#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00403	uniprotkb:P49281-3	intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876	intact:EBI-10828817|ensembl:ENSP00000378364	psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym)	psi-mi:p49281-3(display_long)|uniprotkb:Divalent cation transporter 1(gene name synonym)|uniprotkb:Divalent metal transporter 1(gene name synonym)|uniprotkb:Solute carrier family 11 member 2(gene name synonym)|uniprotkb:OK/SW-cl.20(orf name)|uniprotkb:1A-IRE(isoform synonym)|uniprotkb:SLC11A2(gene name)|psi-mi:SLC11A2(display_short)|uniprotkb:DCT1(gene name synonym)|uniprotkb:DMT1(gene name synonym)|uniprotkb:NRAMP2(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Wolff et al. (2014)	imex:IM-24278|pubmed:24448823	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10826470|imex:IM-24278-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	intact:EBI-4319335(isoform-parent)|ensembl:ENSG00000110911(gene)|ensembl:ENST00000394904(transcript)	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/14	2015/06/04	rogid:NyMmciQe53E935KEZahz8cGPjIM9606	rogid:lj2miekXkfFDDLePXuAe3OxxDms9606	rigid:lxrG8PD2OYbCFJqV4saVCU+1lx0	false	nub:n-n	cub:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96B49	uniprotkb:P49281-3	intact:EBI-10826510|uniprotkb:B2DG15|uniprotkb:Q9UH52|ensembl:ENSP00000381856|ensembl:ENSP00000381859	intact:EBI-10828817|ensembl:ENSP00000378364	psi-mi:tom6_human(display_long)|uniprotkb:TOMM6(gene name)|psi-mi:TOMM6(display_short)|uniprotkb:Overexpressed breast tumor protein(gene name synonym)|uniprotkb:Translocase of outer membrane 6 kDa subunit homolog(gene name synonym)|uniprotkb:OBTP(gene name synonym)|uniprotkb:TOM6(gene name synonym)	psi-mi:p49281-3(display_long)|uniprotkb:Divalent cation transporter 1(gene name synonym)|uniprotkb:Divalent metal transporter 1(gene name synonym)|uniprotkb:Solute carrier family 11 member 2(gene name synonym)|uniprotkb:OK/SW-cl.20(orf name)|uniprotkb:1A-IRE(isoform synonym)|uniprotkb:SLC11A2(gene name)|psi-mi:SLC11A2(display_short)|uniprotkb:DCT1(gene name synonym)|uniprotkb:DMT1(gene name synonym)|uniprotkb:NRAMP2(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Wolff et al. (2014)	imex:IM-24278|pubmed:24448823	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10826530|imex:IM-24278-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127965.1|ensembl:ENSG00000214736(gene)|ensembl:ENST00000398881(transcript)|ensembl:ENST00000398884(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0015031"(protein transport)|interpro:IPR029182|mint:Q96B49|rcsb pdb:7CK6|rcsb pdb:7CP9|reactome:R-HSA-1268020|reactome:R-HSA-5205685	intact:EBI-4319335(isoform-parent)|ensembl:ENSG00000110911(gene)|ensembl:ENST00000394904(transcript)	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/05/14	2015/06/04	rogid:j3q/LBZ1XHboUAcHka+T8XtNsIM9606	rogid:lj2miekXkfFDDLePXuAe3OxxDms9606	rigid:JShBVz3ew+Ngk7EeUZ4qEQUNYo4	false	nub:n-n	cub:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P00403	uniprotkb:P49281	intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876	intact:EBI-4319335|uniprotkb:B3KT08|uniprotkb:O43288|uniprotkb:O60932|uniprotkb:O94801|uniprotkb:Q498Z5|uniprotkb:Q8IUD7|uniprotkb:Q96J35|uniprotkb:B4DK84|uniprotkb:F5H741|ensembl:ENSP00000446769|ensembl:ENSP00000449008|ensembl:ENSP00000494107	psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym)	psi-mi:nram2_human(display_long)|uniprotkb:SLC11A2(gene name)|psi-mi:SLC11A2(display_short)|uniprotkb:DCT1(gene name synonym)|uniprotkb:DMT1(gene name synonym)|uniprotkb:NRAMP2(gene name synonym)|uniprotkb:Divalent cation transporter 1(gene name synonym)|uniprotkb:Divalent metal transporter 1(gene name synonym)|uniprotkb:Solute carrier family 11 member 2(gene name synonym)|uniprotkb:OK/SW-cl.20(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wolff et al. (2014)	