1632852|reactome:R-MMU-8854214|reactome:R-MMU-8876198|reactome:R-MMU-8934903|interpro:IPR017441(Protein kinase ATP binding, conserved site) ensembl:ENSG00000069509(gene)|ensembl:ENST00000378045(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|interpro:IPR007014(FUN14)|rcsb pdb:2N9X|rcsb pdb:5GMV|reactome:R-HSA-8934903|refseq:NP_776155.1 - comment:mint|comment:homomint|function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells - figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2015/02/03 2015/02/19 rogid:mLPj6Pp1VXGMixWyd7MygI4VgPo10090 rogid:ePb5LilgvHruy4JTvgfP43kWUao9606 intact-crc:ACF855CBCF17B4D0|rigid:pEOKmkGbnFAlJu8WSi4bhziW8Ls false green fluorescent protein tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O70405 uniprotkb:Q8IVP5 intact:EBI-8390771|intact:UNK-5365168|uniprotkb:Q6PGB2 intact:EBI-3059266|ensembl:ENSP00000367284 psi-mi:ulk1_mouse(display_long)|uniprotkb:Ulk1(gene name)|psi-mi:Ulk1(display_short)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Unc51.1(gene name synonym) psi-mi:fund1_human(display_long)|uniprotkb:FUNDC1(gene name)|psi-mi:FUNDC1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-10106375|imex:IM-23792-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033495.2|dip:DIP-60541N|mint:O70405|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008104"(protein localization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010941"(regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021933"(radial glia guided migration of cerebellar granule cell)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0051386"(regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR022708|reactome:R-MMU-1632852|reactome:R-MMU-8854214|reactome:R-MMU-8876198|reactome:R-MMU-8934903|interpro:IPR017441(Protein kinase ATP binding, conserved site) ensembl:ENSG00000069509(gene)|ensembl:ENST00000378045(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|interpro:IPR007014(FUN14)|rcsb pdb:2N9X|rcsb pdb:5GMV|reactome:R-HSA-8934903|refseq:NP_776155.1 - comment:mint|comment:homomint|function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells - figure legend:f2i f2j sf7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2015/02/03 2015/02/05 rogid:mLPj6Pp1VXGMixWyd7MygI4VgPo10090 rogid:ePb5LilgvHruy4JTvgfP43kWUao9606 intact-crc:7B0CDAC9C25891D0|rigid:pEOKmkGbnFAlJu8WSi4bhziW8Ls false flag tag:?-? mutation disrupting interaction:118-118|myc tag:?-?|binding-associated region:109-118 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O70405 uniprotkb:Q8IVP5 intact:EBI-8390771|intact:UNK-5365168|uniprotkb:Q6PGB2 intact:EBI-3059266|ensembl:ENSP00000367284 psi-mi:ulk1_mouse(display_long)|uniprotkb:Ulk1(gene name)|psi-mi:Ulk1(display_short)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Unc51.1(gene name synonym) psi-mi:fund1_human(display_long)|uniprotkb:FUNDC1(gene name)|psi-mi:FUNDC1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-10106278|imex:IM-23792-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033495.2|dip:DIP-60541N|mint:O70405|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008104"(protein localization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010941"(regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021933"(radial glia guided migration of cerebellar granule cell)|go:"GO:0030424"(axon)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0051386"(regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR022708|reactome:R-MMU-1632852|reactome:R-MMU-8854214|reactome:R-MMU-8876198|reactome:R-MMU-8934903|interpro:IPR017441(Protein kinase ATP binding, conserved site) ensembl:ENSG00000069509(gene)|ensembl:ENST00000378045(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|interpro:IPR007014(FUN14)|rcsb pdb:2N9X|rcsb pdb:5GMV|reactome:R-HSA-8934903|refseq:NP_776155.1 - comment:mint|comment:homomint|function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells - figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2015/02/03 2015/02/19 rogid:mLPj6Pp1VXGMixWyd7MygI4VgPo10090 rogid:ePb5LilgvHruy4JTvgfP43kWUao9606 intact-crc:7819674A894B9B20|rigid:pEOKmkGbnFAlJu8WSi4bhziW8Ls false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IVP5 uniprotkb:Q9GZQ8 intact:EBI-3059266|ensembl:ENSP00000367284 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 psi-mi:fund1_human(display_long)|uniprotkb:FUNDC1(gene name)|psi-mi:FUNDC1(display_short) psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-10106559|imex:IM-23792-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000069509(gene)|ensembl:ENST00000378045(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|interpro:IPR007014(FUN14)|rcsb pdb:2N9X|rcsb pdb:5GMV|reactome:R-HSA-8934903|refseq:NP_776155.1 ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N - - - figure legend:f3j|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2015/02/03 2015/02/05 rogid:ePb5LilgvHruy4JTvgfP43kWUao9606 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 intact-crc:DF783FE93623C441|rigid:YuRBfB9PFu2SwyRlFetTHRvWAhQ false myc tag:?-?|mutation decreasing interaction:17-17 - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9GZQ8 uniprotkb:Q8IVP5 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 intact:EBI-3059266|ensembl:ENSP00000367284 psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:fund1_human(display_long)|uniprotkb:FUNDC1(gene name)|psi-mi:FUNDC1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wu et al. (2014) imex:IM-23792|pubmed:24671035 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-10106582|imex:IM-23792-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N ensembl:ENSG00000069509(gene)|ensembl:ENST00000378045(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|interpro:IPR007014(FUN14)|rcsb pdb:2N9X|rcsb pdb:5GMV|reactome:R-HSA-8934903|refseq:NP_776155.1 - - - figure legend:f3j|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2015/02/03 2015/02/05 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 rogid:ePb5LilgvHruy4JTvgfP43kWUao9606 intact-crc:AF62DE2DF332699B|rigid:YuRBfB9PFu2SwyRlFetTHRvWAhQ false - myc tag:?-?|mutation increasing interaction:17-17 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot)