#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13153	uniprotkb:A0A0H3NGI8	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-10686676|ensemblbacteria:CBW18776	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:a0a0h3ngi8_salts(display_long)|uniprotkb:sopE(gene name)|psi-mi:sopE(display_short)|uniprotkb:SL1344_2674(locus name)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:216597(salts)|taxid:216597("Salmonella typhimurium (strain SL1344)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689573|imex:IM-25801-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	refseq:WP_000161707.1|uniprotkb:E1WJI8(uniprot-removed-ac)|interpro:IPR005414(Salmonella type III secretion SopE effector protein)|interpro:IPR016018(Salmonella type III secretion SopE effector protein, N-terminal)|interpro:IPR016019(Salmonella type III secretion SopE effector protein, GEF domain)|ensemblbacteria:CBW18776(transcript)|ensemblbacteria:SL1344_2674(gene)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR035949	-	-	-	figure legend:4C and 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:jMZa07tHdR7SmHb8YlAPYdvMMCM216597	rigid:vKR0D7KEjZgmpNUyu/odteXKhbM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13153	uniprotkb:P63000	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689573|imex:IM-25801-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	comment:RAC-1 was GTP bound	figure legend:4C and 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rigid:vKR0D7KEjZgmpNUyu/odteXKhbM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13153	uniprotkb:Q03135	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689573|imex:IM-25801-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:4C and 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rigid:vKR0D7KEjZgmpNUyu/odteXKhbM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63000	uniprotkb:Q03135	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689581|imex:IM-25801-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	comment:RAC-1 was GTP bound	-	figure legend:4C, 5C and suppl. data 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rigid:e3S+mlDmGp0mj45eXwPbZAYNbQc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03135	uniprotkb:A0A0H3NGI8	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	intact:EBI-10686676|ensemblbacteria:CBW18776	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:a0a0h3ngi8_salts(display_long)|uniprotkb:sopE(gene name)|psi-mi:sopE(display_short)|uniprotkb:SL1344_2674(locus name)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:216597(salts)|taxid:216597("Salmonella typhimurium (strain SL1344)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689588|imex:IM-25801-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	refseq:WP_000161707.1|uniprotkb:E1WJI8(uniprot-removed-ac)|interpro:IPR005414(Salmonella type III secretion SopE effector protein)|interpro:IPR016018(Salmonella type III secretion SopE effector protein, N-terminal)|interpro:IPR016019(Salmonella type III secretion SopE effector protein, GEF domain)|ensemblbacteria:CBW18776(transcript)|ensemblbacteria:SL1344_2674(gene)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR035949	-	-	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:jMZa07tHdR7SmHb8YlAPYdvMMCM216597	rigid:+Nuy726NM7CsK2qIGJCPVZpD5y8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03135	uniprotkb:P63000	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689588|imex:IM-25801-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	comment:RAC-1 was GTP bound	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rigid:+Nuy726NM7CsK2qIGJCPVZpD5y8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13153	uniprotkb:P63000	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689595|imex:IM-25801-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	comment:RAC-1 was GTP bound	figure legend:4C, 5C, 5D and suppl. data 1|comment:NSC23766, Rac1 inhibitor, inhibit Rac1-cav1 interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rigid:2BMbjFUCKmoqiLeTUms4smrN1bo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13153	uniprotkb:Q03135	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689595|imex:IM-25801-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:4C, 5C, 5D and suppl. data 1|comment:NSC23766, Rac1 inhibitor, inhibit Rac1-cav1 interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rigid:2BMbjFUCKmoqiLeTUms4smrN1bo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13153	uniprotkb:A0A0H3NGI8	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-10686676|ensemblbacteria:CBW18776	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:a0a0h3ngi8_salts(display_long)|uniprotkb:sopE(gene name)|psi-mi:sopE(display_short)|uniprotkb:SL1344_2674(locus name)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:216597(salts)|taxid:216597("Salmonella typhimurium (strain SL1344)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689603|imex:IM-25801-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	refseq:WP_000161707.1|uniprotkb:E1WJI8(uniprot-removed-ac)|interpro:IPR005414(Salmonella type III secretion SopE effector protein)|interpro:IPR016018(Salmonella type III secretion SopE effector protein, N-terminal)|interpro:IPR016019(Salmonella type III secretion SopE effector protein, GEF domain)|ensemblbacteria:CBW18776(transcript)|ensemblbacteria:SL1344_2674(gene)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR035949	-	-	-	figure legend:suppl. data 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:jMZa07tHdR7SmHb8YlAPYdvMMCM216597	rigid:vKR0D7KEjZgmpNUyu/odteXKhbM	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13153	uniprotkb:P63000	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689603|imex:IM-25801-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	comment:RAC-1 was GTP bound	figure legend:suppl. data 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rigid:vKR0D7KEjZgmpNUyu/odteXKhbM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13153	uniprotkb:Q03135	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689603|imex:IM-25801-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:suppl. data 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rigid:vKR0D7KEjZgmpNUyu/odteXKhbM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A0A0H3NGI8	uniprotkb:Q03135	intact:EBI-10686676|ensemblbacteria:CBW18776	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:a0a0h3ngi8_salts(display_long)|uniprotkb:sopE(gene name)|psi-mi:sopE(display_short)|uniprotkb:SL1344_2674(locus name)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:216597(salts)|taxid:216597("Salmonella typhimurium (strain SL1344)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689612|imex:IM-25801-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000161707.1|uniprotkb:E1WJI8(uniprot-removed-ac)|interpro:IPR005414(Salmonella type III secretion SopE effector protein)|interpro:IPR016018(Salmonella type III secretion SopE effector protein, N-terminal)|interpro:IPR016019(Salmonella type III secretion SopE effector protein, GEF domain)|ensemblbacteria:CBW18776(transcript)|ensemblbacteria:SL1344_2674(gene)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR035949	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:suppl. data 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:jMZa07tHdR7SmHb8YlAPYdvMMCM216597	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rigid:+Nuy726NM7CsK2qIGJCPVZpD5y8	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A0A0H3NGI8	uniprotkb:P63000	intact:EBI-10686676|ensemblbacteria:CBW18776	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:a0a0h3ngi8_salts(display_long)|uniprotkb:sopE(gene name)|psi-mi:sopE(display_short)|uniprotkb:SL1344_2674(locus name)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2014)	imex:IM-25801|pubmed:24625804	taxid:216597(salts)|taxid:216597("Salmonella typhimurium (strain SL1344)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10689612|imex:IM-25801-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000161707.1|uniprotkb:E1WJI8(uniprot-removed-ac)|interpro:IPR005414(Salmonella type III secretion SopE effector protein)|interpro:IPR016018(Salmonella type III secretion SopE effector protein, N-terminal)|interpro:IPR016019(Salmonella type III secretion SopE effector protein, GEF domain)|ensemblbacteria:CBW18776(transcript)|ensemblbacteria:SL1344_2674(gene)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR035949	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	figure legend:suppl. data 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hdf)|taxid:9606(Homo sapiens diploid fibroblasts cells)	-	2015/02/28	2015/03/10	rogid:jMZa07tHdR7SmHb8YlAPYdvMMCM216597	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rigid:+Nuy726NM7CsK2qIGJCPVZpD5y8	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)