imex:IM-24278|pubmed:24448823	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10826573|imex:IM-24278-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	refseq:NP_000608.1|refseq:NP_001167596.1|refseq:NP_001167597.1|refseq:NP_001167598.1|refseq:NP_001167599.1|refseq:NP_001167600.1|refseq:XP_005268968.1|refseq:XP_011536706.1|refseq:XP_011536707.1|refseq:NP_001167601.1|refseq:XP_016874844.1|ensembl:ENSG00000110911(gene)|ensembl:ENST00000546636(transcript)|ensembl:ENST00000547198(transcript)|ensembl:ENST00000644495(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003032"(detection of oxygen)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006824"(cobalt ion transport)|go:"GO:0006825"(copper ion transport)|go:"GO:0006826"(iron ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007611"(learning or memory)|go:"GO:0009986"(cell surface)|go:"GO:0010039"(response to iron ion)|go:"GO:0015086"(cadmium ion transmembrane transporter activity)|go:"GO:0015087"(cobalt ion transmembrane transporter activity)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0015094"(lead ion transmembrane transporter activity)|go:"GO:0015099"(nickel cation transmembrane transporter activity)|go:"GO:0015100"(vanadium ion transmembrane transporter activity)|go:"GO:0015295"("solute:proton symporter activity")|go:"GO:0015675"(nickel cation transport)|go:"GO:0015676"(vanadium ion transport)|go:"GO:0015692"(lead ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022890"(inorganic cation transmembrane transporter activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031526"(brush border membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033212"(iron import into cell)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0046915"(transition metal ion transmembrane transporter activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048821"(erythrocyte development)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0055037"(recycling endosome)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:0070574"(cadmium ion transmembrane transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070826"(paraferritin complex)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001046(Natural resistance-associated macrophage protein)|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:7BLO|rcsb pdb:7BLQ|reactome:R-HSA-425410|reactome:R-HSA-5619048|reactome:R-HSA-917937|dip:DIP-48957N	-	-	-	figure legend:Fig 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line)	-	2015/05/14	2015/06/09	rogid:NyMmciQe53E935KEZahz8cGPjIM9606	rogid:qCceFR102Qx1A3Av7qwS6Qlp4pE9606	rigid:klx7ceFOIUpgfiLUZQOPOgMH+nE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00403	uniprotkb:P49281-3	intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876	intact:EBI-10828817|ensembl:ENSP00000378364	psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym)	psi-mi:p49281-3(display_long)|uniprotkb:Divalent cation transporter 1(gene name synonym)|uniprotkb:Divalent metal transporter 1(gene name synonym)|uniprotkb:Solute carrier family 11 member 2(gene name synonym)|uniprotkb:OK/SW-cl.20(orf name)|uniprotkb:1A-IRE(isoform synonym)|uniprotkb:SLC11A2(gene name)|psi-mi:SLC11A2(display_short)|uniprotkb:DCT1(gene name synonym)|uniprotkb:DMT1(gene name synonym)|uniprotkb:NRAMP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wolff et al. (2014)	imex:IM-24278|pubmed:24448823	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10842329|imex:IM-24278-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	intact:EBI-4319335(isoform-parent)|ensembl:ENSG00000110911(gene)|ensembl:ENST00000394904(transcript)	-	-	-	figure legend:Fig 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line)	-	2015/05/14	2015/06/09	rogid:NyMmciQe53E935KEZahz8cGPjIM9606	rogid:lj2miekXkfFDDLePXuAe3OxxDms9606	rigid:lxrG8PD2OYbCFJqV4saVCU+1lx0	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)